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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR2C1

Z-value: 0.73

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Transcription factors associated with NR2C1

Gene Symbol Gene ID Gene Info
NR2C1
ENSG00000120798.12 nuclear receptor subfamily 2 group C member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NR2C1hg19_v2_chr12_-_95467267_954673500.189.0e-03Click!

Activity profile of NR2C1 motif

Sorted Z-values of NR2C1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_38420783 21.88 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chrX_+_38420623 18.91 ENST00000378482.2
TSPAN7
tetraspanin 7
chr1_+_160097462 10.86 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr3_-_58613323 9.71 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr10_-_118502070 7.66 ENST00000369209.3
HSPA12A
heat shock 70kDa protein 12A
chr14_-_21492251 5.95 ENST00000554398.1
NDRG2
NDRG family member 2
chr14_-_21492113 5.78 ENST00000554094.1
NDRG2
NDRG family member 2
chr22_+_39745930 5.74 ENST00000318801.4
ENST00000216155.7
ENST00000406293.3
ENST00000328933.5
SYNGR1
synaptogyrin 1
chr7_+_121513143 5.30 ENST00000393386.2
PTPRZ1
protein tyrosine phosphatase, receptor-type, Z polypeptide 1
chr3_+_159557637 5.25 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr18_+_54318566 5.25 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr18_+_54318616 5.18 ENST00000254442.3
WDR7
WD repeat domain 7
chr3_+_42897512 4.85 ENST00000493193.1
ACKR2
atypical chemokine receptor 2
chr11_+_131781290 4.79 ENST00000425719.2
ENST00000374784.1
NTM
neurotrimin
chr5_-_42811986 4.28 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
SEPP1
selenoprotein P, plasma, 1
chr17_-_15903002 4.13 ENST00000399277.1
ZSWIM7
zinc finger, SWIM-type containing 7
chr8_-_80680078 3.89 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr6_+_30594619 3.89 ENST00000318999.7
ENST00000376485.4
ENST00000376478.2
ENST00000319027.5
ENST00000376483.4
ENST00000329992.8
ENST00000330083.5
ATAT1
alpha tubulin acetyltransferase 1
chr19_-_38806560 3.85 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B
Yip1 interacting factor homolog B (S. cerevisiae)
chr3_-_33700933 3.52 ENST00000480013.1
CLASP2
cytoplasmic linker associated protein 2
chr3_-_33700589 3.51 ENST00000461133.3
ENST00000496954.2
CLASP2
cytoplasmic linker associated protein 2
chr5_-_42812143 3.46 ENST00000514985.1
SEPP1
selenoprotein P, plasma, 1
chr3_-_50605077 3.22 ENST00000426034.1
ENST00000441239.1
C3orf18
chromosome 3 open reading frame 18
chr20_-_44485835 3.06 ENST00000457981.1
ENST00000426915.1
ENST00000217455.4
ACOT8
acyl-CoA thioesterase 8
chr1_+_44412577 2.98 ENST00000372343.3
IPO13
importin 13
chr21_-_32931290 2.95 ENST00000286827.3
TIAM1
T-cell lymphoma invasion and metastasis 1
chr3_-_50605150 2.86 ENST00000357203.3
C3orf18
chromosome 3 open reading frame 18
chr13_+_21714653 2.86 ENST00000382533.4
SAP18
Sin3A-associated protein, 18kDa
chr12_-_90049828 2.79 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr12_-_90049878 2.74 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr16_-_4292071 2.58 ENST00000399609.3
SRL
sarcalumenin
chr22_-_38851205 2.52 ENST00000303592.3
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr22_+_41777927 2.52 ENST00000266304.4
TEF
thyrotrophic embryonic factor
chr2_-_201936302 2.47 ENST00000453765.1
ENST00000452799.1
ENST00000446678.1
ENST00000418596.3
FAM126B
family with sequence similarity 126, member B
chr15_+_45422131 2.38 ENST00000321429.4
DUOX1
dual oxidase 1
chr13_+_21714711 2.31 ENST00000607003.1
ENST00000492245.1
SAP18
Sin3A-associated protein, 18kDa
chr4_+_159593418 2.29 ENST00000507475.1
ENST00000307738.5
ETFDH
electron-transferring-flavoprotein dehydrogenase
chr6_+_31515337 2.08 ENST00000376148.4
ENST00000376145.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr19_-_51472031 2.05 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr22_-_50699701 2.03 ENST00000395780.1
MAPK12
mitogen-activated protein kinase 12
chr17_-_39743139 1.95 ENST00000167586.6
KRT14
keratin 14
chr3_+_101546827 1.95 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
NFKBIZ
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr15_+_45422178 1.85 ENST00000389037.3
ENST00000558322.1
DUOX1
dual oxidase 1
chr4_-_76598326 1.75 ENST00000503660.1
G3BP2
GTPase activating protein (SH3 domain) binding protein 2
chr13_+_100741269 1.74 ENST00000376286.4
ENST00000376279.3
ENST00000376285.1
PCCA
propionyl CoA carboxylase, alpha polypeptide
chr12_-_42631529 1.73 ENST00000548917.1
YAF2
YY1 associated factor 2
chr12_-_42632016 1.72 ENST00000442791.3
ENST00000327791.4
ENST00000534854.2
ENST00000380788.3
ENST00000380790.4
YAF2
YY1 associated factor 2
chr1_-_229569834 1.67 ENST00000366684.3
ENST00000366683.2
ACTA1
actin, alpha 1, skeletal muscle
chr11_+_67798090 1.66 ENST00000313468.5
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr2_-_202316260 1.63 ENST00000332624.3
TRAK2
trafficking protein, kinesin binding 2
chr7_-_15601595 1.57 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr19_+_39616410 1.56 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr3_+_37284824 1.52 ENST00000431105.1
GOLGA4
golgin A4
chr2_+_120124497 1.51 ENST00000355857.3
ENST00000535617.1
ENST00000535757.1
ENST00000409094.1
ENST00000311521.4
DBI
diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
chr7_+_100770328 1.51 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr13_-_33760216 1.47 ENST00000255486.4
STARD13
StAR-related lipid transfer (START) domain containing 13
chr2_-_38303218 1.47 ENST00000407341.1
ENST00000260630.3
CYP1B1
cytochrome P450, family 1, subfamily B, polypeptide 1
chr14_-_65289812 1.46 ENST00000389720.3
ENST00000389721.5
ENST00000389722.3
SPTB
spectrin, beta, erythrocytic
chr7_-_38948774 1.44 ENST00000395969.2
ENST00000414632.1
ENST00000310301.4
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr10_+_104005272 1.36 ENST00000369983.3
GBF1
golgi brefeldin A resistant guanine nucleotide exchange factor 1
chr19_-_49371711 1.34 ENST00000355496.5
ENST00000263265.6
PLEKHA4
pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
chr2_+_46926326 1.26 ENST00000394861.2
SOCS5
suppressor of cytokine signaling 5
chr19_-_36304201 1.24 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr3_+_183903811 1.20 ENST00000429586.2
ENST00000292808.5
ABCF3
ATP-binding cassette, sub-family F (GCN20), member 3
chr2_-_163099885 1.19 ENST00000443424.1
FAP
fibroblast activation protein, alpha
chr9_-_33402506 1.13 ENST00000377425.4
ENST00000537089.1
ENST00000297988.1
ENST00000539936.1
ENST00000541274.1
AQP7
aquaporin 7
chr3_+_14989186 1.12 ENST00000435454.1
ENST00000323373.6
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr10_+_26986582 1.05 ENST00000376215.5
ENST00000376203.5
PDSS1
prenyl (decaprenyl) diphosphate synthase, subunit 1
chr11_+_67798114 1.01 ENST00000453471.2
ENST00000528492.1
ENST00000526339.1
ENST00000525419.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr16_+_30710462 1.00 ENST00000262518.4
ENST00000395059.2
ENST00000344771.4
SRCAP
Snf2-related CREBBP activator protein
chr3_+_113465866 0.96 ENST00000273398.3
ENST00000538620.1
ENST00000496747.1
ENST00000475322.1
ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
chr15_-_83474806 0.91 ENST00000541889.1
ENST00000334574.8
ENST00000561368.1
FSD2
fibronectin type III and SPRY domain containing 2
chr2_-_163100045 0.90 ENST00000188790.4
FAP
fibroblast activation protein, alpha
chr11_+_111896090 0.90 ENST00000393051.1
DLAT
dihydrolipoamide S-acetyltransferase
chr6_+_149068464 0.90 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr19_-_4066890 0.85 ENST00000322357.4
ZBTB7A
zinc finger and BTB domain containing 7A
chr17_+_79373540 0.85 ENST00000307745.7
RP11-1055B8.7
BAH and coiled-coil domain-containing protein 1
chr12_+_109577202 0.83 ENST00000377848.3
ENST00000377854.5
ACACB
acetyl-CoA carboxylase beta
chr7_-_72936608 0.82 ENST00000404251.1
BAZ1B
bromodomain adjacent to zinc finger domain, 1B
chr1_+_25071848 0.82 ENST00000374379.4
CLIC4
chloride intracellular channel 4
chr16_-_70729496 0.76 ENST00000567648.1
VAC14
Vac14 homolog (S. cerevisiae)
chr19_+_16771936 0.71 ENST00000187762.2
ENST00000599479.1
TMEM38A
transmembrane protein 38A
chr7_+_120969045 0.71 ENST00000222462.2
WNT16
wingless-type MMTV integration site family, member 16
chr6_+_10585979 0.70 ENST00000265012.4
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr12_+_6494285 0.69 ENST00000541102.1
LTBR
lymphotoxin beta receptor (TNFR superfamily, member 3)
chr22_-_31536480 0.68 ENST00000215885.3
PLA2G3
phospholipase A2, group III
chr11_+_67798363 0.68 ENST00000525628.1
NDUFS8
NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
chr9_+_140513438 0.53 ENST00000462484.1
ENST00000334856.6
ENST00000460843.1
EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr1_-_45140074 0.53 ENST00000420706.1
ENST00000372235.3
ENST00000372242.3
ENST00000372243.3
ENST00000372244.3
TMEM53
transmembrane protein 53
chr2_+_33701286 0.51 ENST00000403687.3
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_+_80674559 0.51 ENST00000269373.6
ENST00000535965.1
ENST00000577128.1
ENST00000573158.1
FN3KRP
fructosamine 3 kinase related protein
chr1_-_120439112 0.50 ENST00000369400.1
ADAM30
ADAM metallopeptidase domain 30
chr14_+_74035763 0.49 ENST00000238651.5
ACOT2
acyl-CoA thioesterase 2
chr19_-_41256207 0.48 ENST00000598485.2
ENST00000470681.1
ENST00000339153.3
ENST00000598729.1
C19orf54
chromosome 19 open reading frame 54
chr14_+_74003818 0.47 ENST00000311148.4
ACOT1
acyl-CoA thioesterase 1
chrX_-_128657457 0.43 ENST00000371121.3
ENST00000371123.1
ENST00000371122.4
SMARCA1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr19_-_10679697 0.36 ENST00000335766.2
CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr22_-_29784519 0.36 ENST00000357586.2
ENST00000356015.2
ENST00000432560.2
ENST00000317368.7
AP1B1
adaptor-related protein complex 1, beta 1 subunit
chr20_+_37590942 0.36 ENST00000373325.2
ENST00000252011.3
ENST00000373323.4
DHX35
DEAH (Asp-Glu-Ala-His) box polypeptide 35
chr11_+_64073699 0.36 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr17_+_13972807 0.35 ENST00000429152.2
ENST00000261643.3
ENST00000536205.1
ENST00000537334.1
COX10
cytochrome c oxidase assembly homolog 10 (yeast)
chr12_-_95467267 0.33 ENST00000330677.7
NR2C1
nuclear receptor subfamily 2, group C, member 1
chr10_+_64564469 0.31 ENST00000373783.1
ADO
2-aminoethanethiol (cysteamine) dioxygenase
chr16_+_83932684 0.31 ENST00000262430.4
MLYCD
malonyl-CoA decarboxylase
chr10_-_103815874 0.30 ENST00000370033.4
ENST00000311122.5
C10orf76
chromosome 10 open reading frame 76
chr11_+_111896320 0.22 ENST00000531306.1
ENST00000537636.1
DLAT
dihydrolipoamide S-acetyltransferase
chr19_+_11350278 0.21 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr3_+_179065474 0.20 ENST00000471841.1
ENST00000280653.7
MFN1
mitofusin 1
chr11_-_26743546 0.19 ENST00000280467.6
ENST00000396005.3
SLC5A12
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12
chr11_+_10471836 0.18 ENST00000444303.2
AMPD3
adenosine monophosphate deaminase 3
chr9_-_35685452 0.18 ENST00000607559.1
TPM2
tropomyosin 2 (beta)
chr8_-_30706608 0.18 ENST00000256246.2
TEX15
testis expressed 15
chr17_+_73997419 0.17 ENST00000425876.2
CDK3
cyclin-dependent kinase 3
chr11_-_45939565 0.09 ENST00000525192.1
ENST00000378750.5
PEX16
peroxisomal biogenesis factor 16
chr9_+_33795533 0.03 ENST00000379405.3
PRSS3
protease, serine, 3
chr12_-_118810688 0.02 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr6_+_29364416 0.02 ENST00000383555.2
OR12D2
olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
chr3_-_116164306 0.01 ENST00000490035.2
LSAMP
limbic system-associated membrane protein

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2C1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 10.9 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
1.1 5.5 GO:1990034 calcium ion export from cell(GO:1990034)
1.1 4.2 GO:0042335 cuticle development(GO:0042335)
1.0 3.9 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.9 7.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 11.7 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.7 5.3 GO:0070444 oligodendrocyte progenitor proliferation(GO:0070444) regulation of oligodendrocyte progenitor proliferation(GO:0070445)
0.6 1.7 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
0.5 1.6 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.5 2.1 GO:0097325 melanocyte proliferation(GO:0097325)
0.5 1.5 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.5 3.0 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.5 5.7 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.4 3.9 GO:1900227 positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.4 1.5 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.3 1.4 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.3 2.0 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 1.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.3 1.4 GO:1902774 late endosome to lysosome transport(GO:1902774)
0.3 1.7 GO:0090131 mesenchyme migration(GO:0090131)
0.2 0.7 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.2 3.1 GO:0016559 peroxisome fission(GO:0016559)
0.2 1.1 GO:2001293 malonyl-CoA metabolic process(GO:2001293)
0.2 1.6 GO:0046485 ether lipid metabolic process(GO:0046485)
0.2 1.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 1.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 1.1 GO:0015793 glycerol transport(GO:0015793)
0.2 2.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 2.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.1 2.0 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.1 4.8 GO:0008038 neuron recognition(GO:0008038)
0.1 0.8 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.7 GO:0036438 maintenance of lens transparency(GO:0036438)
0.1 0.9 GO:0006477 protein sulfation(GO:0006477)
0.1 1.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253) stress granule assembly(GO:0034063)
0.1 0.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.5 GO:0060992 response to fungicide(GO:0060992)
0.1 2.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.1 1.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1 2.5 GO:0010107 potassium ion import(GO:0010107)
0.1 1.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.1 2.1 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0 4.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 1.0 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
0.0 0.4 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.4 GO:0000733 DNA strand renaturation(GO:0000733)
0.0 9.5 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 41.8 GO:0016032 viral process(GO:0016032)
0.0 1.5 GO:0051693 actin filament capping(GO:0051693)
0.0 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 0.2 GO:0006196 AMP catabolic process(GO:0006196)
0.0 2.6 GO:0000724 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.0 1.0 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.2 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.0 9.6 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.2 GO:0045023 G0 to G1 transition(GO:0045023)
0.0 1.6 GO:0060996 dendritic spine development(GO:0060996)
0.0 3.9 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.3 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.2 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 3.0 GO:0006606 protein import into nucleus(GO:0006606) protein targeting to nucleus(GO:0044744)
0.0 0.5 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.0 0.4 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.3 GO:0072534 perineuronal net(GO:0072534)
0.7 7.0 GO:0045180 basal cortex(GO:0045180)
0.5 10.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.4 3.7 GO:0061574 ASAP complex(GO:0061574)
0.4 3.9 GO:0097427 microtubule bundle(GO:0097427)
0.3 1.4 GO:0033263 CORVET complex(GO:0033263)
0.3 1.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.3 5.5 GO:0032591 dendritic spine membrane(GO:0032591)
0.2 2.6 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.2 2.1 GO:0071438 invadopodium membrane(GO:0071438)
0.1 3.0 GO:0044295 axonal growth cone(GO:0044295)
0.1 0.8 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.1 1.5 GO:0008091 spectrin(GO:0008091)
0.1 3.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 1.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 2.3 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.1 16.2 GO:0008021 synaptic vesicle(GO:0008021)
0.1 4.1 GO:1990391 DNA repair complex(GO:1990391)
0.1 0.4 GO:0016589 NURF complex(GO:0016589)
0.1 0.4 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 9.9 GO:0030426 growth cone(GO:0030426)
0.1 6.7 GO:0005884 actin filament(GO:0005884)
0.0 2.0 GO:0045095 keratin filament(GO:0045095)
0.0 2.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.3 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 2.8 GO:0005811 lipid particle(GO:0005811)
0.0 0.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 2.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 9.2 GO:0016607 nuclear speck(GO:0016607)
0.0 0.2 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.0 35.2 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 1.6 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.5 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 1.3 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 3.0 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.9 GO:0035939 microsatellite binding(GO:0035939)
0.8 3.9 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.8 10.9 GO:1990239 steroid hormone binding(GO:1990239)
0.4 2.3 GO:0048039 ubiquinone binding(GO:0048039)
0.4 1.1 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.4 4.9 GO:0019957 C-C chemokine binding(GO:0019957)
0.4 4.0 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.3 2.0 GO:1990254 keratin filament binding(GO:1990254)
0.3 1.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.3 7.0 GO:0002162 dystroglycan binding(GO:0002162)
0.3 4.2 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.3 1.1 GO:0015254 glycerol channel activity(GO:0015254)
0.3 2.6 GO:0009374 biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.2 1.6 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.2 5.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.2 5.5 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 2.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 3.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 0.5 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.1 0.7 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.1 2.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.0 GO:0004707 MAP kinase activity(GO:0004707)
0.1 1.5 GO:0070330 aromatase activity(GO:0070330)
0.1 3.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.6 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.7 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 3.3 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 3.7 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 1.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.4 GO:0080025 ARF guanyl-nucleotide exchange factor activity(GO:0005086) phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.4 GO:0036310 annealing helicase activity(GO:0036310)
0.0 0.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.0 1.6 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 0.3 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.0 1.0 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 1.7 GO:0043531 ADP binding(GO:0043531)
0.0 0.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 1.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.9 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.7 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.0 1.4 GO:0043621 protein self-association(GO:0043621)
0.0 0.6 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.4 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.7 GO:0005109 frizzled binding(GO:0005109)
0.0 0.2 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0 1.8 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.9 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 0.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.0 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 11.7 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 3.2 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.1 1.4 PID ARF 3PATHWAY Arf1 pathway
0.1 3.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 3.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 5.5 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.1 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.5 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.0 1.7 PID RHOA PATHWAY RhoA signaling pathway
0.0 2.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.2 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 9.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 3.1 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.1 1.4 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.1 2.0 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 1.7 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1 1.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 1.6 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 0.8 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.1 2.5 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.1 1.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.1 1.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 3.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 3.3 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 1.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 1.5 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0 1.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.8 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0 0.4 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.9 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism