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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for LMX1B_MNX1_RAX2

Z-value: 0.78

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Transcription factors associated with LMX1B_MNX1_RAX2

Gene Symbol Gene ID Gene Info
ENSG00000136944.13 LIM homeobox transcription factor 1 beta
ENSG00000130675.10 motor neuron and pancreas homeobox 1
ENSG00000173976.11 retina and anterior neural fold homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RAX2hg19_v2_chr19_-_3772209_3772236-0.372.5e-08Click!
LMX1Bhg19_v2_chr9_+_129376722_129376748-0.228.7e-04Click!
MNX1hg19_v2_chr7_-_156803329_1568033620.036.2e-01Click!

Activity profile of LMX1B_MNX1_RAX2 motif

Sorted Z-values of LMX1B_MNX1_RAX2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_+_169418195 26.05 ENST00000261509.6
ENST00000335742.7
palladin, cytoskeletal associated protein
chr2_-_136678123 15.97 ENST00000422708.1
aspartyl-tRNA synthetase
chr12_+_28410128 15.15 ENST00000381259.1
ENST00000381256.1
coiled-coil domain containing 91
chr12_-_52967600 13.11 ENST00000549343.1
ENST00000305620.2
keratin 74
chr15_-_37393406 11.10 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
Meis homeobox 2
chr7_+_134464414 10.12 ENST00000361901.2
caldesmon 1
chr7_-_107642348 10.08 ENST00000393561.1
laminin, beta 1
chr7_+_77428149 9.60 ENST00000415251.2
ENST00000275575.7
putative homeodomain transcription factor 2
chr3_-_141747950 9.20 ENST00000497579.1
transcription factor Dp-2 (E2F dimerization partner 2)
chrX_-_106243451 9.01 ENST00000355610.4
ENST00000535534.1
MORC family CW-type zinc finger 4
chr2_-_176046391 8.94 ENST00000392541.3
ENST00000409194.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr3_+_130569429 8.90 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATPase, Ca++ transporting, type 2C, member 1
chr7_+_134464376 8.88 ENST00000454108.1
ENST00000361675.2
caldesmon 1
chr1_+_68150744 8.43 ENST00000370986.4
ENST00000370985.3
growth arrest and DNA-damage-inducible, alpha
chr9_+_12693336 8.18 ENST00000381137.2
ENST00000388918.5
tyrosinase-related protein 1
chrX_-_10851762 7.43 ENST00000380785.1
ENST00000380787.1
midline 1 (Opitz/BBB syndrome)
chr15_+_80351910 7.11 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr7_+_77428066 6.56 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
putative homeodomain transcription factor 2
chr17_+_47448102 6.48 ENST00000576461.1
Uncharacterized protein
chr17_-_77924627 6.41 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1 domain family, member 16
chr8_+_26150628 6.25 ENST00000523925.1
ENST00000315985.7
protein phosphatase 2, regulatory subunit B, alpha
chr3_-_149293990 6.10 ENST00000472417.1
WW domain containing transcription regulator 1
chr4_+_169013666 5.89 ENST00000359299.3
annexin A10
chr2_-_207023918 5.89 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr3_-_49066811 5.69 ENST00000442157.1
ENST00000326739.4
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr5_+_174151536 5.44 ENST00000239243.6
ENST00000507785.1
msh homeobox 2
chr2_-_207024134 5.31 ENST00000457011.1
ENST00000440274.1
ENST00000432169.1
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr12_-_54653313 5.07 ENST00000550411.1
ENST00000439541.2
chromobox homolog 5
chr6_-_32157947 5.03 ENST00000375050.4
pre-B-cell leukemia homeobox 2
chr2_-_61697862 4.86 ENST00000398571.2
ubiquitin specific peptidase 34
chr2_+_109204743 4.80 ENST00000332345.6
LIM and senescent cell antigen-like domains 1
chr2_+_109237717 4.76 ENST00000409441.1
LIM and senescent cell antigen-like domains 1
chr4_+_41614720 4.72 ENST00000509277.1
LIM and calponin homology domains 1
chr17_-_39191107 4.68 ENST00000344363.5
keratin associated protein 1-3
chr2_+_187454749 4.59 ENST00000261023.3
ENST00000374907.3
integrin, alpha V
chr17_-_64225508 4.36 ENST00000205948.6
apolipoprotein H (beta-2-glycoprotein I)
chr4_-_25865159 4.28 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
sel-1 suppressor of lin-12-like 3 (C. elegans)
chrX_-_153602991 4.04 ENST00000369850.3
ENST00000422373.1
filamin A, alpha
chr15_+_75080883 4.02 ENST00000567571.1
c-src tyrosine kinase
chr18_-_33709268 3.93 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
solute carrier family 39 (zinc transporter), member 6
chr1_-_149900122 3.79 ENST00000271628.8
splicing factor 3b, subunit 4, 49kDa
chr12_+_49621658 3.62 ENST00000541364.1
tubulin, alpha 1c
chr7_-_25268104 3.57 ENST00000222674.2
neuropeptide VF precursor
chr12_-_14133053 3.56 ENST00000609686.1
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr3_-_151034734 3.41 ENST00000260843.4
G protein-coupled receptor 87
chr7_-_27169801 3.40 ENST00000511914.1
homeobox A4
chr12_-_28123206 3.25 ENST00000542963.1
ENST00000535992.1
parathyroid hormone-like hormone
chr4_-_139163491 3.23 ENST00000280612.5
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr4_-_143227088 3.19 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr2_-_207024233 3.17 ENST00000423725.1
ENST00000233190.6
NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
chr4_-_39979576 3.16 ENST00000303538.8
ENST00000503396.1
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr7_-_23510086 3.11 ENST00000258729.3
insulin-like growth factor 2 mRNA binding protein 3
chr12_-_28122980 3.05 ENST00000395868.3
ENST00000534890.1
parathyroid hormone-like hormone
chr12_+_20963647 3.04 ENST00000381545.3
solute carrier organic anion transporter family, member 1B3
chr3_+_173116225 2.96 ENST00000457714.1
neuroligin 1
chr12_+_20963632 2.96 ENST00000540853.1
ENST00000261196.2
solute carrier organic anion transporter family, member 1B3
chr3_-_79816965 2.66 ENST00000464233.1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chrX_-_153599578 2.64 ENST00000360319.4
ENST00000344736.4
filamin A, alpha
chr3_-_157824292 2.60 ENST00000483851.2
short stature homeobox 2
chr1_+_154229547 2.60 ENST00000428595.1
ubiquitin associated protein 2-like
chr15_+_44092784 2.60 ENST00000458412.1
huntingtin interacting protein K
chr6_-_41039567 2.59 ENST00000468811.1
O-acyl-ADP-ribose deacylase 1
chr7_+_138145076 2.48 ENST00000343526.4
tripartite motif containing 24
chr5_+_95066823 2.46 ENST00000506817.1
ENST00000379982.3
Rho-related BTB domain containing 3
chr19_+_13049413 2.38 ENST00000316448.5
ENST00000588454.1
calreticulin
chr17_+_42634844 2.35 ENST00000315323.3
frizzled family receptor 2
chr19_+_48949030 2.31 ENST00000253237.5
glutamate-rich WD repeat containing 1
chr13_-_95131923 2.30 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chr8_+_22424551 2.29 ENST00000523348.1
sorbin and SH3 domain containing 3
chr4_+_41614909 2.28 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIM and calponin homology domains 1
chr21_-_35284635 2.26 ENST00000429238.1
AP000304.12
chr1_-_39347255 2.24 ENST00000454994.2
ENST00000357771.3
gap junction protein, alpha 9, 59kDa
chrX_+_105937068 2.18 ENST00000324342.3
ring finger protein 128, E3 ubiquitin protein ligase
chr12_-_86650077 2.18 ENST00000552808.2
ENST00000547225.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr7_-_99716952 2.15 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr18_-_71959159 2.14 ENST00000494131.2
ENST00000397914.4
ENST00000340533.4
cytochrome b5 type A (microsomal)
chr16_+_69345243 2.12 ENST00000254950.11
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr12_+_41831485 2.09 ENST00000539469.2
ENST00000298919.7
PDZ domain containing ring finger 4
chr4_+_169418255 2.08 ENST00000505667.1
ENST00000511948.1
palladin, cytoskeletal associated protein
chrX_+_46771711 2.08 ENST00000424392.1
ENST00000397189.1
jade family PHD finger 3
chr1_-_68698197 2.06 ENST00000370973.2
ENST00000370971.1
wntless Wnt ligand secretion mediator
chr15_-_55563072 2.05 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A, member RAS oncogene family
chr6_+_12290586 2.00 ENST00000379375.5
endothelin 1
chr7_+_55433131 1.96 ENST00000254770.2
LanC lantibiotic synthetase component C-like 2 (bacterial)
chr10_-_48416849 1.94 ENST00000249598.1
growth differentiation factor 2
chr4_-_143226979 1.93 ENST00000514525.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr14_-_38064198 1.91 ENST00000250448.2
forkhead box A1
chr17_+_39240459 1.86 ENST00000391417.4
keratin associated protein 4-7
chr14_-_51027838 1.82 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr3_+_141106643 1.79 ENST00000514251.1
zinc finger and BTB domain containing 38
chr4_-_105416039 1.79 ENST00000394767.2
CXXC finger protein 4
chrX_-_18690210 1.71 ENST00000379984.3
retinoschisin 1
chr5_+_176811431 1.69 ENST00000512593.1
ENST00000324417.5
solute carrier family 34 (type II sodium/phosphate contransporter), member 1
chr3_-_113897545 1.65 ENST00000467632.1
dopamine receptor D3
chr2_+_27440229 1.63 ENST00000264705.4
ENST00000403525.1
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr5_+_119867159 1.61 ENST00000505123.1
proline rich 16
chr20_+_30697298 1.60 ENST00000398022.2
transmembrane 9 superfamily protein member 4
chr4_-_186696425 1.59 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
sorbin and SH3 domain containing 2
chr15_+_80351977 1.57 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
zinc finger, AN1-type domain 6
chr3_-_167191814 1.55 ENST00000466903.1
ENST00000264677.4
serpin peptidase inhibitor, clade I (pancpin), member 2
chr1_-_101360331 1.52 ENST00000416479.1
ENST00000370113.3
exostosin-like glycosyltransferase 2
chr15_-_55562479 1.52 ENST00000564609.1
RAB27A, member RAS oncogene family
chr5_+_125758865 1.43 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr17_-_10372875 1.42 ENST00000255381.2
myosin, heavy chain 4, skeletal muscle
chr3_-_108248169 1.40 ENST00000273353.3
myosin, heavy chain 15
chr12_-_56694142 1.39 ENST00000550655.1
ENST00000548567.1
ENST00000551430.2
ENST00000351328.3
citrate synthase
chr6_-_87804815 1.36 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chrX_-_110655306 1.34 ENST00000371993.2
doublecortin
chr8_-_99129338 1.33 ENST00000520507.1
heat-responsive protein 12
chr5_+_125758813 1.30 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr4_+_37962018 1.29 ENST00000504686.1
pituitary tumor-transforming 2
chr3_+_157827841 1.29 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
arginine/serine-rich coiled-coil 1
chr1_-_190446759 1.27 ENST00000367462.3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr5_+_179159813 1.26 ENST00000292599.3
mastermind-like 1 (Drosophila)
chr4_-_66536057 1.25 ENST00000273854.3
EPH receptor A5
chr3_-_113897899 1.24 ENST00000383673.2
ENST00000295881.7
dopamine receptor D3
chr1_-_227505289 1.21 ENST00000366765.3
CDC42 binding protein kinase alpha (DMPK-like)
chr18_-_47018769 1.19 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
ribosomal protein L17
chr1_-_237167718 1.19 ENST00000464121.2
metallothionein 1H-like 1
chr17_-_60142609 1.19 ENST00000397786.2
mediator complex subunit 13
chr7_+_23286182 1.17 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
glycoprotein (transmembrane) nmb
chr4_-_116034979 1.17 ENST00000264363.2
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr19_+_30433372 1.16 ENST00000312051.6
URI1, prefoldin-like chaperone
chr1_-_68698222 1.15 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
wntless Wnt ligand secretion mediator
chr1_-_94586651 1.11 ENST00000535735.1
ENST00000370225.3
ATP-binding cassette, sub-family A (ABC1), member 4
chr4_+_88529681 1.10 ENST00000399271.1
dentin sialophosphoprotein
chr18_-_3219847 1.08 ENST00000261606.7
myomesin 1
chr4_-_66536196 1.08 ENST00000511294.1
EPH receptor A5
chr17_-_56296580 1.07 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
Meckel syndrome, type 1
chr2_-_216946500 1.05 ENST00000265322.7
peroxisomal trans-2-enoyl-CoA reductase
chr7_-_5998714 1.02 ENST00000539903.1
radial spoke head 10 homolog B (Chlamydomonas)
chr18_-_47018869 1.02 ENST00000583036.1
ENST00000580261.1
ribosomal protein L17
chr14_-_78083112 0.99 ENST00000216484.2
serine palmitoyltransferase, long chain base subunit 2
chr14_-_25479811 0.99 ENST00000550887.1
syntaxin binding protein 6 (amisyn)
chr13_+_53602894 0.99 ENST00000219022.2
olfactomedin 4
chr12_-_10955226 0.97 ENST00000240687.2
taste receptor, type 2, member 7
chr12_-_10978957 0.95 ENST00000240619.2
taste receptor, type 2, member 10
chr18_-_47018897 0.95 ENST00000418495.1
ribosomal protein L17
chr15_-_31393910 0.92 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
transient receptor potential cation channel, subfamily M, member 1
chrX_+_78003204 0.90 ENST00000435339.3
ENST00000514744.1
lysophosphatidic acid receptor 4
chr8_-_93107696 0.89 ENST00000436581.2
ENST00000520583.1
ENST00000519061.1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr12_-_14849470 0.86 ENST00000261170.3
guanylate cyclase 2C (heat stable enterotoxin receptor)
chr12_-_86650045 0.85 ENST00000604798.1
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr14_-_36988882 0.85 ENST00000498187.2
NK2 homeobox 1
chr7_-_87342564 0.85 ENST00000265724.3
ENST00000416177.1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr6_+_46761118 0.85 ENST00000230588.4
meprin A, alpha (PABA peptide hydrolase)
chr12_-_91398796 0.85 ENST00000261172.3
ENST00000551767.1
epiphycan
chr7_-_14029283 0.84 ENST00000433547.1
ENST00000405192.2
ets variant 1
chr6_-_111927449 0.84 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
TRAF3 interacting protein 2
chr19_-_51522955 0.83 ENST00000358789.3
kallikrein-related peptidase 10
chr6_+_151646800 0.83 ENST00000354675.6
A kinase (PRKA) anchor protein 12
chr1_+_62439037 0.82 ENST00000545929.1
InaD-like (Drosophila)
chr2_-_190927447 0.80 ENST00000260950.4
myostatin
chr1_-_204135450 0.80 ENST00000272190.8
ENST00000367195.2
renin
chr11_-_30608413 0.77 ENST00000528686.1
metallophosphoesterase domain containing 2
chr14_+_72052983 0.77 ENST00000358550.2
signal-induced proliferation-associated 1 like 1
chr7_-_99717463 0.76 ENST00000437822.2
TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr5_+_31193847 0.74 ENST00000514738.1
ENST00000265071.2
cadherin 6, type 2, K-cadherin (fetal kidney)
chr1_+_74701062 0.73 ENST00000326637.3
TNNI3 interacting kinase
chr20_+_18447771 0.69 ENST00000377603.4
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chrX_+_99839799 0.68 ENST00000373031.4
tenomodulin
chr12_-_53171128 0.67 ENST00000332411.2
keratin 76
chr18_-_3220106 0.67 ENST00000356443.4
ENST00000400569.3
myomesin 1
chr1_-_186430222 0.65 ENST00000391997.2
phosducin
chr14_+_22739823 0.63 ENST00000390464.2
T cell receptor alpha variable 38-1
chrX_-_71458802 0.61 ENST00000373657.1
ENST00000334463.3
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
chr15_+_69452959 0.60 ENST00000261858.2
glucuronic acid epimerase
chr1_+_160160346 0.56 ENST00000368078.3
calsequestrin 1 (fast-twitch, skeletal muscle)
chr17_-_79876010 0.55 ENST00000328666.6
sirtuin 7
chr13_-_44735393 0.55 ENST00000400419.1
small integral membrane protein 2
chr5_-_145562147 0.53 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
leucyl-tRNA synthetase
chr15_-_55562582 0.53 ENST00000396307.2
RAB27A, member RAS oncogene family
chr1_-_24469602 0.51 ENST00000270800.1
interleukin 22 receptor, alpha 1
chr4_+_69313145 0.50 ENST00000305363.4
transmembrane protease, serine 11E
chr17_-_38859996 0.49 ENST00000264651.2
keratin 24
chr8_+_24298531 0.48 ENST00000175238.6
ADAM metallopeptidase domain 7
chr8_-_42234745 0.47 ENST00000220812.2
dickkopf WNT signaling pathway inhibitor 4
chr13_-_36050819 0.46 ENST00000379919.4
mab-21-like 1 (C. elegans)
chr15_-_68497657 0.45 ENST00000448060.2
ENST00000467889.1
calmodulin-like 4
chr17_+_72427477 0.45 ENST00000342648.5
ENST00000481232.1
G protein-coupled receptor, family C, group 5, member C
chr3_-_52090461 0.43 ENST00000296483.6
ENST00000495880.1
dual specificity phosphatase 7
chr10_-_96829246 0.41 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
cytochrome P450, family 2, subfamily C, polypeptide 8
chr1_+_210501589 0.41 ENST00000413764.2
ENST00000541565.1
hedgehog acyltransferase
chr2_-_145278475 0.40 ENST00000558170.2
zinc finger E-box binding homeobox 2
chr1_+_155023757 0.40 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
ADAM metallopeptidase domain 15
chr2_-_163008903 0.40 ENST00000418842.2
ENST00000375497.3
glucagon
chr8_-_99129384 0.40 ENST00000521560.1
ENST00000254878.3
heat-responsive protein 12
chr6_+_153071925 0.39 ENST00000367244.3
ENST00000367243.3
vasoactive intestinal peptide
chr12_-_53994805 0.37 ENST00000328463.7
activating transcription factor 7
chr8_+_101170563 0.37 ENST00000520508.1
ENST00000388798.2
sperm associated antigen 1
chr1_+_214161272 0.35 ENST00000498508.2
ENST00000366958.4
prospero homeobox 1
chr11_+_33061543 0.34 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
t-complex 11, testis-specific-like 1
chr16_+_57279004 0.33 ENST00000219204.3
ADP-ribosylation factor-like 2 binding protein
chr17_-_39623681 0.33 ENST00000225899.3
keratin 32
chr8_+_24298597 0.33 ENST00000380789.1
ADAM metallopeptidase domain 7
chr3_+_158787041 0.31 ENST00000471575.1
ENST00000476809.1
ENST00000485419.1
IQCJ-SCHIP1 readthrough
chr2_-_100987007 0.31 ENST00000595083.1
Uncharacterized protein
chr3_+_15045419 0.31 ENST00000406272.2
nuclear receptor subfamily 2, group C, member 2
chr19_+_1440838 0.30 ENST00000594262.1
Uncharacterized protein
chr19_-_46088068 0.30 ENST00000263275.4
ENST00000323060.3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)

Network of associatons between targets according to the STRING database.

First level regulatory network of LMX1B_MNX1_RAX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.3 16.0 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
2.5 10.1 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.8 5.4 GO:0051795 positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427)
1.5 8.9 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
1.3 15.1 GO:0090160 Golgi to lysosome transport(GO:0090160)
1.2 28.1 GO:0003334 keratinocyte development(GO:0003334)
1.1 4.6 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
1.1 6.7 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
1.1 3.2 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
1.0 3.0 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.9 5.7 GO:0006177 GMP biosynthetic process(GO:0006177)
0.9 8.5 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.9 2.7 GO:0021823 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.8 4.0 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.7 2.9 GO:0050883 negative regulation of sodium:proton antiporter activity(GO:0032416) gastric motility(GO:0035482) gastric emptying(GO:0035483) musculoskeletal movement, spinal reflex action(GO:0050883)
0.7 2.1 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878) ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.7 4.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.7 0.7 GO:0035992 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.7 2.0 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.6 4.4 GO:1901419 regulation of response to alcohol(GO:1901419)
0.6 6.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.6 7.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.6 1.7 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.5 1.6 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.5 1.9 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.4 10.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.4 2.6 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.4 1.3 GO:0060920 atrioventricular node development(GO:0003162) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.4 2.4 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.4 4.4 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.4 3.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.4 1.5 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.4 3.6 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.3 6.2 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.3 2.3 GO:0003150 muscular septum morphogenesis(GO:0003150)
0.3 8.7 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.3 2.3 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.3 1.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.3 8.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.3 13.1 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.3 0.8 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) negative regulation of skeletal muscle cell proliferation(GO:0014859) regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.3 6.3 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.2 1.0 GO:1904502 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.2 2.2 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.2 2.6 GO:2000172 regulation of branching morphogenesis of a nerve(GO:2000172)
0.2 0.5 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.2 9.6 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.2 1.7 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.2 0.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 1.8 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.2 12.6 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 4.9 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 3.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 0.6 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.2 3.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.2 0.5 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425) valyl-tRNA aminoacylation(GO:0006438)
0.2 9.2 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 3.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.2 0.8 GO:0021759 globus pallidus development(GO:0021759)
0.2 4.7 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 0.6 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.2 3.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 1.7 GO:0009642 response to light intensity(GO:0009642)
0.2 1.1 GO:1990403 embryonic brain development(GO:1990403)
0.2 11.1 GO:0008542 visual learning(GO:0008542)
0.1 6.0 GO:0001919 regulation of receptor recycling(GO:0001919)
0.1 2.1 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 1.0 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 6.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 0.4 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.1 1.6 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.8 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.1 2.3 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.1 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 1.9 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 1.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.3 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 0.3 GO:1990637 response to prolactin(GO:1990637)
0.1 3.6 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 2.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 0.2 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 0.4 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.1 0.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.1 0.2 GO:1900133 regulation of renin secretion into blood stream(GO:1900133)
0.1 1.9 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 0.8 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 5.1 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 0.4 GO:0002933 lipid hydroxylation(GO:0002933)
0.1 0.9 GO:0046548 retinal rod cell development(GO:0046548)
0.1 6.1 GO:0031424 keratinization(GO:0031424)
0.0 1.4 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.7 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 1.1 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 1.3 GO:0016486 peptide hormone processing(GO:0016486)
0.0 1.2 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.8 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.5 GO:0043010 camera-type eye development(GO:0043010)
0.0 0.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 2.9 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 0.4 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 1.2 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.0 1.2 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.8 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 1.3 GO:0045143 homologous chromosome segregation(GO:0045143)
0.0 0.2 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:0018345 protein palmitoylation(GO:0018345)
0.0 11.6 GO:0006936 muscle contraction(GO:0006936)
0.0 0.3 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.8 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.0 3.6 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 1.9 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 3.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.0 1.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.3 GO:0051457 maintenance of protein location in nucleus(GO:0051457)
0.0 0.3 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 2.5 GO:0008584 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 1.2 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 2.5 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.9 GO:0050821 protein stabilization(GO:0050821)
0.0 0.3 GO:0046337 phosphatidylethanolamine metabolic process(GO:0046337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0005607 laminin-2 complex(GO:0005607)
2.9 14.4 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
2.2 6.7 GO:0031523 Myb complex(GO:0031523)
1.5 4.6 GO:0034686 integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
1.3 19.0 GO:0030478 actin cap(GO:0030478)
0.8 14.6 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.8 16.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.5 26.3 GO:0002102 podosome(GO:0002102)
0.5 2.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 8.9 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.5 2.5 GO:0005726 perichromatin fibrils(GO:0005726)
0.4 1.7 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.4 6.5 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 19.3 GO:0045095 keratin filament(GO:0045095)
0.3 2.4 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.3 1.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2 1.0 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 4.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 5.1 GO:0010369 chromocenter(GO:0010369)
0.2 0.9 GO:0035838 growing cell tip(GO:0035838)
0.2 6.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 2.1 GO:0000815 ESCRT III complex(GO:0000815)
0.2 2.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 3.8 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 2.9 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 2.9 GO:0032982 myosin filament(GO:0032982)
0.1 2.2 GO:0005922 connexon complex(GO:0005922)
0.1 7.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 28.2 GO:0005802 trans-Golgi network(GO:0005802)
0.1 3.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.7 GO:0014802 terminal cisterna(GO:0014802)
0.1 6.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.1 GO:0036038 MKS complex(GO:0036038)
0.1 5.8 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 2.3 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 0.7 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.0 GO:0000145 exocyst(GO:0000145)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 1.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 1.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 15.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 14.2 GO:0016607 nuclear speck(GO:0016607)
0.0 3.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.3 GO:0031526 brush border membrane(GO:0031526)
0.0 1.9 GO:0005902 microvillus(GO:0005902)
0.0 2.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 13.5 GO:0005925 focal adhesion(GO:0005925)
0.0 7.0 GO:0005769 early endosome(GO:0005769)
0.0 1.6 GO:0043195 terminal bouton(GO:0043195)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 1.2 GO:0042641 actomyosin(GO:0042641)
0.0 1.0 GO:0005882 intermediate filament(GO:0005882)
0.0 0.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.0 2.2 GO:0005770 late endosome(GO:0005770)
0.0 2.8 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 1.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 2.6 GO:0030139 endocytic vesicle(GO:0030139)
0.0 1.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.8 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 2.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.1 GO:0016013 syntrophin complex(GO:0016013)
0.0 1.8 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 16.0 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
2.2 13.1 GO:1990254 keratin filament binding(GO:1990254)
1.7 6.7 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.4 5.7 GO:0003938 IMP dehydrogenase activity(GO:0003938)
1.3 29.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
1.0 5.1 GO:0017161 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.9 4.4 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.7 14.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.7 19.0 GO:0005523 tropomyosin binding(GO:0005523)
0.7 3.3 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.6 4.6 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.5 1.6 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.4 2.7 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 3.0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.4 2.9 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.4 2.0 GO:0031708 endothelin B receptor binding(GO:0031708)
0.4 3.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.4 2.3 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.4 3.7 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.4 4.9 GO:0030280 structural constituent of epidermis(GO:0030280)
0.4 1.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.3 1.0 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.3 8.9 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.3 6.2 GO:0048156 tau protein binding(GO:0048156)
0.3 6.3 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.3 8.9 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 1.5 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.3 2.4 GO:0001849 complement component C1q binding(GO:0001849)
0.3 3.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.3 1.4 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 6.0 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.3 2.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 2.5 GO:0034056 estrogen response element binding(GO:0034056)
0.2 3.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 1.7 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.2 2.9 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.2 3.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 8.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.2 1.2 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.2 0.6 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.2 0.5 GO:0004819 glutamine-tRNA ligase activity(GO:0004819) valine-tRNA ligase activity(GO:0004832)
0.2 1.9 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 3.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 0.8 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.2 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 4.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 4.1 GO:0031489 myosin V binding(GO:0031489)
0.1 0.7 GO:0031013 troponin I binding(GO:0031013)
0.1 2.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 0.6 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 1.2 GO:0045545 syndecan binding(GO:0045545)
0.1 5.9 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 2.3 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 1.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.9 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 7.0 GO:0005507 copper ion binding(GO:0005507)
0.1 2.3 GO:0017166 vinculin binding(GO:0017166)
0.1 3.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 8.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.4 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1 1.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.9 GO:0015643 toxic substance binding(GO:0015643)
0.1 2.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 5.1 GO:0035064 methylated histone binding(GO:0035064)
0.1 1.8 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.2 GO:0008502 melatonin receptor activity(GO:0008502)
0.1 1.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 4.9 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 0.8 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 2.6 GO:0019213 deacetylase activity(GO:0019213)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 2.6 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 1.0 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0 5.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.3 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.8 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 12.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 2.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.4 GO:0000146 microfilament motor activity(GO:0000146)
0.0 6.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.8 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 13.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.3 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 0.7 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 0.1 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 5.3 GO:0001047 core promoter binding(GO:0001047)
0.0 1.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 15.7 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.2 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.4 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 1.8 GO:0005179 hormone activity(GO:0005179)
0.0 6.3 GO:0008134 transcription factor binding(GO:0008134)
0.0 3.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.3 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 2.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 2.2 GO:0030414 peptidase inhibitor activity(GO:0030414)
0.0 2.2 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 4.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 8.4 PID AURORA A PATHWAY Aurora A signaling
0.1 6.7 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 4.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 9.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 13.5 PID E2F PATHWAY E2F transcription factor network
0.1 3.6 PID REELIN PATHWAY Reelin signaling pathway
0.1 1.9 PID ALK1 PATHWAY ALK1 signaling events
0.1 4.0 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 6.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 2.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.1 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.1 0.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 10.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 2.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.8 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 2.0 PID ENDOTHELIN PATHWAY Endothelins
0.0 1.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 1.8 PID TNF PATHWAY TNF receptor signaling pathway
0.0 4.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 2.1 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.0 1.2 PID CDC42 PATHWAY CDC42 signaling events
0.0 0.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 0.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 0.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 16.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 6.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.3 9.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 5.1 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.3 5.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3 21.3 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 3.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.2 3.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 4.6 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 6.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.2 2.4 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 4.0 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 4.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 12.6 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 7.6 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 3.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 3.0 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 2.2 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.1 1.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.1 2.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 6.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 3.2 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 11.4 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 1.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 2.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.8 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 3.8 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 7.3 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 0.7 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.6 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 2.1 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 3.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 3.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 2.6 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 1.3 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport