ISMARA results: NR3C1

Project

averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for NR3C1

Z-value: 2.68

Motif logo

Transcription factors associated with NR3C1

Gene Symbol	Gene ID	Gene Info
NR3C1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000113580.10	nuclear receptor subfamily 3 group C member 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
NR3C1	hg19_v2_chr5_-_142780280_142780417	0.10	1.5e-01	Click!

Activity profile of NR3C1 motif

Sorted Z-values of NR3C1 motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_106054659 Show fit	116.72	ENST00000390539.2	IGHA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant alpha 2 (A2m marker)
chr22_+_23237555 Show fit	88.89	ENST00000390321.2	IGLC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 1 (Mcg marker)
chr22_+_23248512 Show fit	83.99	ENST00000390325.2	IGLC3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr14_-_106174960 Show fit	74.59	ENST00000390547.2	IGHA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant alpha 1
chr22_+_23243156 Show fit	73.46	ENST00000390323.2	IGLC2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr14_-_106692191 Show fit	56.68	ENST00000390607.2	IGHV3-21 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 3-21
chr22_+_23241661 Show fit	54.04	ENST00000390322.2	IGLJ2 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 2
chr6_+_33048222 Show fit	52.13	ENST00000428835.1	HLA-DPB1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP beta 1
chr14_-_106642049 Show fit	50.09	ENST00000390605.2	IGHV1-18 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy variable 1-18
chr2_-_89513402 Show fit	49.77	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin kappa variable 1-27

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of NR3C1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
8.7	602.0	GO:0006910	phagocytosis, recognition(GO:0006910)
4.6	463.2	GO:0006958	complement activation, classical pathway(GO:0006958)
0.7	228.2	GO:0002250	adaptive immune response(GO:0002250)
19.1	191.3	GO:0060267	positive regulation of respiratory burst(GO:0060267)
1.2	177.5	GO:0002377	immunoglobulin production(GO:0002377)
1.2	134.9	GO:0031295	T cell costimulation(GO:0031295)
6.6	46.0	GO:0044800	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
8.8	43.9	GO:0002901	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.2	43.6	GO:0006909	phagocytosis(GO:0006909)
1.9	33.6	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)

Showing 1 to 10 of 301 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
12.8	601.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
2.0	360.4	GO:0072562	blood microparticle(GO:0072562)
0.1	211.2	GO:0005615	extracellular space(GO:0005615)
63.8	191.3	GO:0071746	IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751)
8.4	177.1	GO:0042613	MHC class II protein complex(GO:0042613)
6.7	33.6	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.1	31.7	GO:0005770	late endosome(GO:0005770)
0.3	31.3	GO:0035579	specific granule membrane(GO:0035579)
1.4	29.3	GO:0042588	zymogen granule(GO:0042588)
3.4	27.6	GO:1990111	spermatoproteasome complex(GO:1990111)

Showing 1 to 10 of 138 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.8	830.0	GO:0003823	antigen binding(GO:0003823)
14.4	793.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
6.2	81.2	GO:0032395	MHC class II receptor activity(GO:0032395)
4.2	46.0	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
8.8	43.9	GO:0042289	MHC class II protein binding(GO:0042289)
0.2	41.6	GO:0030674	protein binding, bridging(GO:0030674)
0.1	36.0	GO:0001227	transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
4.8	33.6	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.2	32.8	GO:0005178	integrin binding(GO:0005178)
0.3	31.7	GO:0005518	collagen binding(GO:0005518)

Showing 1 to 10 of 210 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.1	109.0	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.5	83.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
1.2	56.1	PID S1P S1P3 PATHWAY	S1P3 pathway
0.2	53.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	43.5	PID BCR 5PATHWAY	BCR signaling pathway
0.6	37.0	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.6	31.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.4	24.9	PID FCER1 PATHWAY	Fc-epsilon receptor I signaling in mast cells
0.2	17.9	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	16.9	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells

Showing 1 to 10 of 56 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
6.3	137.5	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
1.4	116.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
9.2	46.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	28.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
2.5	24.9	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
1.2	23.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.4	22.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.8	20.0	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.2	17.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.2	13.6	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions

Showing 1 to 10 of 91 entries

Results for NR3C1

Z-value: 2.68

Motif logo

Transcription factors associated with NR3C1

Activity-expression correlation:

Activity profile of NR3C1 motif

Sorted Z-values of NR3C1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of NR3C1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: