averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)


Results for NRF1

Z-value: 7.10

Motif logo

Transcription factors associated with NRF1

Gene Symbol Gene ID Gene Info
ENSG00000106459.10 nuclear respiratory factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of NRF1 motif

Sorted Z-values of NRF1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_50432782 160.64 ENST00000413454.1
nucleoporin 62kDa
interleukin 4 induced 1
chr19_+_39138320 155.53 ENST00000424234.2
actinin, alpha 4
chr17_+_40761660 147.06 ENST00000251413.3
tubulin, gamma 1
chr17_+_7210898 144.00 ENST00000572815.1
eukaryotic translation initiation factor 5A
chr2_-_33824336 133.36 ENST00000431950.1
family with sequence similarity 98, member A
chr8_-_117886955 130.81 ENST00000297338.2
RAD21 homolog (S. pombe)
chr5_+_170814803 128.67 ENST00000521672.1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr2_-_33824382 115.84 ENST00000238823.8
family with sequence similarity 98, member A
chr9_+_110045537 114.44 ENST00000358015.3
RAD23 homolog B (S. cerevisiae)
chr3_+_120315149 113.47 ENST00000184266.2
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr14_-_23058063 109.61 ENST00000538631.1
defender against cell death 1
chr3_+_120315160 108.82 ENST00000485064.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa
chr2_+_216974020 106.60 ENST00000392132.2
X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
chr20_-_57617831 101.95 ENST00000371033.5
slowmo homolog 2 (Drosophila)
chr5_-_133561752 101.74 ENST00000519718.1
S-phase kinase-associated protein 1
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_47634039 98.31 ENST00000597808.1
SUMO1 activating enzyme subunit 1
chr19_-_2328572 98.06 ENST00000252622.10
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr4_-_120988229 97.50 ENST00000296509.6
MAD2 mitotic arrest deficient-like 1 (yeast)
chr12_+_69080734 96.77 ENST00000378905.2
nucleoporin 107kDa
chr1_-_156308018 95.34 ENST00000496684.2
chaperonin containing TCP1, subunit 3 (gamma)
chr9_-_124922021 95.00 ENST00000537618.1
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
chr10_-_58120996 92.85 ENST00000361148.6
ZW10 interacting kinetochore protein
chr3_+_150321068 89.76 ENST00000471696.1
Selenoprotein T
chr2_+_264869 88.48 ENST00000272067.6
acid phosphatase 1, soluble
chr16_-_66864806 88.28 ENST00000566336.1
NEDD8 activating enzyme E1 subunit 1
chr1_+_154947148 87.67 ENST00000368436.1
CDC28 protein kinase regulatory subunit 1B
chr19_-_10305752 86.01 ENST00000540357.1
DNA (cytosine-5-)-methyltransferase 1
chr7_-_102213030 84.88 ENST00000511313.1
polymerase (RNA) II (DNA directed) polypeptide J3
chr8_+_42249418 83.62 ENST00000521158.1
voltage-dependent anion channel 3
chr1_-_183604794 83.19 ENST00000367534.1
actin related protein 2/3 complex, subunit 5, 16kDa
chr8_+_42249346 82.66 ENST00000392935.3
voltage-dependent anion channel 3
chr5_+_162887556 82.41 ENST00000393915.4
hyaluronan-mediated motility receptor (RHAMM)
chr1_+_154947126 81.86 ENST00000368439.1
CDC28 protein kinase regulatory subunit 1B
chr3_-_150320937 80.54 ENST00000479209.1
stress-associated endoplasmic reticulum protein 1
chr2_-_99952769 80.33 ENST00000409434.1
thioredoxin domain containing 9
chr4_-_103789996 79.90 ENST00000508238.1
ubiquitin-conjugating enzyme E2D 3
chr20_+_57556263 79.45 ENST00000602795.1
negative elongation factor complex member C/D
chr17_+_49337881 78.99 ENST00000225298.7
UTP18 small subunit (SSU) processome component homolog (yeast)
chr21_-_38445470 78.48 ENST00000399098.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr19_+_17416457 78.09 ENST00000252602.1
mitochondrial ribosomal protein L34
chr19_+_49588690 77.62 ENST00000221448.5
small nuclear ribonucleoprotein 70kDa (U1)
chr14_-_102605983 76.69 ENST00000334701.7
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr4_+_57301896 76.67 ENST00000514888.1
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr19_+_39138271 75.99 ENST00000252699.2
actinin, alpha 4
chr19_+_17416609 75.73 ENST00000602206.1
mitochondrial ribosomal protein L34
chr21_-_38445011 73.92 ENST00000464265.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr10_-_16859361 73.35 ENST00000377921.3
Ras suppressor protein 1
chr7_-_102312048 72.94 ENST00000333432.6
DNA-directed RNA polymerase II subunit RPB11-b1
chr22_-_28315115 71.87 ENST00000455418.3
phosphatidylinositol transfer protein, beta
chr12_-_54070098 71.66 ENST00000394349.3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr9_+_91926103 71.27 ENST00000314355.6
CDC28 protein kinase regulatory subunit 2
chr12_-_54069856 70.52 ENST00000602871.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr11_-_47664072 69.82 ENST00000542981.1
mitochondrial carrier 2
chr17_-_40761375 69.17 ENST00000543197.1
family with sequence similarity 134, member C
chr19_+_49588677 68.88 ENST00000598984.1
small nuclear ribonucleoprotein 70kDa (U1)
chr5_+_218356 68.47 ENST00000264932.6
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr10_+_99185917 68.12 ENST00000334828.5
phosphoglycerate mutase 1 (brain)
chr1_+_32479430 67.55 ENST00000327300.7
KH domain containing, RNA binding, signal transduction associated 1
chr4_+_57302297 67.10 ENST00000399688.3
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr17_+_7210921 66.67 ENST00000573542.1
eukaryotic translation initiation factor 5A
chr8_-_55014415 65.67 ENST00000522007.1
lysophospholipase I
chr8_-_55014336 65.38 ENST00000343231.6
lysophospholipase I
chr21_-_33651324 64.68 ENST00000290130.3
MIS18 kinetochore protein A
chr5_+_10250328 64.52 ENST00000515390.1
chaperonin containing TCP1, subunit 5 (epsilon)
chr2_+_190526111 64.52 ENST00000607062.1
asparagine synthetase domain containing 1
chr10_-_16859442 64.06 ENST00000602389.1
Ras suppressor protein 1
chr17_-_4852332 63.85 ENST00000572383.1
profilin 1
chr19_-_2427536 63.45 ENST00000591871.1
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr6_-_36515177 63.32 ENST00000229812.7
serine/threonine kinase 38
chr6_-_41040195 62.57 ENST00000463088.1
O-acyl-ADP-ribose deacylase 1
chr12_+_57623869 62.43 ENST00000414700.3
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_+_11071685 61.93 ENST00000541122.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr21_-_38445443 61.31 ENST00000360525.4
phosphatidylinositol glycan anchor biosynthesis, class P
chr3_-_119396193 61.30 ENST00000484810.1
COX17 cytochrome c oxidase copper chaperone
chr13_+_50656307 61.23 ENST00000378180.4
deleted in lymphocytic leukemia 1 (non-protein coding)
chrX_-_129299847 61.07 ENST00000319908.3
apoptosis-inducing factor, mitochondrion-associated, 1
chr4_+_17616253 60.87 ENST00000237380.7
mediator complex subunit 28
chrX_-_153707246 60.02 ENST00000407062.1
L antigen family, member 3
chr19_+_8509842 59.87 ENST00000325495.4
heterogeneous nuclear ribonucleoprotein M
chr21_-_38445297 59.86 ENST00000430792.1
phosphatidylinositol glycan anchor biosynthesis, class P
chr4_+_57845043 59.51 ENST00000433463.1
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chrX_-_129299638 59.42 ENST00000535724.1
apoptosis-inducing factor, mitochondrion-associated, 1
chr4_+_57845024 58.33 ENST00000431623.2
polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
chr19_+_531713 58.03 ENST00000215574.4
cell division cycle 34
chr18_+_12947981 58.00 ENST00000262124.11
SEH1-like (S. cerevisiae)
chr18_-_54305658 57.56 ENST00000586262.1
thioredoxin-like 1
chr3_-_48647470 57.40 ENST00000203407.5
ubiquinol-cytochrome c reductase core protein I
chr10_-_71993176 57.34 ENST00000373232.3
pyrophosphatase (inorganic) 1
chr8_-_109260897 57.09 ENST00000521297.1
eukaryotic translation initiation factor 3, subunit E
chr6_-_31774714 56.76 ENST00000375661.5
LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr9_+_117350009 56.68 ENST00000374050.3
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr11_+_108535752 56.59 ENST00000322536.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr7_-_102119342 56.34 ENST00000393794.3
polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
chr11_+_18417813 56.12 ENST00000540430.1
lactate dehydrogenase A
chr17_-_47492164 56.08 ENST00000512041.2
chr1_+_41445413 56.00 ENST00000541520.1
CTP synthase 1
chr19_-_40336969 55.85 ENST00000599134.1
chr1_-_246670519 55.77 ENST00000388985.4
SET and MYND domain containing 3
chr1_-_8939265 55.34 ENST00000489867.1
enolase 1, (alpha)
chr22_+_32340481 55.29 ENST00000397492.1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr6_-_35888905 55.18 ENST00000510290.1
SRSF protein kinase 1
chr22_+_32340447 54.88 ENST00000248975.5
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
chr12_+_48357340 54.64 ENST00000256686.6
transmembrane protein 106C
chr12_+_109535373 53.88 ENST00000242576.2
uracil-DNA glycosylase
chr20_-_5107180 53.68 ENST00000379160.3
proliferating cell nuclear antigen
chrX_-_16888448 53.67 ENST00000468092.1
retinoblastoma binding protein 7
chr4_-_103790026 53.64 ENST00000338145.3
ubiquitin-conjugating enzyme E2D 3
chr21_-_46293586 52.80 ENST00000445724.2
pituitary tumor-transforming 1 interacting protein
chr19_+_36630855 52.65 ENST00000589146.1
calpain, small subunit 1
chr20_-_48729670 52.64 ENST00000371657.5
ubiquitin-conjugating enzyme E2 variant 1
chr12_+_48357401 52.37 ENST00000429772.2
transmembrane protein 106C
chr17_+_3572087 52.19 ENST00000248378.5
ER membrane protein complex subunit 6
chr11_-_6704513 52.19 ENST00000532203.1
mitochondrial ribosomal protein L17
chr12_+_57623477 51.97 ENST00000557487.1
serine hydroxymethyltransferase 2 (mitochondrial)
chr19_+_572543 51.67 ENST00000333511.3
basigin (Ok blood group)
chr21_-_46293644 51.63 ENST00000330938.3
pituitary tumor-transforming 1 interacting protein
chr19_+_59055814 51.32 ENST00000594806.1
tripartite motif containing 28
chr19_-_1095330 50.83 ENST00000586746.1
polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
chr19_+_11071546 50.67 ENST00000358026.2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr20_+_62887081 50.08 ENST00000369758.4
protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
chr14_-_102553371 50.07 ENST00000553585.1
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr17_-_4852243 50.05 ENST00000225655.5
profilin 1
chr15_+_78833071 50.03 ENST00000559365.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr6_+_24775153 49.89 ENST00000356509.3
geminin, DNA replication inhibitor
chr10_-_74856608 49.86 ENST00000307116.2
prolyl 4-hydroxylase, alpha polypeptide I
chr11_+_60681346 49.82 ENST00000227525.3
transmembrane protein 109
chr19_+_11071652 49.71 ENST00000344626.4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr13_+_76123883 49.67 ENST00000377595.3
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
chr12_+_108079664 49.25 ENST00000541166.1
PWP1 homolog (S. cerevisiae)
chr10_+_60028818 49.25 ENST00000333926.5
CDGSH iron sulfur domain 1
chr16_-_88878305 48.94 ENST00000569616.1
adenine phosphoribosyltransferase
chr5_-_96518907 48.84 ENST00000508447.1
RIO kinase 2
chr6_+_52535878 48.70 ENST00000211314.4
transmembrane protein 14A
chr15_+_79603404 48.70 ENST00000299705.5
transmembrane emp24 protein transport domain containing 3
chr6_+_24667257 48.70 ENST00000537591.1
acyl-CoA thioesterase 13
chrX_+_70503037 48.63 ENST00000535149.1
non-POU domain containing, octamer-binding
chr11_-_77850629 48.61 ENST00000376156.3
ALG8, alpha-1,3-glucosyltransferase
chr11_+_114310102 48.31 ENST00000265881.5
RNA exonuclease 2
chr7_+_116502605 47.51 ENST00000458284.2
capping protein (actin filament) muscle Z-line, alpha 2
chr12_-_31479045 47.40 ENST00000539409.1
family with sequence similarity 60, member A
chr2_+_86333301 47.34 ENST00000254630.7
pentatricopeptide repeat domain 3
chr10_-_88281494 47.28 ENST00000298767.5
wings apart-like homolog (Drosophila)
chr20_+_39657454 47.08 ENST00000361337.2
topoisomerase (DNA) I
chr8_+_145137489 47.05 ENST00000355091.4
glycosylphosphatidylinositol anchor attachment 1
chr18_-_12884259 46.99 ENST00000353319.4
protein tyrosine phosphatase, non-receptor type 2
chr1_+_16174280 46.97 ENST00000375759.3
spen family transcriptional repressor
chr20_+_61427797 46.93 ENST00000370487.3
MRG/MORF4L binding protein
chr5_+_68462837 46.71 ENST00000256442.5
cyclin B1
chr2_-_106810783 46.23 ENST00000283148.7
UDP-glucuronate decarboxylase 1
chr2_-_86790593 45.92 ENST00000263856.4
charged multivesicular body protein 3
chr20_+_35234137 45.88 ENST00000344795.3
chromosome 20 open reading frame 24
chr15_+_78833105 45.60 ENST00000558341.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr11_+_114310164 45.47 ENST00000544196.1
RNA exonuclease 2
chr3_+_160117087 45.43 ENST00000357388.3
structural maintenance of chromosomes 4
chr11_-_76091986 45.23 ENST00000260045.3
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr2_-_150444300 44.83 ENST00000303319.5
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria
chr19_+_984313 44.79 ENST00000251289.5
WD repeat domain 18
chr1_+_212208919 44.66 ENST00000366991.4
denticleless E3 ubiquitin protein ligase homolog (Drosophila)
chr5_+_154320623 44.62 ENST00000523037.1
mitochondrial ribosomal protein L22
chr20_+_55926274 44.50 ENST00000371242.2
ribonucleic acid export 1
chr10_-_103578182 44.31 ENST00000439817.1
meningioma expressed antigen 5 (hyaluronidase)
chr19_-_55770311 44.05 ENST00000412770.2
protein phosphatase 6, regulatory subunit 1
chr6_-_24667232 44.04 ENST00000378198.4
tyrosyl-DNA phosphodiesterase 2
chr1_+_91966384 44.04 ENST00000430031.2
cell division cycle 7
chr2_-_38978492 43.87 ENST00000409276.1
serine/arginine-rich splicing factor 7
chr6_+_32936353 43.72 ENST00000374825.4
bromodomain containing 2
chr6_+_24403144 43.63 ENST00000274747.7
MRS2 magnesium transporter
chr11_+_114310237 43.62 ENST00000539119.1
RNA exonuclease 2
chr7_+_116502527 43.59 ENST00000361183.3
capping protein (actin filament) muscle Z-line, alpha 2
chr20_+_35234223 43.53 ENST00000342422.3
chromosome 20 open reading frame 24
chr6_-_35888824 43.44 ENST00000361690.3
SRSF protein kinase 1
chr19_-_36606181 43.36 ENST00000221859.4
polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
chr15_+_78832747 43.22 ENST00000560217.1
proteasome (prosome, macropain) subunit, alpha type, 4
chr1_+_91966656 43.20 ENST00000428239.1
cell division cycle 7
chr20_-_32700075 43.10 ENST00000374980.2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
chr16_-_75681522 43.01 ENST00000568378.1
lysyl-tRNA synthetase
chr5_+_33441053 42.94 ENST00000541634.1
threonyl-tRNA synthetase
chr3_+_37035263 42.65 ENST00000458205.2
mutL homolog 1
chr19_-_59066327 42.51 ENST00000596708.1
charged multivesicular body protein 2A
chr1_-_19536744 42.39 ENST00000375267.2
ubiquitin protein ligase E3 component n-recognin 4
chrX_+_51636629 42.28 ENST00000375722.1
melanoma antigen family D, 1
chr6_-_24667180 42.23 ENST00000545995.1
tyrosyl-DNA phosphodiesterase 2
chr5_+_68462944 42.03 ENST00000506572.1
cyclin B1
chr10_+_62538089 41.95 ENST00000519078.2
cyclin-dependent kinase 1
chr1_+_100731749 41.89 ENST00000370128.4
RNA 3'-terminal phosphate cyclase
chr14_+_75230011 41.89 ENST00000552421.1
YLP motif containing 1
chr3_+_52232102 41.85 ENST00000469224.1
aminolevulinate, delta-, synthase 1
chr18_+_12948000 41.82 ENST00000585730.1
SEH1-like (S. cerevisiae)
chr4_+_39699664 41.74 ENST00000261427.5
ubiquitin-conjugating enzyme E2K
chr20_+_11871371 41.74 ENST00000254977.3
BTB (POZ) domain containing 3
chr3_-_107809816 41.65 ENST00000361309.5
CD47 molecule
chr17_+_73201754 41.64 ENST00000583569.1
nucleoporin 85kDa
chr19_-_14530143 41.51 ENST00000242776.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
chr3_+_160117418 41.50 ENST00000465903.1
structural maintenance of chromosomes 4
chr1_-_109968973 41.41 ENST00000271308.4
proteasome (prosome, macropain) subunit, alpha type, 5
chr14_-_104387888 41.29 ENST00000286953.3
chromosome 14 open reading frame 2
chr20_+_55926583 41.25 ENST00000395840.2
ribonucleic acid export 1
chr6_-_41040268 40.91 ENST00000373154.2
O-acyl-ADP-ribose deacylase 1
chr17_-_46178527 40.78 ENST00000393408.3
chromobox homolog 1
chr10_-_103578162 40.63 ENST00000361464.3
meningioma expressed antigen 5 (hyaluronidase)

Network of associatons between targets according to the STRING database.

First level regulatory network of NRF1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
77.2 231.5 GO:1902396 protein localization to bicellular tight junction(GO:1902396)
44.1 176.5 GO:1903490 regulation of cytokinetic process(GO:0032954) regulation of mitotic cytokinetic process(GO:1903436) positive regulation of mitotic cytokinetic process(GO:1903438) positive regulation of mitotic cytokinesis(GO:1903490)
42.7 128.2 GO:0031662 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
38.8 193.9 GO:0007068 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
36.2 144.6 GO:0043335 protein unfolding(GO:0043335)
35.5 106.6 GO:1904430 negative regulation of t-circle formation(GO:1904430)
33.4 100.2 GO:0045950 meiotic metaphase I plate congression(GO:0043060) negative regulation of mitotic recombination(GO:0045950) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
31.0 154.8 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
30.9 92.7 GO:1903722 regulation of centriole elongation(GO:1903722)
29.7 207.7 GO:1903333 negative regulation of protein folding(GO:1903333)
29.5 88.4 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
29.3 176.0 GO:0015853 adenine transport(GO:0015853)
28.4 227.0 GO:0045905 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
28.2 84.5 GO:0018171 peptidyl-cysteine oxidation(GO:0018171)
28.2 112.6 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
26.7 80.2 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
26.3 131.3 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
24.9 74.8 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
24.2 145.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
24.0 72.1 GO:0036353 histone H2A-K119 monoubiquitination(GO:0036353)
22.4 67.2 GO:0033140 negative regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033140)
22.0 88.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
22.0 87.9 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
21.8 65.3 GO:0007057 spindle assembly involved in female meiosis I(GO:0007057)
21.5 64.6 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
21.2 63.5 GO:0090070 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
20.4 265.3 GO:1904871 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
19.4 96.8 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
19.1 57.3 GO:0071344 diphosphate metabolic process(GO:0071344)
19.0 57.0 GO:0002188 translation reinitiation(GO:0002188)
18.9 18.9 GO:1903895 negative regulation of IRE1-mediated unfolded protein response(GO:1903895)
18.7 56.0 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
18.6 241.2 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
18.4 55.3 GO:1903298 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
18.1 144.7 GO:0060699 regulation of endoribonuclease activity(GO:0060699)
18.1 54.2 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
17.8 35.7 GO:0046098 guanine metabolic process(GO:0046098)
17.7 88.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
17.5 52.6 GO:1902661 positive regulation of glucose mediated signaling pathway(GO:1902661)
17.2 120.5 GO:1904044 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650) response to aldosterone(GO:1904044)
17.0 68.1 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
16.9 67.6 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
16.3 114.4 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
16.3 146.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
16.1 80.4 GO:1902410 mitotic cytokinetic process(GO:1902410)
15.7 31.4 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
15.3 92.0 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
14.8 44.5 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
14.7 117.4 GO:0002176 male germ cell proliferation(GO:0002176) germ cell proliferation(GO:0036093)
14.6 87.6 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
14.5 87.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
14.4 43.2 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
14.2 85.4 GO:0071035 nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046)
14.1 42.3 GO:0031126 snoRNA 3'-end processing(GO:0031126)
14.0 14.0 GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144)
13.9 55.7 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
13.8 41.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
13.7 137.2 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
13.6 81.5 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
13.5 53.9 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
13.4 26.8 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
13.4 40.1 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) positive regulation of telomeric DNA binding(GO:1904744)
13.3 266.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
13.3 26.6 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
13.2 105.6 GO:0010032 meiotic chromosome condensation(GO:0010032)
13.2 39.5 GO:0071789 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
13.2 13.2 GO:0030047 actin modification(GO:0030047)
13.1 39.4 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
13.1 52.5 GO:0015910 peroxisomal long-chain fatty acid import(GO:0015910)
13.1 39.3 GO:0070407 oxidation-dependent protein catabolic process(GO:0070407)
13.1 39.2 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
12.9 38.8 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
12.9 38.7 GO:1903970 negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
12.9 64.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
12.9 77.2 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
12.8 12.8 GO:1902822 regulation of late endosome to lysosome transport(GO:1902822)
12.3 160.4 GO:0060340 positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
12.3 61.5 GO:0071475 cellular hyperosmotic salinity response(GO:0071475)
12.2 85.7 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
12.2 36.5 GO:0002276 basophil activation involved in immune response(GO:0002276)
12.0 47.8 GO:0006050 mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051)
11.9 35.6 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
11.8 35.3 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
11.7 668.5 GO:0050434 positive regulation of viral transcription(GO:0050434)
11.5 114.8 GO:0035092 sperm chromatin condensation(GO:0035092)
11.4 113.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
11.4 56.9 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
11.3 22.6 GO:0061739 protein lipidation involved in autophagosome assembly(GO:0061739)
11.1 133.4 GO:0090261 positive regulation of inclusion body assembly(GO:0090261)
11.1 77.8 GO:0007008 outer mitochondrial membrane organization(GO:0007008)
11.1 66.4 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
10.9 349.7 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
10.8 32.5 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
10.7 74.9 GO:1902416 positive regulation of mRNA binding(GO:1902416)
10.6 31.9 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
10.6 31.8 GO:1990737 response to manganese-induced endoplasmic reticulum stress(GO:1990737)
10.6 74.1 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
10.6 31.7 GO:0036071 N-glycan fucosylation(GO:0036071)
10.3 41.2 GO:0046502 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
10.3 133.7 GO:0000212 meiotic spindle organization(GO:0000212)
10.2 82.0 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
10.2 173.9 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
10.1 302.7 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
10.1 30.2 GO:1990922 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
10.0 30.1 GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
10.0 30.0 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
9.9 98.9 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
9.8 48.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
9.7 19.4 GO:0090069 regulation of ribosome biogenesis(GO:0090069)
9.7 58.2 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
9.7 38.8 GO:0016259 selenocysteine metabolic process(GO:0016259) negative regulation of vascular endothelial growth factor production(GO:1904046)
9.6 57.7 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
9.6 96.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
9.6 95.9 GO:0051096 positive regulation of helicase activity(GO:0051096)
9.4 28.1 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
9.4 9.4 GO:0018231 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
9.3 18.5 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
9.2 27.5 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
9.1 27.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
9.1 36.5 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
9.1 45.4 GO:0042780 tRNA 3'-end processing(GO:0042780)
9.0 63.3 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
8.9 35.6 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
8.9 70.9 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
8.8 35.3 GO:0016333 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
8.5 34.0 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
8.5 42.4 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
8.4 42.2 GO:0061198 fungiform papilla formation(GO:0061198)
8.3 83.2 GO:0021769 orbitofrontal cortex development(GO:0021769)
8.3 49.7 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
8.3 8.3 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
8.3 157.1 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
8.2 16.4 GO:1902512 positive regulation of apoptotic DNA fragmentation(GO:1902512)
8.1 24.3 GO:0072554 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
8.1 518.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
8.1 16.2 GO:0002101 tRNA wobble cytosine modification(GO:0002101)
8.1 24.2 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
8.0 56.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
8.0 95.9 GO:0006089 lactate metabolic process(GO:0006089)
7.8 38.9 GO:0090241 negative regulation of histone H4 acetylation(GO:0090241)
7.7 84.9 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
7.7 123.1 GO:0006516 glycoprotein catabolic process(GO:0006516)
7.7 38.4 GO:0090646 mitochondrial tRNA processing(GO:0090646)
7.7 161.3 GO:0042921 glucocorticoid receptor signaling pathway(GO:0042921)
7.7 23.0 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
7.7 30.7 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
7.5 15.0 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072)
7.4 29.5 GO:1903719 regulation of I-kappaB phosphorylation(GO:1903719) positive regulation of I-kappaB phosphorylation(GO:1903721)
7.2 101.2 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
7.1 42.6 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
7.0 13.9 GO:0035617 stress granule disassembly(GO:0035617)
6.9 34.6 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
6.8 47.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
6.8 47.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
6.7 66.9 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
6.4 32.0 GO:0061668 mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
6.4 31.9 GO:0051661 maintenance of centrosome location(GO:0051661)
6.3 37.9 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
6.3 25.2 GO:0030920 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
6.3 18.8 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
6.3 68.8 GO:0031584 activation of phospholipase D activity(GO:0031584)
6.2 112.4 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
6.2 18.6 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
6.1 18.2 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
6.0 42.2 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
6.0 23.9 GO:0006850 mitochondrial pyruvate transport(GO:0006850) mitochondrial pyruvate transmembrane transport(GO:1902361)
6.0 29.8 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
5.9 5.9 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
5.9 41.4 GO:0022417 protein maturation by protein folding(GO:0022417)
5.9 23.6 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
5.9 35.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
5.8 29.2 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
5.8 241.8 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
5.7 136.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
5.6 22.5 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
5.6 72.8 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
5.5 83.1 GO:0090168 Golgi reassembly(GO:0090168)
5.5 38.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
5.5 22.1 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
5.5 27.4 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
5.5 11.0 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
5.5 21.9 GO:1901895 positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
5.4 21.8 GO:0048205 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
5.4 27.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
5.4 10.8 GO:0097327 response to antineoplastic agent(GO:0097327)
5.4 27.0 GO:1902904 vacuolar transmembrane transport(GO:0034486) chaperone-mediated protein transport involved in chaperone-mediated autophagy(GO:0061741) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
5.4 145.9 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
5.4 53.9 GO:0045008 depyrimidination(GO:0045008)
5.3 26.7 GO:1902896 terminal web assembly(GO:1902896)
5.3 16.0 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
5.3 63.4 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
5.2 31.4 GO:2000773 negative regulation of cellular senescence(GO:2000773)
5.1 20.6 GO:0071373 cellular response to cocaine(GO:0071314) cellular response to luteinizing hormone stimulus(GO:0071373)
5.1 30.7 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
5.1 25.6 GO:0016926 protein desumoylation(GO:0016926)
5.1 35.8 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
5.1 121.5 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
5.1 177.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
5.0 5.0 GO:0048372 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
5.0 25.1 GO:0032790 ribosome disassembly(GO:0032790)
5.0 40.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
5.0 40.0 GO:0015846 polyamine transport(GO:0015846)
5.0 24.9 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
5.0 29.9 GO:0051708 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
5.0 10.0 GO:0072321 chaperone-mediated protein transport(GO:0072321)
5.0 29.8 GO:0070071 proton-transporting two-sector ATPase complex assembly(GO:0070071)
4.9 14.8 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
4.9 63.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
4.9 363.0 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
4.9 39.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
4.9 24.5 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
4.9 19.4 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
4.8 52.7 GO:0045116 protein neddylation(GO:0045116)
4.8 23.8 GO:0060356 leucine import(GO:0060356)
4.7 132.6 GO:0043968 histone H2A acetylation(GO:0043968)
4.7 23.6 GO:0051792 medium-chain fatty acid biosynthetic process(GO:0051792)
4.6 111.3 GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
4.6 13.9 GO:0045896 regulation of transcription during mitosis(GO:0045896)
4.6 509.1 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
4.5 49.2 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
4.5 75.9 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
4.4 8.9 GO:0000012 single strand break repair(GO:0000012)
4.4 44.1 GO:0046689 response to mercury ion(GO:0046689)
4.4 8.8 GO:0042256 mature ribosome assembly(GO:0042256)
4.4 148.7 GO:0090383 phagosome acidification(GO:0090383)
4.3 30.3 GO:0070294 renal sodium ion absorption(GO:0070294)
4.3 12.9 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
4.3 12.9 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
4.3 17.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
4.2 50.6 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
4.2 41.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
4.2 108.7 GO:0006825 copper ion transport(GO:0006825)
4.2 54.2 GO:0040016 embryonic cleavage(GO:0040016)
4.2 12.5 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
4.1 12.4 GO:0003383 apical constriction(GO:0003383)
4.1 4.1 GO:1905216 positive regulation of RNA binding(GO:1905216)
4.1 49.2 GO:0043457 regulation of cellular respiration(GO:0043457)
4.0 52.2 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
3.9 15.7 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
3.9 27.4 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
3.9 346.8 GO:0090114 COPII-coated vesicle budding(GO:0090114)
3.9 81.8 GO:0033120 positive regulation of RNA splicing(GO:0033120)
3.9 19.4 GO:0009149 pyrimidine nucleoside triphosphate catabolic process(GO:0009149) pyrimidine deoxyribonucleoside triphosphate catabolic process(GO:0009213)
3.8 11.4 GO:1904386 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
3.8 67.6 GO:0006851 mitochondrial calcium ion transport(GO:0006851)
3.7 82.4 GO:0030214 hyaluronan catabolic process(GO:0030214)
3.7 22.0 GO:0035562 negative regulation of chromatin binding(GO:0035562)
3.6 91.1 GO:0051016 barbed-end actin filament capping(GO:0051016)
3.6 43.4 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
3.6 90.2 GO:0009235 cobalamin metabolic process(GO:0009235)
3.6 10.8 GO:2000395 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
3.5 24.8 GO:0042407 cristae formation(GO:0042407)
3.5 14.1 GO:0072719 cellular response to cisplatin(GO:0072719)
3.5 7.0 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
3.5 10.5 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
3.4 6.8 GO:0071963 establishment or maintenance of cell polarity regulating cell shape(GO:0071963)
3.4 10.3 GO:0046504 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
3.4 85.2 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
3.4 43.9 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
3.4 46.9 GO:0040008 regulation of growth(GO:0040008)
3.3 30.0 GO:0030091 protein repair(GO:0030091)
3.3 29.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.3 6.6 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
3.3 22.9 GO:0031017 exocrine pancreas development(GO:0031017)
3.3 9.8 GO:0018211 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
3.2 130.6 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
3.2 85.8 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
3.2 82.0 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
3.1 18.9 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
3.1 71.3 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
3.1 24.8 GO:1903543 positive regulation of exosomal secretion(GO:1903543)
3.1 12.3 GO:0080009 mRNA methylation(GO:0080009)
3.0 154.4 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
3.0 101.7 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
3.0 12.0 GO:0098789 mRNA cleavage involved in mRNA processing(GO:0098787) pre-mRNA cleavage required for polyadenylation(GO:0098789)
3.0 23.8 GO:0035518 histone H2A monoubiquitination(GO:0035518)
2.9 2.9 GO:0090385 phagosome-lysosome fusion(GO:0090385)
2.9 5.8 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
2.9 14.5 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
2.9 49.0 GO:0035855 megakaryocyte development(GO:0035855)
2.9 28.8 GO:0009414 response to water deprivation(GO:0009414)
2.9 25.9 GO:0035458 cellular response to interferon-beta(GO:0035458)
2.9 23.0 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
2.8 34.1 GO:0031063 regulation of histone deacetylation(GO:0031063)
2.8 22.5 GO:0030263 apoptotic chromosome condensation(GO:0030263)
2.8 25.2 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
2.8 72.6 GO:0006270 DNA replication initiation(GO:0006270)
2.8 22.2 GO:0000470 maturation of LSU-rRNA(GO:0000470)
2.8 8.3 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
2.7 30.2 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
2.7 8.2 GO:1901143 insulin catabolic process(GO:1901143)
2.7 27.1 GO:0030638 polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
2.7 13.5 GO:0098501 polynucleotide dephosphorylation(GO:0098501)
2.7 29.5 GO:0006105 succinate metabolic process(GO:0006105)
2.7 10.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
2.6 7.9 GO:1903422 negative regulation of synaptic vesicle recycling(GO:1903422)
2.6 10.5 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
2.6 23.6 GO:0018344 protein geranylgeranylation(GO:0018344)
2.6 41.7 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
2.6 10.3 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.6 10.3 GO:0035720 intraciliary anterograde transport(GO:0035720)
2.5 15.2 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.5 27.7 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
2.5 32.3 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
2.4 7.3 GO:0071109 superior temporal gyrus development(GO:0071109)
2.4 9.8 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
2.4 14.4 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
2.4 14.4 GO:0006499 N-terminal protein myristoylation(GO:0006499)
2.4 7.2 GO:1904526 regulation of microtubule binding(GO:1904526)
2.4 11.9 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
2.4 23.7 GO:0051382 kinetochore assembly(GO:0051382)
2.4 16.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
2.4 4.7 GO:0036034 mediator complex assembly(GO:0036034) regulation of mediator complex assembly(GO:2001176) positive regulation of mediator complex assembly(GO:2001178)
2.3 27.8 GO:0035067 negative regulation of histone acetylation(GO:0035067)
2.3 20.8 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
2.3 6.9 GO:0060295 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
2.3 20.7 GO:0042373 vitamin K metabolic process(GO:0042373)
2.3 20.5 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
2.3 25.0 GO:2000582 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
2.2 98.7 GO:0006414 translational elongation(GO:0006414)
2.2 15.6 GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968)
2.2 17.7 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
2.2 81.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
2.2 6.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
2.2 15.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
2.2 19.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
2.2 41.7 GO:0008228 opsonization(GO:0008228)
2.2 6.6 GO:0033091 positive regulation of immature T cell proliferation(GO:0033091)
2.2 15.3 GO:0000722 telomere maintenance via recombination(GO:0000722)
2.1 36.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
2.1 8.5 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
2.1 12.6 GO:1903800 regulation of Golgi inheritance(GO:0090170) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
2.1 16.7 GO:0015693 magnesium ion transport(GO:0015693)
2.1 24.9 GO:0006379 mRNA cleavage(GO:0006379)
2.1 12.4 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
2.0 14.3 GO:0071763 nuclear membrane organization(GO:0071763)
2.0 236.6 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
2.0 170.2 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
2.0 32.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
2.0 4.0 GO:0061511 centriole elongation(GO:0061511)
2.0 9.9 GO:0035372 protein localization to microtubule(GO:0035372)
2.0 7.9 GO:0051683 establishment of Golgi localization(GO:0051683)
2.0 7.9 GO:0008063 Toll signaling pathway(GO:0008063)
2.0 15.8 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
2.0 35.4 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.9 17.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
1.9 5.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
1.9 11.5 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.9 26.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
1.9 7.6 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
1.9 17.0 GO:0038007 netrin-activated signaling pathway(GO:0038007)
1.9 80.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
1.9 63.4 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
1.8 14.8 GO:0002759 regulation of antimicrobial humoral response(GO:0002759)
1.8 14.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
1.8 7.2 GO:0000103 sulfate assimilation(GO:0000103)
1.8 35.7 GO:0099601 regulation of neurotransmitter receptor activity(GO:0099601)
1.8 7.0 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
1.8 7.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.7 22.7 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
1.7 10.5 GO:0006537 glutamate biosynthetic process(GO:0006537)
1.7 10.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.7 34.3 GO:0051290 protein heterotetramerization(GO:0051290)
1.7 43.6 GO:0045948 positive regulation of translational initiation(GO:0045948)
1.7 16.7 GO:2000772 regulation of cellular senescence(GO:2000772)
1.7 6.7 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
1.7 24.9 GO:0010867 positive regulation of triglyceride biosynthetic process(GO:0010867)
1.7 16.6 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.6 54.3 GO:0048246 macrophage chemotaxis(GO:0048246)
1.6 11.2 GO:0090382 phagosome maturation(GO:0090382)
1.6 42.3 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
1.5 71.9 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
1.5 3.0 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
1.5 25.7 GO:0006378 mRNA polyadenylation(GO:0006378)
1.5 24.0 GO:0097284 hepatocyte apoptotic process(GO:0097284)
1.5 10.5 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.4 18.7 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
1.4 15.8 GO:0006924 activation-induced cell death of T cells(GO:0006924)
1.4 8.5 GO:0007296 vitellogenesis(GO:0007296)
1.4 9.9 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
1.4 59.8 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
1.3 4.0 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
1.3 12.9 GO:0043651 linoleic acid metabolic process(GO:0043651)
1.3 11.6 GO:0046477 glycosylceramide catabolic process(GO:0046477)
1.3 11.5 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
1.3 13.9 GO:0043086 negative regulation of catalytic activity(GO:0043086)
1.3 35.3 GO:0050435 beta-amyloid metabolic process(GO:0050435)
1.3 15.1 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
1.2 18.6 GO:0006750 glutathione biosynthetic process(GO:0006750)
1.2 48.2 GO:2000142 regulation of DNA-templated transcription, initiation(GO:2000142)
1.2 7.4 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
1.2 6.0 GO:1990834 response to odorant(GO:1990834)
1.2 7.2 GO:0010506 regulation of autophagy(GO:0010506)
1.2 1.2 GO:0031929 TOR signaling(GO:0031929) regulation of TOR signaling(GO:0032006)
1.2 36.6 GO:0007019 microtubule depolymerization(GO:0007019)
1.2 88.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.2 15.1 GO:0042113 B cell activation(GO:0042113)
1.1 13.8 GO:0070327 thyroid hormone transport(GO:0070327)
1.1 3.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
1.1 75.6 GO:0032418 lysosome localization(GO:0032418)
1.1 15.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.1 79.9 GO:0070527 platelet aggregation(GO:0070527)
1.1 5.5 GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
1.1 10.9 GO:0030261 chromosome condensation(GO:0030261)
1.1 3.3 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
1.1 46.5 GO:0007062 sister chromatid cohesion(GO:0007062)
1.1 8.6 GO:0030497 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
1.1 15.1 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.1 8.6 GO:0032482 Rab protein signal transduction(GO:0032482)
1.1 58.7 GO:0032465 regulation of cytokinesis(GO:0032465)
1.1 6.4 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
1.1 117.2 GO:0070268 cornification(GO:0070268)
1.1 29.6 GO:0036297 interstrand cross-link repair(GO:0036297)
1.0 114.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
1.0 17.7 GO:0030488 tRNA methylation(GO:0030488)
1.0 20.8 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
1.0 19.6 GO:0051893 regulation of focal adhesion assembly(GO:0051893) regulation of cell-substrate junction assembly(GO:0090109) regulation of adherens junction organization(GO:1903391)
1.0 8.3 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
1.0 10.2 GO:0070828 heterochromatin organization(GO:0070828)
1.0 6.1 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
1.0 56.5 GO:0045454 cell redox homeostasis(GO:0045454)
1.0 10.1 GO:0009650 UV protection(GO:0009650)
1.0 5.0 GO:2000035 regulation of stem cell division(GO:2000035)
1.0 18.9 GO:0031648 protein destabilization(GO:0031648)
1.0 4.9 GO:0075525 viral translational termination-reinitiation(GO:0075525)
1.0 11.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
1.0 10.5 GO:0035561 regulation of chromatin binding(GO:0035561)
1.0 8.6 GO:0031053 primary miRNA processing(GO:0031053)
1.0 15.2 GO:0017145 stem cell division(GO:0017145)
0.9 2.8 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.9 99.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.9 11.2 GO:0030252 growth hormone secretion(GO:0030252)
0.9 10.2 GO:0006903 vesicle targeting(GO:0006903)
0.9 31.3 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.9 7.3 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.9 49.8 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.9 34.1 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.9 7.7 GO:0051351 positive regulation of ligase activity(GO:0051351)
0.8 26.1 GO:0008033 tRNA processing(GO:0008033)
0.8 12.6 GO:0008105 asymmetric protein localization(GO:0008105)
0.8 12.2 GO:0000338 protein deneddylation(GO:0000338)
0.8 5.6 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.8 2.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.8 3.2 GO:1990167 protein K27-linked deubiquitination(GO:1990167)
0.8 3.2 GO:0051138 regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.8 5.5 GO:0051415 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.8 7.7 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.8 3.8 GO:0003070 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.7 8.2 GO:0030335 positive regulation of cell migration(GO:0030335)
0.7 10.3 GO:0072697 protein localization to cell cortex(GO:0072697)
0.7 8.8 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.7 4.2 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.7 16.6 GO:0034383 low-density lipoprotein particle clearance(GO:0034383)
0.7 1.4 GO:0034773 histone H4-K20 methylation(GO:0034770) histone H4-K20 trimethylation(GO:0034773)
0.7 2.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.7 9.3 GO:0044804 nucleophagy(GO:0044804)
0.7 4.6 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.7 21.0 GO:2000249 regulation of actin cytoskeleton reorganization(GO:2000249)
0.7 10.5 GO:0032508 DNA duplex unwinding(GO:0032508)
0.7 2.6 GO:0003340 negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis(GO:0003340)
0.7 38.5 GO:0006364 rRNA processing(GO:0006364) rRNA metabolic process(GO:0016072)