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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MECP2
Z-value: 2.35
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Transcription factors associated with MECP2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MECP2 | hg19_v2_chrX_-_153363125_153363182 | -0.22 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MECP2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 357.8 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 4.0 | 349.0 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 3.8 | 283.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.5 | 192.6 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 1.8 | 190.1 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 3.6 | 156.8 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.8 | 151.4 | GO:0045815 | positive regulation of gene expression, epigenetic(GO:0045815) |
| 2.1 | 136.9 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 2.2 | 122.2 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 3.4 | 115.3 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 607.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 1.0 | 517.2 | GO:0005925 | focal adhesion(GO:0005925) |
| 2.4 | 384.5 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.8 | 247.9 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.7 | 241.7 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 2.2 | 237.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.2 | 231.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 3.4 | 182.1 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 1.9 | 174.0 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 4.0 | 152.6 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 613.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 546.2 | GO:0003723 | RNA binding(GO:0003723) |
| 1.3 | 454.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 5.2 | 237.3 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 2.9 | 197.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 2.8 | 191.0 | GO:0031491 | nucleosome binding(GO:0031491) |
| 5.5 | 164.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.9 | 161.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 1.9 | 132.4 | GO:0019003 | GDP binding(GO:0019003) |
| 4.5 | 120.4 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 300.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.3 | 280.1 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 3.0 | 155.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.7 | 150.9 | PID E2F PATHWAY | E2F transcription factor network |
| 2.7 | 132.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 2.8 | 124.8 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 1.8 | 113.2 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 2.0 | 112.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.1 | 107.3 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 1.8 | 105.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 497.4 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 6.1 | 474.8 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.4 | 223.3 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 2.1 | 216.4 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 6.2 | 210.5 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 5.3 | 205.1 | REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC | Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC |
| 2.4 | 191.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 3.2 | 164.4 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 3.6 | 156.4 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 4.0 | 141.4 | REACTOME PYRIMIDINE METABOLISM | Genes involved in Pyrimidine metabolism |