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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR1D1

Z-value: 0.86

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Transcription factors associated with NR1D1

Gene Symbol Gene ID Gene Info
NR1D1
ENSG00000126368.5 nuclear receptor subfamily 1 group D member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR1D1hg19_v2_chr17_-_38256973_382569900.267.8e-05Click!

Activity profile of NR1D1 motif

Sorted Z-values of NR1D1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_26233423 11.03 ENST00000357865.2
STMN1
stathmin 1
chr1_-_41131326 7.92 ENST00000372684.3
RIMS3
regulating synaptic membrane exocytosis 3
chr17_-_79139817 7.68 ENST00000326724.4
AATK
apoptosis-associated tyrosine kinase
chr1_-_11866034 6.87 ENST00000376590.3
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr19_-_23578220 6.71 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
ZNF91
zinc finger protein 91
chr13_+_113622757 6.70 ENST00000375604.2
MCF2L
MCF.2 cell line derived transforming sequence-like
chr13_+_113622810 6.17 ENST00000397030.1
MCF2L
MCF.2 cell line derived transforming sequence-like
chr5_-_111312622 5.93 ENST00000395634.3
NREP
neuronal regeneration related protein
chr14_+_24540046 5.89 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
CPNE6
copine VI (neuronal)
chr1_-_11865982 5.85 ENST00000418034.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr9_+_126773880 5.78 ENST00000373615.4
LHX2
LIM homeobox 2
chr14_-_23770683 5.59 ENST00000561437.1
ENST00000559942.1
ENST00000560913.1
ENST00000559314.1
ENST00000558058.1
PPP1R3E
protein phosphatase 1, regulatory subunit 3E
chr2_+_63816087 5.51 ENST00000409908.1
ENST00000442225.1
ENST00000409476.1
ENST00000436321.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr3_-_52002403 5.25 ENST00000490063.1
ENST00000468324.1
ENST00000497653.1
ENST00000484633.1
PCBP4
poly(rC) binding protein 4
chr14_+_24540731 5.18 ENST00000558859.1
ENST00000559197.1
ENST00000560828.1
ENST00000216775.2
ENST00000560884.1
CPNE6
copine VI (neuronal)
chr19_+_22235310 5.01 ENST00000600162.1
ZNF257
zinc finger protein 257
chr10_+_11047259 4.95 ENST00000379261.4
ENST00000416382.2
CELF2
CUGBP, Elav-like family member 2
chr2_+_63816295 4.91 ENST00000539945.1
ENST00000544381.1
MDH1
malate dehydrogenase 1, NAD (soluble)
chr7_+_94139105 4.64 ENST00000297273.4
CASD1
CAS1 domain containing 1
chr19_-_23433144 4.62 ENST00000418100.1
ENST00000597537.1
ENST00000597037.1
ZNF724P
zinc finger protein 724, pseudogene
chr22_-_37880543 4.53 ENST00000442496.1
MFNG
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr1_-_26232522 4.47 ENST00000399728.1
STMN1
stathmin 1
chr8_+_105235572 4.44 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr3_+_58223228 4.36 ENST00000478253.1
ENST00000295962.4
ABHD6
abhydrolase domain containing 6
chr7_+_139025875 4.34 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chrX_+_54947229 4.30 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
TRO
trophinin
chr19_+_21324827 4.04 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431
zinc finger protein 431
chr19_+_21264980 4.03 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
ZNF714
zinc finger protein 714
chr2_+_113342163 3.90 ENST00000409719.1
CHCHD5
coiled-coil-helix-coiled-coil-helix domain containing 5
chr9_+_103790991 3.89 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr19_-_38806560 3.75 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr16_+_71392616 3.75 ENST00000349553.5
ENST00000302628.4
ENST00000562305.1
CALB2
calbindin 2
chr17_-_3599492 3.73 ENST00000435558.1
ENST00000345901.3
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr15_-_81282133 3.73 ENST00000261758.4
MESDC2
mesoderm development candidate 2
chr11_+_46366918 3.72 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr11_+_125365110 3.40 ENST00000527818.1
AP000708.1
AP000708.1
chr17_-_38074842 3.38 ENST00000309481.7
GSDMB
gasdermin B
chr1_-_26232951 3.34 ENST00000426559.2
ENST00000455785.2
STMN1
stathmin 1
chr17_-_38074859 3.12 ENST00000520542.1
ENST00000418519.1
ENST00000394179.1
GSDMB
gasdermin B
chr16_-_18468926 3.11 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chr17_-_3599327 3.00 ENST00000551178.1
ENST00000552276.1
ENST00000547178.1
P2RX5
purinergic receptor P2X, ligand-gated ion channel, 5
chr15_+_65903680 3.00 ENST00000537259.1
SLC24A1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr19_-_12833164 2.93 ENST00000356861.5
TNPO2
transportin 2
chr14_-_50999190 2.87 ENST00000557390.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_-_73053126 2.75 ENST00000272427.6
ENST00000410104.1
EXOC6B
exocyst complex component 6B
chr19_+_21203426 2.66 ENST00000261560.5
ENST00000599548.1
ENST00000594110.1
ZNF430
zinc finger protein 430
chr1_-_11865351 2.53 ENST00000413656.1
ENST00000376585.1
ENST00000423400.1
ENST00000431243.1
MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr2_-_103353277 2.45 ENST00000258436.5
MFSD9
major facilitator superfamily domain containing 9
chr9_-_35112376 2.33 ENST00000488109.2
FAM214B
family with sequence similarity 214, member B
chr7_-_128694927 2.33 ENST00000471166.1
ENST00000265388.5
TNPO3
transportin 3
chr19_-_19932501 2.30 ENST00000540806.2
ENST00000590766.1
ENST00000587452.1
ENST00000545006.1
ENST00000590319.1
ENST00000587461.1
ENST00000450683.2
ENST00000443905.2
ENST00000590274.1
ZNF506
CTC-559E9.4
zinc finger protein 506
CTC-559E9.4
chrX_-_49089771 2.16 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr19_+_21265028 2.10 ENST00000291770.7
ZNF714
zinc finger protein 714
chr1_+_2398876 1.96 ENST00000449969.1
PLCH2
phospholipase C, eta 2
chr16_-_70712229 1.94 ENST00000562883.2
MTSS1L
metastasis suppressor 1-like
chr7_-_142630820 1.94 ENST00000442623.1
ENST00000265310.1
TRPV5
transient receptor potential cation channel, subfamily V, member 5
chr5_-_43313574 1.83 ENST00000325110.6
ENST00000433297.2
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
chr17_-_56358287 1.78 ENST00000225275.3
ENST00000340482.3
MPO
myeloperoxidase
chr17_-_38256973 1.76 ENST00000246672.3
NR1D1
nuclear receptor subfamily 1, group D, member 1
chrX_+_24167828 1.59 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX
zinc finger protein, X-linked
chr19_+_22235279 1.53 ENST00000594363.1
ENST00000597927.1
ENST00000594947.1
ZNF257
zinc finger protein 257
chr2_-_89442621 1.49 ENST00000492167.1
IGKV3-20
immunoglobulin kappa variable 3-20
chr3_-_48723268 1.46 ENST00000439518.1
ENST00000416649.2
ENST00000341520.4
ENST00000294129.2
NCKIPSD
NCK interacting protein with SH3 domain
chr19_-_22605136 1.43 ENST00000357774.5
ENST00000601553.1
ENST00000593657.1
ZNF98
zinc finger protein 98
chr7_-_100493744 1.39 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr1_+_197382957 1.36 ENST00000367397.1
CRB1
crumbs homolog 1 (Drosophila)
chr1_-_168513229 1.32 ENST00000367819.2
XCL2
chemokine (C motif) ligand 2
chr3_-_133648656 1.31 ENST00000408895.2
C3orf36
chromosome 3 open reading frame 36
chr14_+_74815116 1.31 ENST00000256362.4
VRTN
vertebrae development associated
chr15_-_65903574 1.31 ENST00000420799.2
ENST00000313182.2
ENST00000431261.2
ENST00000442903.3
VWA9
von Willebrand factor A domain containing 9
chr15_-_65903407 1.23 ENST00000395644.4
ENST00000567744.1
ENST00000568573.1
ENST00000562830.1
ENST00000569491.1
ENST00000561769.1
VWA9
von Willebrand factor A domain containing 9
chr1_+_110210644 1.22 ENST00000369831.2
ENST00000442650.1
ENST00000369827.3
ENST00000460717.3
ENST00000241337.4
ENST00000467579.3
ENST00000414179.2
ENST00000369829.2
GSTM2
glutathione S-transferase mu 2 (muscle)
chr19_-_58071201 1.21 ENST00000325134.5
ENST00000457177.1
ZNF550
zinc finger protein 550
chr2_+_90153696 1.17 ENST00000417279.2
IGKV3D-15
immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chrY_+_2803322 1.12 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
ZFY
zinc finger protein, Y-linked
chr17_+_6899366 1.10 ENST00000251535.6
ALOX12
arachidonate 12-lipoxygenase
chr2_+_203776937 1.03 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
CARF
calcium responsive transcription factor
chr6_+_167525277 0.99 ENST00000400926.2
CCR6
chemokine (C-C motif) receptor 6
chr7_+_64126535 0.99 ENST00000344930.3
ZNF107
zinc finger protein 107
chr7_-_100493482 0.88 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE
acetylcholinesterase (Yt blood group)
chr7_-_128695147 0.87 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3
transportin 3
chr19_-_12833361 0.86 ENST00000592287.1
TNPO2
transportin 2
chr22_+_27017921 0.85 ENST00000354760.3
CRYBA4
crystallin, beta A4
chr6_-_27440837 0.84 ENST00000211936.6
ZNF184
zinc finger protein 184
chr8_+_11561660 0.79 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr17_-_76128488 0.76 ENST00000322914.3
TMC6
transmembrane channel-like 6
chr11_+_46740730 0.73 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr13_+_100741269 0.65 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chr7_-_44229022 0.62 ENST00000403799.3
GCK
glucokinase (hexokinase 4)
chr1_+_44398943 0.61 ENST00000372359.5
ENST00000414809.3
ARTN
artemin
chr6_+_31543334 0.59 ENST00000449264.2
TNF
tumor necrosis factor
chr19_-_42927251 0.50 ENST00000597001.1
LIPE
lipase, hormone-sensitive
chr1_+_168545711 0.44 ENST00000367818.3
XCL1
chemokine (C motif) ligand 1
chr19_+_21688366 0.29 ENST00000358491.4
ENST00000597078.1
ZNF429
zinc finger protein 429
chrX_+_24167746 0.28 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chrX_+_16964985 0.26 ENST00000303843.7
REPS2
RALBP1 associated Eps domain containing 2
chr11_+_7534999 0.26 ENST00000528947.1
ENST00000299492.4
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr18_-_44336998 0.24 ENST00000315087.7
ST8SIA5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr14_-_50999307 0.22 ENST00000013125.4
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_+_220306745 0.18 ENST00000431523.1
ENST00000396698.1
ENST00000396695.2
SPEG
SPEG complex locus
chr6_+_76458909 0.13 ENST00000369981.3
ENST00000369985.4
MYO6
myosin VI
chr16_+_1832902 0.05 ENST00000262302.9
ENST00000563136.1
ENST00000565987.1
ENST00000543305.1
ENST00000568287.1
ENST00000565134.1
NUBP2
nucleotide binding protein 2
chr17_-_36347030 0.04 ENST00000518551.1
TBC1D3
TBC1 domain family, member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of NR1D1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 18.8 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
3.1 15.3 GO:0033274 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.9 10.4 GO:0006108 malate metabolic process(GO:0006108)
0.8 2.3 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
0.6 4.4 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.6 1.8 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.6 6.7 GO:0015074 DNA integration(GO:0015074)
0.5 4.4 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.5 5.8 GO:0021978 telencephalon regionalization(GO:0021978)
0.4 0.4 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.4 4.8 GO:0009642 response to light intensity(GO:0009642)
0.4 11.1 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.4 4.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.4 7.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.4 1.1 GO:2001302 lipoxin biosynthetic process(GO:2001301) lipoxin A4 metabolic process(GO:2001302) lipoxin A4 biosynthetic process(GO:2001303)
0.3 1.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.3 3.9 GO:0097034 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.3 0.8 GO:0035054 septum secundum development(GO:0003285) embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.3 3.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.2 6.7 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.2 0.6 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.2 1.2 GO:0070458 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) cellular detoxification of nitrogen compound(GO:0070458)
0.2 1.8 GO:0001878 response to yeast(GO:0001878)
0.2 0.6 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of translational initiation by iron(GO:0045994) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.2 0.7 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
0.2 4.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.2 2.2 GO:0050908 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.1 3.1 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 5.0 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 1.9 GO:1990035 calcium ion import across plasma membrane(GO:0098703) calcium ion import into cell(GO:1990035)
0.1 0.6 GO:0061146 Peyer's patch morphogenesis(GO:0061146) lymphocyte migration into lymphoid organs(GO:0097021)
0.1 1.0 GO:0035865 cellular response to potassium ion(GO:0035865)
0.1 1.3 GO:0032196 transposition(GO:0032196)
0.1 0.6 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 11.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.1 4.1 GO:0007566 embryo implantation(GO:0007566)
0.1 1.5 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 1.9 GO:0097178 ruffle assembly(GO:0097178)
0.1 2.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 5.6 GO:0005977 glycogen metabolic process(GO:0005977)
0.1 5.3 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 3.7 GO:0034394 protein localization to cell surface(GO:0034394)
0.0 0.8 GO:0006811 ion transport(GO:0006811)
0.0 1.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.5 GO:0019731 antibacterial humoral response(GO:0019731)
0.0 3.2 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.0 1.3 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 3.8 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.0 2.0 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 3.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 3.7 GO:0051480 regulation of cytosolic calcium ion concentration(GO:0051480)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0071749 IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
0.3 12.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 6.7 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.3 12.4 GO:0048786 presynaptic active zone(GO:0048786)
0.2 2.3 GO:0043083 synaptic cleft(GO:0043083)
0.2 4.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 2.8 GO:0000145 exocyst(GO:0000145)
0.1 10.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 1.0 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.8 GO:0005921 gap junction(GO:0005921)
0.0 2.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.6 GO:0001891 phagocytic cup(GO:0001891)
0.0 16.3 GO:0005874 microtubule(GO:0005874)
0.0 1.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 7.1 GO:0043209 myelin sheath(GO:0043209)
0.0 7.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.9 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 7.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 1.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.4 GO:0005902 microvillus(GO:0005902)
0.0 1.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 1.5 GO:0045202 synapse(GO:0045202)
0.0 3.0 GO:0019867 outer membrane(GO:0019867)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 15.3 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
2.1 10.4 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
1.1 4.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.6 6.7 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.6 3.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.6 2.3 GO:0003990 acetylcholinesterase activity(GO:0003990)
0.4 4.6 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.4 1.1 GO:0047977 hepoxilin-epoxide hydrolase activity(GO:0047977)
0.4 1.8 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 4.4 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.3 1.3 GO:0004803 transposase activity(GO:0004803)
0.2 11.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.2 3.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 7.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.2 3.1 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.2 0.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 3.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 11.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.8 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 2.2 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 5.0 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 0.6 GO:0008865 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.2 GO:0043295 glutathione binding(GO:0043295)
0.1 1.0 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.7 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.1 2.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 0.8 GO:0051525 NFAT protein binding(GO:0051525)
0.1 0.6 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.1 12.4 GO:0044325 ion channel binding(GO:0044325)
0.1 5.3 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 16.3 GO:0015631 tubulin binding(GO:0015631)
0.0 1.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.0 0.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 1.8 GO:0004601 peroxidase activity(GO:0004601)
0.0 4.0 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.9 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.9 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 25.4 GO:0003677 DNA binding(GO:0003677)
0.0 5.7 GO:0004674 protein serine/threonine kinase activity(GO:0004674)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 18.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 12.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.0 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 1.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 3.7 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.8 PID IL23 PATHWAY IL23-mediated signaling events
0.0 2.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 5.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 0.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 15.3 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 4.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.2 10.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 1.0 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.1 2.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 1.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 1.8 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 0.7 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 0.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 11.3 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 1.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.6 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 3.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis