ISMARA results: NR2E1

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NR2E1

Z-value: 1.41

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Transcription factors associated with NR2E1

Gene Symbol	Gene ID	Gene Info
NR2E1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000112333.7	nuclear receptor subfamily 2 group E member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR2E1	hg19_v2_chr6_+_108487245_108487262	0.39	1.7e-09	Click!

Activity profile of NR2E1 motif

Sorted Z-values of NR2E1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_-_21786179 Show fit	60.50	ENST00000377113.5	CASC10 Ensembl NCBI GeneCards UniProt NextProt Show fit	cancer susceptibility candidate 10
chr12_-_91539918 Show fit	49.80	ENST00000548218.1	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_-_111794446 Show fit	26.79	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr5_-_42811986 Show fit	25.70	ENST00000511224.1 ENST00000507920.1 ENST00000510965.1	SEPP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	selenoprotein P, plasma, 1
chr12_-_91572278 Show fit	20.95	ENST00000425043.1 ENST00000420120.2 ENST00000441303.2 ENST00000456569.2	DCN Ensembl NCBI GeneCards UniProt NextProt Show fit	decorin
chr11_-_5276008 Show fit	19.93	ENST00000336906.4	HBG2 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, gamma G
chr11_-_5271122 Show fit	19.65	ENST00000330597.3	HBG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, gamma A
chr14_+_69865401 Show fit	16.78	ENST00000556605.1 ENST00000336643.5 ENST00000031146.4	SLC39A9 Ensembl NCBI GeneCards UniProt NextProt Show fit	solute carrier family 39, member 9
chr11_-_111781454 Show fit	15.87	ENST00000533280.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr17_-_66951474 Show fit	14.95	ENST00000269080.2	ABCA8 Ensembl NCBI GeneCards UniProt NextProt Show fit	ATP-binding cassette, sub-family A (ABC1), member 8

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2E1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
7.1	85.8	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
3.1	55.2	GO:0007021	tubulin complex assembly(GO:0007021)
2.6	39.6	GO:0015671	oxygen transport(GO:0015671)
1.2	30.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.4	21.7	GO:2000144	positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.4	21.4	GO:0015701	bicarbonate transport(GO:0015701)
3.9	19.6	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.7	16.8	GO:0006829	zinc II ion transport(GO:0006829)
0.6	15.6	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
1.5	15.3	GO:0043152	induction of bacterial agglutination(GO:0043152)

Showing 1 to 10 of 161 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.1	85.2	GO:0005589	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
3.4	55.2	GO:0097512	cardiac myofibril(GO:0097512)
0.0	48.8	GO:0005615	extracellular space(GO:0005615)
2.8	39.6	GO:0005833	hemoglobin complex(GO:0005833)
0.1	17.5	GO:0031225	anchored component of membrane(GO:0031225)
0.1	16.7	GO:0072562	blood microparticle(GO:0072562)
0.9	15.3	GO:0042589	zymogen granule membrane(GO:0042589)
0.1	11.5	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.3	11.3	GO:0030173	integral component of Golgi membrane(GO:0030173)
2.6	10.4	GO:0071062	alphav-beta3 integrin-vitronectin complex(GO:0071062)

Showing 1 to 10 of 77 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	95.3	GO:0050840	extracellular matrix binding(GO:0050840)
1.8	57.1	GO:0005212	structural constituent of eye lens(GO:0005212)
3.0	39.6	GO:0005344	oxygen transporter activity(GO:0005344)
0.4	21.7	GO:0070888	E-box binding(GO:0070888)
0.6	20.6	GO:0015301	anion:anion antiporter activity(GO:0015301)
0.2	19.6	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.7	17.2	GO:0038187	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2	16.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.9	15.0	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.1	14.6	GO:0004222	metalloendopeptidase activity(GO:0004222)

Showing 1 to 10 of 129 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	82.8	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.1	35.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	29.3	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.3	28.5	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.4	18.6	ST GAQ PATHWAY	G alpha q Pathway
0.2	12.8	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.0	12.3	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.1	11.2	PID LKB1 PATHWAY	LKB1 signaling events
0.3	10.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4	10.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Showing 1 to 10 of 40 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.2	85.2	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
1.2	18.4	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	15.1	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	15.0	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.7	14.9	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.2	12.8	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.2	12.2	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.5	10.6	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.2	10.4	REACTOME AMINE LIGAND BINDING RECEPTORS	Genes involved in Amine ligand-binding receptors
0.3	10.2	REACTOME INFLAMMASOMES	Genes involved in Inflammasomes

Showing 1 to 10 of 61 entries

Results for NR2E1

Z-value: 1.41

Motif logo

Transcription factors associated with NR2E1

Activity-expression correlation:

Activity profile of NR2E1 motif

Sorted Z-values of NR2E1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR2E1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: