ISMARA results: NFATC2

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NFATC2_NFATC3

Z-value: 1.86

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Transcription factors associated with NFATC2_NFATC3

Gene Symbol	Gene ID	Gene Info
NFATC2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000101096.15	nuclear factor of activated T cells 2
NFATC3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000072736.14	nuclear factor of activated T cells 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NFATC3	hg19_v2_chr16_+_68119247_68119293	-0.67	8.4e-30	Click!

Activity profile of NFATC2_NFATC3 motif

Sorted Z-values of NFATC2_NFATC3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_91573132 Show fit	44.23	ENST00000550563.1 ENST00000546370.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_-_91573249 Show fit	41.61	ENST00000550099.1 ENST00000546391.1 ENST00000551354.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr12_-_91573316 Show fit	34.23	ENST00000393155.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr2_-_238322770 Show fit	29.29	ENST00000472056.1	COL6A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type VI, alpha 3
chr9_-_35691017 Show fit	28.54	ENST00000378292.3	TPM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tropomyosin 2 (beta)
chr1_+_86046433 Show fit	28.07	ENST00000451137.2	CYR61 Ensembl NCBI GeneCards UniProt NextProt Show fit	cysteine-rich, angiogenic inducer, 61
chr2_-_238322800 Show fit	26.80	ENST00000392004.3 ENST00000433762.1 ENST00000347401.3 ENST00000353578.4 ENST00000346358.4 ENST00000392003.2	COL6A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type VI, alpha 3
chr12_-_91539918 Show fit	26.62	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr2_-_238323007 Show fit	24.07	ENST00000295550.4	COL6A3 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type VI, alpha 3
chr14_-_92413353 Show fit	23.58	ENST00000556154.1	FBLN5 Ensembl NCBI GeneCards UniProt NextProt Show fit	fibulin 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC2_NFATC3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
12.2	146.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
1.2	87.8	GO:0030574	collagen catabolic process(GO:0030574)
0.4	65.0	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
6.1	48.6	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
3.7	44.3	GO:0048251	elastic fiber assembly(GO:0048251)
0.7	35.3	GO:0031529	ruffle organization(GO:0031529)
7.4	29.6	GO:0097325	melanocyte proliferation(GO:0097325)
3.1	28.1	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.4	28.1	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
1.8	23.8	GO:0001867	complement activation, lectin pathway(GO:0001867)

Showing 1 to 10 of 354 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
16.2	226.8	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
4.1	77.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.0	65.6	GO:0005887	integral component of plasma membrane(GO:0005887)
0.2	61.2	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.6	44.4	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
4.4	44.3	GO:0071953	elastic fiber(GO:0071953)
0.4	43.5	GO:0005604	basement membrane(GO:0005604)
2.7	29.6	GO:0071438	invadopodium membrane(GO:0071438)
0.3	27.8	GO:0031093	platelet alpha granule lumen(GO:0031093)
1.6	24.5	GO:0030478	actin cap(GO:0030478)

Showing 1 to 10 of 129 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	197.4	GO:0050840	extracellular matrix binding(GO:0050840)
0.9	97.6	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.9	91.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.3	36.0	GO:0005178	integrin binding(GO:0005178)
0.2	35.1	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.6	33.0	GO:0042169	SH2 domain binding(GO:0042169)
0.9	31.9	GO:0001972	retinoic acid binding(GO:0001972)
1.5	29.6	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.7	28.4	GO:0003785	actin monomer binding(GO:0003785)
0.3	24.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)

Showing 1 to 10 of 241 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.9	161.9	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.3	109.2	NABA COLLAGENS	Genes encoding collagen proteins
0.4	79.2	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
1.1	71.0	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.2	58.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	26.3	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	16.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	14.6	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.2	14.5	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.4	14.0	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events

Showing 1 to 10 of 67 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.3	142.0	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.8	119.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.3	85.0	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.3	27.6	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.2	23.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.5	17.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6	15.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.4	14.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.1	13.6	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.7	13.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics

Showing 1 to 10 of 100 entries

Results for NFATC2_NFATC3

Z-value: 1.86

Motif logo

Transcription factors associated with NFATC2_NFATC3

Activity-expression correlation:

Activity profile of NFATC2_NFATC3 motif

Sorted Z-values of NFATC2_NFATC3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NFATC2_NFATC3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: