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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFAT5

Z-value: 1.19

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Transcription factors associated with NFAT5

Gene Symbol Gene ID Gene Info
ENSG00000102908.16 nuclear factor of activated T cells 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFAT5hg19_v2_chr16_+_69600209_696002540.273.9e-05Click!

Activity profile of NFAT5 motif

Sorted Z-values of NFAT5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_60097524 21.11 ENST00000342503.4
reticulon 1
chr11_-_111794446 20.92 ENST00000527950.1
crystallin, alpha B
chr14_-_60097297 20.11 ENST00000395090.1
reticulon 1
chr12_+_10365404 16.11 ENST00000266458.5
ENST00000421801.2
ENST00000544284.1
ENST00000545047.1
ENST00000543602.1
ENST00000545887.1
GABA(A) receptor-associated protein like 1
chr13_-_67804445 15.50 ENST00000456367.1
ENST00000377861.3
ENST00000544246.1
protocadherin 9
chr1_-_57045228 14.85 ENST00000371250.3
phosphatidic acid phosphatase type 2B
chr22_+_23243156 14.25 ENST00000390323.2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr22_+_23248512 13.11 ENST00000390325.2
immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr8_-_27469196 12.88 ENST00000546343.1
ENST00000560566.1
clusterin
chr7_+_149570049 12.47 ENST00000421974.2
ENST00000456496.2
ATPase, H+ transporting V0 subunit e2
chr6_-_134495992 12.21 ENST00000475719.2
ENST00000367857.5
ENST00000237305.7
serum/glucocorticoid regulated kinase 1
chr22_-_38380543 10.72 ENST00000396884.2
SRY (sex determining region Y)-box 10
chr3_+_49027308 9.92 ENST00000383729.4
ENST00000343546.4
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr14_+_100594914 9.81 ENST00000554695.1
Enah/Vasp-like
chr12_+_101988627 9.33 ENST00000547405.1
ENST00000452455.2
ENST00000441232.1
ENST00000360610.2
ENST00000392934.3
ENST00000547509.1
ENST00000361685.2
ENST00000549145.1
ENST00000553190.1
myosin binding protein C, slow type
chr14_+_95078714 9.22 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr7_+_95401877 8.98 ENST00000524053.1
ENST00000324972.6
ENST00000537881.1
ENST00000437599.1
ENST00000359388.4
ENST00000413338.1
dynein, cytoplasmic 1, intermediate chain 1
chr7_+_95401851 8.86 ENST00000447467.2
dynein, cytoplasmic 1, intermediate chain 1
chr5_+_156712372 8.44 ENST00000541131.1
cytoplasmic FMR1 interacting protein 2
chr20_-_23731893 8.42 ENST00000398402.1
cystatin SN
chr17_+_38083977 8.04 ENST00000578802.1
ENST00000578478.1
ENST00000582263.1
RP11-387H17.4
chr7_-_47579188 8.01 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
tensin 3
chr4_+_74718906 7.95 ENST00000226524.3
platelet factor 4 variant 1
chr5_+_140186647 7.57 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
protocadherin alpha 4
chr4_+_71587669 7.17 ENST00000381006.3
ENST00000226328.4
RUN and FYVE domain containing 3
chr7_-_100888313 7.06 ENST00000442303.1
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr10_+_111967345 7.00 ENST00000332674.5
ENST00000453116.1
MAX interactor 1, dimerization protein
chr4_-_74847800 6.82 ENST00000296029.3
platelet factor 4
chr12_+_101988774 6.70 ENST00000545503.2
ENST00000536007.1
ENST00000541119.1
ENST00000361466.2
ENST00000551300.1
ENST00000550270.1
myosin binding protein C, slow type
chr16_-_67514982 6.65 ENST00000565835.1
ENST00000540149.1
ENST00000290949.3
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1
chr12_+_69742121 6.45 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
lysozyme
chr7_-_100888337 6.31 ENST00000223136.4
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
chr11_+_65154070 6.08 ENST00000317568.5
ENST00000531296.1
ENST00000533782.1
ENST00000355991.5
ENST00000416776.2
ENST00000526201.1
FERM domain containing 8
chr20_-_23731569 5.95 ENST00000304749.2
cystatin SN
chr20_+_33104199 5.92 ENST00000357156.2
ENST00000417166.2
ENST00000300469.9
ENST00000374846.3
dynein, light chain, roadblock-type 1
chr11_+_131240373 5.87 ENST00000374791.3
ENST00000436745.1
neurotrimin
chr15_+_43985725 5.82 ENST00000413453.2
creatine kinase, mitochondrial 1A
chr15_+_43985084 5.71 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr6_+_89790459 5.37 ENST00000369472.1
proline-rich nuclear receptor coactivator 1
chr11_+_131781290 5.26 ENST00000425719.2
ENST00000374784.1
neurotrimin
chr14_+_91580357 4.96 ENST00000298858.4
ENST00000521081.1
ENST00000520328.1
ENST00000256324.10
ENST00000524232.1
ENST00000522170.1
ENST00000519950.1
ENST00000523879.1
ENST00000521077.2
ENST00000518665.2
chromosome 14 open reading frame 159
chr19_+_42212501 4.78 ENST00000398599.4
carcinoembryonic antigen-related cell adhesion molecule 5
chr15_+_43885252 4.78 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chr14_+_91580732 4.72 ENST00000519019.1
ENST00000523816.1
ENST00000517518.1
chromosome 14 open reading frame 159
chr6_+_153552455 4.70 ENST00000392385.2
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr2_-_200820459 4.65 ENST00000354611.4
tRNA-yW synthesizing protein 5
chr3_-_9834375 4.51 ENST00000343450.2
ENST00000301964.2
transcriptional adaptor 3
chr14_+_91580777 4.45 ENST00000525393.2
ENST00000428926.2
ENST00000517362.1
chromosome 14 open reading frame 159
chr5_-_35230434 4.29 ENST00000504500.1
prolactin receptor
chr9_-_80263220 4.25 ENST00000341700.6
guanine nucleotide binding protein (G protein), alpha 14
chr18_-_52989217 4.22 ENST00000570287.2
transcription factor 4
chr10_-_124639062 4.20 ENST00000368898.3
ENST00000368896.1
ENST00000545804.1
family with sequence similarity 24, member B
CUB and zona pellucida-like domains 1
chr5_+_140261703 4.14 ENST00000409494.1
ENST00000289272.2
protocadherin alpha 13
chr6_+_89790490 4.12 ENST00000336032.3
proline-rich nuclear receptor coactivator 1
chrX_+_37208540 4.04 ENST00000466533.1
ENST00000542554.1
ENST00000543642.1
ENST00000484460.1
ENST00000449135.2
ENST00000463135.1
ENST00000465127.1
proline rich Gla (G-carboxyglutamic acid) 1
Uncharacterized protein; cDNA FLJ59144, highly similar to Tetraspanin-7
chr3_+_9834227 4.01 ENST00000287613.7
ENST00000397261.3
actin related protein 2/3 complex, subunit 4, 20kDa
chr3_+_9834758 3.86 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
actin related protein 2/3 complex, subunit 4, 20kDa
ARPC4-TTLL3 readthrough
chr17_+_68071458 3.81 ENST00000589377.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr14_+_91580708 3.79 ENST00000518868.1
chromosome 14 open reading frame 159
chrX_+_37208521 3.59 ENST00000378628.4
proline rich Gla (G-carboxyglutamic acid) 1
chr14_+_91581011 3.37 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
chromosome 14 open reading frame 159
chr4_-_76861392 3.37 ENST00000505594.1
N-acylethanolamine acid amidase
chr11_-_8190534 3.33 ENST00000309737.6
ENST00000425599.2
ENST00000539720.1
ENST00000531450.1
ENST00000419822.2
ENST00000335425.7
ENST00000343202.4
RIC3 acetylcholine receptor chaperone
chr3_+_47866490 3.28 ENST00000457607.1
DEAH (Asp-Glu-Ala-His) box helicase 30
chr4_-_83483395 3.27 ENST00000515780.2
transmembrane protein 150C
chr12_+_26274917 3.25 ENST00000538142.1
sarcospan
chr18_-_52989525 3.24 ENST00000457482.3
transcription factor 4
chr1_-_16345245 3.23 ENST00000311890.9
heat shock 27kDa protein family, member 7 (cardiovascular)
chr14_+_97059070 3.22 ENST00000553378.1
ENST00000555496.1
RP11-433J8.1
chr1_+_18958008 3.21 ENST00000420770.2
ENST00000400661.3
paired box 7
chr7_+_147830776 3.20 ENST00000538075.1
contactin associated protein-like 2
chr11_+_19799327 3.17 ENST00000540292.1
neuron navigator 2
chr20_-_23807358 3.11 ENST00000304725.2
cystatin SA
chr1_-_36945097 3.07 ENST00000331941.5
ENST00000418048.2
ENST00000338937.5
ENST00000440588.2
colony stimulating factor 3 receptor (granulocyte)
chr12_-_122018859 3.07 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
lysine (K)-specific demethylase 2B
chr19_+_49999631 3.05 ENST00000270625.2
ENST00000596873.1
ENST00000594493.1
ENST00000599561.1
ribosomal protein S11
chr17_+_68071389 2.88 ENST00000283936.1
ENST00000392671.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr14_+_73704201 2.88 ENST00000340738.5
ENST00000427855.1
ENST00000381166.3
papilin, proteoglycan-like sulfated glycoprotein
chr15_+_49170281 2.81 ENST00000560490.1
EP300 interacting inhibitor of differentiation 1
chr17_-_39093672 2.77 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chr3_-_47950745 2.74 ENST00000429422.1
microtubule-associated protein 4
chr14_-_30396948 2.64 ENST00000331968.5
protein kinase D1
chr19_+_42212526 2.62 ENST00000598976.1
ENST00000435837.2
ENST00000221992.6
ENST00000405816.1
Uncharacterized protein
carcinoembryonic antigen-related cell adhesion molecule 5
chr7_-_92157760 2.56 ENST00000248633.4
peroxisomal biogenesis factor 1
chr1_+_54359854 2.55 ENST00000361921.3
ENST00000322679.6
ENST00000532493.1
ENST00000525202.1
ENST00000524406.1
ENST00000388876.3
deiodinase, iodothyronine, type I
chr4_+_71588372 2.53 ENST00000536664.1
RUN and FYVE domain containing 3
chr19_+_859425 2.49 ENST00000327726.6
complement factor D (adipsin)
chr12_+_110011571 2.46 ENST00000539696.1
ENST00000228510.3
ENST00000392727.3
mevalonate kinase
chr1_+_117297007 2.45 ENST00000369478.3
ENST00000369477.1
CD2 molecule
chr11_+_19798964 2.32 ENST00000527559.2
neuron navigator 2
chr11_+_119039414 2.31 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
NLR family member X1
chr3_+_8543561 2.28 ENST00000397386.3
LIM and cysteine-rich domains 1
chr3_+_185000729 2.25 ENST00000448876.1
ENST00000446828.1
ENST00000447637.1
ENST00000424227.1
ENST00000454237.1
mitogen-activated protein kinase kinase kinase 13
chr17_+_25799008 2.24 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
kinase suppressor of ras 1
chr3_-_48594248 2.11 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
chr5_-_133747589 2.08 ENST00000458198.2
CDKN2A interacting protein N-terminal like
chr12_+_69186125 2.00 ENST00000399333.3
HCG1774533, isoform CRA_a; PRO2268; Uncharacterized protein
chr5_-_150521192 2.00 ENST00000523714.1
ENST00000521749.1
annexin A6
chr15_+_49170083 1.99 ENST00000530028.2
EP300 interacting inhibitor of differentiation 1
chr12_-_123756781 1.99 ENST00000544658.1
cyclin-dependent kinase 2 associated protein 1
chr11_+_128563652 1.92 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr16_-_75498553 1.89 ENST00000569276.1
ENST00000357613.4
ENST00000561878.1
ENST00000566980.1
ENST00000567194.1
transmembrane protein 170A
Uncharacterized protein
chr17_-_40950698 1.89 ENST00000328434.7
cytochrome c oxidase assembly factor 3
chr5_-_137090028 1.87 ENST00000314940.4
heterogeneous nuclear ribonucleoprotein A0
chr3_+_8543533 1.72 ENST00000454244.1
LIM and cysteine-rich domains 1
chr19_+_3178736 1.65 ENST00000246115.3
sphingosine-1-phosphate receptor 4
chr1_-_201346761 1.64 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
troponin T type 2 (cardiac)
chr22_+_24551765 1.58 ENST00000337989.7
calcineurin binding protein 1
chr14_-_25479811 1.58 ENST00000550887.1
syntaxin binding protein 6 (amisyn)
chr19_+_15852203 1.57 ENST00000305892.1
olfactory receptor, family 10, subfamily H, member 3
chr17_-_46608272 1.55 ENST00000577092.1
ENST00000239174.6
homeobox B1
chr7_+_65670186 1.54 ENST00000304842.5
ENST00000442120.1
tyrosylprotein sulfotransferase 1
chr7_+_1126461 1.53 ENST00000297469.3
G protein-coupled estrogen receptor 1
chr1_-_115300579 1.48 ENST00000358528.4
ENST00000525132.1
cold shock domain containing E1, RNA-binding
chr10_-_135122603 1.48 ENST00000368563.2
tubulin, gamma complex associated protein 2
chr2_+_200820494 1.45 ENST00000435773.2
chromosome 2 open reading frame 47
chr2_-_223163465 1.44 ENST00000409828.3
ENST00000350526.4
ENST00000258387.5
ENST00000409551.3
ENST00000392069.2
ENST00000344493.4
ENST00000336840.6
ENST00000392070.2
paired box 3
chr7_-_92157747 1.38 ENST00000428214.1
ENST00000438045.1
peroxisomal biogenesis factor 1
chr1_-_243418344 1.36 ENST00000366542.1
centrosomal protein 170kDa
chr19_-_54876414 1.20 ENST00000474878.1
ENST00000348231.4
leukocyte-associated immunoglobulin-like receptor 1
chr16_+_32077386 1.17 ENST00000354689.6
immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr14_-_106586656 1.12 ENST00000390602.2
immunoglobulin heavy variable 3-13
chr5_-_41261540 1.02 ENST00000263413.3
complement component 6
chr19_+_7598890 1.01 ENST00000221249.6
ENST00000601668.1
ENST00000601001.1
patatin-like phospholipase domain containing 6
chr9_-_13175823 0.96 ENST00000545857.1
multiple PDZ domain protein
chrX_-_45060135 0.94 ENST00000398000.2
ENST00000377934.4
chromosome X open reading frame 36
chr7_+_96634850 0.92 ENST00000518156.2
distal-less homeobox 6
chrX_+_83116142 0.92 ENST00000329312.4
cylicin, basic protein of sperm head cytoskeleton 1
chr17_+_32646055 0.85 ENST00000394620.1
chemokine (C-C motif) ligand 8
chr12_-_7848364 0.83 ENST00000329913.3
growth differentiation factor 3
chr2_-_161056802 0.81 ENST00000283249.2
ENST00000409872.1
integrin, beta 6
chr19_-_54876558 0.80 ENST00000391742.2
ENST00000434277.2
leukocyte-associated immunoglobulin-like receptor 1
chr20_+_36932521 0.77 ENST00000262865.4
bactericidal/permeability-increasing protein
chr19_-_44100275 0.72 ENST00000422989.1
ENST00000598324.1
immunity-related GTPase family, Q
chr19_+_14142535 0.60 ENST00000263379.2
interleukin 27 receptor, alpha
chr9_-_124989804 0.54 ENST00000373755.2
ENST00000373754.2
LIM homeobox 6
chr9_+_114287433 0.52 ENST00000358151.4
ENST00000355824.3
ENST00000374374.3
ENST00000309235.5
zinc finger protein 483
chr18_+_29027696 0.49 ENST00000257189.4
desmoglein 3
chr5_-_35230771 0.39 ENST00000342362.5
prolactin receptor
chr2_+_48796120 0.36 ENST00000394754.1
STON1-GTF2A1L readthrough
chr11_+_12399071 0.25 ENST00000539723.1
ENST00000550549.1
parvin, alpha
chr2_-_161056762 0.22 ENST00000428609.2
ENST00000409967.2
integrin, beta 6
chr17_-_202579 0.15 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
rabphilin 3A-like (without C2 domains)
chrX_+_135579670 0.14 ENST00000218364.4
HIV-1 Tat specific factor 1
chr1_-_115300592 0.14 ENST00000261443.5
ENST00000534699.1
ENST00000339438.6
ENST00000529046.1
ENST00000525970.1
ENST00000369530.1
ENST00000530886.1
cold shock domain containing E1, RNA-binding
chr7_+_1127723 0.08 ENST00000397088.3
G protein-coupled estrogen receptor 1
chr5_-_77844974 0.08 ENST00000515007.2
lipoma HMGIC fusion partner-like 2
chr14_-_102706934 0.07 ENST00000523231.1
ENST00000524370.1
ENST00000517966.1
MOK protein kinase
chr3_+_9834179 0.07 ENST00000498623.2
actin related protein 2/3 complex, subunit 4, 20kDa
chr9_+_139921916 0.07 ENST00000314330.2
chromosome 9 open reading frame 139
chr7_+_1126437 0.05 ENST00000413368.1
ENST00000397092.1
G protein-coupled estrogen receptor 1
chr11_-_2924970 0.02 ENST00000533594.1
solute carrier family 22 (organic cation transporter), member 18 antisense

Network of associatons between targets according to the STRING database.

First level regulatory network of NFAT5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 10.7 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
2.7 13.4 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
2.1 12.9 GO:1902998 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.7 12.2 GO:0070294 renal sodium ion absorption(GO:0070294)
1.6 17.8 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
1.4 5.5 GO:0021564 vagus nerve development(GO:0021564)
1.4 6.8 GO:0045918 negative regulation of cytolysis(GO:0045918)
1.3 3.9 GO:0060151 peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152)
1.3 6.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.2 9.5 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
1.2 20.9 GO:0007021 tubulin complex assembly(GO:0007021)
1.1 16.0 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
1.1 3.2 GO:0071109 superior temporal gyrus development(GO:0071109)
1.1 8.4 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
1.0 11.5 GO:0006600 creatine metabolic process(GO:0006600)
1.0 3.1 GO:0021592 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
1.0 3.9 GO:0018094 protein polyglycylation(GO:0018094)
0.9 16.1 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.8 2.5 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.8 9.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.8 3.2 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.8 4.7 GO:0038161 prolactin signaling pathway(GO:0038161)
0.7 3.3 GO:1902775 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.6 19.1 GO:0007035 vacuolar acidification(GO:0007035)
0.6 4.5 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.6 1.7 GO:2000724 nuclear fragmentation involved in apoptotic nuclear change(GO:0030264) positive regulation of cardiac vascular smooth muscle cell differentiation(GO:2000724)
0.5 4.2 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.5 1.6 GO:0021571 rhombomere 5 development(GO:0021571)
0.5 1.5 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
0.5 21.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.5 9.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.5 2.7 GO:0051012 microtubule sliding(GO:0051012)
0.4 11.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.4 1.6 GO:0032971 regulation of muscle filament sliding(GO:0032971) regulation of muscle filament sliding speed(GO:0032972)
0.4 2.5 GO:0030885 regulation of myeloid dendritic cell activation(GO:0030885)
0.4 4.3 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.4 1.9 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.4 2.6 GO:0089700 protein kinase D signaling(GO:0089700)
0.4 2.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.3 9.7 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.3 7.9 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.3 1.6 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.3 7.4 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.3 1.0 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.2 2.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.2 11.1 GO:0008038 neuron recognition(GO:0008038)
0.2 1.5 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.2 6.7 GO:0042994 cytoplasmic sequestering of transcription factor(GO:0042994)
0.2 0.8 GO:0048859 formation of anatomical boundary(GO:0048859)
0.2 1.9 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.2 0.5 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.2 1.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.2 27.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 8.0 GO:0048286 lung alveolus development(GO:0048286)
0.2 9.9 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.1 3.1 GO:0097186 amelogenesis(GO:0097186)
0.1 3.8 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 6.7 GO:0010107 potassium ion import(GO:0010107)
0.1 5.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.1 1.0 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.1 1.7 GO:0090520 sphingosine-1-phosphate signaling pathway(GO:0003376) sphingolipid mediated signaling pathway(GO:0090520)
0.1 2.0 GO:0001934 positive regulation of protein phosphorylation(GO:0001934)
0.1 2.5 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 2.5 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.9 GO:0035855 megakaryocyte development(GO:0035855)
0.1 1.9 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 4.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.4 GO:0014029 neural crest formation(GO:0014029)
0.1 2.0 GO:0051560 mitochondrial calcium ion homeostasis(GO:0051560)
0.1 4.7 GO:0006400 tRNA modification(GO:0006400)
0.1 0.8 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.1 3.3 GO:0007271 synaptic transmission, cholinergic(GO:0007271)
0.0 26.3 GO:0002250 adaptive immune response(GO:0002250)
0.0 1.0 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.0 1.6 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0 2.2 GO:0000186 activation of MAPKK activity(GO:0000186)
0.0 1.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 2.2 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.1 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 2.8 GO:0070268 cornification(GO:0070268)
0.0 3.4 GO:0006629 lipid metabolic process(GO:0006629)
0.0 0.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.2 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.0 1.2 GO:0035065 regulation of histone acetylation(GO:0035065)
0.0 3.2 GO:0006986 response to unfolded protein(GO:0006986)
0.0 4.9 GO:0045666 positive regulation of neuron differentiation(GO:0045666)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0097679 symbiont-containing vacuole(GO:0020003) symbiont-containing vacuole membrane(GO:0020005) other organism cytoplasm(GO:0097679)
1.4 22.6 GO:0097512 cardiac myofibril(GO:0097512)
1.4 19.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.8 12.9 GO:0097418 neurofibrillary tangle(GO:0097418)
0.8 23.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.6 14.5 GO:0032982 myosin filament(GO:0032982)
0.5 16.1 GO:0032839 dendrite cytoplasm(GO:0032839)
0.5 13.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.5 5.5 GO:0005614 interstitial matrix(GO:0005614)
0.4 7.9 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.3 1.0 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.3 9.1 GO:0071437 invadopodium(GO:0071437)
0.3 10.7 GO:0031312 extrinsic component of organelle membrane(GO:0031312)
0.3 7.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.3 0.9 GO:0043159 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) acrosomal matrix(GO:0043159)
0.3 4.5 GO:0000124 SAGA complex(GO:0000124)
0.3 1.5 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.3 3.2 GO:0033010 paranodal junction(GO:0033010)
0.3 41.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 4.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 1.0 GO:0005579 membrane attack complex(GO:0005579)
0.2 2.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.2 1.6 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.2 36.3 GO:0072562 blood microparticle(GO:0072562)
0.2 1.7 GO:0044327 dendritic spine head(GO:0044327)
0.2 14.0 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 2.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.6 GO:0000145 exocyst(GO:0000145)
0.1 14.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 4.8 GO:0016235 aggresome(GO:0016235)
0.1 2.6 GO:0000421 autophagosome membrane(GO:0000421)
0.1 4.7 GO:0031904 endosome lumen(GO:0031904)
0.1 6.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 2.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 3.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 9.8 GO:0030027 lamellipodium(GO:0030027)
0.1 1.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 1.0 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 3.3 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 5.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 6.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 3.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 20.9 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 2.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 11.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.7 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 2.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 2.8 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0030057 desmosome(GO:0030057)
0.0 2.0 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 20.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 2.0 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 3.3 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 0.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 8.7 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 3.3 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 4.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 15.2 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 21.3 GO:0047820 D-glutamate cyclase activity(GO:0047820)
1.4 11.5 GO:0004111 creatine kinase activity(GO:0004111)
1.4 6.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
1.2 16.1 GO:0030957 Tat protein binding(GO:0030957)
1.1 16.0 GO:0031432 titin binding(GO:0031432)
1.1 6.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.1 6.5 GO:0003796 lysozyme activity(GO:0003796)
1.0 3.9 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.9 4.7 GO:0004925 prolactin receptor activity(GO:0004925)
0.9 7.4 GO:0034235 GPI anchor binding(GO:0034235)
0.9 17.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.8 3.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.7 7.9 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.7 20.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.6 12.9 GO:0051787 misfolded protein binding(GO:0051787)
0.6 7.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.6 1.7 GO:0017082 mineralocorticoid receptor activity(GO:0017082)
0.5 9.8 GO:0005522 profilin binding(GO:0005522)
0.5 12.5 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.5 1.5 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
0.5 12.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.4 9.9 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.4 2.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.4 3.1 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.4 6.7 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.4 2.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.3 5.9 GO:0045505 dynein intermediate chain binding(GO:0045505)
0.3 10.7 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.2 1.6 GO:0030172 troponin C binding(GO:0030172)
0.2 15.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 2.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.2 4.7 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.2 3.3 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.2 4.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 3.2 GO:0031005 filamin binding(GO:0031005)
0.2 1.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.1 29.6 GO:0003823 antigen binding(GO:0003823)
0.1 4.3 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.1 4.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 1.5 GO:0051011 microtubule minus-end binding(GO:0051011)
0.1 2.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 1.6 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 1.6 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.1 0.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.4 GO:0071837 HMG box domain binding(GO:0071837)
0.1 2.0 GO:0070182 DNA polymerase binding(GO:0070182)
0.1 3.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 2.2 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 5.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 1.9 GO:0017091 AU-rich element binding(GO:0017091)
0.0 3.3 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 3.0 GO:0019843 rRNA binding(GO:0019843)
0.0 2.2 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 1.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.0 1.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.9 GO:0008009 chemokine activity(GO:0008009)
0.0 3.3 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810)
0.0 1.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 16.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.8 GO:0005198 structural molecule activity(GO:0005198)
0.0 0.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.0 1.6 GO:0008201 heparin binding(GO:0008201)
0.0 10.2 GO:0032403 protein complex binding(GO:0032403)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 4.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 16.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 12.2 PID INSULIN PATHWAY Insulin Pathway
0.1 36.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 14.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.9 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 4.7 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 5.1 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.1 2.6 PID IGF1 PATHWAY IGF1 pathway
0.1 6.5 PID CMYB PATHWAY C-MYB transcription factor network
0.1 7.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 2.9 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 2.2 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 2.2 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 1.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.6 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.5 17.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.4 4.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 17.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 6.7 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.2 9.8 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 6.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.2 4.7 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 7.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 17.8 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.5 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 2.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 1.5 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.1 2.5 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 6.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 13.8 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 3.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.0 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.6 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.5 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 1.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions