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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MEF2B

Z-value: 0.89

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Transcription factors associated with MEF2B

Gene Symbol Gene ID Gene Info
MEF2B
ENSG00000213999.11 myocyte enhancer factor 2B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
MEF2Bhg19_v2_chr19_-_19302931_193029740.283.1e-05Click!

Activity profile of MEF2B motif

Sorted Z-values of MEF2B motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_21493884 22.18 ENST00000556974.1
ENST00000554419.1
ENST00000298687.5
ENST00000397858.1
ENST00000360463.3
ENST00000350792.3
ENST00000397847.2
NDRG2
NDRG family member 2
chr14_-_21493649 21.23 ENST00000553442.1
ENST00000555869.1
ENST00000556457.1
ENST00000397844.2
ENST00000554415.1
NDRG2
NDRG family member 2
chr20_+_10199468 20.99 ENST00000254976.2
ENST00000304886.2
SNAP25
synaptosomal-associated protein, 25kDa
chr14_-_21493123 20.46 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG2
NDRG family member 2
chr8_-_27115931 19.21 ENST00000523048.1
STMN4
stathmin-like 4
chr2_+_233497931 19.09 ENST00000264059.3
EFHD1
EF-hand domain family, member D1
chr8_-_27115903 17.15 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
STMN4
stathmin-like 4
chr12_-_45269430 15.79 ENST00000395487.2
NELL2
NEL-like 2 (chicken)
chr12_-_49393092 13.57 ENST00000421952.2
DDN
dendrin
chr20_+_44035847 13.53 ENST00000372712.2
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr3_+_127634069 10.40 ENST00000405109.1
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_+_127634312 10.31 ENST00000407609.3
KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr5_-_42811986 10.15 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr20_+_44657845 9.79 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr5_-_42812143 9.42 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr7_-_37488834 9.31 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr2_-_86564776 9.30 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr12_+_52445191 8.84 ENST00000243050.1
ENST00000394825.1
ENST00000550763.1
ENST00000394824.2
ENST00000548232.1
ENST00000562373.1
NR4A1
nuclear receptor subfamily 4, group A, member 1
chr16_+_84328252 8.66 ENST00000219454.5
WFDC1
WAP four-disulfide core domain 1
chr16_+_84328429 8.42 ENST00000568638.1
WFDC1
WAP four-disulfide core domain 1
chr1_+_92632542 7.80 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr12_+_119616447 7.71 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr15_+_42651691 7.35 ENST00000357568.3
ENST00000349748.3
ENST00000318023.7
ENST00000397163.3
CAPN3
calpain 3, (p94)
chr14_-_22005343 7.20 ENST00000327430.3
SALL2
spalt-like transcription factor 2
chr11_-_18034701 6.46 ENST00000265965.5
SERGEF
secretion regulating guanine nucleotide exchange factor
chr3_+_138067521 6.35 ENST00000494949.1
MRAS
muscle RAS oncogene homolog
chr2_-_157198860 6.26 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr3_+_138067314 6.19 ENST00000423968.2
MRAS
muscle RAS oncogene homolog
chr8_+_95565947 5.83 ENST00000523011.1
RP11-267M23.4
RP11-267M23.4
chr22_+_32340447 5.71 ENST00000248975.5
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr22_+_32340481 5.63 ENST00000397492.1
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr1_+_84630645 5.52 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr7_+_86781847 5.46 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
DMTF1
cyclin D binding myb-like transcription factor 1
chr17_+_20059302 5.45 ENST00000395530.2
SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr1_-_19229014 5.20 ENST00000538839.1
ENST00000290597.5
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr5_-_16509101 5.14 ENST00000399793.2
FAM134B
family with sequence similarity 134, member B
chr17_+_7184986 4.75 ENST00000317370.8
ENST00000571308.1
SLC2A4
solute carrier family 2 (facilitated glucose transporter), member 4
chr3_+_138067666 4.56 ENST00000475711.1
ENST00000464896.1
MRAS
muscle RAS oncogene homolog
chr2_+_33661382 4.53 ENST00000402538.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr8_+_107282389 4.29 ENST00000577661.1
ENST00000445937.1
RP11-395G23.3
OXR1
RP11-395G23.3
oxidation resistance 1
chr1_+_77333117 4.07 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr4_+_41362796 3.93 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
LIMCH1
LIM and calponin homology domains 1
chr9_+_100263912 3.74 ENST00000259365.4
TMOD1
tropomodulin 1
chr5_-_131347501 3.50 ENST00000543479.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr7_+_30951461 3.20 ENST00000311813.4
AQP1
aquaporin 1 (Colton blood group)
chr3_+_159570722 3.07 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr12_-_371994 3.04 ENST00000343164.4
ENST00000436453.1
ENST00000445055.2
ENST00000546319.1
SLC6A13
solute carrier family 6 (neurotransmitter transporter), member 13
chr3_+_186739636 2.99 ENST00000440338.1
ENST00000448044.1
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr3_-_188665428 2.90 ENST00000444488.1
TPRG1-AS1
TPRG1 antisense RNA 1
chr1_-_156460391 2.83 ENST00000360595.3
MEF2D
myocyte enhancer factor 2D
chr12_+_25205446 2.79 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr5_-_131347583 2.64 ENST00000379255.1
ENST00000430403.1
ENST00000544770.1
ENST00000379246.1
ENST00000414078.1
ENST00000441995.1
ACSL6
acyl-CoA synthetase long-chain family member 6
chr15_+_40531243 2.63 ENST00000558055.1
ENST00000455577.2
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr21_-_42219065 2.61 ENST00000400454.1
DSCAM
Down syndrome cell adhesion molecule
chr3_-_192445289 2.47 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12
fibroblast growth factor 12
chr12_+_25205666 2.38 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_+_15699286 2.37 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO
protein tyrosine phosphatase, receptor type, O
chr15_+_100106126 2.26 ENST00000558812.1
ENST00000338042.6
MEF2A
myocyte enhancer factor 2A
chr12_+_25205568 2.25 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr17_-_42200996 2.25 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
HDAC5
histone deacetylase 5
chr15_+_100106155 2.06 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr6_+_139094657 2.03 ENST00000332797.6
CCDC28A
coiled-coil domain containing 28A
chr8_+_1993152 2.00 ENST00000262113.4
MYOM2
myomesin 2
chr17_-_42200958 1.95 ENST00000336057.5
HDAC5
histone deacetylase 5
chr20_+_11898507 1.94 ENST00000378226.2
BTBD3
BTB (POZ) domain containing 3
chr3_+_54157480 1.85 ENST00000490478.1
CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_-_40324255 1.76 ENST00000593685.1
ENST00000600611.1
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr1_+_26348259 1.55 ENST00000374280.3
EXTL1
exostosin-like glycosyltransferase 1
chr5_+_53751445 1.55 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr1_+_160051319 1.46 ENST00000368088.3
KCNJ9
potassium inwardly-rectifying channel, subfamily J, member 9
chr11_-_47400078 1.45 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr22_-_51017084 1.44 ENST00000360719.2
ENST00000457250.1
ENST00000440709.1
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr4_+_120056939 1.43 ENST00000307128.5
MYOZ2
myozenin 2
chr11_+_1860682 1.42 ENST00000381906.1
TNNI2
troponin I type 2 (skeletal, fast)
chr7_+_143013198 1.40 ENST00000343257.2
CLCN1
chloride channel, voltage-sensitive 1
chr15_+_40531621 1.38 ENST00000560346.1
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_-_116311402 1.36 ENST00000261448.5
CASQ2
calsequestrin 2 (cardiac muscle)
chr18_+_12407895 1.26 ENST00000590956.1
ENST00000336990.4
ENST00000440960.1
ENST00000588729.1
SLMO1
slowmo homolog 1 (Drosophila)
chr19_-_40324767 1.21 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
DYRK1B
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr1_+_22778337 1.20 ENST00000404138.1
ENST00000400239.2
ENST00000375647.4
ENST00000374651.4
ZBTB40
zinc finger and BTB domain containing 40
chr1_-_27240455 1.19 ENST00000254227.3
NR0B2
nuclear receptor subfamily 0, group B, member 2
chr5_-_131347306 1.15 ENST00000296869.4
ENST00000379249.3
ENST00000379272.2
ENST00000379264.2
ACSL6
acyl-CoA synthetase long-chain family member 6
chr6_-_169654139 1.15 ENST00000366787.3
THBS2
thrombospondin 2
chr10_-_75415825 1.15 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr8_-_70745575 1.13 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr11_+_1860832 1.07 ENST00000252898.7
TNNI2
troponin I type 2 (skeletal, fast)
chr11_-_47374246 1.02 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
MYBPC3
myosin binding protein C, cardiac
chr16_+_12058961 0.93 ENST00000053243.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr22_-_51016846 0.92 ENST00000312108.7
ENST00000395650.2
CPT1B
carnitine palmitoyltransferase 1B (muscle)
chr8_+_1993173 0.90 ENST00000523438.1
MYOM2
myomesin 2
chr8_+_11351876 0.88 ENST00000529894.1
BLK
B lymphoid tyrosine kinase
chr6_-_33160231 0.85 ENST00000395194.1
ENST00000457788.1
ENST00000341947.2
ENST00000357486.1
ENST00000374714.1
ENST00000374713.1
ENST00000395197.1
ENST00000374712.1
ENST00000361917.1
ENST00000374708.4
COL11A2
collagen, type XI, alpha 2
chr11_-_84634447 0.84 ENST00000532653.1
DLG2
discs, large homolog 2 (Drosophila)
chr15_+_100106244 0.83 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr3_+_8543533 0.80 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chr16_-_31439735 0.79 ENST00000287490.4
COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr17_-_34417479 0.78 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr10_-_97200772 0.73 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr11_-_84634217 0.72 ENST00000524982.1
DLG2
discs, large homolog 2 (Drosophila)
chr16_+_12059050 0.71 ENST00000396495.3
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chrX_-_11284095 0.62 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr17_-_1389228 0.58 ENST00000438665.2
MYO1C
myosin IC
chr10_+_135340859 0.55 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr5_-_66492562 0.49 ENST00000256447.4
CD180
CD180 molecule
chr16_+_12059091 0.48 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr11_-_47399942 0.46 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_+_11351494 0.46 ENST00000259089.4
BLK
B lymphoid tyrosine kinase
chr2_+_170366203 0.45 ENST00000284669.1
KLHL41
kelch-like family member 41
chr15_+_68346501 0.45 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr16_+_31225337 0.38 ENST00000322122.3
TRIM72
tripartite motif containing 72
chr11_+_7597639 0.33 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr7_-_113559104 0.19 ENST00000284601.3
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr6_+_152128371 0.12 ENST00000443427.1
ESR1
estrogen receptor 1
chr5_+_138609782 0.08 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
MATR3
matrin 3
chr5_+_132009675 0.02 ENST00000231449.2
ENST00000350025.2
IL4
interleukin 4

Network of associatons between targets according to the STRING database.

First level regulatory network of MEF2B

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 21.0 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
4.0 63.9 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
2.4 9.8 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
2.1 6.3 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
1.3 5.2 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
1.3 8.8 GO:0043435 response to corticotropin-releasing hormone(GO:0043435) cellular response to corticotropin-releasing hormone stimulus(GO:0071376)
1.2 7.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
1.1 15.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
1.1 5.5 GO:0097338 response to clozapine(GO:0097338)
1.1 3.2 GO:0072019 carbon dioxide transmembrane transport(GO:0035378) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229)
0.9 5.1 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.8 2.4 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.7 36.4 GO:0007019 microtubule depolymerization(GO:0007019)
0.6 3.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.6 9.3 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.6 11.3 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.4 1.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.3 7.3 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.3 7.1 GO:0097503 sialylation(GO:0097503)
0.3 4.3 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 2.5 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.2 9.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.2 0.8 GO:0060023 soft palate development(GO:0060023)
0.2 2.8 GO:0007512 adult heart development(GO:0007512)
0.2 2.6 GO:0048842 positive regulation of axon extension involved in axon guidance(GO:0048842)
0.2 3.9 GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.2 3.0 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 17.1 GO:0061045 negative regulation of wound healing(GO:0061045)
0.2 4.8 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 1.4 GO:0071313 cellular response to caffeine(GO:0071313)
0.1 2.4 GO:0006853 carnitine shuttle(GO:0006853)
0.1 17.1 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.1 1.4 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.8 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.1 0.6 GO:0010193 response to ozone(GO:0010193)
0.1 0.5 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.1 7.4 GO:0006903 vesicle targeting(GO:0006903)
0.1 1.6 GO:0097120 receptor localization to synapse(GO:0097120)
0.1 3.0 GO:0007520 myoblast fusion(GO:0007520)
0.1 0.4 GO:0001778 plasma membrane repair(GO:0001778)
0.0 1.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.4 GO:0051152 positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0 0.5 GO:0031272 regulation of pseudopodium assembly(GO:0031272)
0.0 7.2 GO:0021915 neural tube development(GO:0021915)
0.0 1.3 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.6 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 1.5 GO:0010107 potassium ion import(GO:0010107)
0.0 2.1 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.0 0.7 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.0 4.5 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 1.1 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.1 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 3.3 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.0 2.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.8 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 22.7 GO:0031175 neuron projection development(GO:0031175)
0.0 4.0 GO:0007266 Rho protein signal transduction(GO:0007266)
0.0 1.2 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 12.3 GO:0016567 protein ubiquitination(GO:0016567)
0.0 1.0 GO:0030282 bone mineralization(GO:0030282)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 21.0 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
1.2 13.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.1 3.2 GO:0020005 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005)
0.6 13.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.6 4.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.5 105.2 GO:0030426 growth cone(GO:0030426)
0.3 1.4 GO:0030314 junctional membrane complex(GO:0030314)
0.3 21.2 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 5.5 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 9.8 GO:0043198 dendritic shaft(GO:0043198)
0.2 7.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 13.5 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 0.7 GO:0005899 insulin receptor complex(GO:0005899)
0.1 2.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.1 7.3 GO:0030315 T-tubule(GO:0030315)
0.1 10.5 GO:0014704 intercalated disc(GO:0014704)
0.1 6.5 GO:0016235 aggresome(GO:0016235)
0.1 7.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 7.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 3.7 GO:0008180 COP9 signalosome(GO:0008180)
0.1 0.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 1.6 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.0 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 7.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 5.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 2.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 0.7 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
1.1 3.2 GO:0035379 carbon dioxide transmembrane transporter activity(GO:0035379)
1.0 4.2 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
1.0 3.0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.9 6.5 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.9 9.8 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.7 17.6 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.7 21.0 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 8.4 GO:0031432 titin binding(GO:0031432)
0.5 3.0 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.5 17.1 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.5 1.4 GO:0051373 FATZ binding(GO:0051373)
0.5 2.4 GO:0004095 carnitine O-palmitoyltransferase activity(GO:0004095)
0.4 7.3 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 5.5 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 4.8 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.3 2.0 GO:0031014 troponin T binding(GO:0031014)
0.3 1.5 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.3 4.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 5.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.2 17.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 0.8 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.2 1.7 GO:0051525 NFAT protein binding(GO:0051525)
0.1 3.7 GO:0005523 tropomyosin binding(GO:0005523)
0.1 5.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.8 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 1.2 GO:0046965 retinoid X receptor binding(GO:0046965)
0.1 37.2 GO:0015631 tubulin binding(GO:0015631)
0.1 8.4 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.1 0.4 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 2.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 1.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.6 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 4.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 2.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 21.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 3.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.6 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 1.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 0.8 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 9.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.6 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.7 GO:0005158 insulin receptor binding(GO:0005158)
0.0 1.8 GO:0005262 calcium channel activity(GO:0005262)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 65.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.4 16.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 8.8 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 9.3 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 5.5 PID IL3 PATHWAY IL3-mediated signaling events
0.1 19.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 5.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 4.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 2.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.0 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.1 0.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.1 4.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.1 16.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.5 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 1.2 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 2.4 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.0 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.7 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 0.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.8 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 21.0 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.3 7.3 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 3.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.2 4.8 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 5.5 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 9.3 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.2 8.8 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.2 2.6 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 4.0 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 8.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 3.0 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.1 9.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.4 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.1 7.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 1.1 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 4.5 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 1.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.3 REACTOME SIGNALING BY THE B CELL RECEPTOR BCR Genes involved in Signaling by the B Cell Receptor (BCR)
0.0 5.2 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines