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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MAX_TFEB

Z-value: 2.55

Motif logo

Transcription factors associated with MAX_TFEB

Gene Symbol Gene ID Gene Info
ENSG00000125952.14 MYC associated factor X
ENSG00000112561.13 transcription factor EB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TFEBhg19_v2_chr6_-_41701581_41701613-0.767.3e-43Click!
MAXhg19_v2_chr14_-_65569186_655692430.385.9e-09Click!

Activity profile of MAX_TFEB motif

Sorted Z-values of MAX_TFEB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_58146128 303.08 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
cyclin-dependent kinase 4
chr12_-_58146048 295.02 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
cyclin-dependent kinase 4
chr4_-_100871506 104.28 ENST00000296417.5
H2A histone family, member Z
chr8_+_98656336 95.75 ENST00000336273.3
metadherin
chr2_+_216176540 89.25 ENST00000236959.9
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr6_-_109703600 88.98 ENST00000512821.1
CD164 molecule, sialomucin
chr20_+_44520009 85.04 ENST00000607482.1
ENST00000372459.2
cathepsin A
chr20_+_44519948 81.98 ENST00000354880.5
ENST00000191018.5
cathepsin A
chr6_-_33385854 81.60 ENST00000488478.1
cutA divalent cation tolerance homolog (E. coli)
chr2_+_216176761 80.64 ENST00000540518.1
ENST00000435675.1
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr4_-_99850243 80.55 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
eukaryotic translation initiation factor 4E
chr1_+_44440575 80.41 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr4_-_47465666 78.60 ENST00000381571.4
COMM domain containing 8
chr2_-_10587897 76.21 ENST00000405333.1
ENST00000443218.1
ornithine decarboxylase 1
chr19_+_5681153 71.74 ENST00000579559.1
ENST00000577222.1
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chrX_-_100662881 70.74 ENST00000218516.3
galactosidase, alpha
chr14_+_20923350 66.08 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr3_+_158519654 65.50 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr6_-_33385655 64.53 ENST00000440279.3
ENST00000607266.1
cutA divalent cation tolerance homolog (E. coli)
chr6_-_109703663 61.35 ENST00000368961.5
CD164 molecule, sialomucin
chr8_+_98656693 60.68 ENST00000519934.1
metadherin
chr1_-_183604794 58.47 ENST00000367534.1
ENST00000359856.6
ENST00000294742.6
actin related protein 2/3 complex, subunit 5, 16kDa
chr6_+_160390102 57.23 ENST00000356956.1
insulin-like growth factor 2 receptor
chr12_-_2986107 57.17 ENST00000359843.3
ENST00000342628.2
ENST00000361953.3
forkhead box M1
chr6_-_33385823 56.19 ENST00000494751.1
ENST00000374496.3
cutA divalent cation tolerance homolog (E. coli)
chr1_+_33116765 54.97 ENST00000544435.1
ENST00000373485.1
ENST00000458695.2
ENST00000490500.1
ENST00000445722.2
retinoblastoma binding protein 4
chr17_-_46688334 54.87 ENST00000239165.7
homeobox B7
chr19_+_8509842 54.26 ENST00000325495.4
ENST00000600092.1
ENST00000594907.1
ENST00000596984.1
ENST00000601645.1
heterogeneous nuclear ribonucleoprotein M
chr5_+_65440032 54.22 ENST00000334121.6
splicing regulatory glutamine/lysine-rich protein 1
chr9_-_34048873 51.92 ENST00000449054.1
ENST00000379239.4
ENST00000539807.1
ENST00000379238.1
ENST00000418786.2
ENST00000360802.1
ENST00000412543.1
ubiquitin associated protein 2
chr11_-_64014379 51.55 ENST00000309318.3
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr10_-_120840309 50.34 ENST00000369144.3
eukaryotic translation initiation factor 3, subunit A
chr12_-_56709786 49.98 ENST00000547423.1
ENST00000548360.1
ENST00000551475.1
Uncharacterized protein
canopy FGF signaling regulator 2
chrX_+_23685653 48.81 ENST00000379331.3
peroxiredoxin 4
chr6_-_33385870 48.34 ENST00000488034.1
cutA divalent cation tolerance homolog (E. coli)
chr12_+_56110247 48.13 ENST00000551926.1
biogenesis of lysosomal organelles complex-1, subunit 1
chr21_-_46237883 47.70 ENST00000397893.3
small ubiquitin-like modifier 3
chr3_+_127317066 47.48 ENST00000265056.7
minichromosome maintenance complex component 2
chr1_+_33116743 46.47 ENST00000414241.3
ENST00000373493.5
retinoblastoma binding protein 4
chr19_+_47634039 46.44 ENST00000597808.1
ENST00000413379.3
ENST00000600706.1
ENST00000540850.1
ENST00000598840.1
ENST00000600753.1
ENST00000270225.7
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr10_+_51827648 46.44 ENST00000351071.6
ENST00000314664.7
ENST00000282633.5
family with sequence similarity 21, member A
chr5_+_110074685 45.72 ENST00000355943.3
ENST00000447245.2
solute carrier family 25, member 46
chr6_-_109703634 45.48 ENST00000324953.5
ENST00000310786.4
ENST00000275080.7
ENST00000413644.2
CD164 molecule, sialomucin
chr11_-_47664072 45.11 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
mitochondrial carrier 2
chr12_-_56709674 44.51 ENST00000551286.1
ENST00000549318.1
canopy FGF signaling regulator 2
Uncharacterized protein
chr17_+_49337881 44.23 ENST00000225298.7
UTP18 small subunit (SSU) processome component homolog (yeast)
chr5_+_122110691 44.16 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
sorting nexin 2
chr6_+_30689350 44.01 ENST00000330914.3
tubulin, beta class I
chr1_-_222885770 43.44 ENST00000355727.2
ENST00000340020.6
axin interactor, dorsalization associated
chr1_-_51425902 43.12 ENST00000396153.2
Fas (TNFRSF6) associated factor 1
chr10_+_70883908 42.75 ENST00000263559.6
ENST00000395098.1
ENST00000546041.1
ENST00000541711.1
vacuolar protein sorting 26 homolog A (S. pombe)
chr20_+_48552908 42.05 ENST00000244061.2
ring finger protein 114
chr18_+_3247413 41.54 ENST00000579226.1
ENST00000217652.3
myosin, light chain 12A, regulatory, non-sarcomeric
chr1_-_78148324 41.26 ENST00000370801.3
ENST00000433749.1
zinc finger, ZZ-type containing 3
chr7_+_100464760 39.84 ENST00000200457.4
thyroid hormone receptor interactor 6
chr15_-_72668805 39.25 ENST00000268097.5
hexosaminidase A (alpha polypeptide)
chr21_-_38445470 38.71 ENST00000399098.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr11_+_63706444 38.66 ENST00000377793.4
ENST00000456907.2
ENST00000539656.1
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr6_-_43197189 38.59 ENST00000509253.1
ENST00000393987.2
ENST00000230431.6
2'-deoxynucleoside 5'-phosphate N-hydrolase 1
chrX_+_100663243 38.06 ENST00000316594.5
heterogeneous nuclear ribonucleoprotein H2 (H')
chr6_+_36562132 37.91 ENST00000373715.6
ENST00000339436.7
serine/arginine-rich splicing factor 3
chr7_-_99699538 37.80 ENST00000343023.6
ENST00000303887.5
minichromosome maintenance complex component 7
chr12_-_56710118 37.68 ENST00000273308.4
canopy FGF signaling regulator 2
chr18_+_3247779 37.57 ENST00000578611.1
ENST00000583449.1
myosin, light chain 12A, regulatory, non-sarcomeric
chr6_+_30689401 37.55 ENST00000396389.1
ENST00000396384.1
tubulin, beta class I
chr5_+_133707252 37.48 ENST00000506787.1
ENST00000507277.1
ubiquitin-conjugating enzyme E2B
chr3_-_113465065 37.35 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr2_-_44223138 36.96 ENST00000260665.7
leucine-rich pentatricopeptide repeat containing
chr17_+_49230897 36.84 ENST00000393196.3
ENST00000336097.3
ENST00000480143.1
ENST00000511355.1
ENST00000013034.3
ENST00000393198.3
ENST00000608447.1
ENST00000393193.2
ENST00000376392.6
ENST00000555572.1
NME/NM23 nucleoside diphosphate kinase 1
NME1-NME2 readthrough
NME/NM23 nucleoside diphosphate kinase 2
chrX_+_23685563 36.49 ENST00000379341.4
peroxiredoxin 4
chr1_-_51425772 36.27 ENST00000371778.4
Fas (TNFRSF6) associated factor 1
chr19_+_12848299 35.99 ENST00000357332.3
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr1_-_155232221 35.83 ENST00000355379.3
secretory carrier membrane protein 3
chr20_+_31407692 35.75 ENST00000375571.5
microtubule-associated protein, RP/EB family, member 1
chr1_+_32479430 35.62 ENST00000327300.7
ENST00000492989.1
KH domain containing, RNA binding, signal transduction associated 1
chr8_+_98788003 35.44 ENST00000521545.2
lysosomal protein transmembrane 4 beta
chr2_-_10588630 35.34 ENST00000234111.4
ornithine decarboxylase 1
chr17_-_47492164 35.27 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
prohibitin
chr1_-_3816779 35.15 ENST00000361605.3
chromosome 1 open reading frame 174
chr8_+_55047763 35.14 ENST00000260102.4
ENST00000519831.1
mitochondrial ribosomal protein L15
chr14_+_35591928 35.06 ENST00000605870.1
ENST00000557404.3
KIAA0391
chr7_+_150759634 34.72 ENST00000392826.2
ENST00000461735.1
solute carrier family 4 (anion exchanger), member 2
chr12_+_72148614 34.65 ENST00000261263.3
RAB21, member RAS oncogene family
chr21_-_38445011 34.36 ENST00000464265.1
ENST00000399102.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr6_-_33385902 34.34 ENST00000374500.5
cutA divalent cation tolerance homolog (E. coli)
chr1_-_154600421 34.24 ENST00000368471.3
ENST00000292205.5
adenosine deaminase, RNA-specific
chr5_+_172410757 34.15 ENST00000519374.1
ENST00000519911.1
ENST00000265093.4
ENST00000517669.1
ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
chr1_-_28559502 34.10 ENST00000263697.4
DnaJ (Hsp40) homolog, subfamily C, member 8
chr11_+_114310102 33.73 ENST00000265881.5
RNA exonuclease 2
chrX_+_48432892 33.66 ENST00000376759.3
ENST00000430348.2
RNA binding motif (RNP1, RRM) protein 3
chr2_-_26101374 33.65 ENST00000435504.4
additional sex combs like 2 (Drosophila)
chrX_+_48433326 33.34 ENST00000376755.1
RNA binding motif (RNP1, RRM) protein 3
chr1_+_42921761 32.93 ENST00000372562.1
phosphopantothenoylcysteine synthetase
chr17_-_7218403 32.76 ENST00000570780.1
G protein pathway suppressor 2
chr17_+_7476136 32.70 ENST00000582169.1
ENST00000578754.1
ENST00000578495.1
ENST00000293831.8
ENST00000380512.5
ENST00000585024.1
ENST00000583802.1
ENST00000577269.1
ENST00000584784.1
ENST00000582746.1
eukaryotic translation initiation factor 4A1
chr19_+_50180317 32.65 ENST00000534465.1
protein arginine methyltransferase 1
chr11_+_65770227 32.49 ENST00000527348.1
barrier to autointegration factor 1
chr5_+_159848854 32.37 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
pituitary tumor-transforming 1
chr16_+_88923494 32.29 ENST00000567895.1
ENST00000301021.3
ENST00000565504.1
ENST00000567312.1
ENST00000568583.1
ENST00000561840.1
trafficking protein particle complex 2-like
chr15_-_65281775 31.91 ENST00000433215.2
ENST00000558415.1
ENST00000557795.1
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr12_-_65153175 31.72 ENST00000543646.1
ENST00000542058.1
ENST00000258145.3
glucosamine (N-acetyl)-6-sulfatase
chr15_+_45315302 31.67 ENST00000267814.9
sorbitol dehydrogenase
chr12_+_57624085 31.48 ENST00000553474.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_155232047 31.24 ENST00000302631.3
secretory carrier membrane protein 3
chr3_-_195163803 31.19 ENST00000326793.6
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr12_+_56109926 31.13 ENST00000547076.1
biogenesis of lysosomal organelles complex-1, subunit 1
chr3_+_140660743 31.12 ENST00000453248.2
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr2_+_113403434 31.12 ENST00000272542.3
solute carrier family 20 (phosphate transporter), member 1
chrX_+_41192595 31.04 ENST00000399959.2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr22_-_39096661 30.61 ENST00000216039.5
Josephin domain containing 1
chr1_-_110950564 30.45 ENST00000256644.4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
chr19_+_41768401 30.24 ENST00000352456.3
ENST00000595018.1
ENST00000597725.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr10_+_112327425 30.00 ENST00000361804.4
structural maintenance of chromosomes 3
chrX_-_100872911 29.71 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
armadillo repeat containing, X-linked 6
chr1_+_43148625 29.60 ENST00000436427.1
Y box binding protein 1
chr21_-_38445443 29.51 ENST00000360525.4
phosphatidylinositol glycan anchor biosynthesis, class P
chr17_-_7137857 29.21 ENST00000005340.5
dishevelled segment polarity protein 2
chr14_-_35591433 28.91 ENST00000261475.5
ENST00000555644.1
protein phosphatase 2, regulatory subunit B'', gamma
chr21_-_38445297 28.87 ENST00000430792.1
ENST00000399103.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr22_+_20105259 28.78 ENST00000416427.1
ENST00000421656.1
ENST00000423859.1
ENST00000418705.2
RAN binding protein 1
chr12_-_76953573 28.71 ENST00000549646.1
ENST00000550628.1
ENST00000553139.1
ENST00000261183.3
ENST00000393250.4
oxysterol binding protein-like 8
chr1_-_8939265 28.51 ENST00000489867.1
enolase 1, (alpha)
chr1_-_68962805 28.40 ENST00000370966.5
DEP domain containing 1
chr7_+_73868220 28.14 ENST00000455841.2
GTF2I repeat domain containing 1
chr6_-_7313381 28.04 ENST00000489567.1
ENST00000479365.1
ENST00000462112.1
ENST00000397511.2
ENST00000534851.1
ENST00000474597.1
ENST00000244763.4
signal sequence receptor, alpha
chr21_-_46238034 27.92 ENST00000332859.6
small ubiquitin-like modifier 3
chr11_+_114310164 27.85 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
RNA exonuclease 2
chr11_-_61560254 27.71 ENST00000543510.1
transmembrane protein 258
chr3_+_33840050 27.65 ENST00000457054.2
ENST00000413073.1
programmed cell death 6 interacting protein
chr5_+_34656569 27.64 ENST00000428746.2
retinoic acid induced 14
chr11_+_114310237 27.62 ENST00000539119.1
RNA exonuclease 2
chr2_-_26101314 27.59 ENST00000336112.4
ENST00000272341.4
additional sex combs like 2 (Drosophila)
chr2_-_198299726 27.58 ENST00000409915.4
ENST00000487698.1
ENST00000414963.2
ENST00000335508.6
splicing factor 3b, subunit 1, 155kDa
chr1_-_39325431 27.57 ENST00000373001.3
Ras-related GTP binding C
chr12_-_76477707 27.54 ENST00000551992.1
nucleosome assembly protein 1-like 1
chr13_+_113951607 27.52 ENST00000397181.3
lysosomal-associated membrane protein 1
chr10_-_43903217 27.51 ENST00000357065.4
heterogeneous nuclear ribonucleoprotein F
chr11_-_122931881 27.43 ENST00000526110.1
ENST00000227378.3
heat shock 70kDa protein 8
chr12_+_57624119 27.37 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_+_13049413 27.11 ENST00000316448.5
ENST00000588454.1
calreticulin
chr4_-_2935674 27.11 ENST00000514800.1
major facilitator superfamily domain containing 10
chr19_-_4670345 26.96 ENST00000599630.1
ENST00000262947.3
chromosome 19 open reading frame 10
chr15_-_65282232 26.47 ENST00000416889.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr5_+_126112794 26.33 ENST00000261366.5
ENST00000395354.1
lamin B1
chr6_+_158589374 26.32 ENST00000607778.1
general transcription factor IIH, polypeptide 5
chr4_+_57302297 26.30 ENST00000399688.3
ENST00000512576.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_+_100271355 26.26 ENST00000436220.1
ENST00000424361.1
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr21_-_40720974 26.07 ENST00000380748.1
high mobility group nucleosome binding domain 1
chr2_+_131100423 25.99 ENST00000409935.1
ENST00000409649.1
ENST00000428740.1
IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)
chr11_-_61560053 25.90 ENST00000537328.1
transmembrane protein 258
chr19_+_1275917 25.90 ENST00000469144.1
chromosome 19 open reading frame 24
chr19_-_8386238 25.81 ENST00000301457.2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
chr3_+_133292851 25.70 ENST00000503932.1
CDV3 homolog (mouse)
chr8_+_22224760 25.39 ENST00000359741.5
ENST00000520644.1
ENST00000240095.6
solute carrier family 39 (zinc transporter), member 14
chrX_+_131157322 25.32 ENST00000481105.1
ENST00000354719.6
ENST00000394335.2
Serine/threonine-protein kinase MST4
chr20_+_35202909 25.26 ENST00000558530.1
ENST00000558028.1
ENST00000560025.1
TGIF2-C20orf24 readthrough
TGFB-induced factor homeobox 2
chr12_+_53645870 25.17 ENST00000329548.4
major facilitator superfamily domain containing 5
chr7_+_100271446 25.08 ENST00000419828.1
ENST00000427895.1
guanine nucleotide binding protein (G protein), beta polypeptide 2
chr1_-_43638168 25.01 ENST00000431635.2
EBNA1 binding protein 2
chr2_+_198365095 24.95 ENST00000409468.1
heat shock 10kDa protein 1
chr17_+_49243639 24.93 ENST00000512737.1
ENST00000503064.1
NME1-NME2 readthrough
chr13_+_27998681 24.72 ENST00000381140.4
general transcription factor IIIA
chr1_+_26798955 24.68 ENST00000361427.5
high mobility group nucleosomal binding domain 2
chr5_+_34656331 24.68 ENST00000265109.3
retinoic acid induced 14
chr9_-_19127474 24.67 ENST00000380465.3
ENST00000380464.3
ENST00000411567.1
ENST00000276914.2
perilipin 2
chr15_-_65282274 24.37 ENST00000204566.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr9_+_117350009 24.30 ENST00000374050.3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr12_+_104359576 24.23 ENST00000392872.3
ENST00000436021.2
thymine-DNA glycosylase
chr14_-_54955721 24.20 ENST00000554908.1
glia maturation factor, beta
chr19_+_50180507 24.10 ENST00000454376.2
ENST00000524771.1
protein arginine methyltransferase 1
chr3_+_127323739 24.04 ENST00000491422.1
minichromosome maintenance complex component 2
chr8_-_144679296 24.04 ENST00000317198.6
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
chr18_+_12947981 23.59 ENST00000262124.11
SEH1-like (S. cerevisiae)
chr2_-_98612350 23.57 ENST00000186436.5
transmembrane protein 131
chr7_+_150065879 23.57 ENST00000397281.2
ENST00000444957.1
ENST00000466559.1
ENST00000489432.2
ENST00000475514.1
ENST00000482680.1
ENST00000488943.1
ENST00000518514.1
ENST00000478789.1
replication initiator 1
zinc finger protein 775
chr19_+_1067271 23.50 ENST00000536472.1
ENST00000590214.1
histocompatibility (minor) HA-1
chr3_+_52719936 23.45 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr21_-_46237959 23.23 ENST00000397898.3
ENST00000411651.2
small ubiquitin-like modifier 3
chr8_+_22224811 23.16 ENST00000381237.1
solute carrier family 39 (zinc transporter), member 14
chr12_+_57623869 22.83 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr20_-_61847586 22.83 ENST00000370339.3
YTH domain family, member 1
chr4_-_83295103 22.79 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr7_+_12726474 22.73 ENST00000396662.1
ENST00000356797.3
ENST00000396664.2
ADP-ribosylation factor-like 4A
chr15_+_75628394 22.65 ENST00000564815.1
ENST00000338995.6
COMM domain containing 4
chr5_+_133706865 22.63 ENST00000265339.2
ubiquitin-conjugating enzyme E2B
chr4_-_54930790 22.57 ENST00000263921.3
cysteine-rich hydrophobic domain 2
chr11_-_85779971 22.47 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr19_+_10765003 22.42 ENST00000407004.3
ENST00000589998.1
ENST00000589600.1
interleukin enhancer binding factor 3, 90kDa
chr11_-_64013663 22.34 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_+_131157290 22.33 ENST00000394334.2
Serine/threonine-protein kinase MST4
chr15_+_75628232 22.32 ENST00000267935.8
ENST00000567195.1
COMM domain containing 4
chr15_+_44084503 22.25 ENST00000409960.2
ENST00000409646.1
ENST00000594896.1
ENST00000339624.5
ENST00000409291.1
ENST00000402131.1
ENST00000403425.1
ENST00000430901.1
small EDRK-rich factor 2
chr10_-_99258135 22.19 ENST00000327238.10
ENST00000327277.7
ENST00000355839.6
ENST00000437002.1
ENST00000422685.1
MMS19 nucleotide excision repair homolog (S. cerevisiae)
chr10_+_75910960 22.18 ENST00000539909.1
ENST00000286621.2
adenosine kinase
chr10_+_81107271 22.15 ENST00000448165.1
peptidylprolyl isomerase F
chr17_+_30677136 21.99 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
zinc finger protein 207
chr19_-_10530784 21.99 ENST00000593124.1
cell division cycle 37
chr10_+_124913930 21.95 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr21_-_40720995 21.95 ENST00000380749.5
high mobility group nucleosome binding domain 1
chr19_+_797443 21.88 ENST00000394601.4
ENST00000589575.1
polypyrimidine tract binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of MAX_TFEB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
119.6 598.1 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
42.5 169.9 GO:0046452 dihydrofolate metabolic process(GO:0046452)
27.9 111.5 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
22.0 66.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
20.0 60.1 GO:0010845 positive regulation of reciprocal meiotic recombination(GO:0010845)
19.8 178.0 GO:1904715 negative regulation of chaperone-mediated autophagy(GO:1904715)
17.5 122.2 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
17.1 85.3 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
16.8 50.3 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732) translation reinitiation(GO:0002188)
15.2 45.7 GO:0090149 mitochondrial membrane fission(GO:0090149)
14.9 44.7 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
14.7 132.2 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
14.6 43.8 GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
14.4 57.6 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
13.8 27.6 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
13.7 41.0 GO:0044209 AMP salvage(GO:0044209)
13.6 54.3 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
12.9 51.7 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
12.8 38.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
12.4 61.9 GO:0014886 transition between slow and fast fiber(GO:0014886)
12.4 74.3 GO:0046985 positive regulation of hemoglobin biosynthetic process(GO:0046985)
11.9 35.8 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
11.9 35.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
11.4 34.2 GO:1900368 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
10.6 31.7 GO:0006059 hexitol metabolic process(GO:0006059)
10.5 63.2 GO:0090646 mitochondrial tRNA processing(GO:0090646)
10.5 104.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
10.5 83.8 GO:0016139 glycoside catabolic process(GO:0016139)
10.4 10.4 GO:2000157 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
10.3 31.0 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
10.0 10.0 GO:0090291 negative regulation of osteoclast proliferation(GO:0090291)
9.9 79.2 GO:0060155 platelet dense granule organization(GO:0060155)
9.8 98.3 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
9.8 39.1 GO:0006218 uridine catabolic process(GO:0006218) uridine metabolic process(GO:0046108)
9.8 48.8 GO:0042256 mature ribosome assembly(GO:0042256)
9.7 48.5 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
9.6 28.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
9.3 27.9 GO:0061470 T follicular helper cell differentiation(GO:0061470)
9.2 36.6 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
9.1 54.7 GO:2000323 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
8.9 35.6 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
8.1 24.2 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
8.0 39.8 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
7.9 15.9 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
7.6 22.8 GO:1901355 response to rapamycin(GO:1901355)
7.3 66.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
7.3 51.3 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
7.2 7.2 GO:0016071 mRNA metabolic process(GO:0016071)
7.1 49.5 GO:0090204 protein localization to nuclear pore(GO:0090204)
7.0 34.8 GO:0006344 maintenance of chromatin silencing(GO:0006344)
6.9 61.8 GO:1902903 regulation of fibril organization(GO:1902903)
6.8 47.9 GO:1902570 protein localization to nucleolus(GO:1902570)
6.8 20.4 GO:0039689 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
6.6 79.4 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
6.6 131.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
6.3 50.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
6.2 24.6 GO:0000957 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
6.0 23.9 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
6.0 185.6 GO:0090383 phagosome acidification(GO:0090383)
5.9 29.5 GO:0016321 female meiosis chromosome segregation(GO:0016321)
5.8 58.5 GO:0021769 orbitofrontal cortex development(GO:0021769)
5.8 57.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
5.6 16.7 GO:0006166 purine ribonucleoside salvage(GO:0006166)
5.6 61.2 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
5.3 21.2 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
5.1 51.0 GO:0015074 DNA integration(GO:0015074)
5.1 35.5 GO:2001171 positive regulation of ATP biosynthetic process(GO:2001171)
5.0 15.1 GO:0071051 polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
5.0 15.0 GO:0031938 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) regulation of chromatin silencing at telomere(GO:0031938) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
4.9 9.8 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
4.8 19.3 GO:0046035 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
4.8 19.3 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
4.7 37.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
4.6 13.8 GO:0015883 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350)
4.5 27.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
4.4 17.8 GO:0048254 snoRNA localization(GO:0048254)
4.4 13.3 GO:0072711 cellular response to hydroxyurea(GO:0072711)
4.4 48.8 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
4.4 44.2 GO:0018202 peptidyl-histidine modification(GO:0018202)
4.2 29.6 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
4.2 21.1 GO:0006740 NADPH regeneration(GO:0006740)
4.2 50.2 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
4.1 20.7 GO:0009213 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
4.0 15.8 GO:0072402 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423)
3.9 39.4 GO:0045008 depyrimidination(GO:0045008)
3.9 11.7 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
3.8 42.3 GO:0048262 determination of dorsal/ventral asymmetry(GO:0048262)
3.8 11.5 GO:1903674 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
3.8 188.9 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
3.8 15.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
3.7 11.2 GO:0005997 xylulose metabolic process(GO:0005997)
3.6 28.9 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
3.5 10.5 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
3.5 21.1 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
3.5 31.1 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
3.5 24.2 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
3.4 10.3 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
3.4 20.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
3.4 44.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
3.3 19.9 GO:0015866 adenine transport(GO:0015853) ADP transport(GO:0015866) negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
3.3 33.1 GO:0006294 nucleotide-excision repair, preincision complex assembly(GO:0006294)
3.3 36.1 GO:0030043 actin filament fragmentation(GO:0030043)
3.3 9.8 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)
3.3 13.1 GO:0002572 pro-T cell differentiation(GO:0002572)
3.2 189.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
3.2 9.5 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
3.2 9.5 GO:0010587 miRNA catabolic process(GO:0010587)
3.1 9.4 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
3.1 12.5 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
3.1 9.4 GO:0006014 D-ribose metabolic process(GO:0006014)
3.1 15.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
3.1 9.2 GO:0022604 regulation of cell morphogenesis(GO:0022604)
3.0 18.3 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
3.0 9.1 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
3.0 30.3 GO:2000643 positive regulation of early endosome to late endosome transport(GO:2000643)
3.0 15.1 GO:0019348 dolichol metabolic process(GO:0019348)
3.0 9.0 GO:0072719 heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806) cellular response to cisplatin(GO:0072719)
3.0 30.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
2.9 14.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
2.9 14.7 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
2.9 8.6 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
2.8 8.5 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
2.8 19.7 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
2.8 16.7 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
2.8 11.0 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
2.7 59.6 GO:0030488 tRNA methylation(GO:0030488)
2.7 10.6 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
2.7 18.6 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
2.6 34.1 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
2.6 101.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
2.6 38.6 GO:0009125 nucleoside monophosphate catabolic process(GO:0009125)
2.6 23.1 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
2.6 5.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
2.5 89.2 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
2.5 5.1 GO:0046654 tetrahydrofolate biosynthetic process(GO:0046654)
2.5 12.6 GO:0002011 morphogenesis of an epithelial sheet(GO:0002011)
2.5 12.6 GO:0006041 glucosamine metabolic process(GO:0006041)
2.5 47.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
2.5 7.4 GO:0051684 maintenance of Golgi location(GO:0051684)
2.4 7.3 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
2.4 7.2 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
2.4 14.4 GO:0050685 positive regulation of mRNA processing(GO:0050685)
2.4 7.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
2.4 11.8 GO:0016240 autophagosome docking(GO:0016240)
2.4 4.7 GO:0019087 transformation of host cell by virus(GO:0019087)
2.4 49.4 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
2.3 15.8 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
2.3 72.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
2.2 6.7 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
2.2 8.9 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
2.2 15.5 GO:0008295 spermidine biosynthetic process(GO:0008295)
2.1 15.0 GO:0090160 Golgi to lysosome transport(GO:0090160)
2.1 66.3 GO:0032008 positive regulation of TOR signaling(GO:0032008)
2.1 10.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
2.1 12.6 GO:0018206 peptidyl-methionine modification(GO:0018206)
2.1 6.3 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
2.1 10.4 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
2.1 27.0 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
2.1 10.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
2.1 8.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
2.0 6.0 GO:1904245 regulation of polynucleotide adenylyltransferase activity(GO:1904245) positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
2.0 139.2 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
2.0 43.0 GO:0006337 nucleosome disassembly(GO:0006337)
1.9 5.8 GO:0060279 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.9 15.3 GO:0044351 macropinocytosis(GO:0044351)
1.9 17.1 GO:0002183 cytoplasmic translational initiation(GO:0002183)
1.9 49.3 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
1.9 17.1 GO:0051451 myoblast migration(GO:0051451)
1.9 5.7 GO:1902498 regulation of protein autoubiquitination(GO:1902498) positive regulation of protein autoubiquitination(GO:1902499)
1.9 39.4 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
1.9 31.9 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
1.9 16.9 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
1.9 29.8 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
1.9 33.5 GO:0097502 mannosylation(GO:0097502)
1.9 7.4 GO:0072553 terminal button organization(GO:0072553)
1.8 74.0 GO:0097421 liver regeneration(GO:0097421)
1.8 31.2 GO:0036010 protein localization to endosome(GO:0036010)
1.8 7.3 GO:0043335 protein unfolding(GO:0043335)
1.8 12.7 GO:0015936 coenzyme A metabolic process(GO:0015936)
1.8 7.2 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
1.8 10.6 GO:0006689 ganglioside catabolic process(GO:0006689)
1.8 21.2 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
1.7 10.2 GO:0032328 alanine transport(GO:0032328)
1.7 30.6 GO:1990126 retrograde transport, endosome to plasma membrane(GO:1990126)
1.7 18.5 GO:0033572 transferrin transport(GO:0033572)
1.7 5.0 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
1.6 9.8 GO:0034625 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
1.6 16.1 GO:0006983 ER overload response(GO:0006983)
1.6 62.7 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.6 8.0 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
1.6 9.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.6 53.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.5 4.6 GO:0051661 maintenance of centrosome location(GO:0051661)
1.5 18.4 GO:0007379 segment specification(GO:0007379)
1.5 18.4 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
1.5 42.9 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
1.5 22.6 GO:0038092 nodal signaling pathway(GO:0038092)
1.5 16.3 GO:0090161 Golgi ribbon formation(GO:0090161)
1.5 4.4 GO:0032986 protein-DNA complex disassembly(GO:0032986)
1.5 4.4 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
1.4 10.1 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.4 20.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
1.4 12.9 GO:0051382 kinetochore assembly(GO:0051382)
1.4 22.9 GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
1.4 7.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
1.4 102.4 GO:0006342 chromatin silencing(GO:0006342)
1.4 303.7 GO:0006364 rRNA processing(GO:0006364)
1.4 20.5 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
1.4 13.6 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
1.4 9.5 GO:0015755 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
1.3 8.1 GO:1903753 negative regulation of p38MAPK cascade(GO:1903753)
1.3 9.4 GO:0042276 error-prone translesion synthesis(GO:0042276)
1.3 14.2 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
1.3 9.0 GO:0033484 nitric oxide homeostasis(GO:0033484)
1.3 81.6 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
1.3 12.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
1.2 6.1 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
1.2 22.0 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.2 22.0 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
1.2 7.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
1.2 22.7 GO:0031639 plasminogen activation(GO:0031639)
1.2 45.8 GO:0046329 negative regulation of JNK cascade(GO:0046329)
1.2 9.4 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
1.1 10.3 GO:0006564 L-serine biosynthetic process(GO:0006564)
1.1 22.8 GO:0045948 positive regulation of translational initiation(GO:0045948)
1.1 1.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
1.1 76.2 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
1.1 8.9 GO:0048752 semicircular canal morphogenesis(GO:0048752)
1.1 4.4 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
1.1 24.0 GO:0009303 rRNA transcription(GO:0009303)
1.1 3.2 GO:0015680 intracellular copper ion transport(GO:0015680)
1.1 1.1 GO:1902774 late endosome to lysosome transport(GO:1902774)
1.1 3.2 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
1.0 15.5 GO:0030050 vesicle transport along actin filament(GO:0030050)
1.0 9.2 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
1.0 30.7 GO:0006378 mRNA polyadenylation(GO:0006378) RNA polyadenylation(GO:0043631)
1.0 2.0 GO:0032639 TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759)
1.0 12.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
1.0 85.7 GO:0070527 platelet aggregation(GO:0070527)
1.0 5.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.9 19.8 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.9 24.1 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.9 6.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.9 35.3 GO:1901998 toxin transport(GO:1901998)
0.9 81.8 GO:0006353 DNA-templated transcription, termination(GO:0006353)
0.9 14.3 GO:0032836 glomerular basement membrane development(GO:0032836)
0.9 4.4 GO:0007498 mesoderm development(GO:0007498)
0.9 8.5 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
0.8 20.3 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.8 38.4 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.8 47.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.8 87.1 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.8 23.5 GO:0060260 regulation of transcription initiation from RNA polymerase II promoter(GO:0060260)
0.8 47.4 GO:0031100 organ regeneration(GO:0031100)
0.8 25.1 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.8 5.3 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.7 11.2 GO:0000338 protein deneddylation(GO:0000338)
0.7 5.9 GO:0010452 histone H3-K36 methylation(GO:0010452)
0.7 2.2 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.7 8.1 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.7 8.0 GO:0051601 exocyst localization(GO:0051601)
0.7 10.7 GO:0006265 DNA topological change(GO:0006265)
0.7 3.4 GO:0050957 equilibrioception(GO:0050957)
0.7 7.4 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.7 30.5 GO:0006446 regulation of translational initiation(GO:0006446)
0.7 67.5 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.7 15.2 GO:0015804 neutral amino acid transport(GO:0015804)
0.7 14.5 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.7 4.6 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.6 3.1 GO:0009650 UV protection(GO:0009650)
0.6 140.7 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
0.6 16.2 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.6 4.4 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.6 1.8 GO:0042727 flavin-containing compound biosynthetic process(GO:0042727)
0.6 3.0 GO:0006824 cobalt ion transport(GO:0006824)
0.6 41.9 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.6 183.7 GO:0010038 response to metal ion(GO:0010038)
0.5 41.9 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.5 2.7 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.5 5.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.5 9.5 GO:0002021 response to dietary excess(GO:0002021)
0.5 33.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.5 7.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.5 2.5 GO:1901490 positive regulation of mast cell chemotaxis(GO:0060754) regulation of lymphangiogenesis(GO:1901490)
0.5 3.4 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.5 1.4 GO:0000255 allantoin metabolic process(GO:0000255)
0.5 6.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.5 10.3 GO:0051904 melanosome transport(GO:0032402) pigment granule transport(GO:0051904)
0.5 23.3 GO:0015701 bicarbonate transport(GO:0015701)
0.5 24.7 GO:0019915 lipid storage(GO:0019915)
0.5 2.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.4 1.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.4 5.4 GO:0043457 regulation of cellular respiration(GO:0043457)
0.4 67.6 GO:0070585 protein localization to mitochondrion(GO:0070585)
0.4 3.9 GO:1904350 regulation of protein catabolic process in the vacuole(GO:1904350)
0.4 48.2 GO:0006414 translational elongation(GO:0006414)
0.4 35.5 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.4 26.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.4 8.8 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.4 4.6 GO:0050872 white fat cell differentiation(GO:0050872)
0.4 18.4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.4 3.5 GO:0007010 cytoskeleton organization(GO:0007010)
0.4 11.7 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.4 1.2 GO:0070459 prolactin secretion(GO:0070459)
0.4 8.4 GO:0051290 protein heterotetramerization(GO:0051290)
0.4 4.6 GO:0001778 plasma membrane repair(GO:0001778)
0.4 9.0 GO:1902583 intracellular transport of virus(GO:0075733) multi-organism intracellular transport(GO:1902583)
0.4 8.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.4 1.1 GO:0046203 spermidine catabolic process(GO:0046203)
0.4 1.8 GO:0045022 early endosome to late endosome transport(GO:0045022)
0.4 4.2 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.4 1.1 GO:0045605 negative regulation of epidermal cell differentiation(GO:0045605) negative regulation of keratinocyte differentiation(GO:0045617)
0.3 10.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.3 7.7 GO:0070207 protein homotrimerization(GO:0070207)
0.3 9.5 GO:0048246 macrophage chemotaxis(GO:0048246)
0.3 15.1 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.3 21.8 GO:0006334 nucleosome assembly(GO:0006334)
0.3 8.3 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.3 4.5 GO:0006020 inositol metabolic process(GO:0006020)
0.3 8.1 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.3 1.8 GO:1904062 regulation of calcium ion transmembrane transport(GO:1903169) regulation of cation transmembrane transport(GO:1904062)
0.3 4.6 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.3 2.0 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 6.6 GO:0006400 tRNA modification(GO:0006400)
0.3 2.3 GO:0010628 positive regulation of gene expression(GO:0010628)
0.2 5.5 GO:0007015 actin filament organization(GO:0007015)
0.2 4.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 11.2 GO:0045454 cell redox homeostasis(GO:0045454)
0.2 2.2 GO:0007219 Notch signaling pathway(GO:0007219)
0.2 2.6 GO:0007588 excretion(GO:0007588)
0.2 3.5 GO:0003334 keratinocyte development(GO:0003334)
0.2 4.6 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.2 3.3 GO:0034453 microtubule anchoring(GO:0034453)
0.2 2.7 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.2 1.1 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 0.6 GO:0034351 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.2 4.4 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.1 0.7 GO:1903421 regulation of synaptic vesicle recycling(GO:1903421)
0.1 3.8 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.1 2.3 GO:0006308 DNA catabolic process(GO:0006308)
0.1 1.3 GO:0016180 snRNA processing(GO:0016180)
0.1 3.1 GO:0010608 posttranscriptional regulation of gene expression(GO:0010608)
0.1 2.1 GO:0060009 Sertoli cell development(GO:0060009)
0.1 4.7 GO:0006270 DNA replication initiation(GO:0006270)
0.1 1.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 6.7 GO:0006401 RNA catabolic process(GO:0006401)
0.1 2.0 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.1 3.1 GO:0061045 negative regulation of wound healing(GO:0061045)
0.1 1.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.1 12.4 GO:0031424 keratinization(GO:0031424)
0.1 3.1 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.1 0.4 GO:2000117 negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.1 3.0 GO:0055010 ventricular cardiac muscle tissue morphogenesis(GO:0055010)
0.1 1.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.1 5.9 GO:2001234 negative regulation of apoptotic signaling pathway(GO:2001234)
0.1 2.0 GO:0033198 response to ATP(GO:0033198)
0.1 4.6 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 1.9 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 0.9 GO:0007100 mitotic centrosome separation(GO:0007100) centrosome separation(GO:0051299)
0.1 4.3 GO:0042246 tissue regeneration(GO:0042246)
0.1 4.2 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.1 0.3 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.1 2.5 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.1 0.6 GO:0006068 ethanol catabolic process(GO:0006068)
0.1 7.5 GO:0060041 retina development in camera-type eye(GO:0060041)
0.1 2.4 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 0.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.1 1.9 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.6 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 0.5 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.0 0.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 10.3 GO:0050851 antigen receptor-mediated signaling pathway(GO:0050851)
0.0 3.5 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.1 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.9 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.0 4.7 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.0 0.4 GO:0022011 myelination in peripheral nervous system(GO:0022011) peripheral nervous system axon ensheathment(GO:0032292)
0.0 9.0 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.0 0.3 GO:1903364 positive regulation of cellular protein catabolic process(GO:1903364)
0.0 0.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.1 GO:0043585 nose morphogenesis(GO:0043585) alveolar primary septum development(GO:0061143) paramesonephric duct development(GO:0061205)
0.0 0.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.1 GO:0042976 activation of Janus kinase activity(GO:0042976)
0.0 0.1 GO:0050821 protein stabilization(GO:0050821)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
99.7 598.1 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
28.2 197.3 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
24.6 98.3 GO:0033186 CAF-1 complex(GO:0033186)
22.3 156.3 GO:0046581 intercellular canaliculus(GO:0046581)
17.4 104.3 GO:0001740 Barr body(GO:0001740)
13.1 131.4 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
12.8 51.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
12.6 63.2 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
12.6 100.9 GO:0070552 BRISC complex(GO:0070552)
12.1 36.4 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
12.0 60.1 GO:0033503 HULC complex(GO:0033503)
11.2 67.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
11.0 44.1 GO:0042721 mitochondrial inner membrane protein insertion complex(GO:0042721)
10.5 83.8 GO:0042382 paraspeckles(GO:0042382)
10.5 94.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
10.2 30.6 GO:0030906 retromer, cargo-selective complex(GO:0030906)
10.0 30.0 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
9.0 45.1 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
9.0 44.9 GO:0071986 Ragulator complex(GO:0071986)
8.9 80.4 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
8.4 67.6 GO:0097208 alveolar lamellar body(GO:0097208)
8.4 109.3 GO:0042555 MCM complex(GO:0042555)
8.3 33.1 GO:0070985 TFIIK complex(GO:0070985)
8.3 123.8 GO:0005641 nuclear envelope lumen(GO:0005641)
8.1 48.5 GO:0072589 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
8.0 23.9 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
8.0 39.8 GO:0045323 interleukin-1 receptor complex(GO:0045323)
7.6 38.2 GO:0034457 Mpp10 complex(GO:0034457)
7.4 67.0 GO:0000439 core TFIIH complex(GO:0000439)
7.4 44.2 GO:0030905 retromer, tubulation complex(GO:0030905)
7.3 80.5 GO:0033391 chromatoid body(GO:0033391)
7.1 35.3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
7.0 42.1 GO:0071817 MMXD complex(GO:0071817)
6.8 34.2 GO:0044530 supraspliceosomal complex(GO:0044530)
6.5 32.6 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
6.4 89.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
6.0 35.8 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
5.6 16.7 GO:0097447 dendritic tree(GO:0097447)
5.3 37.3 GO:0031415 NatA complex(GO:0031415)
5.0 15.0 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
4.6 82.5 GO:0031083 BLOC-1 complex(GO:0031083)
4.5 81.1 GO:0034709 methylosome(GO:0034709)
4.5 53.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
4.4 43.9 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
4.4 21.9 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
4.2 29.6 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
4.1 16.5 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
4.1 73.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
4.0 32.2 GO:1990111 spermatoproteasome complex(GO:1990111)
3.9 19.6 GO:0016589 NURF complex(GO:0016589)
3.9 31.3 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
3.7 147.6 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
3.6 10.7 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
3.5 10.6 GO:0005960 glycine cleavage complex(GO:0005960)
3.5 34.9 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
3.4 20.4 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
3.4 16.9 GO:0071148 TEAD-1-YAP complex(GO:0071148)
3.4 23.6 GO:0061700 GATOR2 complex(GO:0061700)
3.3 13.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
3.3 112.4 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
3.2 12.9 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
3.0 24.3 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
2.9 55.7 GO:0005885 Arp2/3 protein complex(GO:0005885)
2.9 17.2 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
2.9 42.9 GO:0090543 Flemming body(GO:0090543)
2.8 34.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
2.7 13.6 GO:0005899 insulin receptor complex(GO:0005899)
2.6 10.5 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
2.6 23.6 GO:0005798 Golgi-associated vesicle(GO:0005798)
2.6 7.7 GO:0005879 axonemal microtubule(GO:0005879)
2.6 40.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
2.5 12.7 GO:0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
2.4 14.7 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
2.3 9.3 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
2.3 115.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.2 17.8 GO:0070761 pre-snoRNP complex(GO:0070761)
2.2 12.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.1 44.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
2.1 37.6 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
2.0 16.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
2.0 289.6 GO:0015934 large ribosomal subunit(GO:0015934)
1.9 11.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
1.9 5.8 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.9 26.7 GO:0097227 sperm annulus(GO:0097227)
1.9 3.7 GO:0035838 growing cell tip(GO:0035838)
1.8 27.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
1.8 10.9 GO:0008537 proteasome activator complex(GO:0008537)
1.8 7.2 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
1.8 7.2 GO:0071001 U4/U6 snRNP(GO:0071001)
1.8 12.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.8 21.5 GO:0030008 TRAPP complex(GO:0030008)
1.7 20.8 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
1.7 41.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
1.7 21.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.6 6.3 GO:0032044 DSIF complex(GO:0032044)
1.6 48.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.5 12.0 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.5 7.4 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
1.5 4.4 GO:1903349 omegasome membrane(GO:1903349)
1.5 33.6 GO:0005685 U1 snRNP(GO:0005685)
1.4 29.7 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.4 16.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
1.4 15.1 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
1.4 42.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
1.3 10.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
1.3 123.0 GO:0017053 transcriptional repressor complex(GO:0017053)
1.2 6.2 GO:0035578 azurophil granule lumen(GO:0035578)
1.2 14.7 GO:0000815 ESCRT III complex(GO:0000815)
1.2 152.5 GO:0000776 kinetochore(GO:0000776)
1.2 9.5 GO:0072546 ER membrane protein complex(GO:0072546)
1.2 161.7 GO:0005840 ribosome(GO:0005840)
1.1 12.5 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
1.1 29.6 GO:0000930 gamma-tubulin complex(GO:0000930)
1.1 3.4 GO:0030532 small nuclear ribonucleoprotein complex(GO:0030532)
1.1 84.8 GO:0005758 mitochondrial intermembrane space(GO:0005758)
1.1 17.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
1.1 21.5 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
1.0 5.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
1.0 8.8 GO:0097413 Lewy body(GO:0097413)
1.0 62.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.9 65.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.9 10.9 GO:0031595 nuclear proteasome complex(GO:0031595)
0.9 5.4 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.9 3.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.8 116.4 GO:0043202 lysosomal lumen(GO:0043202)
0.8 8.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.8 4.9 GO:0031082 BLOC complex(GO:0031082)
0.8 40.8 GO:0015030 Cajal body(GO:0015030)
0.8 6.8 GO:0032009 early phagosome(GO:0032009)
0.7 8.1 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.7 11.7 GO:0071141 SMAD protein complex(GO:0071141)
0.7 21.6 GO:0099738 cell cortex region(GO:0099738)
0.7 2.8 GO:0001739 sex chromatin(GO:0001739)
0.7 2.7 GO:0055087 Ski complex(GO:0055087)
0.6 2.6 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 3.1 GO:0071012 catalytic step 1 spliceosome(GO:0071012)
0.6 14.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.6 97.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.6 7.8 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.5 2.5 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.5 38.8 GO:0005643 nuclear pore(GO:0005643)
0.5 23.5 GO:0045171 intercellular bridge(GO:0045171)
0.5 67.5 GO:0005681 spliceosomal complex(GO:0005681)
0.5 38.3 GO:0016459 myosin complex(GO:0016459)
0.5 54.1 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.4 4.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 34.4 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.4 11.2 GO:0008180 COP9 signalosome(GO:0008180)
0.4 3.1 GO:0032059 bleb(GO:0032059)
0.4 36.5 GO:0005901 caveola(GO:0005901)
0.4 48.6 GO:0030027 lamellipodium(GO:0030027)
0.4 37.9 GO:0016607 nuclear speck(GO:0016607)
0.4 5.9 GO:0009925 basal plasma membrane(GO:0009925)
0.4 3.2 GO:0030686 90S preribosome(GO:0030686)
0.4 34.5 GO:0070821 tertiary granule membrane(GO:0070821)
0.4 1.8 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.3 38.1 GO:0005903 brush border(GO:0005903)
0.3 2.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 31.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.3 6.1 GO:0071565 npBAF complex(GO:0071564) nBAF complex(GO:0071565)
0.3 12.2 GO:0045095 keratin filament(GO:0045095)
0.3 5.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 5.5 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.3 3.4 GO:0032420 stereocilium(GO:0032420)
0.3 7.2 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 22.3 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.2 4.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 13.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.2 11.4 GO:0000502 proteasome complex(GO:0000502)
0.2 13.6 GO:0005811 lipid particle(GO:0005811)
0.2 23.9 GO:0016605 PML body(GO:0016605)
0.2 4.6 GO:0031264 death-inducing signaling complex(GO:0031264)
0.2 4.6 GO:0043034 costamere(GO:0043034)
0.2 85.7 GO:0005925 focal adhesion(GO:0005925)
0.2 19.2 GO:0001650 fibrillar center(GO:0001650)
0.2 1.8 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 8.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.2 58.3 GO:0005635 nuclear envelope(GO:0005635)
0.2 2.4 GO:0005771 multivesicular body(GO:0005771)
0.2 1.3 GO:0032039 integrator complex(GO:0032039)
0.2 41.2 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.2 3.3 GO:0031519 PcG protein complex(GO:0031519)
0.1 2.0 GO:0030426 growth cone(GO:0030426)
0.1 2.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 310.9 GO:0070062 extracellular exosome(GO:0070062)
0.1 1.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 14.7 GO:0031968 organelle outer membrane(GO:0031968)
0.1 7.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 5.8 GO:0005581 collagen trimer(GO:0005581)
0.1 2.2 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 5.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 112.4 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 1.2 GO:0030175 filopodium(GO:0030175)
0.1 0.3 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 1.9 GO:0016235 aggresome(GO:0016235)
0.1 1.5 GO:0001533 cornified envelope(GO:0001533)
0.1 3.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 2.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.2 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.4 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 0.8 GO:0000118 histone deacetylase complex(GO:0000118)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
35.4 70.7 GO:0016936 galactoside binding(GO:0016936)
26.8 160.9 GO:0019238 cyclohydrolase activity(GO:0019238)
22.2 177.7 GO:0016997 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
22.0 66.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
20.6 82.3 GO:0031871 proteinase activated receptor binding(GO:0031871)
19.2 57.6 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
17.7 53.1 GO:0042134 rRNA primary transcript binding(GO:0042134)
17.5 122.2 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
16.5 66.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
15.0 613.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
14.9 44.7 GO:0004730 pseudouridylate synthase activity(GO:0004730)
13.1 131.4 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
12.8 38.3 GO:0070364 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
12.2 73.1 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
10.7 85.3 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
10.1 80.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
9.8 39.1 GO:0004850 uridine phosphorylase activity(GO:0004850)
9.6 28.7 GO:0008859 exoribonuclease II activity(GO:0008859)
9.0 27.0 GO:0004853 uroporphyrinogen decarboxylase activity(GO:0004853)
8.8 44.2 GO:1990460 leptin receptor binding(GO:1990460)
8.6 103.5 GO:0031386 protein tag(GO:0031386)
8.6 34.2 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
8.2 253.6 GO:0051059 NF-kappaB binding(GO:0051059)
8.1 48.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
8.1 24.2 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
7.9 31.7 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
7.8 31.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
7.7 46.4 GO:0044388 ubiquitin activating enzyme activity(GO:0004839) small protein activating enzyme binding(GO:0044388)
7.7 38.7 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
7.6 30.3 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
7.6 22.7 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
7.5 30.1 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
7.5 30.0 GO:0036033 mediator complex binding(GO:0036033)
6.9 48.5 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
6.7 40.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
6.5 19.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
6.5 291.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
6.3 145.6 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
6.2 31.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
5.9 17.8 GO:0030984 kininogen binding(GO:0030984)
5.6 67.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
5.5 32.9 GO:0019776 Atg8 ligase activity(GO:0019776)
5.3 15.9 GO:0033149 FFAT motif binding(GO:0033149)
5.3 15.8 GO:0097322 7SK snRNA binding(GO:0097322)
5.2 57.2 GO:0031995 insulin-like growth factor II binding(GO:0031995)
5.2 15.5 GO:0004766 spermidine synthase activity(GO:0004766)
5.2 87.6 GO:0003688 DNA replication origin binding(GO:0003688)
5.1 15.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
5.0 15.1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
5.0 19.9 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
4.9 19.7 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
4.9 63.8 GO:0043024 ribosomal small subunit binding(GO:0043024)
4.9 14.7 GO:0035500 MH2 domain binding(GO:0035500)
4.8 38.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
4.7 75.7 GO:0004526 ribonuclease P activity(GO:0004526)
4.6 13.8 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
4.3 60.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
4.3 43.0 GO:1990446 U1 snRNP binding(GO:1990446)
4.2 29.5 GO:0032552 deoxyribonucleotide binding(GO:0032552)
4.1 81.8 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
4.0 51.7 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
4.0 305.6 GO:0005507 copper ion binding(GO:0005507)
4.0 87.1 GO:0016881 acid-amino acid ligase activity(GO:0016881)
4.0 15.8 GO:0048256 flap endonuclease activity(GO:0048256)
3.8 30.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
3.8 41.7 GO:0008097 5S rRNA binding(GO:0008097)
3.8 82.7 GO:0042609 CD4 receptor binding(GO:0042609)
3.8 26.3 GO:0000182 rDNA binding(GO:0000182)
3.7 18.6 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
3.7 11.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
3.7 33.2 GO:0015288 porin activity(GO:0015288)
3.7 29.3 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
3.6 7.1 GO:0043398 HLH domain binding(GO:0043398)
3.5 14.0 GO:0004774 succinate-CoA ligase activity(GO:0004774)
3.5 10.4 GO:0005047 signal recognition particle binding(GO:0005047)
3.5 10.4 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
3.4 20.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
3.4 72.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
3.3 13.0 GO:0004348 glucosylceramidase activity(GO:0004348)
3.2 54.0 GO:0019206 nucleoside kinase activity(GO:0019206)
3.2 44.4 GO:0000339 RNA cap binding(GO:0000339)
3.1 12.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
3.1 9.4 GO:0000702 oxidized base lesion DNA N-glycosylase activity(GO:0000702) oxidized purine nucleobase lesion DNA N-glycosylase activity(GO:0008534)
3.1 64.8 GO:0032794 GTPase activating protein binding(GO:0032794)
3.0 24.2 GO:0071933 Arp2/3 complex binding(GO:0071933)
3.0 9.0 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
3.0 59.8 GO:0005095 GTPase inhibitor activity(GO:0005095)
2.9 31.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
2.9 8.6 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
2.9 17.2 GO:0010997 anaphase-promoting complex binding(GO:0010997)
2.7 30.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
2.7 91.1 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
2.6 10.6 GO:0004047 aminomethyltransferase activity(GO:0004047)
2.6 28.3 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
2.6 56.5 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
2.5 12.7 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
2.5 9.9 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
2.5 47.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
2.4 7.2 GO:0004832 valine-tRNA ligase activity(GO:0004832)
2.4 113.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
2.3 13.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
2.3 11.5 GO:0071074 eukaryotic initiation factor eIF2 binding(GO:0071074)
2.3 27.1 GO:0019534 toxin transporter activity(GO:0019534)
2.2 44.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
2.2 13.0 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
2.2 13.0 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
2.1 8.4 GO:0032038 myosin II heavy chain binding(GO:0032038)
2.1 29.4 GO:0016018 cyclosporin A binding(GO:0016018)
2.1 14.7 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
2.1 22.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
2.1 10.3 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
2.0 21.6 GO:0051434 BH3 domain binding(GO:0051434)
1.9 9.7 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
1.9 98.8 GO:0016831 carboxy-lyase activity(GO:0016831)
1.9 34.7 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
1.9 11.6 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.9 5.8 GO:0070699 type II activin receptor binding(GO:0070699)
1.9 100.6 GO:0003743 translation initiation factor activity(GO:0003743)
1.9 5.6 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
1.8 38.6 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
1.8 18.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
1.8 41.9 GO:0001056 RNA polymerase III activity(GO:0001056)
1.8 7.2 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
1.8 71.4 GO:0048487 beta-tubulin binding(GO:0048487)
1.8 10.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
1.8 12.4 GO:0032051 clathrin light chain binding(GO:0032051)
1.8 22.8 GO:0003680 AT DNA binding(GO:0003680)
1.7 42.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.7 80.4 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
1.7 27.7 GO:0017049 GTP-Rho binding(GO:0017049)
1.7 20.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
1.7 15.2 GO:0070883 pre-miRNA binding(GO:0070883)
1.7 31.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.6 9.8 GO:0102336 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
1.6 11.2 GO:0001849 complement component C1q binding(GO:0001849)
1.6 14.3 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
1.6 20.4 GO:0035613 RNA stem-loop binding(GO:0035613)
1.6 10.9 GO:0061133 endopeptidase activator activity(GO:0061133)
1.5 6.2 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
1.5 6.1 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
1.5 16.7 GO:0008139 nuclear localization sequence binding(GO:0008139)
1.5 7.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
1.5 40.1 GO:0051010 microtubule plus-end binding(GO:0051010)
1.5 26.3 GO:0043274 phospholipase binding(GO:0043274)
1.5 8.8 GO:0003998 acylphosphatase activity(GO:0003998)
1.4 23.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
1.4 8.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
1.4 34.3 GO:0003746 translation elongation factor activity(GO:0003746)
1.4 9.5 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
1.3 25.9 GO:0004697 protein kinase C activity(GO:0004697)
1.2 21.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
1.2 8.7 GO:0000832 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) inositol hexakisphosphate kinase activity(GO:0000828) inositol heptakisphosphate kinase activity(GO:0000829) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
1.2 41.8 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
1.2 17.8 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
1.2 4.7 GO:0033906 protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
1.2 1.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
1.2 26.8 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
1.2 2.3 GO:0004530 deoxyribonuclease I activity(GO:0004530)
1.2 34.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.1 245.3 GO:0003735 structural constituent of ribosome(GO:0003735)
1.1 10.2 GO:0043426 MRF binding(GO:0043426)
1.1 38.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
1.1 15.3 GO:0010857 calcium-dependent protein serine/threonine kinase activity(GO:0009931) calcium-dependent protein kinase activity(GO:0010857)
1.1 75.5 GO:0019003 GDP binding(GO:0019003)
1.1 31.6 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.0 27.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.0 10.9 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.9 81.4 GO:0032947 protein complex scaffold(GO:0032947)
0.9 13.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.8 9.1 GO:0016413 palmitoyl-CoA hydrolase activity(GO:0016290) O-acetyltransferase activity(GO:0016413)
0.8 5.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.8 25.7 GO:0000049 tRNA binding(GO:0000049)
0.8 93.3 GO:0008565 protein transporter activity(GO:0008565)
0.8 7.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.8 6.9 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.8 4.6 GO:0070513 death domain binding(GO:0070513)
0.7 15.7 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.7 8.6 GO:0048156 tau protein binding(GO:0048156)
0.7 13.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.7 5.7 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.7 19.6 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.7 4.7 GO:0004046 aminoacylase activity(GO:0004046)
0.7 5.3 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.7 2.0 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.7 4.6 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.6 2.6 GO:0001054 RNA polymerase I activity(GO:0001054)
0.6 17.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.6 10.5 GO:0034185 apolipoprotein binding(GO:0034185)
0.6 15.2 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.6 2.4 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.6 13.5 GO:0070064 proline-rich region binding(GO:0070064)
0.6 5.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.6 7.2 GO:0008143 poly(A) binding(GO:0008143)
0.5 29.2 GO:0005246 calcium channel regulator activity(GO:0005246)
0.5 3.7 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.5 23.7 GO:0005484 SNAP receptor activity(GO:0005484)
0.5 3.1 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.5 37.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.5 5.5 GO:0097602 cullin family protein binding(GO:0097602)
0.5 15.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.5 13.3 GO:0046965 retinoid X receptor binding(GO:0046965)
0.5 15.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.5 32.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.5 5.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.4 13.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.4 17.0 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.4 2.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 5.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.4 35.8 GO:0001618 virus receptor activity(GO:0001618)
0.4 45.3 GO:0051082 unfolded protein binding(GO:0051082)
0.4 1.1 GO:0034038 deoxyhypusine synthase activity(GO:0034038)
0.4 1.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.4 2.1 GO:0098821 BMP receptor activity(GO:0098821)
0.3 23.0 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.3 54.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.3 8.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.6 GO:0000403 Y-form DNA binding(GO:0000403)
0.3 15.0 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.3 15.5 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.3 1.1 GO:0050473 prostaglandin-endoperoxide synthase activity(GO:0004666) arachidonate 15-lipoxygenase activity(GO:0050473)
0.3 16.1 GO:0003684 damaged DNA binding(GO:0003684)
0.3 6.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.3 1.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.3 8.2 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 3.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 3.0 GO:0031419 cobalamin binding(GO:0031419)
0.3 41.3 GO:0005178 integrin binding(GO:0005178)
0.3 80.8 GO:0045296 cadherin binding(GO:0045296)
0.3 9.4 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 0.8 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.2 5.1 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.2 9.5 GO:0008009 chemokine activity(GO:0008009)
0.2 2.0 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.2 12.8 GO:0051287 NAD binding(GO:0051287)
0.2 23.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 9.7 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 2.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.2 2.0 GO:0048406 nerve growth factor binding(GO:0048406)
0.2 11.9 GO:0008276 protein methyltransferase activity(GO:0008276)
0.2 3.0 GO:0051117 ATPase binding(GO:0051117)
0.2 12.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 1.1 GO:0051425 PTB domain binding(GO:0051425)
0.2 0.7 GO:0031208 POZ domain binding(GO:0031208)
0.2 1.2 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.2 1.8 GO:0070566 adenylyltransferase activity(GO:0070566)
0.2 2.0 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.2 9.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 6.2 GO:0030695 GTPase activator activity(GO:0005096) GTPase regulator activity(GO:0030695) nucleoside-triphosphatase regulator activity(GO:0060589)
0.2 162.5 GO:0003723 RNA binding(GO:0003723)
0.1 9.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 0.5 GO:0004594 pantothenate kinase activity(GO:0004594)
0.1 3.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 0.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 3.9 GO:0001972 retinoic acid binding(GO:0001972)
0.1 2.9 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 1.2 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1 10.6 GO:0051015 actin filament binding(GO:0051015)
0.1 1.9 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 4.1 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 2.4 GO:0016504 peptidase activator activity(GO:0016504)
0.1 17.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 3.9 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.1 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 0.6 GO:0003713 transcription coactivator activity(GO:0003713)
0.1 0.6 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.1 12.1 GO:0015631 tubulin binding(GO:0015631)
0.1 2.0 GO:0005109 frizzled binding(GO:0005109)
0.1 1.4 GO:0042169 SH2 domain binding(GO:0042169)
0.0 27.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.4 GO:0019894 kinesin binding(GO:0019894)
0.0 1.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 2.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.1 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 1.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.1 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 1.6 GO:0008022 protein C-terminus binding(GO:0008022)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
24.6 613.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
4.5 13.6 PID S1P S1P2 PATHWAY S1P2 pathway
3.6 62.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
3.6 500.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
2.4 12.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
2.3 111.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
2.1 110.1 PID FOXM1 PATHWAY FOXM1 transcription factor network
1.9 172.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
1.8 103.0 PID ATR PATHWAY ATR signaling pathway
1.2 131.9 PID CMYB PATHWAY C-MYB transcription factor network
1.2 87.4 PID ILK PATHWAY Integrin-linked kinase signaling
1.0 50.3 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
1.0 62.0 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.0 92.3 PID CDC42 PATHWAY CDC42 signaling events
1.0 27.6 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.9 83.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.9 21.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.9 15.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.9 63.8 PID E2F PATHWAY E2F transcription factor network
0.8 25.2 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.8 42.6 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.8 32.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.8 33.1 PID ARF6 PATHWAY Arf6 signaling events
0.7 25.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.7 14.6 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.7 20.0 PID ATM PATHWAY ATM pathway
0.6 161.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 15.3 PID RHOA PATHWAY RhoA signaling pathway
0.6 38.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.6 13.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.6 23.4 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.5 20.4 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.5 11.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.5 31.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.5 19.5 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.5 9.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4 16.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 51.7 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.4 21.6 PID P73PATHWAY p73 transcription factor network
0.4 2.5 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.3 4.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.3 20.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.3 11.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 9.9 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.2 6.1 PID IFNG PATHWAY IFN-gamma pathway
0.2 2.1 PID BMP PATHWAY BMP receptor signaling
0.2 19.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.2 5.8 PID ALK1 PATHWAY ALK1 signaling events
0.2 5.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 9.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 5.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 0.6 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.6 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.6 PID ENDOTHELIN PATHWAY Endothelins
0.0 0.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.0 0.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 2.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 220.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
9.6 652.0 REACTOME G1 PHASE Genes involved in G1 Phase
7.8 124.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
7.4 133.0 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
6.4 185.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
5.7 131.4 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
5.5 105.0 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
5.2 47.0 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
4.9 230.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
4.8 118.9 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
4.1 178.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
4.1 179.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
3.8 34.6 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
3.7 63.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
3.6 47.1 REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX Genes involved in Formation of the HIV-1 Early Elongation Complex
3.6 50.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
3.5 41.9 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
3.1 72.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
2.9 31.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
2.8 59.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
2.4 81.9 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
2.3 54.1 REACTOME PURINE METABOLISM Genes involved in Purine metabolism
2.2 24.6 REACTOME REGULATORY RNA PATHWAYS Genes involved in Regulatory RNA pathways
2.2 51.3 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
2.1 177.7 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
2.1 104.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
2.0 200.3 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
2.0 320.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
2.0 6.1 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.9 104.3 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
1.8 27.5 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
1.7 8.6 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
1.7 163.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
1.7 15.1 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
1.5 29.6 REACTOME METABOLISM OF NUCLEOTIDES Genes involved in Metabolism of nucleotides
1.5 39.9 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.4 28.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
1.4 8.5 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
1.4 50.3 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
1.3 21.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
1.3 37.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
1.3 68.9 REACTOME TRANSLATION Genes involved in Translation
1.2 32.4 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
1.2 41.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.2 32.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
1.2 19.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
1.1 36.5 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
1.1 32.5 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
1.1 40.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.0 8.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
1.0 37.8 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.0 19.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.0 35.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.9 37.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.9 78.3 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.9 17.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.9 11.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.9 64.0 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.9 25.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.8 11.7 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.8 6.6 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.8 135.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.7 54.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.7 5.7 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.7 14.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.7 18.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.7 28.4 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.6 46.7 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.6 27.6 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.6 15.3 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.6 28.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 16.3 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.6 9.2 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.6 26.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.6 29.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.6 10.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 32.9 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5 92.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.5 5.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.5 9.7 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.5 5.5 REACTOME GLOBAL GENOMIC NER GG NER Genes involved in Global Genomic NER (GG-NER)
0.5 10.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.4 29.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.4 9.1 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.4 5.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.4 8.6 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 4.4 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 8.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 1.9 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.4 10.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 4.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.4 4.6 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.4 8.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3 8.1 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 5.4 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 2.2 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3 35.6 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 21.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 6.1 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.3 3.9 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.3 7.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 2.1 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.2 5.9 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.2 4.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 4.4 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.2 1.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.2 1.5 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 6.7 REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1
0.1 11.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 9.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 1.1 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.1 1.9 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 2.2 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.1 1.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL