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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for NOTO_VSX2_DLX2_DLX6_NKX6-1
Z-value: 0.76
Motif logo
Transcription factors associated with NOTO_VSX2_DLX2_DLX6_NKX6-1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
NOTO
|
ENSG00000214513.3 | notochord homeobox |
|
VSX2
|
ENSG00000119614.2 | visual system homeobox 2 |
|
DLX2
|
ENSG00000115844.6 | distal-less homeobox 2 |
|
DLX6
|
ENSG00000006377.9 | distal-less homeobox 6 |
|
NKX6-1
|
ENSG00000163623.5 | NK6 homeobox 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NKX6-1 | hg19_v2_chr4_-_85419603_85419603 | 0.42 | 1.4e-10 | Click! |
| DLX6 | hg19_v2_chr7_+_96634850_96634874, hg19_v2_chr7_+_96635277_96635301 | 0.42 | 1.6e-10 | Click! |
| DLX2 | hg19_v2_chr2_-_172967621_172967637 | 0.24 | 2.6e-04 | Click! |
| NOTO | hg19_v2_chr2_+_73429386_73429386 | 0.05 | 4.3e-01 | Click! |
Activity profile of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif
Sorted Z-values of NOTO_VSX2_DLX2_DLX6_NKX6-1 motif
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_16761007 | 17.30 |
ENST00000354662.1
ENST00000441439.2 |
LMO3
|
LIM domain only 3 (rhombotin-like 2) |
| chr5_+_66300446 | 13.50 |
ENST00000261569.7
|
MAST4
|
microtubule associated serine/threonine kinase family member 4 |
| chr3_+_111718036 | 12.90 |
ENST00000455401.2
|
TAGLN3
|
transgelin 3 |
| chr3_+_111717600 | 11.92 |
ENST00000273368.4
|
TAGLN3
|
transgelin 3 |
| chr11_-_117747434 | 11.89 |
ENST00000529335.2
ENST00000530956.1 ENST00000260282.4 |
FXYD6
|
FXYD domain containing ion transport regulator 6 |
| chr11_-_117747607 | 11.81 |
ENST00000540359.1
ENST00000539526.1 |
FXYD6
|
FXYD domain containing ion transport regulator 6 |
| chr3_+_111717511 | 11.46 |
ENST00000478951.1
ENST00000393917.2 |
TAGLN3
|
transgelin 3 |
| chr12_-_6233828 | 11.07 |
ENST00000572068.1
ENST00000261405.5 |
VWF
|
von Willebrand factor |
| chr11_-_117748138 | 11.04 |
ENST00000527717.1
|
FXYD6
|
FXYD domain containing ion transport regulator 6 |
| chr6_-_87804815 | 10.70 |
ENST00000369582.2
|
CGA
|
glycoprotein hormones, alpha polypeptide |
| chr3_+_111718173 | 10.15 |
ENST00000494932.1
|
TAGLN3
|
transgelin 3 |
| chr14_-_92413727 | 6.76 |
ENST00000267620.10
|
FBLN5
|
fibulin 5 |
| chr12_-_16759711 | 6.46 |
ENST00000447609.1
|
LMO3
|
LIM domain only 3 (rhombotin-like 2) |
| chrX_-_13835147 | 6.45 |
ENST00000493677.1
ENST00000355135.2 |
GPM6B
|
glycoprotein M6B |
| chr12_+_81110684 | 6.32 |
ENST00000228644.3
|
MYF5
|
myogenic factor 5 |
| chr7_-_14029283 | 6.10 |
ENST00000433547.1
ENST00000405192.2 |
ETV1
|
ets variant 1 |
| chr14_-_92413353 | 5.54 |
ENST00000556154.1
|
FBLN5
|
fibulin 5 |
| chr7_+_73442422 | 5.49 |
ENST00000358929.4
ENST00000431562.1 ENST00000320492.7 ENST00000438906.1 |
ELN
|
elastin |
| chr5_-_24645078 | 5.47 |
ENST00000264463.4
|
CDH10
|
cadherin 10, type 2 (T2-cadherin) |
| chr6_-_22297730 | 5.36 |
ENST00000306482.1
|
PRL
|
prolactin |
| chr14_+_61654271 | 5.36 |
ENST00000555185.1
ENST00000557294.1 ENST00000556778.1 |
PRKCH
|
protein kinase C, eta |
| chr15_+_93443419 | 5.33 |
ENST00000557381.1
ENST00000420239.2 |
CHD2
|
chromodomain helicase DNA binding protein 2 |
| chr17_-_78450398 | 4.61 |
ENST00000306773.4
|
NPTX1
|
neuronal pentraxin I |
| chr16_-_29910853 | 4.55 |
ENST00000308713.5
|
SEZ6L2
|
seizure related 6 homolog (mouse)-like 2 |
| chr11_-_129062093 | 4.32 |
ENST00000310343.9
|
ARHGAP32
|
Rho GTPase activating protein 32 |
| chr7_+_73442487 | 4.09 |
ENST00000380575.4
ENST00000380584.4 ENST00000458204.1 ENST00000357036.5 ENST00000417091.1 ENST00000429192.1 ENST00000442310.1 ENST00000380553.4 ENST00000380576.5 ENST00000428787.1 ENST00000320399.6 |
ELN
|
elastin |
| chr4_+_3388057 | 4.08 |
ENST00000538395.1
|
RGS12
|
regulator of G-protein signaling 12 |
| chr17_-_77924627 | 3.99 |
ENST00000572862.1
ENST00000573782.1 ENST00000574427.1 ENST00000570373.1 ENST00000340848.7 ENST00000576768.1 |
TBC1D16
|
TBC1 domain family, member 16 |
| chr7_+_73442457 | 3.98 |
ENST00000438880.1
ENST00000414324.1 ENST00000380562.4 |
ELN
|
elastin |
| chr19_-_7968427 | 3.95 |
ENST00000539278.1
|
AC010336.1
|
Uncharacterized protein |
| chr7_+_73442102 | 3.95 |
ENST00000445912.1
ENST00000252034.7 |
ELN
|
elastin |
| chr14_+_22977587 | 3.93 |
ENST00000390504.1
|
TRAJ33
|
T cell receptor alpha joining 33 |
| chr13_-_88323218 | 3.85 |
ENST00000436290.2
ENST00000453832.2 ENST00000606590.1 |
MIR4500HG
|
MIR4500 host gene (non-protein coding) |
| chr3_-_58613323 | 3.77 |
ENST00000474531.1
ENST00000465970.1 |
FAM107A
|
family with sequence similarity 107, member A |
| chr6_+_39760129 | 3.51 |
ENST00000274867.4
|
DAAM2
|
dishevelled associated activator of morphogenesis 2 |
| chrX_+_13671225 | 3.41 |
ENST00000545566.1
ENST00000544987.1 ENST00000314720.4 |
TCEANC
|
transcription elongation factor A (SII) N-terminal and central domain containing |
| chr1_+_180601139 | 3.37 |
ENST00000367590.4
ENST00000367589.3 |
XPR1
|
xenotropic and polytropic retrovirus receptor 1 |
| chr7_-_14028488 | 3.07 |
ENST00000405358.4
|
ETV1
|
ets variant 1 |
| chr4_-_57547870 | 3.04 |
ENST00000381260.3
ENST00000420433.1 ENST00000554144.1 ENST00000557328.1 |
HOPX
|
HOP homeobox |
| chr1_-_68698222 | 2.98 |
ENST00000370976.3
ENST00000354777.2 ENST00000262348.4 ENST00000540432.1 |
WLS
|
wntless Wnt ligand secretion mediator |
| chr4_+_71457970 | 2.96 |
ENST00000322937.6
|
AMBN
|
ameloblastin (enamel matrix protein) |
| chr4_-_186696425 | 2.93 |
ENST00000430503.1
ENST00000319454.6 ENST00000450341.1 |
SORBS2
|
sorbin and SH3 domain containing 2 |
| chr2_+_171034646 | 2.87 |
ENST00000409044.3
ENST00000408978.4 |
MYO3B
|
myosin IIIB |
| chr3_+_115342349 | 2.86 |
ENST00000393780.3
|
GAP43
|
growth associated protein 43 |
| chr7_-_14029515 | 2.85 |
ENST00000430479.1
ENST00000405218.2 ENST00000343495.5 |
ETV1
|
ets variant 1 |
| chr17_-_40337470 | 2.78 |
ENST00000293330.1
|
HCRT
|
hypocretin (orexin) neuropeptide precursor |
| chr1_+_183774240 | 2.67 |
ENST00000360851.3
|
RGL1
|
ral guanine nucleotide dissociation stimulator-like 1 |
| chr14_-_36988882 | 2.64 |
ENST00000498187.2
|
NKX2-1
|
NK2 homeobox 1 |
| chr11_+_65554493 | 2.60 |
ENST00000335987.3
|
OVOL1
|
ovo-like zinc finger 1 |
| chr5_-_95297534 | 2.54 |
ENST00000513343.1
ENST00000431061.2 |
ELL2
|
elongation factor, RNA polymerase II, 2 |
| chr1_-_57045228 | 2.53 |
ENST00000371250.3
|
PPAP2B
|
phosphatidic acid phosphatase type 2B |
| chr4_+_71108300 | 2.53 |
ENST00000304954.3
|
CSN3
|
casein kappa |
| chr7_-_73038822 | 2.49 |
ENST00000414749.2
ENST00000429400.2 ENST00000434326.1 |
MLXIPL
|
MLX interacting protein-like |
| chr9_+_12693336 | 2.48 |
ENST00000381137.2
ENST00000388918.5 |
TYRP1
|
tyrosinase-related protein 1 |
| chr4_-_74486347 | 2.47 |
ENST00000342081.3
|
RASSF6
|
Ras association (RalGDS/AF-6) domain family member 6 |
| chr4_+_71458012 | 2.47 |
ENST00000449493.2
|
AMBN
|
ameloblastin (enamel matrix protein) |
| chr6_+_131571535 | 2.47 |
ENST00000474850.2
|
AKAP7
|
A kinase (PRKA) anchor protein 7 |
| chr2_-_182545603 | 2.44 |
ENST00000295108.3
|
NEUROD1
|
neuronal differentiation 1 |
| chr17_-_64225508 | 2.41 |
ENST00000205948.6
|
APOH
|
apolipoprotein H (beta-2-glycoprotein I) |
| chr13_-_36050819 | 2.35 |
ENST00000379919.4
|
MAB21L1
|
mab-21-like 1 (C. elegans) |
| chrX_-_73512411 | 2.31 |
ENST00000602576.1
ENST00000429124.1 |
FTX
|
FTX transcript, XIST regulator (non-protein coding) |
| chr5_+_148786423 | 2.27 |
ENST00000505254.2
ENST00000602964.1 ENST00000519898.1 |
MIR143HG
|
MIR143 host gene (non-protein coding) |
| chr16_-_4852915 | 2.25 |
ENST00000322048.7
|
ROGDI
|
rogdi homolog (Drosophila) |
| chr2_-_50201327 | 2.23 |
ENST00000412315.1
|
NRXN1
|
neurexin 1 |
| chr2_+_234826016 | 2.22 |
ENST00000324695.4
ENST00000433712.2 |
TRPM8
|
transient receptor potential cation channel, subfamily M, member 8 |
| chr7_-_27169801 | 2.21 |
ENST00000511914.1
|
HOXA4
|
homeobox A4 |
| chr7_-_73038867 | 2.21 |
ENST00000313375.3
ENST00000354613.1 ENST00000395189.1 ENST00000453275.1 |
MLXIPL
|
MLX interacting protein-like |
| chr4_+_88754069 | 2.18 |
ENST00000395102.4
ENST00000497649.2 |
MEPE
|
matrix extracellular phosphoglycoprotein |
| chr19_+_50016411 | 2.16 |
ENST00000426395.3
ENST00000600273.1 ENST00000599988.1 |
FCGRT
|
Fc fragment of IgG, receptor, transporter, alpha |
| chr7_+_23286182 | 2.13 |
ENST00000258733.4
ENST00000381990.2 ENST00000409458.3 ENST00000539136.1 ENST00000453162.2 |
GPNMB
|
glycoprotein (transmembrane) nmb |
| chr19_+_50016610 | 2.11 |
ENST00000596975.1
|
FCGRT
|
Fc fragment of IgG, receptor, transporter, alpha |
| chr6_-_31107127 | 2.11 |
ENST00000259845.4
|
PSORS1C2
|
psoriasis susceptibility 1 candidate 2 |
| chr9_-_215744 | 2.09 |
ENST00000382387.2
|
C9orf66
|
chromosome 9 open reading frame 66 |
| chr12_-_118796910 | 2.07 |
ENST00000541186.1
ENST00000539872.1 |
TAOK3
|
TAO kinase 3 |
| chr4_+_88754113 | 2.06 |
ENST00000560249.1
ENST00000540395.1 ENST00000511670.1 ENST00000361056.3 |
MEPE
|
matrix extracellular phosphoglycoprotein |
| chr7_-_83278322 | 2.03 |
ENST00000307792.3
|
SEMA3E
|
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E |
| chr16_+_8768422 | 1.99 |
ENST00000268251.8
ENST00000564714.1 |
ABAT
|
4-aminobutyrate aminotransferase |
| chr20_+_56136136 | 1.98 |
ENST00000319441.4
ENST00000543666.1 |
PCK1
|
phosphoenolpyruvate carboxykinase 1 (soluble) |
| chr5_-_95297678 | 1.98 |
ENST00000237853.4
|
ELL2
|
elongation factor, RNA polymerase II, 2 |
| chr21_-_42219065 | 1.91 |
ENST00000400454.1
|
DSCAM
|
Down syndrome cell adhesion molecule |
| chr11_-_13517565 | 1.89 |
ENST00000282091.1
ENST00000529816.1 |
PTH
|
parathyroid hormone |
| chr10_-_21786179 | 1.88 |
ENST00000377113.5
|
CASC10
|
cancer susceptibility candidate 10 |
| chr4_-_74486217 | 1.85 |
ENST00000335049.5
ENST00000307439.5 |
RASSF6
|
Ras association (RalGDS/AF-6) domain family member 6 |
| chr1_+_62439037 | 1.84 |
ENST00000545929.1
|
INADL
|
InaD-like (Drosophila) |
| chr11_-_2160180 | 1.82 |
ENST00000381406.4
|
IGF2
|
insulin-like growth factor 2 (somatomedin A) |
| chr8_+_50824233 | 1.82 |
ENST00000522124.1
|
SNTG1
|
syntrophin, gamma 1 |
| chrX_-_73512177 | 1.80 |
ENST00000603672.1
ENST00000418855.1 |
FTX
|
FTX transcript, XIST regulator (non-protein coding) |
| chr2_-_224467093 | 1.80 |
ENST00000305409.2
|
SCG2
|
secretogranin II |
| chr2_+_234959376 | 1.76 |
ENST00000425558.1
|
SPP2
|
secreted phosphoprotein 2, 24kDa |
| chr6_-_100912785 | 1.73 |
ENST00000369208.3
|
SIM1
|
single-minded family bHLH transcription factor 1 |
| chr13_-_36788718 | 1.72 |
ENST00000317764.6
ENST00000379881.3 |
SOHLH2
|
spermatogenesis and oogenesis specific basic helix-loop-helix 2 |
| chr7_-_37026108 | 1.70 |
ENST00000396045.3
|
ELMO1
|
engulfment and cell motility 1 |
| chr2_-_136288113 | 1.69 |
ENST00000401392.1
|
ZRANB3
|
zinc finger, RAN-binding domain containing 3 |
| chr8_+_105235572 | 1.69 |
ENST00000523362.1
|
RIMS2
|
regulating synaptic membrane exocytosis 2 |
| chr19_-_14952689 | 1.67 |
ENST00000248058.1
|
OR7A10
|
olfactory receptor, family 7, subfamily A, member 10 |
| chr21_-_31538971 | 1.66 |
ENST00000286808.3
|
CLDN17
|
claudin 17 |
| chr8_-_57359131 | 1.63 |
ENST00000518974.1
ENST00000523051.1 ENST00000518770.1 ENST00000451791.2 |
PENK
|
proenkephalin |
| chr3_-_114477787 | 1.63 |
ENST00000464560.1
|
ZBTB20
|
zinc finger and BTB domain containing 20 |
| chr6_+_151646800 | 1.63 |
ENST00000354675.6
|
AKAP12
|
A kinase (PRKA) anchor protein 12 |
| chr3_-_114790179 | 1.62 |
ENST00000462705.1
|
ZBTB20
|
zinc finger and BTB domain containing 20 |
| chr17_-_46690839 | 1.60 |
ENST00000498634.2
|
HOXB8
|
homeobox B8 |
| chrX_+_43515467 | 1.58 |
ENST00000338702.3
ENST00000542639.1 |
MAOA
|
monoamine oxidase A |
| chr5_-_1882858 | 1.58 |
ENST00000511126.1
ENST00000231357.2 |
IRX4
|
iroquois homeobox 4 |
| chr3_+_69985792 | 1.57 |
ENST00000531774.1
|
MITF
|
microphthalmia-associated transcription factor |
| chr5_-_134871639 | 1.57 |
ENST00000314744.4
|
NEUROG1
|
neurogenin 1 |
| chr18_+_46065393 | 1.55 |
ENST00000256413.3
|
CTIF
|
CBP80/20-dependent translation initiation factor |
| chr5_+_174151536 | 1.54 |
ENST00000239243.6
ENST00000507785.1 |
MSX2
|
msh homeobox 2 |
| chr8_-_25281747 | 1.53 |
ENST00000421054.2
|
GNRH1
|
gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) |
| chr4_-_89205879 | 1.53 |
ENST00000608933.1
ENST00000315194.4 ENST00000514204.1 |
PPM1K
|
protein phosphatase, Mg2+/Mn2+ dependent, 1K |
| chr12_+_26348246 | 1.52 |
ENST00000422622.2
|
SSPN
|
sarcospan |
| chr16_-_30102547 | 1.51 |
ENST00000279386.2
|
TBX6
|
T-box 6 |
| chr3_+_35722487 | 1.51 |
ENST00000441454.1
|
ARPP21
|
cAMP-regulated phosphoprotein, 21kDa |
| chrX_+_68835911 | 1.50 |
ENST00000525810.1
ENST00000527388.1 ENST00000374553.2 ENST00000374552.4 ENST00000338901.3 ENST00000524573.1 |
EDA
|
ectodysplasin A |
| chr16_+_22501658 | 1.48 |
ENST00000415833.2
|
NPIPB5
|
nuclear pore complex interacting protein family, member B5 |
| chr1_-_92952433 | 1.47 |
ENST00000294702.5
|
GFI1
|
growth factor independent 1 transcription repressor |
| chr6_-_33160231 | 1.46 |
ENST00000395194.1
ENST00000457788.1 ENST00000341947.2 ENST00000357486.1 ENST00000374714.1 ENST00000374713.1 ENST00000395197.1 ENST00000374712.1 ENST00000361917.1 ENST00000374708.4 |
COL11A2
|
collagen, type XI, alpha 2 |
| chr9_+_82188077 | 1.45 |
ENST00000425506.1
|
TLE4
|
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila) |
| chr14_-_101295407 | 1.45 |
ENST00000596284.1
|
AL117190.2
|
AL117190.2 |
| chr5_-_140998481 | 1.44 |
ENST00000518047.1
|
DIAPH1
|
diaphanous-related formin 1 |
| chr8_-_9760839 | 1.41 |
ENST00000519461.1
ENST00000517675.1 |
LINC00599
|
long intergenic non-protein coding RNA 599 |
| chr14_-_69261310 | 1.40 |
ENST00000336440.3
|
ZFP36L1
|
ZFP36 ring finger protein-like 1 |
| chr17_-_39623681 | 1.39 |
ENST00000225899.3
|
KRT32
|
keratin 32 |
| chr12_-_112123524 | 1.38 |
ENST00000327551.6
|
BRAP
|
BRCA1 associated protein |
| chr6_+_151042224 | 1.37 |
ENST00000358517.2
|
PLEKHG1
|
pleckstrin homology domain containing, family G (with RhoGef domain) member 1 |
| chr5_+_140797296 | 1.36 |
ENST00000398594.2
|
PCDHGB7
|
protocadherin gamma subfamily B, 7 |
| chr15_+_58702742 | 1.35 |
ENST00000356113.6
ENST00000414170.3 |
LIPC
|
lipase, hepatic |
| chr17_+_42264556 | 1.35 |
ENST00000319511.6
ENST00000589785.1 ENST00000592825.1 ENST00000589184.1 |
TMUB2
|
transmembrane and ubiquitin-like domain containing 2 |
| chr7_-_37488834 | 1.33 |
ENST00000310758.4
|
ELMO1
|
engulfment and cell motility 1 |
| chr13_-_110438914 | 1.32 |
ENST00000375856.3
|
IRS2
|
insulin receptor substrate 2 |
| chr10_-_71169031 | 1.32 |
ENST00000373307.1
|
TACR2
|
tachykinin receptor 2 |
| chr3_-_114477962 | 1.32 |
ENST00000471418.1
|
ZBTB20
|
zinc finger and BTB domain containing 20 |
| chr10_+_114710425 | 1.31 |
ENST00000352065.5
ENST00000369395.1 |
TCF7L2
|
transcription factor 7-like 2 (T-cell specific, HMG-box) |
| chr4_+_88571429 | 1.31 |
ENST00000339673.6
ENST00000282479.7 |
DMP1
|
dentin matrix acidic phosphoprotein 1 |
| chr4_-_57547454 | 1.31 |
ENST00000556376.2
|
HOPX
|
HOP homeobox |
| chr1_-_45956822 | 1.30 |
ENST00000372086.3
ENST00000341771.6 |
TESK2
|
testis-specific kinase 2 |
| chr10_-_102989551 | 1.30 |
ENST00000370193.2
|
LBX1
|
ladybird homeobox 1 |
| chr3_+_148447887 | 1.30 |
ENST00000475347.1
ENST00000474935.1 ENST00000461609.1 |
AGTR1
|
angiotensin II receptor, type 1 |
| chr2_-_183291741 | 1.28 |
ENST00000351439.5
ENST00000409365.1 |
PDE1A
|
phosphodiesterase 1A, calmodulin-dependent |
| chr6_+_161123270 | 1.26 |
ENST00000366924.2
ENST00000308192.9 ENST00000418964.1 |
PLG
|
plasminogen |
| chr4_+_155484155 | 1.25 |
ENST00000509493.1
|
FGB
|
fibrinogen beta chain |
| chr7_+_97361388 | 1.24 |
ENST00000350485.4
ENST00000346867.4 |
TAC1
|
tachykinin, precursor 1 |
| chrX_+_22050546 | 1.24 |
ENST00000379374.4
|
PHEX
|
phosphate regulating endopeptidase homolog, X-linked |
| chr9_-_95166841 | 1.23 |
ENST00000262551.4
|
OGN
|
osteoglycin |
| chr2_+_45168875 | 1.22 |
ENST00000260653.3
|
SIX3
|
SIX homeobox 3 |
| chr1_-_48937821 | 1.21 |
ENST00000396199.3
|
SPATA6
|
spermatogenesis associated 6 |
| chr2_+_169757750 | 1.21 |
ENST00000375363.3
ENST00000429379.2 ENST00000421979.1 |
G6PC2
|
glucose-6-phosphatase, catalytic, 2 |
| chr1_+_202317815 | 1.20 |
ENST00000608999.1
ENST00000336894.4 ENST00000480184.1 |
PPP1R12B
|
protein phosphatase 1, regulatory subunit 12B |
| chr2_-_214016314 | 1.19 |
ENST00000434687.1
ENST00000374319.4 |
IKZF2
|
IKAROS family zinc finger 2 (Helios) |
| chr1_-_48937838 | 1.18 |
ENST00000371847.3
|
SPATA6
|
spermatogenesis associated 6 |
| chr12_+_52695617 | 1.18 |
ENST00000293525.5
|
KRT86
|
keratin 86 |
| chr5_-_137475071 | 1.16 |
ENST00000265191.2
|
NME5
|
NME/NM23 family member 5 |
| chr2_+_183943464 | 1.16 |
ENST00000354221.4
|
DUSP19
|
dual specificity phosphatase 19 |
| chr8_-_17579726 | 1.15 |
ENST00000381861.3
|
MTUS1
|
microtubule associated tumor suppressor 1 |
| chr8_-_70745575 | 1.14 |
ENST00000524945.1
|
SLCO5A1
|
solute carrier organic anion transporter family, member 5A1 |
| chr2_-_228582709 | 1.12 |
ENST00000541617.1
ENST00000409456.2 ENST00000409287.1 ENST00000258403.3 |
SLC19A3
|
solute carrier family 19 (thiamine transporter), member 3 |
| chr12_-_71031220 | 1.11 |
ENST00000334414.6
|
PTPRB
|
protein tyrosine phosphatase, receptor type, B |
| chr12_-_71031185 | 1.09 |
ENST00000548122.1
ENST00000551525.1 ENST00000550358.1 |
PTPRB
|
protein tyrosine phosphatase, receptor type, B |
| chr5_-_160279207 | 1.06 |
ENST00000327245.5
|
ATP10B
|
ATPase, class V, type 10B |
| chr11_-_115375107 | 1.05 |
ENST00000545380.1
ENST00000452722.3 ENST00000537058.1 ENST00000536727.1 ENST00000542447.2 ENST00000331581.6 |
CADM1
|
cell adhesion molecule 1 |
| chr5_+_140767452 | 1.05 |
ENST00000519479.1
|
PCDHGB4
|
protocadherin gamma subfamily B, 4 |
| chr18_+_61445007 | 1.04 |
ENST00000447428.1
ENST00000546027.1 |
SERPINB7
|
serpin peptidase inhibitor, clade B (ovalbumin), member 7 |
| chrX_+_77166172 | 1.02 |
ENST00000343533.5
ENST00000350425.4 ENST00000341514.6 |
ATP7A
|
ATPase, Cu++ transporting, alpha polypeptide |
| chr1_+_160160283 | 1.00 |
ENST00000368079.3
|
CASQ1
|
calsequestrin 1 (fast-twitch, skeletal muscle) |
| chr7_-_151217001 | 1.00 |
ENST00000262187.5
|
RHEB
|
Ras homolog enriched in brain |
| chr12_-_58135903 | 1.00 |
ENST00000257897.3
|
AGAP2
|
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 |
| chrX_+_135251783 | 0.99 |
ENST00000394153.2
|
FHL1
|
four and a half LIM domains 1 |
| chr8_+_77593448 | 0.99 |
ENST00000521891.2
|
ZFHX4
|
zinc finger homeobox 4 |
| chr10_+_102222798 | 0.98 |
ENST00000343737.5
|
WNT8B
|
wingless-type MMTV integration site family, member 8B |
| chr17_-_10421853 | 0.97 |
ENST00000226207.5
|
MYH1
|
myosin, heavy chain 1, skeletal muscle, adult |
| chr13_-_67802549 | 0.97 |
ENST00000328454.5
ENST00000377865.2 |
PCDH9
|
protocadherin 9 |
| chr1_+_215747118 | 0.96 |
ENST00000448333.1
|
KCTD3
|
potassium channel tetramerization domain containing 3 |
| chr8_+_121137333 | 0.95 |
ENST00000309791.4
ENST00000297848.3 ENST00000247781.3 |
COL14A1
|
collagen, type XIV, alpha 1 |
| chr6_-_76203345 | 0.94 |
ENST00000393004.2
|
FILIP1
|
filamin A interacting protein 1 |
| chr13_-_30424821 | 0.94 |
ENST00000380680.4
|
UBL3
|
ubiquitin-like 3 |
| chrX_+_70435044 | 0.94 |
ENST00000374029.1
ENST00000374022.3 ENST00000447581.1 |
GJB1
|
gap junction protein, beta 1, 32kDa |
| chr9_-_123812542 | 0.93 |
ENST00000223642.1
|
C5
|
complement component 5 |
| chr11_-_72070206 | 0.93 |
ENST00000544382.1
|
CLPB
|
ClpB caseinolytic peptidase B homolog (E. coli) |
| chr14_-_50698276 | 0.92 |
ENST00000216373.5
|
SOS2
|
son of sevenless homolog 2 (Drosophila) |
| chr2_-_25391507 | 0.92 |
ENST00000380794.1
|
POMC
|
proopiomelanocortin |
| chr18_-_500692 | 0.91 |
ENST00000400256.3
|
COLEC12
|
collectin sub-family member 12 |
| chr9_+_131062367 | 0.91 |
ENST00000601297.1
|
AL359091.2
|
CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein |
| chr1_-_20250110 | 0.89 |
ENST00000375116.3
|
PLA2G2E
|
phospholipase A2, group IIE |
| chr10_-_62332357 | 0.89 |
ENST00000503366.1
|
ANK3
|
ankyrin 3, node of Ranvier (ankyrin G) |
| chr4_+_88720698 | 0.88 |
ENST00000226284.5
|
IBSP
|
integrin-binding sialoprotein |
| chrX_-_14047996 | 0.88 |
ENST00000380523.4
ENST00000398355.3 |
GEMIN8
|
gem (nuclear organelle) associated protein 8 |
| chr3_-_101039402 | 0.88 |
ENST00000193391.7
|
IMPG2
|
interphotoreceptor matrix proteoglycan 2 |
| chr2_+_166428839 | 0.88 |
ENST00000342316.4
|
CSRNP3
|
cysteine-serine-rich nuclear protein 3 |
| chr2_-_25391468 | 0.87 |
ENST00000395826.2
|
POMC
|
proopiomelanocortin |
| chr2_-_25391772 | 0.86 |
ENST00000405623.1
|
POMC
|
proopiomelanocortin |
| chr4_+_94750014 | 0.86 |
ENST00000306011.3
|
ATOH1
|
atonal homolog 1 (Drosophila) |
| chrX_+_135252050 | 0.86 |
ENST00000449474.1
ENST00000345434.3 |
FHL1
|
four and a half LIM domains 1 |
| chr9_-_95166884 | 0.83 |
ENST00000375561.5
|
OGN
|
osteoglycin |
| chr9_+_470288 | 0.83 |
ENST00000382303.1
|
KANK1
|
KN motif and ankyrin repeat domains 1 |
| chr8_-_72274095 | 0.83 |
ENST00000303824.7
|
EYA1
|
eyes absent homolog 1 (Drosophila) |
| chr2_+_210444142 | 0.83 |
ENST00000360351.4
ENST00000361559.4 |
MAP2
|
microtubule-associated protein 2 |
| chr20_+_42136308 | 0.82 |
ENST00000434666.1
ENST00000427442.2 ENST00000439769.1 ENST00000418998.1 |
L3MBTL1
|
l(3)mbt-like 1 (Drosophila) |
| chr14_-_98444386 | 0.82 |
ENST00000556462.1
ENST00000556138.1 |
C14orf64
|
chromosome 14 open reading frame 64 |
| chr12_+_26348429 | 0.82 |
ENST00000242729.2
|
SSPN
|
sarcospan |
| chr12_-_102591604 | 0.82 |
ENST00000329406.4
|
PMCH
|
pro-melanin-concentrating hormone |
| chrX_-_18690210 | 0.82 |
ENST00000379984.3
|
RS1
|
retinoschisin 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of NOTO_VSX2_DLX2_DLX6_NKX6-1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 23.8 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.3 | 1.3 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
| 1.1 | 13.3 | GO:0048251 | elastic fiber assembly(GO:0048251) |
| 0.9 | 2.7 | GO:1901993 | meiotic cell cycle phase transition(GO:0044771) regulation of meiotic cell cycle phase transition(GO:1901993) negative regulation of meiotic cell cycle phase transition(GO:1901994) |
| 0.7 | 2.2 | GO:0061357 | positive regulation of Wnt protein secretion(GO:0061357) |
| 0.7 | 4.7 | GO:0090324 | negative regulation of oxidative phosphorylation(GO:0090324) |
| 0.7 | 5.4 | GO:0050861 | positive regulation of B cell receptor signaling pathway(GO:0050861) |
| 0.6 | 6.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.6 | 1.9 | GO:1900158 | positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 0.6 | 1.2 | GO:0021798 | forebrain dorsal/ventral pattern formation(GO:0021798) |
| 0.6 | 4.3 | GO:0002414 | immunoglobulin transcytosis in epithelial cells(GO:0002414) |
| 0.6 | 15.7 | GO:0007638 | mechanosensory behavior(GO:0007638) |
| 0.6 | 13.5 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.6 | 4.7 | GO:2000852 | corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852) |
| 0.5 | 5.3 | GO:0060385 | axonogenesis involved in innervation(GO:0060385) |
| 0.5 | 1.6 | GO:0003147 | neural crest cell migration involved in heart formation(GO:0003147) cell migration involved in heart formation(GO:0060974) anterior neural tube closure(GO:0061713) |
| 0.5 | 1.5 | GO:0051795 | positive regulation of catagen(GO:0051795) activation of meiosis(GO:0090427) |
| 0.5 | 1.5 | GO:1990637 | response to prolactin(GO:1990637) |
| 0.5 | 2.0 | GO:0061528 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) aspartate secretion(GO:0061528) regulation of aspartate secretion(GO:1904448) positive regulation of aspartate secretion(GO:1904450) |
| 0.5 | 2.5 | GO:0021759 | globus pallidus development(GO:0021759) |
| 0.5 | 2.0 | GO:0006114 | glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640) |
| 0.5 | 5.4 | GO:0048743 | positive regulation of skeletal muscle fiber development(GO:0048743) |
| 0.5 | 1.5 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 0.5 | 2.4 | GO:0060729 | intestinal epithelial structure maintenance(GO:0060729) |
| 0.5 | 1.4 | GO:0048382 | mesendoderm development(GO:0048382) |
| 0.5 | 0.9 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.5 | 2.8 | GO:0051970 | negative regulation of transmission of nerve impulse(GO:0051970) |
| 0.4 | 2.2 | GO:0050955 | thermoception(GO:0050955) |
| 0.4 | 34.0 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 0.4 | 1.3 | GO:0014057 | positive regulation of acetylcholine secretion, neurotransmission(GO:0014057) |
| 0.4 | 1.6 | GO:0051866 | general adaptation syndrome(GO:0051866) |
| 0.4 | 1.1 | GO:0071934 | thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934) |
| 0.4 | 1.5 | GO:0060023 | soft palate development(GO:0060023) |
| 0.3 | 1.7 | GO:0048478 | replication fork protection(GO:0048478) |
| 0.3 | 1.3 | GO:0070309 | lens fiber cell morphogenesis(GO:0070309) |
| 0.3 | 1.3 | GO:0086097 | phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097) |
| 0.3 | 3.0 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.3 | 0.3 | GO:0086092 | regulation of the force of heart contraction by cardiac conduction(GO:0086092) |
| 0.3 | 1.1 | GO:0035992 | tendon cell differentiation(GO:0035990) tendon formation(GO:0035992) |
| 0.3 | 0.8 | GO:2000393 | negative regulation of lamellipodium morphogenesis(GO:2000393) |
| 0.3 | 11.8 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.3 | 1.3 | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809) |
| 0.3 | 1.1 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.3 | 1.0 | GO:0090362 | positive regulation of platelet-derived growth factor production(GO:0090362) |
| 0.3 | 1.5 | GO:0014043 | negative regulation of neuron maturation(GO:0014043) |
| 0.2 | 1.5 | GO:0061153 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.2 | 2.5 | GO:0048664 | neuron fate determination(GO:0048664) |
| 0.2 | 1.2 | GO:1904383 | response to sodium phosphate(GO:1904383) |
| 0.2 | 1.9 | GO:0048842 | positive regulation of axon extension involved in axon guidance(GO:0048842) |
| 0.2 | 1.4 | GO:0015842 | aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) |
| 0.2 | 0.9 | GO:0046013 | regulation of T cell homeostatic proliferation(GO:0046013) |
| 0.2 | 3.2 | GO:0098828 | positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828) |
| 0.2 | 2.1 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.2 | 2.5 | GO:0046459 | short-chain fatty acid metabolic process(GO:0046459) |
| 0.2 | 0.4 | GO:0061551 | trigeminal ganglion development(GO:0061551) regulation of branch elongation involved in ureteric bud branching(GO:0072095) |
| 0.2 | 1.3 | GO:0010748 | regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) |
| 0.2 | 1.5 | GO:0070166 | enamel mineralization(GO:0070166) |
| 0.2 | 5.0 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.2 | 5.3 | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397) |
| 0.2 | 4.2 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.2 | 15.8 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.2 | 0.6 | GO:0030309 | poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311) |
| 0.2 | 1.8 | GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) |
| 0.2 | 0.8 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.2 | 0.8 | GO:0036269 | swimming behavior(GO:0036269) |
| 0.2 | 1.0 | GO:1904879 | positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879) |
| 0.2 | 0.6 | GO:0039694 | viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.2 | 0.8 | GO:0042539 | hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) |
| 0.2 | 2.4 | GO:0034374 | low-density lipoprotein particle remodeling(GO:0034374) |
| 0.1 | 1.1 | GO:0035356 | cellular triglyceride homeostasis(GO:0035356) |
| 0.1 | 0.7 | GO:0021853 | cerebral cortex tangential migration(GO:0021800) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936) |
| 0.1 | 1.8 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.1 | 0.8 | GO:0010133 | proline catabolic process to glutamate(GO:0010133) |
| 0.1 | 1.6 | GO:0042135 | neurotransmitter catabolic process(GO:0042135) |
| 0.1 | 1.6 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.1 | 3.9 | GO:0018105 | peptidyl-serine phosphorylation(GO:0018105) |
| 0.1 | 4.0 | GO:0001919 | regulation of receptor recycling(GO:0001919) |
| 0.1 | 0.7 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.1 | 4.1 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 0.1 | 3.0 | GO:0044458 | motile cilium assembly(GO:0044458) |
| 0.1 | 0.5 | GO:2000504 | positive regulation of blood vessel remodeling(GO:2000504) |
| 0.1 | 2.1 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 0.1 | 1.2 | GO:0003351 | epithelial cilium movement(GO:0003351) |
| 0.1 | 1.9 | GO:0034776 | response to histamine(GO:0034776) cellular response to histamine(GO:0071420) |
| 0.1 | 0.9 | GO:0016264 | gap junction assembly(GO:0016264) |
| 0.1 | 3.0 | GO:0061049 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 0.1 | 0.4 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
| 0.1 | 0.9 | GO:0060355 | positive regulation of cell adhesion molecule production(GO:0060355) |
| 0.1 | 7.3 | GO:0042475 | odontogenesis of dentin-containing tooth(GO:0042475) |
| 0.1 | 1.0 | GO:0048263 | determination of dorsal identity(GO:0048263) |
| 0.1 | 0.5 | GO:0072502 | cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502) |
| 0.1 | 3.8 | GO:0001558 | regulation of cell growth(GO:0001558) |
| 0.1 | 0.8 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.1 | 0.5 | GO:0010735 | positive regulation of transcription via serum response element binding(GO:0010735) |
| 0.1 | 0.3 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.1 | 0.4 | GO:0002331 | B cell lineage commitment(GO:0002326) pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) |
| 0.1 | 1.3 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.7 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.1 | 0.3 | GO:0035378 | carbon dioxide transmembrane transport(GO:0035378) |
| 0.1 | 0.2 | GO:0014816 | skeletal muscle satellite cell differentiation(GO:0014816) |
| 0.1 | 0.3 | GO:0021997 | response to chlorate(GO:0010157) neural plate axis specification(GO:0021997) |
| 0.1 | 3.0 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.1 | 0.2 | GO:1990523 | bone regeneration(GO:1990523) |
| 0.1 | 0.4 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 0.1 | 0.1 | GO:0061113 | pancreas morphogenesis(GO:0061113) |
| 0.1 | 0.2 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.1 | 1.0 | GO:1901215 | negative regulation of neuron death(GO:1901215) |
| 0.1 | 0.5 | GO:0033353 | S-adenosylmethionine cycle(GO:0033353) |
| 0.1 | 1.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 0.1 | 0.4 | GO:0045078 | positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.1 | 0.3 | GO:2000342 | negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342) |
| 0.1 | 1.1 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 2.1 | GO:0009081 | branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083) |
| 0.1 | 2.6 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.1 | 1.2 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.1 | 2.3 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.1 | 0.5 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.1 | 0.6 | GO:0086024 | adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024) |
| 0.1 | 3.0 | GO:2000144 | positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 2.6 | GO:0032728 | positive regulation of interferon-beta production(GO:0032728) |
| 0.1 | 0.5 | GO:0098532 | histone H3-K27 trimethylation(GO:0098532) |
| 0.1 | 9.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 2.5 | GO:0007595 | lactation(GO:0007595) |
| 0.1 | 0.3 | GO:0014877 | response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) |
| 0.1 | 0.5 | GO:1904352 | positive regulation of protein catabolic process in the vacuole(GO:1904352) |
| 0.1 | 0.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.1 | 0.7 | GO:1901299 | negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299) |
| 0.1 | 1.5 | GO:0001525 | angiogenesis(GO:0001525) |
| 0.0 | 1.3 | GO:0045332 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.0 | 0.1 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.0 | 2.4 | GO:1904837 | beta-catenin-TCF complex assembly(GO:1904837) |
| 0.0 | 0.2 | GO:0052405 | negative regulation by host of symbiont molecular function(GO:0052405) |
| 0.0 | 0.1 | GO:0042320 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.0 | 0.3 | GO:0019532 | oxalate transport(GO:0019532) |
| 0.0 | 0.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 0.3 | GO:2000389 | regulation of neutrophil extravasation(GO:2000389) |
| 0.0 | 1.1 | GO:0030728 | ovulation(GO:0030728) |
| 0.0 | 0.2 | GO:0010519 | negative regulation of phospholipase activity(GO:0010519) |
| 0.0 | 0.4 | GO:0000712 | resolution of meiotic recombination intermediates(GO:0000712) |
| 0.0 | 0.3 | GO:0060134 | prepulse inhibition(GO:0060134) |
| 0.0 | 0.3 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 3.6 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 0.7 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.2 | GO:0042421 | norepinephrine biosynthetic process(GO:0042421) |
| 0.0 | 4.6 | GO:0060218 | hematopoietic stem cell differentiation(GO:0060218) |
| 0.0 | 1.0 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 1.0 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 0.4 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 0.0 | 1.2 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 0.0 | 0.5 | GO:0030299 | intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856) |
| 0.0 | 0.7 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 2.0 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
| 0.0 | 0.6 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 1.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.0 | 1.2 | GO:0046461 | neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464) |
| 0.0 | 0.6 | GO:0060964 | regulation of gene silencing by miRNA(GO:0060964) |
| 0.0 | 4.9 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 2.1 | GO:0042130 | negative regulation of T cell proliferation(GO:0042130) |
| 0.0 | 0.2 | GO:0086073 | cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 0.7 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.1 | GO:0002074 | extraocular skeletal muscle development(GO:0002074) |
| 0.0 | 0.3 | GO:0072257 | metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307) |
| 0.0 | 0.8 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) |
| 0.0 | 0.1 | GO:0090063 | positive regulation of microtubule nucleation(GO:0090063) |
| 0.0 | 0.1 | GO:0006933 | negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933) |
| 0.0 | 0.0 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.0 | 0.4 | GO:0060009 | Sertoli cell development(GO:0060009) |
| 0.0 | 0.7 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.2 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.0 | 0.4 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.3 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 17.5 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.0 | 0.5 | GO:0070884 | regulation of calcineurin-NFAT signaling cascade(GO:0070884) |
| 0.0 | 0.5 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.0 | 0.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 0.1 | GO:0010513 | positive regulation of phosphatidylinositol biosynthetic process(GO:0010513) |
| 0.0 | 1.1 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 0.0 | 0.3 | GO:0060732 | regulation of inositol phosphate biosynthetic process(GO:0010919) positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 1.6 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.0 | 0.6 | GO:0009798 | axis specification(GO:0009798) |
| 0.0 | 0.8 | GO:0021954 | central nervous system neuron development(GO:0021954) |
| 0.0 | 0.9 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.0 | 1.9 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.1 | GO:0043517 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) |
| 0.0 | 0.3 | GO:0038095 | Fc-epsilon receptor signaling pathway(GO:0038095) |
| 0.0 | 0.4 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.0 | 0.6 | GO:0070301 | cellular response to hydrogen peroxide(GO:0070301) |
| 0.0 | 0.0 | GO:0021877 | forebrain neuron fate commitment(GO:0021877) commitment of neuronal cell to specific neuron type in forebrain(GO:0021902) |
| 0.0 | 0.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.3 | GO:0001958 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 29.8 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.6 | 2.4 | GO:0097224 | sperm connecting piece(GO:0097224) |
| 0.5 | 2.0 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.4 | 2.9 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.3 | 1.6 | GO:0032280 | symmetric synapse(GO:0032280) |
| 0.3 | 3.0 | GO:0032045 | guanyl-nucleotide exchange factor complex(GO:0032045) |
| 0.2 | 4.2 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 1.5 | GO:0098554 | cytoplasmic side of endoplasmic reticulum membrane(GO:0098554) |
| 0.2 | 1.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.2 | 1.8 | GO:0016013 | syntrophin complex(GO:0016013) |
| 0.2 | 0.6 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.2 | 2.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.2 | 1.3 | GO:0014802 | terminal cisterna(GO:0014802) |
| 0.2 | 46.6 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.2 | 1.4 | GO:0070081 | clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.1 | 1.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 1.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.1 | 1.5 | GO:0005583 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.1 | 1.8 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 1.0 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.1 | 0.9 | GO:0097504 | Gemini of coiled bodies(GO:0097504) |
| 0.1 | 0.9 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 1.2 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 0.4 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.1 | 1.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 12.1 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 4.6 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 1.3 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.1 | 2.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 4.5 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.1 | 1.0 | GO:1990454 | L-type voltage-gated calcium channel complex(GO:1990454) |
| 0.1 | 3.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.1 | 0.7 | GO:0097443 | sorting endosome(GO:0097443) |
| 0.1 | 0.4 | GO:0043240 | Fanconi anaemia nuclear complex(GO:0043240) |
| 0.1 | 0.9 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.7 | GO:0097524 | sperm plasma membrane(GO:0097524) |
| 0.0 | 3.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.3 | GO:0044294 | dendritic growth cone(GO:0044294) |
| 0.0 | 0.4 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.2 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 2.4 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 9.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 5.2 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 1.7 | GO:0043596 | nuclear replication fork(GO:0043596) |
| 0.0 | 1.0 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 0.3 | GO:0016012 | dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012) |
| 0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 2.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 2.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0042584 | chromaffin granule membrane(GO:0042584) |
| 0.0 | 0.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 2.1 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.3 | GO:0090665 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 5.3 | GO:0070820 | tertiary granule(GO:0070820) |
| 0.0 | 0.1 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 7.8 | GO:0030133 | transport vesicle(GO:0030133) |
| 0.0 | 3.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.6 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.0 | 2.1 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.1 | GO:0097550 | transcriptional preinitiation complex(GO:0097550) |
| 0.0 | 0.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.0 | 0.3 | GO:0090533 | cation-transporting ATPase complex(GO:0090533) |
| 0.0 | 0.3 | GO:0097225 | sperm midpiece(GO:0097225) |
| 0.0 | 1.7 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.1 | GO:0070826 | paraferritin complex(GO:0070826) |
| 0.0 | 0.3 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 3.7 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 1.2 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 2.2 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 1.6 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 0.6 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 1.4 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 26.2 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 1.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.9 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 1.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 1.1 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.4 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 1.1 | 5.4 | GO:0004699 | calcium-independent protein kinase C activity(GO:0004699) |
| 1.1 | 4.3 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.9 | 2.7 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.9 | 3.4 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
| 0.8 | 5.9 | GO:0030345 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.8 | 3.4 | GO:0000822 | inositol hexakisphosphate binding(GO:0000822) |
| 0.8 | 4.0 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 0.7 | 2.0 | GO:0004611 | phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613) |
| 0.6 | 35.6 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.5 | 2.0 | GO:0003867 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 0.5 | 2.4 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.5 | 1.4 | GO:0015222 | serotonin transmembrane transporter activity(GO:0015222) |
| 0.4 | 1.3 | GO:0001596 | angiotensin type I receptor activity(GO:0001596) |
| 0.4 | 11.4 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.4 | 1.6 | GO:0061714 | folic acid receptor activity(GO:0061714) |
| 0.4 | 1.1 | GO:0015234 | thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403) |
| 0.3 | 1.0 | GO:0032767 | copper-dependent protein binding(GO:0032767) |
| 0.3 | 1.2 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.3 | 2.9 | GO:0035727 | lysophosphatidic acid binding(GO:0035727) |
| 0.3 | 0.8 | GO:0032093 | SAM domain binding(GO:0032093) |
| 0.3 | 1.3 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.2 | 1.6 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 2.1 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 1.5 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.2 | 0.6 | GO:0008532 | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532) |
| 0.2 | 2.3 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.2 | 11.9 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 1.6 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.2 | 16.6 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.2 | 0.8 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.2 | 2.2 | GO:0032027 | myosin light chain binding(GO:0032027) |
| 0.2 | 1.3 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.2 | 1.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 0.5 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.2 | 1.7 | GO:0036310 | annealing helicase activity(GO:0036310) |
| 0.2 | 2.5 | GO:0044213 | intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213) |
| 0.2 | 19.0 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 1.3 | GO:1990405 | protein antigen binding(GO:1990405) |
| 0.2 | 2.0 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 2.2 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 0.7 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 32.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 1.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 1.0 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 0.9 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.7 | GO:0004705 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.1 | 1.2 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 2.5 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.1 | 0.5 | GO:0001190 | transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811) |
| 0.1 | 0.8 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
| 0.1 | 0.4 | GO:0005134 | interleukin-2 receptor binding(GO:0005134) |
| 0.1 | 0.8 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.1 | 1.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.6 | GO:0035005 | 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005) |
| 0.1 | 1.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 1.7 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.1 | 0.3 | GO:0035379 | carbon dioxide transmembrane transporter activity(GO:0035379) |
| 0.1 | 0.5 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.1 | 0.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.8 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.1 | 2.2 | GO:0019198 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 12.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 0.2 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 0.5 | GO:0008597 | calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597) |
| 0.1 | 3.2 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.3 | GO:0042030 | ATPase inhibitor activity(GO:0042030) |
| 0.1 | 0.7 | GO:0038085 | vascular endothelial growth factor binding(GO:0038085) |
| 0.1 | 1.0 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
| 0.1 | 0.2 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134) |
| 0.1 | 11.2 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 0.9 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.3 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 0.7 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.1 | 9.9 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.3 | GO:0097108 | hedgehog family protein binding(GO:0097108) |
| 0.1 | 0.7 | GO:0039706 | co-receptor binding(GO:0039706) |
| 0.1 | 1.8 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 0.4 | GO:0004351 | glutamate decarboxylase activity(GO:0004351) |
| 0.1 | 3.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.6 | GO:0004977 | melanocortin receptor activity(GO:0004977) |
| 0.1 | 1.2 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 0.2 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.1 | 1.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 0.2 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.1 | 0.2 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
| 0.1 | 0.3 | GO:0019531 | oxalate transmembrane transporter activity(GO:0019531) |
| 0.1 | 0.5 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.7 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.3 | GO:0004991 | parathyroid hormone receptor activity(GO:0004991) |
| 0.0 | 0.3 | GO:0004301 | epoxide hydrolase activity(GO:0004301) |
| 0.0 | 1.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 11.9 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 1.7 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.0 | 1.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.1 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981) |
| 0.0 | 1.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.2 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.0 | 0.2 | GO:0001849 | complement component C1q binding(GO:0001849) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 2.1 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.5 | GO:0043522 | leucine zipper domain binding(GO:0043522) |
| 0.0 | 2.3 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.7 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 1.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.0 | 0.3 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.0 | 3.4 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0071889 | 14-3-3 protein binding(GO:0071889) |
| 0.0 | 1.1 | GO:0061135 | endopeptidase inhibitor activity(GO:0004866) endopeptidase regulator activity(GO:0061135) |
| 0.0 | 0.9 | GO:0004623 | phospholipase A2 activity(GO:0004623) |
| 0.0 | 1.2 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.0 | 0.4 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.0 | 0.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 2.4 | GO:0004497 | monooxygenase activity(GO:0004497) |
| 0.0 | 0.4 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0001223 | transcription coactivator binding(GO:0001223) |
| 0.0 | 0.1 | GO:0015639 | cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639) |
| 0.0 | 0.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 1.2 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.1 | GO:0001093 | TFIIB-class transcription factor binding(GO:0001093) |
| 0.0 | 0.3 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 1.7 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.1 | GO:0004087 | carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088) |
| 0.0 | 1.7 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 0.2 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.0 | 0.1 | GO:0043532 | angiostatin binding(GO:0043532) |
| 0.0 | 0.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.4 | GO:0008329 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
| 0.0 | 1.3 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 1.8 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 53.6 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 9.5 | PID P38 MK2 PATHWAY | p38 signaling mediated by MAPKAP kinases |
| 0.2 | 19.4 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 1.5 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.1 | 1.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 3.0 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.1 | 5.4 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 2.2 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 7.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 0.6 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.1 | 2.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 1.0 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 3.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.1 | 4.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 2.4 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.0 | 2.2 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.0 | 2.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 2.0 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.0 | 2.7 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 0.7 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 0.5 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 0.7 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 0.0 | 1.3 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 0.3 | ST INTERLEUKIN 4 PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.4 | ST GA13 PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 0.7 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 0.5 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.6 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.0 | 0.1 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 0.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 0.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 0.7 | PID BMP PATHWAY | BMP receptor signaling |
| 0.0 | 0.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 0.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 14.2 | REACTOME ANDROGEN BIOSYNTHESIS | Genes involved in Androgen biosynthesis |
| 0.7 | 11.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.2 | 5.3 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.2 | 6.4 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 3.1 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.1 | 2.1 | REACTOME HORMONE LIGAND BINDING RECEPTORS | Genes involved in Hormone ligand-binding receptors |
| 0.1 | 1.6 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.1 | 2.4 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |
| 0.1 | 5.1 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 3.1 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 2.1 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.1 | 1.7 | REACTOME COMMON PATHWAY | Genes involved in Common Pathway |
| 0.1 | 1.1 | REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION | Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation |
| 0.1 | 1.9 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 0.1 | 2.0 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 1.4 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |
| 0.1 | 2.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.1 | 2.9 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 0.1 | 3.0 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.1 | 0.7 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 1.3 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.1 | 1.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.1 | 0.9 | REACTOME ACYL CHAIN REMODELLING OF PG | Genes involved in Acyl chain remodelling of PG |
| 0.1 | 0.5 | REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS | Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins |
| 0.1 | 0.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 10.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 2.0 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 0.7 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.0 | 2.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 0.9 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 1.0 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.0 | 2.4 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 1.3 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 5.7 | REACTOME INTEGRATION OF ENERGY METABOLISM | Genes involved in Integration of energy metabolism |
| 0.0 | 1.3 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.0 | 1.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.0 | 0.6 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.0 | 0.6 | REACTOME KERATAN SULFATE KERATIN METABOLISM | Genes involved in Keratan sulfate/keratin metabolism |
| 0.0 | 0.4 | REACTOME LIPOPROTEIN METABOLISM | Genes involved in Lipoprotein metabolism |
| 0.0 | 0.1 | REACTOME REGULATION OF BETA CELL DEVELOPMENT | Genes involved in Regulation of beta-cell development |
| 0.0 | 1.2 | REACTOME GLUCOSE TRANSPORT | Genes involved in Glucose transport |
| 0.0 | 1.3 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.0 | 0.6 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 0.4 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 0.9 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 0.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.0 | 0.5 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.0 | 0.2 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.0 | 0.3 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.0 | 1.0 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.0 | 0.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 0.3 | REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | Genes involved in NGF signalling via TRKA from the plasma membrane |