Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for MYB
Z-value: 3.59
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Transcription factors associated with MYB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| MYB | hg19_v2_chr6_+_135502408_135502459 | 0.26 | 1.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of MYB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 335.9 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 7.3 | 210.6 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 2.3 | 157.7 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
| 39.4 | 157.4 | GO:0071733 | transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579) |
| 3.6 | 124.5 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.7 | 116.2 | GO:0006626 | protein targeting to mitochondrion(GO:0006626) |
| 8.2 | 106.2 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 1.4 | 101.5 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 10.6 | 95.6 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 2.1 | 88.1 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 347.4 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 20.7 | 186.7 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.5 | 177.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 15.7 | 157.4 | GO:0097255 | R2TP complex(GO:0097255) |
| 5.2 | 156.9 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 7.6 | 144.0 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.8 | 103.8 | GO:0000922 | spindle pole(GO:0000922) |
| 5.0 | 94.1 | GO:0036020 | endolysosome membrane(GO:0036020) |
| 0.9 | 88.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.1 | 86.5 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 282.4 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 4.3 | 159.8 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 26.2 | 157.4 | GO:0043141 | ATP-dependent 5'-3' DNA helicase activity(GO:0043141) |
| 0.1 | 146.8 | GO:0003723 | RNA binding(GO:0003723) |
| 7.1 | 121.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 19.9 | 119.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 0.4 | 95.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 4.3 | 94.1 | GO:0098748 | clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748) |
| 2.7 | 93.5 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.9 | 87.8 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 215.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 3.5 | 181.3 | PID MYC PATHWAY | C-MYC pathway |
| 1.9 | 111.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 2.0 | 105.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.8 | 88.4 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 1.3 | 61.6 | PID ATM PATHWAY | ATM pathway |
| 0.8 | 59.6 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 0.7 | 53.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 51.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.5 | 46.5 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.9 | 165.2 | REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A | Genes involved in APC-Cdc20 mediated degradation of Nek2A |
| 4.3 | 163.9 | REACTOME EXTENSION OF TELOMERES | Genes involved in Extension of Telomeres |
| 1.7 | 159.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.6 | 133.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 2.3 | 126.9 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 3.2 | 111.0 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.6 | 102.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 1.6 | 95.5 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 4.3 | 94.1 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.5 | 86.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |