ISMARA results: MEIS2

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MEIS2

Z-value: 2.11

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Transcription factors associated with MEIS2

Gene Symbol	Gene ID	Gene Info
MEIS2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000134138.15	Meis homeobox 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MEIS2	hg19_v2_chr15_-_37392086_37392116	-0.17	9.9e-03	Click!

Activity profile of MEIS2 motif

Sorted Z-values of MEIS2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_29648761 Show fit	39.35	ENST00000247270.3 ENST00000462804.2	EVI2A Ensembl NCBI GeneCards UniProt NextProt Show fit	ecotropic viral integration site 2A
chr6_-_33048483 Show fit	32.16	ENST00000419277.1	HLA-DPA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP alpha 1
chr22_-_27620603 Show fit	31.62	ENST00000418271.1 ENST00000444114.1	RP5-1172A22.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP5-1172A22.1
chr4_-_88450244 Show fit	30.36	ENST00000503414.1	SPARCL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SPARC-like 1 (hevin)
chr4_-_88450612 Show fit	30.33	ENST00000418378.1 ENST00000282470.6	SPARCL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	SPARC-like 1 (hevin)
chr11_-_5255696 Show fit	30.14	ENST00000292901.3 ENST00000417377.1	HBD Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, delta
chr6_+_33043703 Show fit	29.97	ENST00000418931.2 ENST00000535465.1	HLA-DPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP beta 1
chr11_-_5255861 Show fit	28.09	ENST00000380299.3	HBD Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, delta
chr6_+_32407619 Show fit	27.41	ENST00000395388.2 ENST00000374982.5	HLA-DRA Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DR alpha
chr6_+_33048222 Show fit	26.29	ENST00000428835.1	HLA-DPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP beta 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	253.4	GO:0031295	T cell costimulation(GO:0031295)
0.5	113.4	GO:0002250	adaptive immune response(GO:0002250)
6.7	100.2	GO:0015671	oxygen transport(GO:0015671)
5.1	91.6	GO:0007021	tubulin complex assembly(GO:0007021)
1.4	90.3	GO:0006910	phagocytosis, recognition(GO:0006910)
1.0	90.3	GO:0006958	complement activation, classical pathway(GO:0006958)
0.6	84.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
5.6	55.5	GO:0090292	nuclear matrix anchoring at nuclear membrane(GO:0090292)
2.0	49.5	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
7.9	47.5	GO:0070315	G1 to G0 transition involved in cell differentiation(GO:0070315)

Showing 1 to 10 of 956 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
10.9	229.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.3	160.8	GO:0045202	synapse(GO:0045202)
6.5	103.5	GO:0097512	cardiac myofibril(GO:0097512)
7.1	99.5	GO:0005833	hemoglobin complex(GO:0005833)
1.8	88.5	GO:0042571	immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571)
1.0	75.5	GO:0030315	T-tubule(GO:0030315)
0.8	71.1	GO:0043195	terminal bouton(GO:0043195)
0.4	61.8	GO:0009897	external side of plasma membrane(GO:0009897)
0.8	56.5	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
2.9	55.9	GO:0001891	phagocytic cup(GO:0001891)

Showing 1 to 10 of 306 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	185.4	GO:0003823	antigen binding(GO:0003823)
8.3	116.7	GO:0032395	MHC class II receptor activity(GO:0032395)
3.4	106.5	GO:0005212	structural constituent of eye lens(GO:0005212)
7.7	100.2	GO:0005344	oxygen transporter activity(GO:0005344)
3.2	91.9	GO:0042605	peptide antigen binding(GO:0042605)
1.3	89.9	GO:0001540	beta-amyloid binding(GO:0001540)
1.7	84.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.1	81.8	GO:0001071	nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
1.1	79.1	GO:0050840	extracellular matrix binding(GO:0050840)
2.8	72.0	GO:0005521	lamin binding(GO:0005521)

Showing 1 to 10 of 590 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	149.9	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
0.5	87.6	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.2	62.8	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
1.5	60.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
2.2	55.5	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
1.2	40.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.8	38.4	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.8	38.3	PID BCR 5PATHWAY	BCR signaling pathway
1.5	38.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.7	37.6	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 99 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.1	185.6	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
2.0	170.6	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.0	98.2	REACTOME GPVI MEDIATED ACTIVATION CASCADE	Genes involved in GPVI-mediated activation cascade
0.5	76.0	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.4	69.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
1.0	54.2	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.6	49.1	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.8	48.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
2.8	47.0	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	45.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+

Showing 1 to 10 of 155 entries

Results for MEIS2

Z-value: 2.11

Motif logo

Transcription factors associated with MEIS2

Activity-expression correlation:

Activity profile of MEIS2 motif

Sorted Z-values of MEIS2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MEIS2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: