ISMARA results: MYOD1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for MYOD1

Z-value: 1.25

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Transcription factors associated with MYOD1

Gene Symbol	Gene ID	Gene Info
MYOD1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000129152.3	myogenic differentiation 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYOD1	hg19_v2_chr11_+_17741111_17741124	0.24	3.3e-04	Click!

Activity profile of MYOD1 motif

Sorted Z-values of MYOD1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_152590946 Show fit	20.71	ENST00000172853.10	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin
chr11_+_1860200 Show fit	16.75	ENST00000381911.1	TNNI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin I type 2 (skeletal, fast)
chrX_-_107018969 Show fit	16.45	ENST00000372383.4	TSC22D3 Ensembl NCBI GeneCards UniProt NextProt Show fit	TSC22 domain family, member 3
chr19_-_45826125 Show fit	15.24	ENST00000221476.3	CKM Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, muscle
chr16_+_30387141 Show fit	14.70	ENST00000566955.1	MYLPF Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr9_-_35689900 Show fit	13.00	ENST00000378300.5 ENST00000329305.2 ENST00000360958.2	TPM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tropomyosin 2 (beta)
chr2_+_220283091 Show fit	12.32	ENST00000373960.3	DES Ensembl NCBI GeneCards UniProt NextProt Show fit	desmin
chr16_+_30383613 Show fit	12.03	ENST00000568749.1	MYLPF Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr11_+_1860682 Show fit	11.72	ENST00000381906.1	TNNI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin I type 2 (skeletal, fast)
chr11_+_1860832 Show fit	11.29	ENST00000252898.7	TNNI2 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin I type 2 (skeletal, fast)

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of MYOD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	114.8	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
8.2	41.2	GO:1904274	tricellular tight junction assembly(GO:1904274)
0.2	33.7	GO:0007519	skeletal muscle tissue development(GO:0007519)
7.7	30.8	GO:0007525	somatic muscle development(GO:0007525)
3.0	23.7	GO:0070235	regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
1.9	20.5	GO:0006600	creatine metabolic process(GO:0006600)
1.8	16.4	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
2.0	16.2	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.2	14.0	GO:2000649	regulation of sodium ion transmembrane transporter activity(GO:2000649)
1.7	13.2	GO:0001661	conditioned taste aversion(GO:0001661)

Showing 1 to 10 of 254 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	73.7	GO:0005861	troponin complex(GO:0005861)
1.7	62.9	GO:0005859	muscle myosin complex(GO:0005859)
6.9	41.2	GO:0061689	tricellular tight junction(GO:0061689)
0.3	41.0	GO:0030018	Z disc(GO:0030018)
1.2	21.9	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
2.3	18.0	GO:0035976	AP1 complex(GO:0035976)
1.6	17.6	GO:0097512	cardiac myofibril(GO:0097512)
0.5	12.8	GO:0034706	sodium channel complex(GO:0034706)
0.1	11.3	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.3	10.5	GO:0046658	anchored component of plasma membrane(GO:0046658)

Showing 1 to 10 of 113 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	119.2	GO:0008307	structural constituent of muscle(GO:0008307)
3.5	49.2	GO:0031014	troponin T binding(GO:0031014)
2.9	25.9	GO:0043426	MRF binding(GO:0043426)
0.4	19.7	GO:0001102	RNA polymerase II activating transcription factor binding(GO:0001102)
3.3	16.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
1.2	16.2	GO:0005344	oxygen transporter activity(GO:0005344)
0.3	16.1	GO:0017080	sodium channel regulator activity(GO:0017080)
1.9	15.2	GO:0004111	creatine kinase activity(GO:0004111)
2.6	10.5	GO:0060422	peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.7	10.5	GO:0036374	glutathione hydrolase activity(GO:0036374)

Showing 1 to 10 of 176 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	20.5	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.4	17.3	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.2	17.2	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	15.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	15.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	9.2	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.1	7.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	7.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	6.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.2	5.6	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining

Showing 1 to 10 of 54 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.1	143.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.3	18.1	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.7	14.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.4	10.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.3	10.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.3	9.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	9.3	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.3	6.8	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.1	6.4	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.3	6.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Showing 1 to 10 of 69 entries

Results for MYOD1

Z-value: 1.25

Motif logo

Transcription factors associated with MYOD1

Activity-expression correlation:

Activity profile of MYOD1 motif

Sorted Z-values of MYOD1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of MYOD1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: