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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NANOG

Z-value: 0.71

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Transcription factors associated with NANOG

Gene Symbol Gene ID Gene Info
NANOG
ENSG00000111704.6 Nanog homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NANOGhg19_v2_chr12_+_7941989_7942014-0.045.9e-01Click!

Activity profile of NANOG motif

Sorted Z-values of NANOG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_156693091 5.47 ENST00000318218.6
ENST00000442283.2
ENST00000522463.1
ENST00000521420.1
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_+_71820057 5.22 ENST00000539225.1
TJP2
tight junction protein 2
chr6_+_32407619 5.16 ENST00000395388.2
ENST00000374982.5
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr9_+_71819927 5.15 ENST00000535702.1
TJP2
tight junction protein 2
chr5_+_156693159 5.13 ENST00000347377.6
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr3_+_23847394 4.86 ENST00000306627.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr4_+_166248775 4.66 ENST00000261507.6
ENST00000507013.1
ENST00000393766.2
ENST00000504317.1
MSMO1
methylsterol monooxygenase 1
chr3_+_23847432 4.63 ENST00000346855.3
UBE2E1
ubiquitin-conjugating enzyme E2E 1
chr15_-_78526855 4.30 ENST00000541759.1
ENST00000558130.1
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr8_-_27468842 4.22 ENST00000523500.1
CLU
clusterin
chr10_+_129845823 3.47 ENST00000306042.5
PTPRE
protein tyrosine phosphatase, receptor type, E
chr19_-_39342962 3.40 ENST00000600873.1
HNRNPL
heterogeneous nuclear ribonucleoprotein L
chr19_+_42381173 3.38 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr11_-_67205538 3.09 ENST00000326294.3
PTPRCAP
protein tyrosine phosphatase, receptor type, C-associated protein
chr8_-_27468945 3.08 ENST00000405140.3
CLU
clusterin
chr3_-_98241358 3.03 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1
claudin domain containing 1
chr6_+_292459 2.97 ENST00000419235.2
ENST00000605035.1
ENST00000605863.1
DUSP22
dual specificity phosphatase 22
chrX_-_118827333 2.88 ENST00000360156.7
ENST00000354228.4
ENST00000489216.1
ENST00000354416.3
ENST00000394610.1
ENST00000343984.5
SEPT6
septin 6
chr8_-_27469196 2.77 ENST00000546343.1
ENST00000560566.1
CLU
clusterin
chr6_+_292051 2.76 ENST00000344450.5
DUSP22
dual specificity phosphatase 22
chr17_-_56606664 2.66 ENST00000580844.1
SEPT4
septin 4
chr19_-_42806919 2.64 ENST00000595530.1
ENST00000538771.1
ENST00000601865.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr15_+_78832747 2.55 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chrX_+_47092314 2.50 ENST00000218348.3
USP11
ubiquitin specific peptidase 11
chr19_-_42806444 2.48 ENST00000594989.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr15_+_78833105 2.46 ENST00000558341.1
ENST00000559437.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr19_-_42806723 2.44 ENST00000262890.3
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr10_+_64133934 2.43 ENST00000395254.3
ENST00000395255.3
ENST00000410046.3
ZNF365
zinc finger protein 365
chr14_+_23791159 2.35 ENST00000557702.1
PABPN1
poly(A) binding protein, nuclear 1
chr4_-_16900184 2.28 ENST00000515064.1
LDB2
LIM domain binding 2
chr2_-_175113088 2.26 ENST00000409546.1
ENST00000428402.2
OLA1
Obg-like ATPase 1
chr5_+_32585605 2.21 ENST00000265073.4
ENST00000515355.1
ENST00000502897.1
ENST00000510442.1
SUB1
SUB1 homolog (S. cerevisiae)
chr1_+_44870866 2.16 ENST00000355387.2
ENST00000361799.2
RNF220
ring finger protein 220
chr15_+_78833071 2.12 ENST00000559365.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr2_-_175113301 2.11 ENST00000344357.5
ENST00000284719.3
OLA1
Obg-like ATPase 1
chr4_-_16900217 2.11 ENST00000441778.2
LDB2
LIM domain binding 2
chr4_-_16900242 2.09 ENST00000502640.1
ENST00000506732.1
LDB2
LIM domain binding 2
chr17_-_34417479 2.05 ENST00000225245.5
CCL3
chemokine (C-C motif) ligand 3
chr11_-_57004658 2.01 ENST00000606794.1
APLNR
apelin receptor
chr4_+_79567362 1.92 ENST00000512322.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr4_+_79567314 1.87 ENST00000503539.1
ENST00000504675.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr4_-_16900410 1.85 ENST00000304523.5
LDB2
LIM domain binding 2
chr8_+_42752053 1.64 ENST00000307602.4
HOOK3
hook microtubule-tethering protein 3
chr8_-_91095099 1.56 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr12_-_123187890 1.55 ENST00000328880.5
HCAR2
hydroxycarboxylic acid receptor 2
chr2_+_219081817 1.43 ENST00000315717.5
ENST00000420104.1
ENST00000295685.10
ARPC2
actin related protein 2/3 complex, subunit 2, 34kDa
chr16_+_6069072 1.43 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_-_123201337 1.41 ENST00000528880.2
HCAR3
hydroxycarboxylic acid receptor 3
chr10_-_1034237 1.38 ENST00000381466.1
AL359878.1
Uncharacterized protein
chr7_+_102715315 1.37 ENST00000428183.2
ENST00000323716.3
ENST00000441711.2
ENST00000454559.1
ENST00000425331.1
ENST00000541300.1
ARMC10
armadillo repeat containing 10
chr7_+_6414128 1.36 ENST00000348035.4
ENST00000356142.4
RAC1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
chr19_-_42806842 1.34 ENST00000596265.1
PAFAH1B3
platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
chr4_-_5891918 1.27 ENST00000512574.1
CRMP1
collapsin response mediator protein 1
chr12_-_51477333 1.25 ENST00000228515.1
ENST00000548206.1
ENST00000546935.1
ENST00000548981.1
CSRNP2
cysteine-serine-rich nuclear protein 2
chr10_-_27443155 1.25 ENST00000427324.1
ENST00000326799.3
YME1L1
YME1-like 1 ATPase
chr2_+_171673072 1.23 ENST00000358196.3
ENST00000375272.1
GAD1
glutamate decarboxylase 1 (brain, 67kDa)
chr6_+_31540056 1.18 ENST00000418386.2
LTA
lymphotoxin alpha
chr1_-_202129105 1.17 ENST00000367279.4
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr4_-_16077741 1.15 ENST00000447510.2
ENST00000540805.1
ENST00000539194.1
PROM1
prominin 1
chr20_-_21494654 1.10 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chr1_-_202129704 1.09 ENST00000476061.1
ENST00000544762.1
ENST00000467283.1
ENST00000464870.1
ENST00000435759.2
ENST00000486116.1
ENST00000543735.1
ENST00000308986.5
ENST00000477625.1
PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr5_-_115872142 1.05 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr1_+_161632937 1.05 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr3_-_15469006 1.02 ENST00000443029.1
ENST00000383790.3
ENST00000383789.5
METTL6
methyltransferase like 6
chr4_+_154074217 1.01 ENST00000437508.2
TRIM2
tripartite motif containing 2
chr22_-_32026810 0.98 ENST00000266095.5
ENST00000397500.1
PISD
phosphatidylserine decarboxylase
chr6_+_34204642 0.94 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
HMGA1
high mobility group AT-hook 1
chr1_-_28520384 0.94 ENST00000305392.3
PTAFR
platelet-activating factor receptor
chrX_-_107019181 0.87 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr19_+_926000 0.85 ENST00000263620.3
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr1_+_159272111 0.84 ENST00000368114.1
FCER1A
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr6_+_31633011 0.80 ENST00000375885.4
CSNK2B
casein kinase 2, beta polypeptide
chr1_-_155959853 0.80 ENST00000462460.2
ENST00000368316.1
ARHGEF2
Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr3_+_32147997 0.79 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr6_+_30525051 0.78 ENST00000376557.3
PRR3
proline rich 3
chr14_-_98444386 0.76 ENST00000556462.1
ENST00000556138.1
C14orf64
chromosome 14 open reading frame 64
chr22_-_42084863 0.76 ENST00000401959.1
ENST00000355257.3
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr15_+_73976715 0.75 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276
CD276 molecule
chr2_+_170590321 0.72 ENST00000392647.2
KLHL23
kelch-like family member 23
chr15_-_78526942 0.71 ENST00000258873.4
ACSBG1
acyl-CoA synthetase bubblegum family member 1
chr19_+_50084561 0.68 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chr6_+_30524663 0.63 ENST00000376560.3
PRR3
proline rich 3
chr3_+_132379154 0.62 ENST00000468022.1
ENST00000473651.1
ENST00000494238.2
UBA5
ubiquitin-like modifier activating enzyme 5
chr6_+_151561085 0.61 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr17_+_75372165 0.61 ENST00000427674.2
SEPT9
septin 9
chr3_-_52567792 0.61 ENST00000307092.4
ENST00000422318.2
ENST00000459839.1
NT5DC2
5'-nucleotidase domain containing 2
chr10_+_69644404 0.61 ENST00000212015.6
SIRT1
sirtuin 1
chr6_+_148663729 0.58 ENST00000367467.3
SASH1
SAM and SH3 domain containing 1
chr6_+_107077435 0.58 ENST00000369046.4
QRSL1
glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
chr1_+_201924619 0.55 ENST00000367287.4
TIMM17A
translocase of inner mitochondrial membrane 17 homolog A (yeast)
chr12_-_123215306 0.54 ENST00000356987.2
ENST00000436083.2
HCAR1
hydroxycarboxylic acid receptor 1
chr11_-_46142948 0.52 ENST00000257821.4
PHF21A
PHD finger protein 21A
chr12_-_101604185 0.51 ENST00000536262.2
SLC5A8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr10_+_123922941 0.46 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr17_+_43224684 0.46 ENST00000332499.2
HEXIM1
hexamethylene bis-acetamide inducible 1
chr3_+_44916098 0.45 ENST00000296125.4
TGM4
transglutaminase 4
chr14_-_92198403 0.44 ENST00000553329.1
ENST00000256343.3
CATSPERB
catsper channel auxiliary subunit beta
chr10_+_1034646 0.42 ENST00000360059.5
ENST00000545048.1
GTPBP4
GTP binding protein 4
chr16_+_3508063 0.40 ENST00000576787.1
ENST00000572942.1
ENST00000576916.1
ENST00000575076.1
ENST00000572131.1
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
chr5_-_169816638 0.39 ENST00000521859.1
ENST00000274629.4
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr18_+_13218769 0.39 ENST00000399848.3
ENST00000361205.4
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr19_-_50370799 0.39 ENST00000600910.1
ENST00000322344.3
ENST00000600573.1
PNKP
polynucleotide kinase 3'-phosphatase
chr22_+_26565440 0.38 ENST00000404234.3
ENST00000529632.2
ENST00000360929.3
ENST00000248933.6
ENST00000343706.4
SEZ6L
seizure related 6 homolog (mouse)-like
chr16_+_30759563 0.38 ENST00000563588.1
ENST00000565924.1
ENST00000424889.3
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr17_-_61777459 0.37 ENST00000578993.1
ENST00000583211.1
ENST00000259006.3
LIMD2
LIM domain containing 2
chr10_+_5566916 0.37 ENST00000315238.1
CALML3
calmodulin-like 3
chr16_+_30759700 0.37 ENST00000328273.7
PHKG2
phosphorylase kinase, gamma 2 (testis)
chr16_-_70719925 0.36 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr2_-_240322643 0.35 ENST00000345617.3
HDAC4
histone deacetylase 4
chrX_+_47082408 0.32 ENST00000518022.1
ENST00000276052.6
CDK16
cyclin-dependent kinase 16
chr10_-_70092635 0.31 ENST00000309049.4
PBLD
phenazine biosynthesis-like protein domain containing
chr8_-_102181718 0.31 ENST00000565617.1
KB-1460A1.5
KB-1460A1.5
chr10_+_123923205 0.31 ENST00000369004.3
ENST00000260733.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr10_+_123923105 0.31 ENST00000368999.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr1_+_203096831 0.30 ENST00000337894.4
ADORA1
adenosine A1 receptor
chr11_-_72504637 0.29 ENST00000536377.1
ENST00000359373.5
STARD10
ARAP1
StAR-related lipid transfer (START) domain containing 10
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr11_+_63870660 0.23 ENST00000246841.3
FLRT1
fibronectin leucine rich transmembrane protein 1
chr19_-_54327542 0.23 ENST00000391775.3
ENST00000324134.6
ENST00000535162.1
ENST00000351894.4
ENST00000354278.3
ENST00000391773.1
ENST00000345770.5
ENST00000391772.1
NLRP12
NLR family, pyrin domain containing 12
chr10_-_49813090 0.23 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr1_+_203097407 0.23 ENST00000367235.1
ADORA1
adenosine A1 receptor
chr8_+_9413410 0.22 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
TNKS
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr7_-_2883928 0.19 ENST00000275364.3
GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr19_+_4969116 0.18 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B
lysine (K)-specific demethylase 4B
chr16_+_3507985 0.17 ENST00000421765.3
ENST00000360862.5
ENST00000414063.2
ENST00000610180.1
ENST00000608993.1
NAA60
NAA60
N(alpha)-acetyltransferase 60, NatF catalytic subunit
N-alpha-acetyltransferase 60
chr3_+_15468862 0.15 ENST00000396842.2
EAF1
ELL associated factor 1
chr19_-_36870087 0.14 ENST00000270001.7
ZFP14
ZFP14 zinc finger protein
chr6_+_88032299 0.14 ENST00000608353.1
ENST00000392863.1
ENST00000229570.5
ENST00000608525.1
ENST00000608868.1
SMIM8
small integral membrane protein 8
chr20_-_61557821 0.13 ENST00000354665.4
ENST00000370368.1
ENST00000395343.1
ENST00000395340.1
DIDO1
death inducer-obliterator 1
chr12_-_57410304 0.11 ENST00000441881.1
ENST00000458521.2
TAC3
tachykinin 3
chr19_-_13213662 0.11 ENST00000264824.4
LYL1
lymphoblastic leukemia derived sequence 1
chr1_+_145576007 0.09 ENST00000369298.1
PIAS3
protein inhibitor of activated STAT, 3
chr19_+_8455077 0.09 ENST00000328024.6
RAB11B
RAB11B, member RAS oncogene family
chr20_+_43343886 0.07 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr1_+_161551101 0.07 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
FCGR2B
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr3_+_121774202 0.06 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86
CD86 molecule
chr16_+_640055 0.06 ENST00000568586.1
ENST00000538492.1
ENST00000248139.3
RAB40C
RAB40C, member RAS oncogene family
chr20_+_43343517 0.06 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr6_-_131277510 0.05 ENST00000525193.1
ENST00000527659.1
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chr2_-_69664586 0.04 ENST00000303698.3
ENST00000394305.1
ENST00000410022.2
NFU1
NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)
chr17_+_7387677 0.03 ENST00000322644.6
POLR2A
polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
chr1_+_145575980 0.03 ENST00000393045.2
PIAS3
protein inhibitor of activated STAT, 3
chr21_-_34960930 0.01 ENST00000437395.1
DONSON
downstream neighbor of SON
chr20_+_43343476 0.00 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2

Network of associatons between targets according to the STRING database.

First level regulatory network of NANOG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 10.1 GO:0061517 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.3 10.6 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.3 5.2 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
1.1 9.2 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.0 10.4 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.8 2.4 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
0.5 2.7 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.5 1.4 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
0.4 1.3 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
0.4 1.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.4 1.2 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.4 2.0 GO:0001810 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.4 1.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 0.9 GO:1904316 positive regulation of neutrophil degranulation(GO:0043315) cellular response to gravity(GO:0071258) positive regulation of neutrophil activation(GO:1902565) regulation of transcytosis(GO:1904298) positive regulation of transcytosis(GO:1904300) regulation of maternal process involved in parturition(GO:1904301) positive regulation of maternal process involved in parturition(GO:1904303) response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904316) cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine(GO:1904317)
0.3 1.6 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.3 1.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.3 2.1 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.3 1.2 GO:2000768 glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768)
0.3 5.3 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.3 7.3 GO:0010669 epithelial structure maintenance(GO:0010669)
0.2 0.9 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.2 1.6 GO:0035502 metanephric part of ureteric bud development(GO:0035502)
0.2 5.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 1.2 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
0.2 0.6 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.2 0.8 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.2 0.8 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072) negative regulation of protein kinase C signaling(GO:0090038)
0.2 0.5 GO:0032900 regulation of nucleoside transport(GO:0032242) negative regulation of neurotrophin production(GO:0032900)
0.2 2.0 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.1 0.6 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.1 0.4 GO:1903413 cellular response to bile acid(GO:1903413)
0.1 0.7 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.1 0.8 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.1 0.9 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 0.3 GO:0033341 regulation of collagen binding(GO:0033341)
0.1 0.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1 0.8 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.1 0.6 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 1.1 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.1 2.2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.1 1.8 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.1 4.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 0.2 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.1 0.2 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 3.5 GO:0046627 negative regulation of insulin receptor signaling pathway(GO:0046627)
0.1 7.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.1 0.3 GO:0098502 DNA dephosphorylation(GO:0098502)
0.0 4.7 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.0 0.6 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.0 0.5 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 2.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 3.4 GO:0042100 B cell proliferation(GO:0042100)
0.0 0.4 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.0 0.6 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.4 GO:0048240 sperm capacitation(GO:0048240)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.5 GO:1901798 positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.0 0.1 GO:0032641 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0 10.6 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0 3.0 GO:0002576 platelet degranulation(GO:0002576)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 0.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.0 GO:0001172 transcription, RNA-templated(GO:0001172)
0.0 0.1 GO:0001955 blood vessel maturation(GO:0001955)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.1 GO:0097418 neurofibrillary tangle(GO:0097418)
0.6 7.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.5 3.4 GO:0019815 B cell receptor complex(GO:0019815)
0.5 1.4 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.4 1.6 GO:0070695 FHF complex(GO:0070695)
0.4 5.5 GO:0097227 sperm annulus(GO:0097227)
0.2 5.2 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 2.4 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 0.6 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.8 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 1.2 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.4 GO:0036128 CatSper complex(GO:0036128)
0.1 0.9 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.1 0.7 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 1.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.1 11.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 0.6 GO:0031105 septin complex(GO:0031105)
0.1 0.3 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.5 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.8 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.0 8.3 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 3.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 4.6 GO:0043197 dendritic spine(GO:0043197)
0.0 9.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.5 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.2 GO:0032809 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 2.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 8.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 2.4 GO:0035770 ribonucleoprotein granule(GO:0035770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.9 GO:0047179 platelet-activating factor acetyltransferase activity(GO:0047179)
1.6 9.5 GO:0042296 ISG15 transferase activity(GO:0042296)
0.8 8.3 GO:0030274 LIM domain binding(GO:0030274)
0.5 10.1 GO:0051787 misfolded protein binding(GO:0051787)
0.4 2.1 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.4 5.2 GO:0032395 MHC class II receptor activity(GO:0032395)
0.4 5.0 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.3 1.0 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.3 2.6 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.3 1.1 GO:0019770 IgG receptor activity(GO:0019770)
0.3 10.4 GO:0004385 guanylate kinase activity(GO:0004385)
0.3 1.6 GO:0005499 vitamin D binding(GO:0005499)
0.2 7.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.4 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
0.2 0.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 0.6 GO:0071566 UFM1 activating enzyme activity(GO:0071566)
0.2 0.6 GO:0004040 amidase activity(GO:0004040)
0.2 0.9 GO:0004992 platelet activating factor receptor activity(GO:0004992)
0.2 1.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 0.3 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
0.2 1.2 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.2 0.6 GO:0043398 HLH domain binding(GO:0043398)
0.1 3.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 0.5 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.1 4.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.9 GO:0043426 MRF binding(GO:0043426)
0.1 4.7 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.1 0.3 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.1 0.7 GO:0004689 phosphorylase kinase activity(GO:0004689)
0.1 0.9 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 1.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.1 1.3 GO:0031005 filamin binding(GO:0031005)
0.1 0.5 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 0.5 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0 2.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.6 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0 2.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 1.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.2 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 6.8 GO:0005525 GTP binding(GO:0005525)
0.0 0.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0 0.0 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.0 0.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 1.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 10.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 10.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 19.2 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.2 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 2.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 4.5 PID BCR 5PATHWAY BCR signaling pathway
0.0 2.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 1.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.8 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.0 0.9 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.8 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 0.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.0 PID HNF3A PATHWAY FOXA1 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 10.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 9.5 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.2 4.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.4 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 0.9 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1 7.1 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.1 2.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 3.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 8.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 1.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 0.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 1.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 4.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 5.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.0 0.8 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.9 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling