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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for NRF1

Z-value: 7.10

Motif logo

Transcription factors associated with NRF1

Gene Symbol Gene ID Gene Info
ENSG00000106459.10 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NRF1hg19_v2_chr7_+_129251531_129251601-0.371.7e-08Click!

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_50432782 160.64 ENST00000413454.1
ENST00000596437.1
ENST00000341114.3
ENST00000595948.1
nucleoporin 62kDa
interleukin 4 induced 1
chr19_+_39138320 155.53 ENST00000424234.2
ENST00000390009.3
ENST00000589528.1
actinin, alpha 4
chr17_+_40761660 147.06 ENST00000251413.3
ENST00000591509.1
tubulin, gamma 1
chr17_+_7210898 144.00 ENST00000572815.1
eukaryotic translation initiation factor 5A
chr2_-_33824336 133.36 ENST00000431950.1
ENST00000403368.1
ENST00000441530.2
family with sequence similarity 98, member A
chr8_-_117886955 130.81 ENST00000297338.2
RAD21 homolog (S. pombe)
chr5_+_170814803 128.67 ENST00000521672.1
ENST00000351986.6
ENST00000393820.2
ENST00000523622.1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr2_-_33824382 115.84 ENST00000238823.8
family with sequence similarity 98, member A
chr9_+_110045537 114.44 ENST00000358015.3
RAD23 homolog B (S. cerevisiae)
chr3_+_120315149 113.47 ENST00000184266.2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr14_-_23058063 109.61 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
defender against cell death 1
chr3_+_120315160 108.82 ENST00000485064.1
ENST00000492739.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr2_+_216974020 106.60 ENST00000392132.2
ENST00000417391.1
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr20_-_57617831 101.95 ENST00000371033.5
ENST00000355937.4
slowmo homolog 2 (Drosophila)
chr5_-_133561752 101.74 ENST00000519718.1
ENST00000481195.1
S-phase kinase-associated protein 1
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_47634039 98.31 ENST00000597808.1
ENST00000413379.3
ENST00000600706.1
ENST00000540850.1
ENST00000598840.1
ENST00000600753.1
ENST00000270225.7
ENST00000392776.3
SUMO1 activating enzyme subunit 1
chr19_-_2328572 98.06 ENST00000252622.10
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_-_120988229 97.50 ENST00000296509.6
MAD2 mitotic arrest deficient-like 1 (yeast)
chr12_+_69080734 96.77 ENST00000378905.2
nucleoporin 107kDa
chr1_-_156308018 95.34 ENST00000496684.2
ENST00000368259.2
ENST00000368261.3
ENST00000472765.2
ENST00000533194.1
ENST00000478640.2
chaperonin containing TCP1, subunit 3 (gamma)
chr9_-_124922021 95.00 ENST00000537618.1
ENST00000373768.3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chr10_-_58120996 92.85 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZW10 interacting kinetochore protein
chr3_+_150321068 89.76 ENST00000471696.1
ENST00000477889.1
ENST00000485923.1
Selenoprotein T
chr2_+_264869 88.48 ENST00000272067.6
ENST00000272065.5
ENST00000407983.3
acid phosphatase 1, soluble
chr16_-_66864806 88.28 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
NEDD8 activating enzyme E1 subunit 1
chr1_+_154947148 87.67 ENST00000368436.1
ENST00000308987.5
CDC28 protein kinase regulatory subunit 1B
chr19_-_10305752 86.01 ENST00000540357.1
ENST00000359526.4
ENST00000340748.4
DNA (cytosine-5-)-methyltransferase 1
chr7_-_102213030 84.88 ENST00000511313.1
ENST00000513438.1
ENST00000513506.1
polymerase (RNA) II (DNA directed) polypeptide J3
chr8_+_42249418 83.62 ENST00000521158.1
ENST00000022615.4
voltage-dependent anion channel 3
chr1_-_183604794 83.19 ENST00000367534.1
ENST00000359856.6
ENST00000294742.6
actin related protein 2/3 complex, subunit 5, 16kDa
chr8_+_42249346 82.66 ENST00000392935.3
ENST00000520115.1
ENST00000522069.1
ENST00000522572.1
voltage-dependent anion channel 3
chr5_+_162887556 82.41 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
hyaluronan-mediated motility receptor (RHAMM)
chr1_+_154947126 81.86 ENST00000368439.1
CDC28 protein kinase regulatory subunit 1B
chr3_-_150320937 80.54 ENST00000479209.1
stress-associated endoplasmic reticulum protein 1
chr2_-_99952769 80.33 ENST00000409434.1
ENST00000434323.1
ENST00000264255.3
thioredoxin domain containing 9
chr4_-_103789996 79.90 ENST00000508238.1
ubiquitin-conjugating enzyme E2D 3
chr20_+_57556263 79.45 ENST00000602795.1
ENST00000344018.3
negative elongation factor complex member C/D
chr17_+_49337881 78.99 ENST00000225298.7
UTP18 small subunit (SSU) processome component homolog (yeast)
chr21_-_38445470 78.48 ENST00000399098.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr19_+_17416457 78.09 ENST00000252602.1
mitochondrial ribosomal protein L34
chr19_+_49588690 77.62 ENST00000221448.5
small nuclear ribonucleoprotein 70kDa (U1)
chr14_-_102605983 76.69 ENST00000334701.7
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr4_+_57301896 76.67 ENST00000514888.1
ENST00000264221.2
ENST00000505164.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_+_39138271 75.99 ENST00000252699.2
actinin, alpha 4
chr19_+_17416609 75.73 ENST00000602206.1
mitochondrial ribosomal protein L34
chr21_-_38445011 73.92 ENST00000464265.1
ENST00000399102.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr10_-_16859361 73.35 ENST00000377921.3
Ras suppressor protein 1
chr7_-_102312048 72.94 ENST00000333432.6
ENST00000591000.1
ENST00000358438.5
DNA-directed RNA polymerase II subunit RPB11-b1
chr22_-_28315115 71.87 ENST00000455418.3
ENST00000436663.1
ENST00000320996.10
ENST00000335272.5
phosphatidylinositol transfer protein, beta
chr12_-_54070098 71.66 ENST00000394349.3
ENST00000549164.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr9_+_91926103 71.27 ENST00000314355.6
CDC28 protein kinase regulatory subunit 2
chr12_-_54069856 70.52 ENST00000602871.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr11_-_47664072 69.82 ENST00000542981.1
ENST00000530428.1
ENST00000302503.3
mitochondrial carrier 2
chr17_-_40761375 69.17 ENST00000543197.1
ENST00000309428.5
family with sequence similarity 134, member C
chr19_+_49588677 68.88 ENST00000598984.1
ENST00000598441.1
small nuclear ribonucleoprotein 70kDa (U1)
chr5_+_218356 68.47 ENST00000264932.6
ENST00000504309.1
ENST00000510361.1
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr10_+_99185917 68.12 ENST00000334828.5
phosphoglycerate mutase 1 (brain)
chr1_+_32479430 67.55 ENST00000327300.7
ENST00000492989.1
KH domain containing, RNA binding, signal transduction associated 1
chr4_+_57302297 67.10 ENST00000399688.3
ENST00000512576.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr17_+_7210921 66.67 ENST00000573542.1
eukaryotic translation initiation factor 5A
chr8_-_55014415 65.67 ENST00000522007.1
ENST00000521898.1
ENST00000518546.1
ENST00000316963.3
lysophospholipase I
chr8_-_55014336 65.38 ENST00000343231.6
lysophospholipase I
chr21_-_33651324 64.68 ENST00000290130.3
MIS18 kinetochore protein A
chr5_+_10250328 64.52 ENST00000515390.1
chaperonin containing TCP1, subunit 5 (epsilon)
chr2_+_190526111 64.52 ENST00000607062.1
ENST00000260952.4
ENST00000425590.1
ENST00000607535.1
ENST00000420250.1
ENST00000606910.1
ENST00000607690.1
ENST00000607829.1
asparagine synthetase domain containing 1
chr10_-_16859442 64.06 ENST00000602389.1
ENST00000345264.5
Ras suppressor protein 1
chr17_-_4852332 63.85 ENST00000572383.1
profilin 1
chr19_-_2427536 63.45 ENST00000591871.1
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr6_-_36515177 63.32 ENST00000229812.7
serine/threonine kinase 38
chr6_-_41040195 62.57 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
O-acyl-ADP-ribose deacylase 1
chr12_+_57623869 62.43 ENST00000414700.3
ENST00000557703.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_+_11071685 61.93 ENST00000541122.2
ENST00000589677.1
ENST00000444061.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr21_-_38445443 61.31 ENST00000360525.4
phosphatidylinositol glycan anchor biosynthesis, class P
chr3_-_119396193 61.30 ENST00000484810.1
ENST00000497116.1
ENST00000261070.2
COX17 cytochrome c oxidase copper chaperone
chr13_+_50656307 61.23 ENST00000378180.4
deleted in lymphocytic leukemia 1 (non-protein coding)
chrX_-_129299847 61.07 ENST00000319908.3
ENST00000287295.3
apoptosis-inducing factor, mitochondrion-associated, 1
chr4_+_17616253 60.87 ENST00000237380.7
mediator complex subunit 28
chrX_-_153707246 60.02 ENST00000407062.1
L antigen family, member 3
chr19_+_8509842 59.87 ENST00000325495.4
ENST00000600092.1
ENST00000594907.1
ENST00000596984.1
ENST00000601645.1
heterogeneous nuclear ribonucleoprotein M
chr21_-_38445297 59.86 ENST00000430792.1
ENST00000399103.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr4_+_57845043 59.51 ENST00000433463.1
ENST00000314595.5
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chrX_-_129299638 59.42 ENST00000535724.1
ENST00000346424.2
apoptosis-inducing factor, mitochondrion-associated, 1
chr4_+_57845024 58.33 ENST00000431623.2
ENST00000441246.2
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr19_+_531713 58.03 ENST00000215574.4
cell division cycle 34
chr18_+_12947981 58.00 ENST00000262124.11
SEH1-like (S. cerevisiae)
chr18_-_54305658 57.56 ENST00000586262.1
ENST00000217515.6
thioredoxin-like 1
chr3_-_48647470 57.40 ENST00000203407.5
ubiquinol-cytochrome c reductase core protein I
chr10_-_71993176 57.34 ENST00000373232.3
pyrophosphatase (inorganic) 1
chr8_-_109260897 57.09 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
eukaryotic translation initiation factor 3, subunit E
chr6_-_31774714 56.76 ENST00000375661.5
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_+_117350009 56.68 ENST00000374050.3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr11_+_108535752 56.59 ENST00000322536.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr7_-_102119342 56.34 ENST00000393794.3
ENST00000292614.5
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr11_+_18417813 56.12 ENST00000540430.1
ENST00000379412.5
lactate dehydrogenase A
chr17_-_47492164 56.08 ENST00000512041.2
ENST00000446735.1
ENST00000504124.1
prohibitin
chr1_+_41445413 56.00 ENST00000541520.1
CTP synthase 1
chr19_-_40336969 55.85 ENST00000599134.1
ENST00000597634.1
ENST00000598417.1
ENST00000601274.1
ENST00000594309.1
ENST00000221801.3
fibrillarin
chr1_-_246670519 55.77 ENST00000388985.4
ENST00000490107.1
SET and MYND domain containing 3
chr1_-_8939265 55.34 ENST00000489867.1
enolase 1, (alpha)
chr22_+_32340481 55.29 ENST00000397492.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr6_-_35888905 55.18 ENST00000510290.1
ENST00000423325.2
ENST00000373822.1
SRSF protein kinase 1
chr22_+_32340447 54.88 ENST00000248975.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr12_+_48357340 54.64 ENST00000256686.6
ENST00000549288.1
ENST00000552561.1
ENST00000546749.1
ENST00000552546.1
ENST00000550552.1
transmembrane protein 106C
chr12_+_109535373 53.88 ENST00000242576.2
uracil-DNA glycosylase
chr20_-_5107180 53.68 ENST00000379160.3
proliferating cell nuclear antigen
chrX_-_16888448 53.67 ENST00000468092.1
ENST00000404022.1
ENST00000380087.2
retinoblastoma binding protein 7
chr4_-_103790026 53.64 ENST00000338145.3
ENST00000357194.6
ubiquitin-conjugating enzyme E2D 3
chr21_-_46293586 52.80 ENST00000445724.2
ENST00000397887.3
pituitary tumor-transforming 1 interacting protein
chr19_+_36630855 52.65 ENST00000589146.1
calpain, small subunit 1
chr20_-_48729670 52.64 ENST00000371657.5
ubiquitin-conjugating enzyme E2 variant 1
chr12_+_48357401 52.37 ENST00000429772.2
ENST00000449758.2
transmembrane protein 106C
chr17_+_3572087 52.19 ENST00000248378.5
ENST00000397133.2
ER membrane protein complex subunit 6
chr11_-_6704513 52.19 ENST00000532203.1
ENST00000288937.6
mitochondrial ribosomal protein L17
chr12_+_57623477 51.97 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_+_572543 51.67 ENST00000333511.3
ENST00000573216.1
ENST00000353555.4
basigin (Ok blood group)
chr21_-_46293644 51.63 ENST00000330938.3
pituitary tumor-transforming 1 interacting protein
chr19_+_59055814 51.32 ENST00000594806.1
ENST00000253024.5
ENST00000341753.6
tripartite motif containing 28
chr19_-_1095330 50.83 ENST00000586746.1
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr19_+_11071546 50.67 ENST00000358026.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr20_+_62887081 50.08 ENST00000369758.4
ENST00000299468.7
ENST00000609372.1
ENST00000610196.1
ENST00000308824.6
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr14_-_102553371 50.07 ENST00000553585.1
ENST00000216281.8
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr17_-_4852243 50.05 ENST00000225655.5
profilin 1
chr15_+_78833071 50.03 ENST00000559365.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr6_+_24775153 49.89 ENST00000356509.3
ENST00000230056.3
geminin, DNA replication inhibitor
chr10_-_74856608 49.86 ENST00000307116.2
ENST00000373008.2
ENST00000412021.2
ENST00000394890.2
ENST00000263556.3
ENST00000440381.1
prolyl 4-hydroxylase, alpha polypeptide I
chr11_+_60681346 49.82 ENST00000227525.3
transmembrane protein 109
chr19_+_11071652 49.71 ENST00000344626.4
ENST00000429416.3
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr13_+_76123883 49.67 ENST00000377595.3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr12_+_108079664 49.25 ENST00000541166.1
PWP1 homolog (S. cerevisiae)
chr10_+_60028818 49.25 ENST00000333926.5
CDGSH iron sulfur domain 1
chr16_-_88878305 48.94 ENST00000569616.1
ENST00000563655.1
ENST00000567713.1
ENST00000426324.2
ENST00000378364.3
adenine phosphoribosyltransferase
chr5_-_96518907 48.84 ENST00000508447.1
ENST00000283109.3
RIO kinase 2
chr6_+_52535878 48.70 ENST00000211314.4
transmembrane protein 14A
chr15_+_79603404 48.70 ENST00000299705.5
transmembrane emp24 protein transport domain containing 3
chr6_+_24667257 48.70 ENST00000537591.1
ENST00000230048.4
acyl-CoA thioesterase 13
chrX_+_70503037 48.63 ENST00000535149.1
non-POU domain containing, octamer-binding
chr11_-_77850629 48.61 ENST00000376156.3
ENST00000525870.1
ENST00000530454.1
ENST00000525755.1
ENST00000527099.1
ENST00000525761.1
ENST00000299626.5
ALG8, alpha-1,3-glucosyltransferase
chr11_+_114310102 48.31 ENST00000265881.5
RNA exonuclease 2
chr7_+_116502605 47.51 ENST00000458284.2
ENST00000490693.1
capping protein (actin filament) muscle Z-line, alpha 2
chr12_-_31479045 47.40 ENST00000539409.1
ENST00000395766.1
family with sequence similarity 60, member A
chr2_+_86333301 47.34 ENST00000254630.7
pentatricopeptide repeat domain 3
chr10_-_88281494 47.28 ENST00000298767.5
wings apart-like homolog (Drosophila)
chr20_+_39657454 47.08 ENST00000361337.2
topoisomerase (DNA) I
chr8_+_145137489 47.05 ENST00000355091.4
ENST00000525087.1
ENST00000361036.6
ENST00000524418.1
glycosylphosphatidylinositol anchor attachment 1
chr18_-_12884259 46.99 ENST00000353319.4
ENST00000327283.3
protein tyrosine phosphatase, non-receptor type 2
chr1_+_16174280 46.97 ENST00000375759.3
spen family transcriptional repressor
chr20_+_61427797 46.93 ENST00000370487.3
MRG/MORF4L binding protein
chr5_+_68462837 46.71 ENST00000256442.5
cyclin B1
chr2_-_106810783 46.23 ENST00000283148.7
UDP-glucuronate decarboxylase 1
chr2_-_86790593 45.92 ENST00000263856.4
ENST00000409225.2
charged multivesicular body protein 3
chr20_+_35234137 45.88 ENST00000344795.3
ENST00000373852.5
chromosome 20 open reading frame 24
chr15_+_78833105 45.60 ENST00000558341.1
ENST00000559437.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr11_+_114310164 45.47 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
RNA exonuclease 2
chr3_+_160117087 45.43 ENST00000357388.3
structural maintenance of chromosomes 4
chr11_-_76091986 45.23 ENST00000260045.3
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr2_-_150444300 44.83 ENST00000303319.5
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr19_+_984313 44.79 ENST00000251289.5
ENST00000587001.2
ENST00000607440.1
WD repeat domain 18
chr1_+_212208919 44.66 ENST00000366991.4
ENST00000542077.1
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr5_+_154320623 44.62 ENST00000523037.1
ENST00000265229.8
ENST00000439747.3
ENST00000522038.1
mitochondrial ribosomal protein L22
chr20_+_55926274 44.50 ENST00000371242.2
ENST00000527947.1
ribonucleic acid export 1
chr10_-_103578182 44.31 ENST00000439817.1
meningioma expressed antigen 5 (hyaluronidase)
chr19_-_55770311 44.05 ENST00000412770.2
protein phosphatase 6, regulatory subunit 1
chr6_-_24667232 44.04 ENST00000378198.4
tyrosyl-DNA phosphodiesterase 2
chr1_+_91966384 44.04 ENST00000430031.2
ENST00000234626.6
cell division cycle 7
chr2_-_38978492 43.87 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
serine/arginine-rich splicing factor 7
chr6_+_32936353 43.72 ENST00000374825.4
bromodomain containing 2
chr6_+_24403144 43.63 ENST00000274747.7
ENST00000543597.1
ENST00000535061.1
ENST00000378353.1
ENST00000378386.3
ENST00000443868.2
MRS2 magnesium transporter
chr11_+_114310237 43.62 ENST00000539119.1
RNA exonuclease 2
chr7_+_116502527 43.59 ENST00000361183.3
capping protein (actin filament) muscle Z-line, alpha 2
chr20_+_35234223 43.53 ENST00000342422.3
chromosome 20 open reading frame 24
chr6_-_35888824 43.44 ENST00000361690.3
ENST00000512445.1
SRSF protein kinase 1
chr19_-_36606181 43.36 ENST00000221859.4
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr15_+_78832747 43.22 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr1_+_91966656 43.20 ENST00000428239.1
ENST00000426137.1
cell division cycle 7
chr20_-_32700075 43.10 ENST00000374980.2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr16_-_75681522 43.01 ENST00000568378.1
ENST00000568682.1
ENST00000570215.1
ENST00000319410.5
ENST00000302445.3
lysyl-tRNA synthetase
chr5_+_33441053 42.94 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
threonyl-tRNA synthetase
chr3_+_37035263 42.65 ENST00000458205.2
ENST00000539477.1
mutL homolog 1
chr19_-_59066327 42.51 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
charged multivesicular body protein 2A
chr1_-_19536744 42.39 ENST00000375267.2
ENST00000375217.2
ENST00000375226.2
ENST00000375254.3
ubiquitin protein ligase E3 component n-recognin 4
chrX_+_51636629 42.28 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
melanoma antigen family D, 1
chr6_-_24667180 42.23 ENST00000545995.1
tyrosyl-DNA phosphodiesterase 2
chr5_+_68462944 42.03 ENST00000506572.1
cyclin B1
chr10_+_62538089 41.95 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
cyclin-dependent kinase 1
chr1_+_100731749 41.89 ENST00000370128.4
ENST00000260563.4
RNA 3'-terminal phosphate cyclase
chr14_+_75230011 41.89 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLP motif containing 1
chr3_+_52232102 41.85 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
aminolevulinate, delta-, synthase 1
chr18_+_12948000 41.82 ENST00000585730.1
ENST00000399892.2
ENST00000589446.1
ENST00000587761.1
SEH1-like (S. cerevisiae)
chr4_+_39699664 41.74 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
ubiquitin-conjugating enzyme E2K
chr20_+_11871371 41.74 ENST00000254977.3
BTB (POZ) domain containing 3
chr3_-_107809816 41.65 ENST00000361309.5
ENST00000355354.7
CD47 molecule
chr17_+_73201754 41.64 ENST00000583569.1
ENST00000245544.4
ENST00000579324.1
ENST00000541827.1
ENST00000579298.1
ENST00000447371.2
nucleoporin 85kDa
chr19_-_14530143 41.51 ENST00000242776.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr3_+_160117418 41.50 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
structural maintenance of chromosomes 4
chr1_-_109968973 41.41 ENST00000271308.4
ENST00000538610.1
proteasome (prosome, macropain) subunit, alpha type, 5
chr14_-_104387888 41.29 ENST00000286953.3
chromosome 14 open reading frame 2
chr20_+_55926583 41.25 ENST00000395840.2
ribonucleic acid export 1
chr6_-_41040268 40.91 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
O-acyl-ADP-ribose deacylase 1
chr17_-_46178527 40.78 ENST00000393408.3
chromobox homolog 1
chr10_-_103578162 40.63 ENST00000361464.3
ENST00000357797.5
ENST00000370094.3
meningioma expressed antigen 5 (hyaluronidase)

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
77.2 231.5 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
44.1 176.5 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
42.7 128.2 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
38.8 193.9 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
36.2 144.6 GO:0043335 protein unfolding(GO:0043335)
35.5 106.6 GO:1904430 negative regulation of t-circle formation(GO:1904430)
33.4 100.2 GO:0045950 meiotic metaphase I plate congression(GO:0043060) negative regulation of mitotic recombination(GO:0045950) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
31.0 154.8 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
30.9 92.7 GO:1903722 regulation of centriole elongation(GO:1903722)
29.7 207.7 GO:1903333 negative regulation of protein folding(GO:1903333)
29.5 88.4 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
29.3 176.0 GO:0015853 adenine transport(GO:0015853)
28.4 227.0 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
28.2 84.5 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
28.2 112.6 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
26.7 80.2 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
26.3 131.3 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
24.9 74.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
24.2 145.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
24.0 72.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
22.4 67.2 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
22.0 88.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
22.0 87.9 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
21.8 65.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
21.5 64.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
21.2 63.5 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
20.4 265.3 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
19.4 96.8 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
19.1 57.3 GO:0071344 diphosphate metabolic process(GO:0071344)
19.0 57.0 GO:0002188 translation reinitiation(GO:0002188)
18.9 18.9 GO:1903895 negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
18.7 56.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
18.6 241.2 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
18.4 55.3 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
18.1 144.7 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
18.1 54.2 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
17.8 35.7 GO:0046098 guanine metabolic process(GO:0046098)
17.7 88.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
17.5 52.6 GO:1902661 positive regulation of glucose mediated signaling pathway(GO:1902661)
17.2 120.5 GO:1904044 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
17.0 68.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
16.9 67.6 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
16.3 114.4 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
16.3 146.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
16.1 80.4 GO:1902410 mitotic cytokinetic process(GO:1902410)
15.7 31.4 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
15.3 92.0 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
14.8 44.5 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
14.7 117.4 GO:0002176 male germ cell proliferation(GO:0002176) germ cell proliferation(GO:0036093)
14.6 87.6 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
14.5 87.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
14.4 43.2 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
14.2 85.4 GO:0071035 nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046)
14.1 42.3 GO:0031126 snoRNA 3'-end processing(GO:0031126)
14.0 14.0 GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144)
13.9 55.7 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
13.8 41.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
13.7 137.2 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
13.6 81.5 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
13.5 53.9 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
13.4 26.8 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
13.4 40.1 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) positive regulation of telomeric DNA binding(GO:1904744)
13.3 266.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
13.3 26.6 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
13.2 105.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
13.2 39.5 GO:0071789 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
13.2 13.2 GO:0030047 actin modification(GO:0030047)
13.1 39.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
13.1 52.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
13.1 39.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
13.1 39.2 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
12.9 38.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
12.9 38.7 GO:1903970 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
12.9 64.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
12.9 77.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
12.8 12.8 GO:1902822 regulation of late endosome to lysosome transport(GO:1902822)
12.3 160.4 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
12.3 61.5 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
12.2 85.7 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
12.2 36.5 GO:0002276 basophil activation involved in immune response(GO:0002276)
12.0 47.8 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
11.9 35.6 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
11.8 35.3 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
11.7 668.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
11.5 114.8 GO:0035092 sperm chromatin condensation(GO:0035092)
11.4 113.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
11.4 56.9 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
11.3 22.6 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
11.1 133.4 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
11.1 77.8 GO:0007008 outer mitochondrial membrane organization(GO:0007008)
11.1 66.4 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
10.9 349.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
10.8 32.5 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
10.7 74.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
10.6 31.9 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
10.6 31.8 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
10.6 74.1 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
10.6 31.7 GO:0036071 N-glycan fucosylation(GO:0036071)
10.3 41.2 GO:0046502 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
10.3 133.7 GO:0000212 meiotic spindle organization(GO:0000212)
10.2 82.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
10.2 173.9 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
10.1 302.7 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
10.1 30.2 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
10.0 30.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
10.0 30.0 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
9.9 98.9 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
9.8 48.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
9.7 19.4 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
9.7 58.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
9.7 38.8 GO:0016259 selenocysteine metabolic process(GO:0016259) negative regulation of vascular endothelial growth factor production(GO:1904046)
9.6 57.7 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
9.6 96.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
9.6 95.9 GO:0051096 positive regulation of helicase activity(GO:0051096)
9.4 28.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
9.4 9.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
9.3 18.5 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
9.2 27.5 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
9.1 27.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
9.1 36.5 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
9.1 45.4 GO:0042780 tRNA 3'-end processing(GO:0042780)
9.0 63.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
8.9 35.6 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
8.9 70.9 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
8.8 35.3 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
8.5 34.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
8.5 42.4 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
8.4 42.2 GO:0061198 fungiform papilla formation(GO:0061198)
8.3 83.2 GO:0021769 orbitofrontal cortex development(GO:0021769)
8.3 49.7 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
8.3 8.3 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
8.3 157.1 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
8.2 16.4 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
8.1 24.3 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
8.1 518.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
8.1 16.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
8.1 24.2 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
8.0 56.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
8.0 95.9 GO:0006089 lactate metabolic process(GO:0006089)
7.8 38.9 GO:0090241 negative regulation of histone H4 acetylation(GO:0090241)
7.7 84.9 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
7.7 123.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
7.7 38.4 GO:0090646 mitochondrial tRNA processing(GO:0090646)
7.7 161.3 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
7.7 23.0 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
7.7 30.7 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
7.5 15.0 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
7.4 29.5 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
7.2 101.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
7.1 42.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
7.0 13.9 GO:0035617 stress granule disassembly(GO:0035617)
6.9 34.6 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
6.8 47.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
6.8 47.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
6.7 66.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
6.4 32.0 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
6.4 31.9 GO:0051661 maintenance of centrosome location(GO:0051661)
6.3 37.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
6.3 25.2 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
6.3 18.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
6.3 68.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
6.2 112.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
6.2 18.6 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
6.1 18.2 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
6.0 42.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
6.0 23.9 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
6.0 29.8 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
5.9 5.9 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
5.9 41.4 GO:0022417 protein maturation by protein folding(GO:0022417)
5.9 23.6 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
5.9 35.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
5.8 29.2 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
5.8 241.8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
5.7 136.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
5.6 22.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
5.6 72.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
5.5 83.1 GO:0090168 Golgi reassembly(GO:0090168)
5.5 38.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
5.5 22.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
5.5 27.4 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
5.5 11.0 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
5.5 21.9 GO:1901895 positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
5.4 21.8 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
5.4 27.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
5.4 10.8 GO:0097327 response to antineoplastic agent(GO:0097327)
5.4 27.0 GO:1902904 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
5.4 145.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
5.4 53.9 GO:0045008 depyrimidination(GO:0045008)
5.3 26.7 GO:1902896 terminal web assembly(GO:1902896)
5.3 16.0 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
5.3 63.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
5.2 31.4 GO:2000773 negative regulation of cellular senescence(GO:2000773)
5.1 20.6 GO:0071373 cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373)
5.1 30.7 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
5.1 25.6 GO:0016926 protein desumoylation(GO:0016926)
5.1 35.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
5.1 121.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
5.1 177.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
5.0 5.0 GO:0048372 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
5.0 25.1 GO:0032790 ribosome disassembly(GO:0032790)
5.0 40.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
5.0 40.0 GO:0015846 polyamine transport(GO:0015846)
5.0 24.9 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
5.0 29.9 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
5.0 10.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
5.0 29.8 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
4.9 14.8 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
4.9 63.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
4.9 363.0 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
4.9 39.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
4.9 24.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
4.9 19.4 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
4.8 52.7 GO:0045116 protein neddylation(GO:0045116)
4.8 23.8 GO:0060356 leucine import(GO:0060356)
4.7 132.6 GO:0043968 histone H2A acetylation(GO:0043968)
4.7 23.6 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
4.6 111.3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
4.6 13.9 GO:0045896 regulation of transcription during mitosis(GO:0045896)
4.6 509.1 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
4.5 49.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
4.5 75.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
4.4 8.9 GO:0000012 single strand break repair(GO:0000012)
4.4 44.1 GO:0046689 response to mercury ion(GO:0046689)
4.4 8.8 GO:0042256 mature ribosome assembly(GO:0042256)
4.4 148.7 GO:0090383 phagosome acidification(GO:0090383)
4.3 30.3 GO:0070294 renal sodium ion absorption(GO:0070294)
4.3 12.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
4.3 12.9 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
4.3 17.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
4.2 50.6 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
4.2 41.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
4.2 108.7 GO:0006825 copper ion transport(GO:0006825)
4.2 54.2 GO:0040016 embryonic cleavage(GO:0040016)
4.2 12.5 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
4.1 12.4 GO:0003383 apical constriction(GO:0003383)
4.1 4.1 GO:1905216 positive regulation of RNA binding(GO:1905216)
4.1 49.2 GO:0043457 regulation of cellular respiration(GO:0043457)
4.0 52.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
3.9 15.7 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
3.9 27.4 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
3.9 346.8 GO:0090114 COPII-coated vesicle budding(GO:0090114)
3.9 81.8 GO:0033120 positive regulation of RNA splicing(GO:0033120)
3.9 19.4 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
3.8 11.4 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
3.8 67.6 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
3.7 82.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
3.7 22.0 GO:0035562 negative regulation of chromatin binding(GO:0035562)
3.6 91.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
3.6 43.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
3.6 90.2 GO:0009235 cobalamin metabolic process(GO:0009235)
3.6 10.8 GO:2000395 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
3.5 24.8 GO:0042407 cristae formation(GO:0042407)
3.5 14.1 GO:0072719 cellular response to cisplatin(GO:0072719)
3.5 7.0 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
3.5 10.5 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
3.4 6.8 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
3.4 10.3 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
3.4 85.2 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
3.4 43.9 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
3.4 46.9 GO:0040008 regulation of growth(GO:0040008)
3.3 30.0 GO:0030091 protein repair(GO:0030091)
3.3 29.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.3 6.6 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
3.3 22.9 GO:0031017 exocrine pancreas development(GO:0031017)
3.3 9.8 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
3.2 130.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
3.2 85.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
3.2 82.0 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
3.1 18.9 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
3.1 71.3 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
3.1 24.8 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
3.1 12.3 GO:0080009 mRNA methylation(GO:0080009)
3.0 154.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
3.0 101.7 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
3.0 12.0 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
3.0 23.8 GO:0035518 histone H2A monoubiquitination(GO:0035518)
2.9 2.9 GO:0090385 phagosome-lysosome fusion(GO:0090385)
2.9 5.8 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
2.9 14.5 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
2.9 49.0 GO:0035855 megakaryocyte development(GO:0035855)
2.9 28.8 GO:0009414 response to water deprivation(GO:0009414)
2.9 25.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
2.9 23.0 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
2.8 34.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
2.8 22.5 GO:0030263 apoptotic chromosome condensation(GO:0030263)
2.8 25.2 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
2.8 72.6 GO:0006270 DNA replication initiation(GO:0006270)
2.8 22.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
2.8 8.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
2.7 30.2 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
2.7 8.2 GO:1901143 insulin catabolic process(GO:1901143)
2.7 27.1 GO:0030638 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
2.7 13.5 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
2.7 29.5 GO:0006105 succinate metabolic process(GO:0006105)
2.7 10.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
2.6 7.9 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
2.6 10.5 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
2.6 23.6 GO:0018344 protein geranylgeranylation(GO:0018344)
2.6 41.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
2.6 10.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.6 10.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
2.5 15.2 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.5 27.7 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
2.5 32.3 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
2.4 7.3 GO:0071109 superior temporal gyrus development(GO:0071109)
2.4 9.8 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
2.4 14.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
2.4 14.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
2.4 7.2 GO:1904526 regulation of microtubule binding(GO:1904526)
2.4 11.9 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
2.4 23.7 GO:0051382 kinetochore assembly(GO:0051382)
2.4 16.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
2.4 4.7 GO:0036034 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
2.3 27.8 GO:0035067 negative regulation of histone acetylation(GO:0035067)
2.3 20.8 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
2.3 6.9 GO:0060295 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
2.3 20.7 GO:0042373 vitamin K metabolic process(GO:0042373)
2.3 20.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
2.3 25.0 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
2.2 98.7 GO:0006414 translational elongation(GO:0006414)
2.2 15.6 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
2.2 17.7 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
2.2 81.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
2.2 6.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
2.2 15.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
2.2 19.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
2.2 41.7 GO:0008228 opsonization(GO:0008228)
2.2 6.6 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
2.2 15.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
2.1 36.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
2.1 8.5 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
2.1 12.6 GO:1903800 regulation of Golgi inheritance(GO:0090170) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
2.1 16.7 GO:0015693 magnesium ion transport(GO:0015693)
2.1 24.9 GO:0006379 mRNA cleavage(GO:0006379)
2.1 12.4 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
2.0 14.3 GO:0071763 nuclear membrane organization(GO:0071763)
2.0 236.6 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
2.0 170.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
2.0 32.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.0 4.0 GO:0061511 centriole elongation(GO:0061511)
2.0 9.9 GO:0035372 protein localization to microtubule(GO:0035372)
2.0 7.9 GO:0051683 establishment of Golgi localization(GO:0051683)
2.0 7.9 GO:0008063 Toll signaling pathway(GO:0008063)
2.0 15.8 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
2.0 35.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.9 17.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
1.9 5.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
1.9 11.5 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.9 26.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
1.9 7.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.9 17.0 GO:0038007 netrin-activated signaling pathway(GO:0038007)
1.9 80.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
1.9 63.4 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
1.8 14.8 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
1.8 14.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
1.8 7.2 GO:0000103 sulfate assimilation(GO:0000103)
1.8 35.7 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
1.8 7.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
1.8 7.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.7 22.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.7 10.5 GO:0006537 glutamate biosynthetic process(GO:0006537)
1.7 10.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.7 34.3 GO:0051290 protein heterotetramerization(GO:0051290)
1.7 43.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
1.7 16.7 GO:2000772 regulation of cellular senescence(GO:2000772)
1.7 6.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
1.7 24.9 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
1.7 16.6 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.6 54.3 GO:0048246 macrophage chemotaxis(GO:0048246)
1.6 11.2 GO:0090382 phagosome maturation(GO:0090382)
1.6 42.3 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
1.5 71.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
1.5 3.0 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
1.5 25.7 GO:0006378 mRNA polyadenylation(GO:0006378)
1.5 24.0 GO:0097284 hepatocyte apoptotic process(GO:0097284)
1.5 10.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.4 18.7 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
1.4 15.8 GO:0006924 activation-induced cell death of T cells(GO:0006924)
1.4 8.5 GO:0007296 vitellogenesis(GO:0007296)
1.4 9.9 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
1.4 59.8 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
1.3 4.0 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.3 12.9 GO:0043651 linoleic acid metabolic process(GO:0043651)
1.3 11.6 GO:0046477 glycosylceramide catabolic process(GO:0046477)
1.3 11.5 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
1.3 13.9 GO:0043086 negative regulation of catalytic activity(GO:0043086)
1.3 35.3 GO:0050435 beta-amyloid metabolic process(GO:0050435)
1.3 15.1 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
1.2 18.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
1.2 48.2 GO:2000142 regulation of DNA-templated transcription, initiation(GO:2000142)
1.2 7.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.2 6.0 GO:1990834 response to odorant(GO:1990834)
1.2 7.2 GO:0010506 regulation of autophagy(GO:0010506)
1.2 1.2 GO:0031929 TOR signaling(GO:0031929) regulation of TOR signaling(GO:0032006)
1.2 36.6 GO:0007019 microtubule depolymerization(GO:0007019)
1.2 88.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.2 15.1 GO:0042113 B cell activation(GO:0042113)
1.1 13.8 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 3.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.1 75.6 GO:0032418 lysosome localization(GO:0032418)
1.1 15.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.1 79.9 GO:0070527 platelet aggregation(GO:0070527)
1.1 5.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
1.1 10.9 GO:0030261 chromosome condensation(GO:0030261)
1.1 3.3 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
1.1 46.5 GO:0007062 sister chromatid cohesion(GO:0007062)
1.1 8.6 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
1.1 15.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.1 8.6 GO:0032482 Rab protein signal transduction(GO:0032482)
1.1 58.7 GO:0032465 regulation of cytokinesis(GO:0032465)
1.1 6.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.1 117.2 GO:0070268 cornification(GO:0070268)
1.1 29.6 GO:0036297 interstrand cross-link repair(GO:0036297)
1.0 114.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 17.7 GO:0030488 tRNA methylation(GO:0030488)
1.0 20.8 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.0 19.6 GO:0051893 regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) regulation of adherens junction organization(GO:1903391)
1.0 8.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.0 10.2 GO:0070828 heterochromatin organization(GO:0070828)
1.0 6.1 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
1.0 56.5 GO:0045454 cell redox homeostasis(GO:0045454)
1.0 10.1 GO:0009650 UV protection(GO:0009650)
1.0 5.0 GO:2000035 regulation of stem cell division(GO:2000035)
1.0 18.9 GO:0031648 protein destabilization(GO:0031648)
1.0 4.9 GO:0075525 viral translational termination-reinitiation(GO:0075525)
1.0 11.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
1.0 10.5 GO:0035561 regulation of chromatin binding(GO:0035561)
1.0 8.6 GO:0031053 primary miRNA processing(GO:0031053)
1.0 15.2 GO:0017145 stem cell division(GO:0017145)
0.9 2.8 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.9 99.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.9 11.2 GO:0030252 growth hormone secretion(GO:0030252)
0.9 10.2 GO:0006903 vesicle targeting(GO:0006903)
0.9 31.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.9 7.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.9 49.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.9 34.1 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.9 7.7 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.8 26.1 GO:0008033 tRNA processing(GO:0008033)
0.8 12.6 GO:0008105 asymmetric protein localization(GO:0008105)
0.8 12.2 GO:0000338 protein deneddylation(GO:0000338)
0.8 5.6 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.8 2.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.8 3.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.8 3.2 GO:0051138 regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.8 5.5 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.8 7.7 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.8 3.8 GO:0003070 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.7 8.2 GO:0030335 positive regulation of cell migration(GO:0030335)
0.7 10.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.7 8.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 4.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.7 16.6 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.7 1.4 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.7 2.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.7 9.3 GO:0044804 nucleophagy(GO:0044804)
0.7 4.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.7 21.0 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.7 10.5 GO:0032508 DNA duplex unwinding(GO:0032508)
0.7 2.6 GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.7 38.5 GO:0006364 rRNA processing(GO:0006364) rRNA metabolic process(GO:0016072)
0.7 1.3 GO:1903061 positive regulation of lipoprotein metabolic process(GO:0050747) regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061)
0.6 4.4 GO:0019068 virion assembly(GO:0019068)
0.6 5.6 GO:0097264 self proteolysis(GO:0097264)
0.6 2.5 GO:0003409 optic cup structural organization(GO:0003409)
0.6 11.3 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
0.6 2.4 GO:0061635 regulation of protein complex stability(GO:0061635)
0.6 4.1 GO:0001701 in utero embryonic development(GO:0001701)
0.6 16.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.6 6.4 GO:0001649 osteoblast differentiation(GO:0001649)
0.6 4.6 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.6 93.6 GO:0006457 protein folding(GO:0006457)
0.6 18.8 GO:0050819 negative regulation of coagulation(GO:0050819)
0.5 3.8 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.5 0.5 GO:0007135 meiosis II(GO:0007135) meiotic sister chromatid segregation(GO:0045144)
0.5 9.5 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.5 1.0 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.5 21.0 GO:0035722 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.4 4.4 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.4 10.4 GO:0097120 receptor localization to synapse(GO:0097120)
0.4 18.5 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.4 3.4 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.4 44.6 GO:0008213 protein methylation(GO:0006479) protein alkylation(GO:0008213)
0.4 2.5 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.4 7.5 GO:1901796 regulation of signal transduction by p53 class mediator(GO:1901796)
0.4 5.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.4 11.4 GO:0006342 chromatin silencing(GO:0006342)
0.4 4.9 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.4 3.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.4 23.1 GO:0031100 organ regeneration(GO:0031100)
0.4 1.1 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.4 2.5 GO:0008218 bioluminescence(GO:0008218)
0.4 18.6 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.3 2.4 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.3 5.4 GO:0032060 bleb assembly(GO:0032060)
0.3 34.2 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.3 0.6 GO:1903214 regulation of protein targeting to mitochondrion(GO:1903214)
0.3 4.9 GO:0016579 protein deubiquitination(GO:0016579)
0.3 0.9 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.3 5.4 GO:0001960 negative regulation of cytokine-mediated signaling pathway(GO:0001960)
0.3 1.2 GO:0038203 TORC2 signaling(GO:0038203)
0.3 0.3 GO:0098917 retrograde trans-synaptic signaling(GO:0098917)
0.3 9.8 GO:0007031 peroxisome organization(GO:0007031)
0.3 2.9 GO:0098877 neurotransmitter receptor transport to plasma membrane(GO:0098877)
0.2 7.9 GO:0016575 histone deacetylation(GO:0016575)
0.2 0.7 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.2 1.0 GO:0002021 response to dietary excess(GO:0002021)
0.2 2.8 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.2 1.1 GO:1903844 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.2 2.9 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.2 2.2 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 11.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.2 9.9 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.2 7.4 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.2 1.2 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.2 3.3 GO:0031397 negative regulation of protein ubiquitination(GO:0031397)
0.2 7.9 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.2 0.9 GO:0042118 endothelial cell activation(GO:0042118)
0.2 0.5 GO:0015791 polyol transport(GO:0015791)
0.2 4.8 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway(GO:2001243)
0.2 6.9 GO:0051492 regulation of stress fiber assembly(GO:0051492)
0.2 3.7 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.2 2.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.2 20.9 GO:0030336 negative regulation of cell migration(GO:0030336)
0.2 2.4 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 14.0 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.1 0.1 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223)
0.1 0.3 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 0.5 GO:0097384 cellular lipid biosynthetic process(GO:0097384)
0.1 6.2 GO:0007224 smoothened signaling pathway(GO:0007224)
0.1 1.4 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.1 2.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 3.5 GO:0055007 cardiac muscle cell differentiation(GO:0055007)
0.1 0.8 GO:0048636 positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863)
0.0 1.1 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 3.4 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 1.5 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.4 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.3 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.0 0.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 0.9 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.2 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.7 GO:0050729 positive regulation of inflammatory response(GO:0050729)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
41.0 205.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
39.6 277.2 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
33.6 168.1 GO:0043564 Ku70:Ku80 complex(GO:0043564)
33.6 403.5 GO:0005642 annulate lamellae(GO:0005642)
33.4 100.2 GO:0005715 late recombination nodule(GO:0005715)
32.7 130.8 GO:0000798 nuclear cohesin complex(GO:0000798)
28.3 141.3 GO:0032021 NELF complex(GO:0032021)
27.4 273.6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
26.2 78.6 GO:0033597 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
26.1 104.2 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
25.4 177.9 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
25.0 74.9 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
24.6 98.3 GO:0031510 SUMO activating enzyme complex(GO:0031510)
24.0 120.0 GO:0035370 UBC13-UEV1A complex(GO:0035370)
23.3 279.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
21.7 65.2 GO:0031428 box C/D snoRNP complex(GO:0031428)
20.6 618.2 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
20.4 265.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
19.9 159.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
19.8 98.8 GO:0001940 male pronucleus(GO:0001940)
19.5 97.3 GO:0000408 EKC/KEOPS complex(GO:0000408)
17.9 53.7 GO:0070557 PCNA-p21 complex(GO:0070557)
17.8 53.5 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
17.4 52.2 GO:1903349 omegasome membrane(GO:1903349)
17.3 138.6 GO:0042382 paraspeckles(GO:0042382)
16.4 49.3 GO:0032302 MutSbeta complex(GO:0032302)
16.0 111.8 GO:0000172 ribonuclease MRP complex(GO:0000172)
15.8 79.0 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
15.7 283.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
15.7 47.1 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
15.7 47.0 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
15.2 121.8 GO:0031931 TORC1 complex(GO:0031931)
15.0 60.2 GO:0001405 presequence translocase-associated import motor(GO:0001405)
14.9 238.2 GO:0031080 nuclear pore outer ring(GO:0031080)
14.4 143.7 GO:0000796 condensin complex(GO:0000796)
14.3 114.4 GO:0070552 BRISC complex(GO:0070552)
14.3 128.7 GO:0005827 polar microtubule(GO:0005827)
14.0 83.9 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
13.5 94.7 GO:0031415 NatA complex(GO:0031415)
13.4 174.5 GO:0000815 ESCRT III complex(GO:0000815)
13.2 39.5 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
11.5 46.1 GO:0031417 NatC complex(GO:0031417)
11.4 125.7 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
11.2 145.3 GO:0000243 commitment complex(GO:0000243)
11.1 121.9 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
10.8 182.8 GO:0031616 spindle pole centrosome(GO:0031616)
10.7 53.5 GO:0097422 tubular endosome(GO:0097422)
10.6 31.9 GO:0043159 acrosomal matrix(GO:0043159)
10.2 112.4 GO:0070765 gamma-secretase complex(GO:0070765)
10.1 30.2 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
10.0 70.3 GO:0046581 intercellular canaliculus(GO:0046581)
9.9 29.8 GO:0043291 RAVE complex(GO:0043291)
9.9 256.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
9.6 105.4 GO:0044666 MLL3/4 complex(GO:0044666)
9.5 113.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
9.4 93.9 GO:0030015 CCR4-NOT core complex(GO:0030015)
9.3 46.3 GO:1990425 ryanodine receptor complex(GO:1990425)
9.2 55.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
9.1 27.4 GO:0019008 molybdopterin synthase complex(GO:0019008)
9.1 91.1 GO:0008290 F-actin capping protein complex(GO:0008290)
8.9 212.6 GO:0046930 pore complex(GO:0046930)
8.8 212.3 GO:0071564 npBAF complex(GO:0071564)
8.7 103.8 GO:0097431 mitotic spindle pole(GO:0097431)
8.5 42.4 GO:0005663 DNA replication factor C complex(GO:0005663)
8.5 237.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
8.3 83.3 GO:0097255 R2TP complex(GO:0097255)
8.3 24.9 GO:0071595 Nem1-Spo7 phosphatase complex(GO:0071595)
8.2 229.3 GO:0031143 pseudopodium(GO:0031143)
8.2 89.9 GO:0032797 SMN complex(GO:0032797)
8.1 533.9 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
8.1 64.6 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
8.0 217.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
8.0 24.1 GO:0032133 chromosome passenger complex(GO:0032133)
7.9 79.4 GO:0030126 COPI vesicle coat(GO:0030126)
7.9 55.0 GO:0070531 BRCA1-A complex(GO:0070531)
7.8 39.2 GO:0097149 centralspindlin complex(GO:0097149)
7.8 46.7 GO:0005688 U6 snRNP(GO:0005688)
7.7 38.4 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
7.5 37.6 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
7.4 29.5 GO:0005726 perichromatin fibrils(GO:0005726)
7.3 36.6 GO:0035061 interchromatin granule(GO:0035061)
7.2 43.2 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
7.1 35.3 GO:0042643 actomyosin, actin portion(GO:0042643)
7.0 35.2 GO:0031594 neuromuscular junction(GO:0031594)
6.8 54.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
6.7 33.3 GO:0009368 endopeptidase Clp complex(GO:0009368)
6.6 125.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
6.6 65.8 GO:0090543 Flemming body(GO:0090543)
6.4 44.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
6.4 76.5 GO:0031595 nuclear proteasome complex(GO:0031595)
6.3 157.5 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
6.3 18.8 GO:0072563 endothelial microparticle(GO:0072563)
6.2 18.5 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
6.2 61.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
6.1 245.6 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
6.1 85.4 GO:0097227 sperm annulus(GO:0097227)
6.0 90.0 GO:0005869 dynactin complex(GO:0005869)
5.9 17.7 GO:0033565 ESCRT-0 complex(GO:0033565)
5.9 23.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
5.9 310.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
5.7 28.6 GO:0034715 pICln-Sm protein complex(GO:0034715)
5.7 68.1 GO:0000346 transcription export complex(GO:0000346)
5.7 96.2 GO:0000109 nucleotide-excision repair complex(GO:0000109)
5.6 101.3 GO:0032433 filopodium tip(GO:0032433)
5.6 56.3 GO:0035749 myelin sheath adaxonal region(GO:0035749)
5.6 33.5 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
5.5 33.2 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
5.4 48.6 GO:0033588 Elongator holoenzyme complex(GO:0033588)
5.2 41.9 GO:0030688 preribosome, small subunit precursor(GO:0030688)
5.2 51.9 GO:0070187 telosome(GO:0070187)
5.1 15.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
5.1 20.4 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
5.0 29.8 GO:0070545 PeBoW complex(GO:0070545)
4.9 34.1 GO:0000812 Swr1 complex(GO:0000812)
4.9 24.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
4.8 62.4 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
4.8 19.1 GO:0055087 Ski complex(GO:0055087)
4.7 126.8 GO:0071682 endocytic vesicle lumen(GO:0071682)
4.5 86.3 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
4.5 26.7 GO:1990357 terminal web(GO:1990357)
4.3 21.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
4.3 25.8 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
4.2 8.4 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
4.2 29.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
4.2 66.6 GO:0071004 U2-type prespliceosome(GO:0071004)
4.1 8.3 GO:0071203 WASH complex(GO:0071203)
4.1 302.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
4.0 59.8 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
3.9 7.9 GO:0048787 presynaptic active zone membrane(GO:0048787)
3.9 203.6 GO:0045171 intercellular bridge(GO:0045171)
3.9 11.7 GO:0097134 cyclin E1-CDK2 complex(GO:0097134)
3.9 27.0 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
3.9 27.0 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
3.8 26.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
3.8 15.2 GO:0070876 SOSS complex(GO:0070876)
3.8 45.5 GO:0030008 TRAPP complex(GO:0030008)
3.6 83.2 GO:0017053 transcriptional repressor complex(GO:0017053)
3.6 21.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
3.5 24.8 GO:0061617 MICOS complex(GO:0061617)
3.5 10.6 GO:0071159 NF-kappaB complex(GO:0071159)
3.5 24.6 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
3.5 69.1 GO:0005838 proteasome regulatory particle(GO:0005838)
3.4 23.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
3.4 33.8 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
3.4 50.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
3.3 13.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
3.3 6.6 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
3.2 28.7 GO:0000439 core TFIIH complex(GO:0000439)
3.2 88.7 GO:0005868 cytoplasmic dynein complex(GO:0005868)
3.2 72.8 GO:0005746 mitochondrial respiratory chain(GO:0005746)
3.1 18.8 GO:0071817 MMXD complex(GO:0071817)
3.1 28.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
3.1 12.4 GO:0032044 DSIF complex(GO:0032044)
3.1 15.5 GO:0071986 Ragulator complex(GO:0071986)
3.0 21.3 GO:1990635 proximal dendrite(GO:1990635)
3.0 74.2 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
3.0 20.8 GO:0005685 U1 snRNP(GO:0005685)
2.9 20.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
2.9 8.6 GO:0005674 transcription factor TFIIF complex(GO:0005674)
2.8 53.1 GO:0036020 endolysosome membrane(GO:0036020)
2.8 11.0 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
2.8 88.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
2.7 27.0 GO:0030137 COPI-coated vesicle(GO:0030137)
2.6 55.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
2.6 12.9 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
2.6 20.5 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
2.5 130.0 GO:0072686 mitotic spindle(GO:0072686)
2.5 27.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
2.5 32.2 GO:0008385 IkappaB kinase complex(GO:0008385)
2.5 29.7 GO:0042555 MCM complex(GO:0042555)
2.5 9.8 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
2.4 102.4 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
2.4 33.3 GO:0031970 organelle envelope lumen(GO:0031970)
2.3 7.0 GO:0005607 laminin-2 complex(GO:0005607)
2.3 34.7 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
2.3 6.9 GO:0060091 kinocilium(GO:0060091) kinociliary basal body(GO:1902636)
2.3 29.8 GO:0071011 precatalytic spliceosome(GO:0071011)
2.3 104.9 GO:0005881 cytoplasmic microtubule(GO:0005881)
2.3 25.0 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
2.3 15.8 GO:0031371 ubiquitin conjugating enzyme complex(GO:0031371)
2.3 38.3 GO:0032059 bleb(GO:0032059)
2.2 29.2 GO:0031209 SCAR complex(GO:0031209)
2.2 64.3 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
2.2 15.5 GO:0016272 prefoldin complex(GO:0016272)
2.2 11.0 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
2.2 15.2 GO:0035253 ciliary rootlet(GO:0035253)
2.2 97.6 GO:0000502 proteasome complex(GO:0000502)
2.2 51.7 GO:0002080 acrosomal membrane(GO:0002080)
2.1 332.2 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
2.1 46.5 GO:0005721 pericentric heterochromatin(GO:0005721)
2.0 24.5 GO:0000118 histone deacetylase complex(GO:0000118)
2.0 22.3 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
2.0 18.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
2.0 76.3 GO:0005844 polysome(GO:0005844)
2.0 33.9 GO:0005720 nuclear heterochromatin(GO:0005720)
2.0 27.9 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
2.0 49.8 GO:0005640 nuclear outer membrane(GO:0005640)
2.0 211.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.0 185.4 GO:0005840 ribosome(GO:0005840)
1.9 15.6 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
1.9 34.7 GO:0031265 CD95 death-inducing signaling complex(GO:0031265) ripoptosome(GO:0097342)
1.8 29.9 GO:0097526 spliceosomal tri-snRNP complex(GO:0097526)
1.8 10.5 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
1.7 59.3 GO:0031258 lamellipodium membrane(GO:0031258)
1.7 15.5 GO:0070419 nonhomologous end joining complex(GO:0070419)
1.7 11.9 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
1.7 13.6 GO:0030057 desmosome(GO:0030057)
1.7 6.7 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
1.7 33.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
1.6 18.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.6 109.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
1.5 4.5 GO:0089701 U2AF(GO:0089701)
1.5 19.0 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.4 2.9 GO:0072487 MSL complex(GO:0072487)
1.4 5.7 GO:1990075 periciliary membrane compartment(GO:1990075)
1.4 14.3 GO:0030127 COPII vesicle coat(GO:0030127)
1.4 71.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.4 4.2 GO:0031213 RSF complex(GO:0031213)
1.4 6.9 GO:0031514 motile cilium(GO:0031514)
1.3 5.4 GO:0070469 respiratory chain(GO:0070469)
1.3 5.3 GO:0032593 insulin-responsive compartment(GO:0032593)
1.3 32.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.3 170.4 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
1.3 29.0 GO:0005921 gap junction(GO:0005921)
1.2 11.9 GO:0030686 90S preribosome(GO:0030686)
1.2 14.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
1.2 10.5 GO:0097470 ribbon synapse(GO:0097470)
1.2 15.0 GO:0035577 azurophil granule membrane(GO:0035577)
1.1 10.3 GO:0044292 dendrite terminus(GO:0044292)
1.1 89.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
1.1 22.8 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.1 5.3 GO:0032039 integrator complex(GO:0032039)
1.1 3.2 GO:0030123 AP-3 adaptor complex(GO:0030123)
1.0 247.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
1.0 4.1 GO:0005846 nuclear cap binding complex(GO:0005846)
1.0 4.9 GO:0032389 MutLalpha complex(GO:0032389)
1.0 110.3 GO:0035579 specific granule membrane(GO:0035579)
1.0 6.7 GO:0000813 ESCRT I complex(GO:0000813)
1.0 51.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.9 8.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.9 20.0 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.9 101.9 GO:0016605 PML body(GO:0016605)
0.9 5.2 GO:0015629 actin cytoskeleton(GO:0015629)
0.9 10.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.8 14.3 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.8 24.4 GO:0016363 nuclear matrix(GO:0016363)
0.8 27.3 GO:0043198 dendritic shaft(GO:0043198)
0.7 6.7 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.7 2.9 GO:0005686 U2 snRNP(GO:0005686)
0.7 23.7 GO:0008180 COP9 signalosome(GO:0008180)
0.7 18.6 GO:0097228 sperm principal piece(GO:0097228)
0.7 3.4 GO:0000306 extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313)
0.7 3.3 GO:0005899 insulin receptor complex(GO:0005899)
0.7 47.0 GO:0014704 intercalated disc(GO:0014704)
0.7 54.5 GO:0031902 late endosome membrane(GO:0031902)
0.7 7.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.7 265.7 GO:0005925 focal adhesion(GO:0005925)
0.6 12.2 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.6 5.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.6 17.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.6 3.0 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.6 54.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.6 25.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.6 1.7 GO:0045293 MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.6 4.5 GO:0030904 retromer complex(GO:0030904)
0.6 8.4 GO:0000242 pericentriolar material(GO:0000242)
0.5 13.6 GO:0044815 DNA packaging complex(GO:0044815)
0.5 0.5 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
0.5 18.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 68.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.4 9.8 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 10.4 GO:0001772 immunological synapse(GO:0001772)
0.4 12.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.3 1.7 GO:0005902 microvillus(GO:0005902)
0.3 5.3 GO:0035861 site of double-strand break(GO:0035861)
0.3 752.1 GO:0070062 extracellular exosome(GO:0070062)
0.3 9.9 GO:0030315 T-tubule(GO:0030315)
0.2 7.0 GO:0005901 caveola(GO:0005901)
0.2 28.1 GO:0031966 mitochondrial membrane(GO:0031966)
0.2 2.0 GO:0097346 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) INO80-type complex(GO:0097346)
0.2 1.1 GO:0002102 podosome(GO:0002102)
0.2 0.5 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.1 3.3 GO:0012507 ER to Golgi transport vesicle membrane(GO:0012507)
0.1 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 3.3 GO:0036379 myofilament(GO:0036379)
0.1 5.5 GO:0030018 Z disc(GO:0030018)
0.1 1.5 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.1 44.3 GO:0005739 mitochondrion(GO:0005739)
0.1 1.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 0.3 GO:0043196 varicosity(GO:0043196)
0.0 2.7 GO:0030027 lamellipodium(GO:0030027)
0.0 1.2 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
52.7 369.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
41.9 125.6 GO:0070260 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
34.7 104.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
31.4 31.4 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
30.3 424.8 GO:0030957 Tat protein binding(GO:0030957)
29.5 88.6 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
29.5 88.4 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
27.4 273.6 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
27.3 573.3 GO:0001055 RNA polymerase II activity(GO:0001055)
27.3 245.5 GO:0015288 porin activity(GO:0015288)
26.7 80.2 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
24.9 99.4 GO:0031871 proteinase activated receptor binding(GO:0031871)
22.8 68.5 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
22.6 428.5 GO:0017070 U6 snRNA binding(GO:0017070)
22.5 112.6 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
20.6 103.0 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
20.4 61.2 GO:0010698 acetyltransferase activator activity(GO:0010698)
20.0 100.2 GO:0032137 guanine/thymine mispair binding(GO:0032137)
19.4 19.4 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
19.1 114.8 GO:0016531 copper chaperone activity(GO:0016531)
18.7 56.0 GO:0003883 CTP synthase activity(GO:0003883)
18.6 55.7 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
17.7 70.7 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
17.6 176.5 GO:0051425 PTB domain binding(GO:0051425)
17.3 17.3 GO:0001884 pyrimidine nucleoside binding(GO:0001884) UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
17.0 102.2 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
17.0 68.1 GO:0004619 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
16.9 118.5 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
16.8 168.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
16.4 131.1 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
16.3 114.4 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
16.3 48.8 GO:0004775 succinate-CoA ligase (ADP-forming) activity(GO:0004775)
16.2 48.6 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
15.9 47.8 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
15.8 31.5 GO:0010340 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
15.7 47.0 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
14.9 14.9 GO:0051536 iron-sulfur cluster binding(GO:0051536) 4 iron, 4 sulfur cluster binding(GO:0051539) metal cluster binding(GO:0051540)
14.7 58.7 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
14.7 146.5 GO:1990446 U1 snRNP binding(GO:1990446)
14.3 86.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
14.3 57.3 GO:0004427 inorganic diphosphatase activity(GO:0004427)
13.9 41.8 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
13.4 134.2 GO:0030911 TPR domain binding(GO:0030911)
13.1 39.4 GO:0017057 6-phosphogluconolactonase activity(GO:0017057)
13.1 39.3 GO:0070361 mitochondrial light strand promoter anti-sense binding(GO:0070361) mitochondrial heavy strand promoter anti-sense binding(GO:0070362) mitochondrial heavy strand promoter sense binding(GO:0070364)
12.9 38.8 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
12.9 64.6 GO:0030942 endoplasmic reticulum signal peptide binding(GO:0030942)
12.9 64.5 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
12.6 88.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
12.2 48.9 GO:0002060 purine nucleobase binding(GO:0002060)
11.8 23.6 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
11.6 139.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
11.6 92.6 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
11.4 34.3 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
11.4 159.4 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
11.4 113.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
11.2 33.7 GO:0033149 FFAT motif binding(GO:0033149)
11.2 33.6 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
11.2 78.2 GO:1990226 histone methyltransferase binding(GO:1990226)
11.1 55.6 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
10.8 53.9 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
10.7 53.5 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
10.6 31.9 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
10.6 84.9 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
10.6 63.7 GO:0019776 Atg8 ligase activity(GO:0019776)
10.6 31.7 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
10.5 42.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
10.5 31.4 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
10.4 20.8 GO:0070990 snRNP binding(GO:0070990)
10.4 62.2 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
10.1 30.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
10.0 60.2 GO:0051021 GDP-dissociation inhibitor binding(GO:0051021) Rho GDP-dissociation inhibitor binding(GO:0051022)
9.9 267.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
9.7 252.7 GO:0008266 poly(U) RNA binding(GO:0008266)
9.5 503.2 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
9.3 56.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
9.3 56.0 GO:0044547 DNA topoisomerase binding(GO:0044547)
9.3 74.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
9.2 55.3 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
9.1 27.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
9.1 27.4 GO:0030366 molybdopterin synthase activity(GO:0030366)
9.1 273.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
9.1 72.4 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
9.0 125.4 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
8.9 26.8 GO:0004828 serine-tRNA ligase activity(GO:0004828)
8.9 35.7 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
8.9 44.4 GO:0015140 malate transmembrane transporter activity(GO:0015140)
8.9 8.9 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
8.8 35.4 GO:0004307 ethanolaminephosphotransferase activity(GO:0004307)
8.6 25.8 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
8.4 25.2 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
8.3 24.9 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
8.2 57.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
8.2 342.5 GO:0004532 exoribonuclease activity(GO:0004532)
8.0 120.5 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
8.0 56.1 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
7.9 31.6 GO:0035613 RNA stem-loop binding(GO:0035613)
7.8 47.1 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
7.7 30.9 GO:0043515 kinetochore binding(GO:0043515)
7.4 268.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
7.3 51.2 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
7.3 21.9 GO:0045322 unmethylated CpG binding(GO:0045322)
7.2 50.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
7.1 28.5 GO:0019826 oxygen sensor activity(GO:0019826)
7.1 49.4 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
7.0 76.5 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
6.9 62.2 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
6.7 33.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
6.6 171.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
6.4 51.3 GO:0070087 chromo shadow domain binding(GO:0070087)
6.4 102.4 GO:0004526 ribonuclease P activity(GO:0004526)
6.3 44.1 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
6.2 55.9 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
6.2 283.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
6.0 24.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
6.0 42.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
5.8 58.0 GO:0015266 protein channel activity(GO:0015266)
5.8 46.3 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
5.6 33.5 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
5.6 11.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
5.5 66.5 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
5.5 65.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
5.4 54.3 GO:0019784 NEDD8-specific protease activity(GO:0019784)
5.3 42.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
5.2 110.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
5.2 10.5 GO:0015616 DNA translocase activity(GO:0015616)
5.2 114.7 GO:0016881 acid-amino acid ligase activity(GO:0016881)
5.2 31.0 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
5.0 14.9 GO:0051880 G-quadruplex DNA binding(GO:0051880)
4.9 44.5 GO:0070878 primary miRNA binding(GO:0070878)
4.9 34.0 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
4.9 92.4 GO:0050811 GABA receptor binding(GO:0050811)
4.8 188.3 GO:0031593 polyubiquitin binding(GO:0031593)
4.8 38.6 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
4.8 57.5 GO:0089720 caspase binding(GO:0089720)
4.8 194.9 GO:0042974 retinoic acid receptor binding(GO:0042974)
4.7 23.6 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
4.6 13.9 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
4.6 23.0 GO:0000339 RNA cap binding(GO:0000339)
4.5 320.6 GO:0003743 translation initiation factor activity(GO:0003743)
4.5 13.5 GO:0098518 polynucleotide phosphatase activity(GO:0098518)
4.5 147.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
4.4 70.3 GO:0047617 acyl-CoA hydrolase activity(GO:0047617)
4.3 155.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
4.3 47.5 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
4.3 38.7 GO:0035174 histone serine kinase activity(GO:0035174)
4.2 126.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
4.2 41.7 GO:0070053 thrombospondin receptor activity(GO:0070053)
4.1 16.6 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
4.1 20.7 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
4.1 28.8 GO:0008097 5S rRNA binding(GO:0008097)
4.1 32.5 GO:0016929 SUMO-specific protease activity(GO:0016929)
4.0 72.5 GO:0008143 poly(A) binding(GO:0008143)
4.0 40.1 GO:0070182 DNA polymerase binding(GO:0070182)
4.0 27.9 GO:0001165 RNA polymerase I upstream control element sequence-specific DNA binding(GO:0001165)
3.9 15.8 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
3.9 27.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
3.9 92.7 GO:0070410 co-SMAD binding(GO:0070410)
3.8 56.6 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
3.8 18.8 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
3.7 85.1 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
3.7 62.8 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
3.6 18.2 GO:1990460 leptin receptor binding(GO:1990460)
3.5 10.6 GO:0031859 platelet activating factor receptor binding(GO:0031859)
3.5 7.0 GO:0038025 reelin receptor activity(GO:0038025)
3.5 13.9 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
3.4 175.8 GO:0019213 deacetylase activity(GO:0019213)
3.4 47.8 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
3.3 60.0 GO:0045505 dynein intermediate chain binding(GO:0045505)
3.3 16.5 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
3.3 65.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
3.3 9.8 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
3.3 22.9 GO:0000827 inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) inositol hexakisphosphate kinase activity(GO:0000828) inositol heptakisphosphate kinase activity(GO:0000829) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
3.3 91.1 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
3.2 15.8 GO:0004771 sterol esterase activity(GO:0004771)
3.1 122.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
3.1 9.4 GO:0034511 U3 snoRNA binding(GO:0034511)
3.1 15.6 GO:0050815 phosphoserine binding(GO:0050815)
3.1 62.2 GO:0005537 mannose binding(GO:0005537)
3.1 49.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
3.1 12.3 GO:0008174 mRNA methyltransferase activity(GO:0008174)
3.0 15.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158) enhancer binding(GO:0035326)
3.0 30.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
3.0 11.9 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
2.9 20.6 GO:0000182 rDNA binding(GO:0000182)
2.9 11.6 GO:0016936 galactoside binding(GO:0016936)
2.9 8.6 GO:0033130 acetylcholine receptor binding(GO:0033130)
2.9 60.0 GO:0070403 NAD+ binding(GO:0070403)
2.8 67.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
2.8 41.7 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
2.7 16.1 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
2.6 12.9 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
2.6 36.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
2.6 7.7 GO:0032184 SUMO polymer binding(GO:0032184)
2.6 38.6 GO:0017160 Ral GTPase binding(GO:0017160)
2.6 10.3 GO:0008187 poly-pyrimidine tract binding(GO:0008187)
2.6 28.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
2.5 15.2 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.5 528.9 GO:0003735 structural constituent of ribosome(GO:0003735)
2.5 27.5 GO:0016421 CoA carboxylase activity(GO:0016421)
2.5 40.0 GO:0097602 cullin family protein binding(GO:0097602)
2.4 9.7 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
2.4 19.4 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
2.4 14.4 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
2.4 60.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
2.4 64.7 GO:0070064 proline-rich region binding(GO:0070064)
2.4 45.5 GO:0003746 translation elongation factor activity(GO:0003746)
2.4 7.2 GO:0015235 cobalamin transporter activity(GO:0015235)
2.4 7.2 GO:0004020 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
2.4 7.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
2.4 23.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
2.4 19.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
2.3 27.9 GO:0001056 RNA polymerase III activity(GO:0001056)
2.3 229.7 GO:0008565 protein transporter activity(GO:0008565)
2.3 6.9 GO:0005137 interleukin-5 receptor binding(GO:0005137)
2.3 32.2 GO:0008432 JUN kinase binding(GO:0008432)
2.3 74.9 GO:0000049 tRNA binding(GO:0000049)
2.3 22.7 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
2.2 6.7 GO:0004758 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
2.2 61.8 GO:0051059 NF-kappaB binding(GO:0051059)
2.2 24.0 GO:0031996 thioesterase binding(GO:0031996)
2.2 36.9 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
2.2 17.4 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
2.1 62.3 GO:0031210 phosphatidylcholine binding(GO:0031210)
2.1 116.8 GO:0043130 ubiquitin binding(GO:0043130)
2.1 40.2 GO:0032794 GTPase activating protein binding(GO:0032794)
2.1 40.1 GO:0031491 nucleosome binding(GO:0031491)
2.1 27.4 GO:0016004 phospholipase activator activity(GO:0016004)
2.1 29.3 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
2.1 16.7 GO:0008135 translation factor activity, RNA binding(GO:0008135)
2.1 45.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.1 68.2 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
2.0 24.3 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
2.0 6.0 GO:0030984 kininogen binding(GO:0030984)
1.9 11.5 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.9 75.8 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
1.9 3.8 GO:0008184 glycogen phosphorylase activity(GO:0008184)
1.9 22.5 GO:0043022 ribosome binding(GO:0043022)
1.9 91.2 GO:0035064 methylated histone binding(GO:0035064)
1.9 29.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
1.9 64.9 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
1.8 53.2 GO:0005540 hyaluronic acid binding(GO:0005540)
1.8 49.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.8 124.1 GO:0008276 protein methyltransferase activity(GO:0008276)
1.7 19.1 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
1.7 13.8 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
1.7 18.7 GO:0004312 fatty acid synthase activity(GO:0004312)
1.7 6.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
1.7 43.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
1.6 88.8 GO:0002039 p53 binding(GO:0002039)
1.5 254.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.5 42.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
1.5 4.5 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
1.5 64.0 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
1.4 130.4 GO:0051082 unfolded protein binding(GO:0051082)
1.4 26.8 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
1.4 16.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
1.4 19.4 GO:0070513 death domain binding(GO:0070513)
1.4 5.5 GO:0004966 galanin receptor activity(GO:0004966)
1.3 13.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
1.3 22.1 GO:0036002 pre-mRNA binding(GO:0036002)
1.2 8.4 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
1.2 7.2 GO:0048156 tau protein binding(GO:0048156)
1.2 8.2 GO:0043559 insulin binding(GO:0043559)
1.2 15.2 GO:0017091 AU-rich element binding(GO:0017091)
1.1 6.7 GO:0017018 myosin phosphatase activity(GO:0017018)
1.1 17.8 GO:0004659 prenyltransferase activity(GO:0004659)
1.1 5.4 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
1.1 15.1 GO:0042043 neurexin family protein binding(GO:0042043)
1.0 22.3 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
1.0 40.2 GO:0042826 histone deacetylase binding(GO:0042826)
1.0 18.8 GO:0004859 phospholipase inhibitor activity(GO:0004859)
1.0 18.7 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.9 12.1 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.9 41.8 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
0.9 31.5 GO:0019894 kinesin binding(GO:0019894)
0.9 8.0 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.9 8.8 GO:0008252 nucleotidase activity(GO:0008252)
0.9 2.6 GO:0010484 H3 histone acetyltransferase activity(GO:0010484)
0.8 12.7 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.8 8.4 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.8 17.6 GO:0008242 omega peptidase activity(GO:0008242)
0.8 36.1 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.8 5.0 GO:0098821 BMP receptor activity(GO:0098821)
0.8 2.5 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.8 8.7 GO:0019211 phosphatase activator activity(GO:0019211)
0.8 33.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.8 2.3 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.8 12.4 GO:0017049 GTP-Rho binding(GO:0017049)
0.8 16.3 GO:0019903 protein phosphatase binding(GO:0019903)
0.8 1.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.8 200.9 GO:0044389 ubiquitin-like protein ligase binding(GO:0044389)
0.8 25.9 GO:0030331 estrogen receptor binding(GO:0030331)
0.8 3.0 GO:0051393 actinin binding(GO:0042805) alpha-actinin binding(GO:0051393)
0.7 10.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.7 13.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.7 10.3 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.7 3.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.6 5.8 GO:0008158 hedgehog receptor activity(GO:0008158)
0.6 17.9 GO:0000149 SNARE binding(GO:0000149)
0.6 18.9 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.6 1.7 GO:0030332 cyclin binding(GO:0030332)
0.6 15.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.6 22.4 GO:0043531 ADP binding(GO:0043531)
0.5 19.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 7.5 GO:0009881 photoreceptor activity(GO:0009881)
0.5 10.6 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.5 10.9 GO:0033613 activating transcription factor binding(GO:0033613)
0.5 2.4 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.5 4.3 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.5 31.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.5 10.5 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.5 3.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.5 8.0 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.5 79.8 GO:0051015 actin filament binding(GO:0051015)
0.5 16.7 GO:0030145 manganese ion binding(GO:0030145)
0.4 2.2 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 3.0 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.4 23.0 GO:0005507 copper ion binding(GO:0005507)
0.4 22.3 GO:0051087 chaperone binding(GO:0051087)
0.4 5.4 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.4 71.8 GO:0003779 actin binding(GO:0003779)
0.4 94.7 GO:0045296 cadherin binding(GO:0045296)
0.4 29.5 GO:0019905 syntaxin binding(GO:0019905)
0.4 7.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 3.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 3.0 GO:0019902 phosphatase binding(GO:0019902)
0.3 0.6 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.3 12.6 GO:0008009 chemokine activity(GO:0008009)
0.3 4.0 GO:0046527 glucosyltransferase activity(GO:0046527)
0.3 56.8 GO:0030246 carbohydrate binding(GO:0030246)
0.2 23.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 3.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.2 2.4 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 5.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 5.5 GO:0005080 protein kinase C binding(GO:0005080)
0.2 11.7 GO:0017022 myosin binding(GO:0017022)
0.2 0.8 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.2 3.2 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 3.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 11.7 GO:0030165 PDZ domain binding(GO:0030165)
0.1 0.9 GO:0003998 acylphosphatase activity(GO:0003998)
0.1 0.5 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 3.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 4.6 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 1.9 GO:0031072 heat shock protein binding(GO:0031072)
0.1 14.3 GO:0019207 kinase regulator activity(GO:0019207)
0.1 0.5 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.1 2.6 GO:0005109 frizzled binding(GO:0005109)
0.1 1.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 8.5 GO:0005178 integrin binding(GO:0005178)
0.1 7.0 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 70.3 GO:0003723 RNA binding(GO:0003723)
0.1 1.5 GO:0030276 clathrin binding(GO:0030276)
0.1 5.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 1.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.0 0.1 GO:0005112 Notch binding(GO:0005112)
0.0 1.7 GO:0008237 metallopeptidase activity(GO:0008237)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
9.9 516.2 PID BARD1 PATHWAY BARD1 signaling events
9.9 227.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
9.6 652.8 PID PLK1 PATHWAY PLK1 signaling events
6.0 385.3 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
4.3 137.8 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
3.8 199.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
3.8 191.9 PID AURORA B PATHWAY Aurora B signaling
3.7 114.5 PID ATM PATHWAY ATM pathway
3.7 114.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
3.4 288.7 PID TELOMERASE PATHWAY Regulation of Telomerase
3.3 133.6 PID CD40 PATHWAY CD40/CD40L signaling
3.3 66.5 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
3.2 194.2 PID FOXM1 PATHWAY FOXM1 transcription factor network
3.0 27.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
2.9 318.8 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
2.9 167.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
2.9 31.5 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
2.6 62.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
2.5 166.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
2.5 72.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
2.4 55.8 PID FANCONI PATHWAY Fanconi anemia pathway
2.4 116.6 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
2.2 79.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
2.2 10.8 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
2.1 92.4 PID P53 REGULATION PATHWAY p53 pathway
2.1 275.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
2.0 75.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
1.9 26.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
1.9 148.2 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
1.8 8.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
1.7 24.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
1.6 62.2 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
1.5 60.3 PID IL1 PATHWAY IL1-mediated signaling events
1.5 10.6 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
1.4 6.9 PID IL5 PATHWAY IL5-mediated signaling events
1.4 18.9 ST G ALPHA S PATHWAY G alpha s Pathway
1.3 6.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
1.1 53.5 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
1.1 35.2 PID CDC42 PATHWAY CDC42 signaling events
1.1 22.9 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
1.1 29.6 PID TGFBR PATHWAY TGF-beta receptor signaling
1.1 19.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
1.0 17.7 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
1.0 23.8 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
1.0 15.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
1.0 51.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
1.0 51.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.9 38.6 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.8 42.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.8 3.3 PID IGF1 PATHWAY IGF1 pathway
0.8 14.5 PID ARF 3PATHWAY Arf1 pathway
0.8 12.5 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.7 50.8 PID CMYB PATHWAY C-MYB transcription factor network
0.7 8.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.7 4.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.7 6.6 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.7 50.8 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.6 5.8 PID S1P S1P1 PATHWAY S1P1 pathway
0.6 24.2 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.6 5.0 PID BMP PATHWAY BMP receptor signaling
0.6 14.4 PID RHOA PATHWAY RhoA signaling pathway
0.5 22.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.5 30.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.5 24.3 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 12.8 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.4 6.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 14.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.4 3.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.3 14.5 PID E2F PATHWAY E2F transcription factor network
0.2 3.2 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.2 7.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 5.5 PID FGF PATHWAY FGF signaling pathway
0.1 1.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.1 1.6 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 0.9 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 12.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 3.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
19.5 467.5 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
18.7 298.7 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
13.5 526.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
12.4 211.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
12.1 108.6 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
11.6 266.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
10.0 90.0 REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
9.9 19.8 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
9.8 48.9 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
9.6 96.1 REACTOME POL SWITCHING Genes involved in Polymerase switching
9.6 239.7 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
9.3 158.7 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
9.3 289.3 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
8.7 183.4 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
8.5 723.7 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
8.5 153.1 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
8.3 283.1 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
8.2 131.0 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
7.7 123.0 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
7.7 230.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
7.6 220.5 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
7.4 657.5 REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 Genes involved in SCF(Skp2)-mediated degradation of p27/p21
7.4 398.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
7.2 7.2 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
6.7 93.2 REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX Genes involved in CDT1 association with the CDC6:ORC:origin complex
6.6 26.6 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
6.6 152.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
6.5 38.7 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
6.4 231.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
6.0 299.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
5.9 53.1 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
5.8 144.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
5.7 195.3 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
5.5 82.6 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
5.5 54.5 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
5.4 107.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
5.4 128.4 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
5.3 53.0 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
5.1 148.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
5.0 80.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
4.9 116.9 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
4.8 47.7 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
4.7 51.9 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
4.7 292.1 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
4.4 196.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
4.3 82.4 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
4.1 299.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
4.0 272.3 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
3.8 68.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
3.7 78.3 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
3.7 44.7 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
3.6 332.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
3.5 31.8 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
3.5 27.7 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
3.4 61.7 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
3.3 46.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
3.3 91.1 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
3.2 51.6 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
3.2 508.6 REACTOME TRANSLATION Genes involved in Translation
3.2 28.5 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
3.2 34.7 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
3.1 61.4 REACTOME KINESINS Genes involved in Kinesins
3.0 42.3 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
2.7 285.7 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
2.6 112.7 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
2.6 99.0 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
2.5 12.4 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
2.5 37.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
2.4 34.0 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
2.4 45.2 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
2.4 42.6 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
2.2 69.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
2.1 322.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
2.1 80.3 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
2.0 7.9 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
1.9 52.4 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
1.9 9.4 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
1.8 12.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1.8 45.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
1.8 63.3 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
1.8 108.4 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
1.8 23.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
1.8 35.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
1.7 3.3 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
1.6 27.5 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
1.6 44.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
1.5 27.2 REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS Genes involved in TGF-beta receptor signaling activates SMADs
1.5 4.5 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
1.5 29.8 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
1.4 39.1 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
1.4 25.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
1.3 45.2 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
1.3 31.5 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
1.2 23.7 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
1.2 65.5 REACTOME PI METABOLISM Genes involved in PI Metabolism
1.2 7.0 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
1.1 23.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.1 10.7 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
1.1 42.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.0 12.4 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
1.0 26.7 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.0 34.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.9 15.8 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.9 31.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.9 56.5 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.8 27.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.8 17.4 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.8 10.6 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.7 51.5 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.6 13.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.6 13.8 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.6 18.1 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.5 87.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.5 22.2 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.4 4.9 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.4 5.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 10.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 5.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.3 4.4 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.3 36.5 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.3 15.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 2.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.2 3.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 8.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 2.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.2 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.8 REACTOME GLUCURONIDATION Genes involved in Glucuronidation