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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ONECUT2_ONECUT3

Z-value: 0.79

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Transcription factors associated with ONECUT2_ONECUT3

Gene Symbol Gene ID Gene Info
ONECUT2
ENSG00000119547.5 one cut homeobox 2
ONECUT3
ENSG00000205922.4 one cut homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ONECUT2hg19_v2_chr18_+_55102917_55102985-0.581.1e-20Click!
ONECUT3hg19_v2_chr19_+_1752372_1752372-0.473.7e-13Click!

Activity profile of ONECUT2_ONECUT3 motif

Sorted Z-values of ONECUT2_ONECUT3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_32384693 20.71 ENST00000602683.1
ENST00000470404.1
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr20_+_36405665 14.36 ENST00000373469.1
CTNNBL1
catenin, beta like 1
chr2_+_102413726 12.99 ENST00000350878.4
MAP4K4
mitogen-activated protein kinase kinase kinase kinase 4
chr1_+_207943667 9.50 ENST00000462968.2
CD46
CD46 molecule, complement regulatory protein
chr1_+_99127225 9.42 ENST00000370189.5
ENST00000529992.1
SNX7
sorting nexin 7
chr3_-_141747439 8.71 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr9_-_139372141 7.83 ENST00000313050.7
SEC16A
SEC16 homolog A (S. cerevisiae)
chr7_-_23510086 7.82 ENST00000258729.3
IGF2BP3
insulin-like growth factor 2 mRNA binding protein 3
chr3_+_159557637 7.13 ENST00000445224.2
SCHIP1
schwannomin interacting protein 1
chr6_+_56954808 7.06 ENST00000510483.1
ENST00000370706.4
ENST00000357489.3
ZNF451
zinc finger protein 451
chr5_-_82969405 6.97 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr11_-_107729887 6.77 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr1_-_26233423 6.46 ENST00000357865.2
STMN1
stathmin 1
chr7_-_26240357 5.98 ENST00000354667.4
ENST00000356674.7
HNRNPA2B1
heterogeneous nuclear ribonucleoprotein A2/B1
chr7_-_104909435 5.98 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr12_-_54653313 5.93 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr18_+_29671812 5.91 ENST00000261593.3
ENST00000578914.1
RNF138
ring finger protein 138, E3 ubiquitin protein ligase
chr1_-_151431647 5.34 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
POGZ
pogo transposable element with ZNF domain
chr4_-_103746683 5.25 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr12_+_32832134 5.06 ENST00000452533.2
DNM1L
dynamin 1-like
chr9_-_70490107 5.02 ENST00000377395.4
ENST00000429800.2
ENST00000430059.2
ENST00000377384.1
ENST00000382405.3
CBWD5
COBW domain containing 5
chr14_-_23426322 5.01 ENST00000555367.1
HAUS4
HAUS augmin-like complex, subunit 4
chr4_-_103747011 5.01 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_-_23426337 4.98 ENST00000342454.8
ENST00000555986.1
ENST00000541587.1
ENST00000554516.1
ENST00000347758.2
ENST00000206474.7
ENST00000555040.1
HAUS4
HAUS augmin-like complex, subunit 4
chr8_+_133787586 4.93 ENST00000395379.1
ENST00000395386.2
ENST00000337920.4
PHF20L1
PHD finger protein 20-like 1
chr9_+_70856397 4.89 ENST00000360171.6
CBWD3
COBW domain containing 3
chrX_-_16887963 4.88 ENST00000380084.4
RBBP7
retinoblastoma binding protein 7
chr19_+_7599128 4.86 ENST00000545201.2
PNPLA6
patatin-like phospholipase domain containing 6
chr2_+_58655461 4.85 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1
long intergenic non-protein coding RNA 1122
chr17_-_79876010 4.80 ENST00000328666.6
SIRT7
sirtuin 7
chr5_+_65440032 4.72 ENST00000334121.6
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr14_-_23426270 4.69 ENST00000557591.1
ENST00000397409.4
ENST00000490506.1
ENST00000554406.1
HAUS4
HAUS augmin-like complex, subunit 4
chr20_-_62587735 4.66 ENST00000354216.6
ENST00000369892.3
ENST00000358711.3
UCKL1
uridine-cytidine kinase 1-like 1
chr12_+_32832203 4.62 ENST00000553257.1
ENST00000549701.1
ENST00000358214.5
ENST00000266481.6
ENST00000551476.1
ENST00000550154.1
ENST00000547312.1
ENST00000414834.2
ENST00000381000.4
ENST00000548750.1
DNM1L
dynamin 1-like
chr2_+_109204909 4.52 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr5_+_138940742 4.45 ENST00000398733.3
ENST00000253815.2
ENST00000505007.1
UBE2D2
ubiquitin-conjugating enzyme E2D 2
chr4_-_103746924 4.45 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr16_-_2013101 4.45 ENST00000526586.2
RPS2
ribosomal protein S2
chr19_+_7598890 4.35 ENST00000221249.6
ENST00000601668.1
ENST00000601001.1
PNPLA6
patatin-like phospholipase domain containing 6
chr1_+_198608146 4.34 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
PTPRC
protein tyrosine phosphatase, receptor type, C
chr1_+_145883868 4.33 ENST00000447947.2
GPR89C
G protein-coupled receptor 89C
chr1_+_144811744 4.21 ENST00000338347.4
ENST00000440491.2
ENST00000375552.4
NBPF9
neuroblastoma breakpoint family, member 9
chr10_-_121296045 4.20 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr11_-_10828892 3.88 ENST00000525681.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr7_-_100239132 3.85 ENST00000223051.3
ENST00000431692.1
TFR2
transferrin receptor 2
chr6_-_79787902 3.64 ENST00000275034.4
PHIP
pleckstrin homology domain interacting protein
chr12_+_6833237 3.61 ENST00000229251.3
ENST00000539735.1
ENST00000538410.1
COPS7A
COP9 signalosome subunit 7A
chr4_-_102268628 3.40 ENST00000323055.6
ENST00000512215.1
ENST00000394854.3
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr8_+_31497271 3.39 ENST00000520407.1
NRG1
neuregulin 1
chr1_-_115259337 3.31 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_-_141747459 3.28 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr1_+_207262881 3.27 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr10_+_95517566 3.00 ENST00000542308.1
LGI1
leucine-rich, glioma inactivated 1
chr5_+_162887556 2.92 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
HMMR
hyaluronan-mediated motility receptor (RHAMM)
chr12_+_4385230 2.90 ENST00000536537.1
CCND2
cyclin D2
chr2_+_109204743 2.75 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr22_-_36220420 2.66 ENST00000473487.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chrX_+_123480194 2.63 ENST00000371139.4
SH2D1A
SH2 domain containing 1A
chr16_-_8962200 2.63 ENST00000562843.1
ENST00000561530.1
ENST00000396593.2
CARHSP1
calcium regulated heat stable protein 1, 24kDa
chr1_-_151431909 2.56 ENST00000361398.3
ENST00000271715.2
POGZ
pogo transposable element with ZNF domain
chr4_-_102268484 2.56 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_24207039 2.52 ENST00000280696.5
THRB
thyroid hormone receptor, beta
chr1_+_207262578 2.50 ENST00000243611.5
ENST00000367076.3
C4BPB
complement component 4 binding protein, beta
chr10_-_127505167 2.32 ENST00000368786.1
UROS
uroporphyrinogen III synthase
chr5_-_146833222 2.25 ENST00000534907.1
DPYSL3
dihydropyrimidinase-like 3
chr1_-_147610081 2.24 ENST00000369226.3
NBPF24
neuroblastoma breakpoint family, member 24
chr1_+_207262627 2.23 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr5_+_147774275 2.22 ENST00000513826.1
FBXO38
F-box protein 38
chr10_+_63661053 2.22 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_+_130650738 2.14 ENST00000504612.1
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr5_-_143550159 2.11 ENST00000448443.2
ENST00000513112.1
ENST00000519064.1
ENST00000274496.5
YIPF5
Yip1 domain family, member 5
chr1_+_207262540 2.08 ENST00000452902.2
C4BPB
complement component 4 binding protein, beta
chr5_-_9630463 2.08 ENST00000382492.2
TAS2R1
taste receptor, type 2, member 1
chr10_+_70980051 1.95 ENST00000354624.5
ENST00000395086.2
HKDC1
hexokinase domain containing 1
chrX_+_46771711 1.92 ENST00000424392.1
ENST00000397189.1
PHF16
jade family PHD finger 3
chr1_-_894620 1.92 ENST00000327044.6
NOC2L
nucleolar complex associated 2 homolog (S. cerevisiae)
chr6_+_37400974 1.90 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr10_+_95517616 1.88 ENST00000371418.4
LGI1
leucine-rich, glioma inactivated 1
chr15_-_37392703 1.87 ENST00000382766.2
ENST00000444725.1
MEIS2
Meis homeobox 2
chr6_+_158733692 1.84 ENST00000367094.2
ENST00000367097.3
TULP4
tubby like protein 4
chrX_+_46771848 1.81 ENST00000218343.4
PHF16
jade family PHD finger 3
chr19_+_13135386 1.80 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr12_+_59989918 1.70 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr15_-_37392086 1.68 ENST00000561208.1
MEIS2
Meis homeobox 2
chr17_-_2304365 1.64 ENST00000575394.1
ENST00000174618.4
MNT
MAX network transcriptional repressor
chr3_+_39424828 1.63 ENST00000273158.4
ENST00000431510.1
SLC25A38
solute carrier family 25, member 38
chr1_-_146068184 1.62 ENST00000604894.1
ENST00000369323.3
ENST00000479926.2
NBPF11
neuroblastoma breakpoint family, member 11
chr12_+_100594557 1.60 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chr2_-_192016316 1.60 ENST00000358470.4
ENST00000432798.1
ENST00000450994.1
STAT4
signal transducer and activator of transcription 4
chr8_-_108510224 1.59 ENST00000517746.1
ENST00000297450.3
ANGPT1
angiopoietin 1
chr3_-_11685345 1.51 ENST00000430365.2
VGLL4
vestigial like 4 (Drosophila)
chr11_-_116658695 1.49 ENST00000429220.1
ENST00000444935.1
ZNF259
zinc finger protein 259
chr10_+_133753533 1.48 ENST00000422256.2
PPP2R2D
protein phosphatase 2, regulatory subunit B, delta
chr9_+_77230499 1.46 ENST00000396204.2
RORB
RAR-related orphan receptor B
chr1_-_159684371 1.44 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr18_+_11752040 1.40 ENST00000423027.3
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chrX_-_64196376 1.37 ENST00000447788.2
ZC4H2
zinc finger, C4H2 domain containing
chr7_+_80231466 1.30 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr7_-_14026063 1.26 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chr19_+_35940486 1.25 ENST00000246549.2
FFAR2
free fatty acid receptor 2
chr16_-_75467318 1.20 ENST00000283882.3
CFDP1
craniofacial development protein 1
chr6_+_114178512 1.20 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr5_-_143550241 1.19 ENST00000522203.1
YIPF5
Yip1 domain family, member 5
chr11_-_116658758 1.16 ENST00000227322.3
ZNF259
zinc finger protein 259
chrX_-_64196351 1.15 ENST00000374839.3
ZC4H2
zinc finger, C4H2 domain containing
chr11_-_60623437 1.09 ENST00000332539.4
PTGDR2
prostaglandin D2 receptor 2
chr10_-_73975657 1.08 ENST00000394919.1
ENST00000526751.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr5_-_146833485 1.03 ENST00000398514.3
DPYSL3
dihydropyrimidinase-like 3
chr4_-_102267953 1.01 ENST00000523694.2
ENST00000507176.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr16_+_25228242 0.99 ENST00000219660.5
AQP8
aquaporin 8
chr12_+_4699244 0.98 ENST00000540757.2
DYRK4
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4
chr17_+_28705921 0.95 ENST00000225719.4
CPD
carboxypeptidase D
chr21_-_15918618 0.84 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr4_+_169418195 0.82 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr10_+_95517660 0.80 ENST00000371413.3
LGI1
leucine-rich, glioma inactivated 1
chr19_+_9361606 0.79 ENST00000456448.1
OR7E24
olfactory receptor, family 7, subfamily E, member 24
chr1_-_116383322 0.78 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr2_-_39348137 0.78 ENST00000426016.1
SOS1
son of sevenless homolog 1 (Drosophila)
chrX_-_64196307 0.77 ENST00000545618.1
ZC4H2
zinc finger, C4H2 domain containing
chr1_-_53686261 0.75 ENST00000294360.4
C1orf123
chromosome 1 open reading frame 123
chr12_+_86268065 0.75 ENST00000551529.1
ENST00000256010.6
NTS
neurotensin
chr10_+_71561649 0.73 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr2_-_55646412 0.73 ENST00000413716.2
CCDC88A
coiled-coil domain containing 88A
chr4_+_187187098 0.72 ENST00000403665.2
ENST00000264692.4
F11
coagulation factor XI
chr3_+_69985734 0.69 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chr14_+_23012122 0.66 ENST00000390534.1
TRAJ3
T cell receptor alpha joining 3
chr12_-_7818474 0.62 ENST00000229304.4
APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr7_-_14026123 0.59 ENST00000420159.2
ENST00000399357.3
ENST00000403527.1
ETV1
ets variant 1
chr5_-_135701164 0.57 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chrX_-_133792480 0.53 ENST00000359237.4
PLAC1
placenta-specific 1
chr14_+_55034599 0.53 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr10_+_71561704 0.51 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr2_+_170440902 0.48 ENST00000448752.2
ENST00000418888.1
ENST00000414307.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr8_+_110098850 0.45 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr17_+_7461613 0.43 ENST00000438470.1
ENST00000436057.1
TNFSF13
tumor necrosis factor (ligand) superfamily, member 13
chr16_-_66952779 0.41 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16
cadherin 16, KSP-cadherin
chr6_+_29068386 0.41 ENST00000377171.3
OR2J1
olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr11_-_118550375 0.39 ENST00000525958.1
ENST00000264029.4
ENST00000397925.1
ENST00000529101.1
TREH
trehalase (brush-border membrane glycoprotein)
chr1_-_46664074 0.31 ENST00000371986.3
ENST00000371984.3
POMGNT1
protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
chr4_-_111563076 0.19 ENST00000354925.2
ENST00000511990.1
PITX2
paired-like homeodomain 2
chr4_-_70518941 0.19 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1
UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr1_-_217262933 0.18 ENST00000359162.2
ESRRG
estrogen-related receptor gamma
chr14_+_37131058 0.16 ENST00000361487.6
PAX9
paired box 9
chr11_-_102651343 0.14 ENST00000279441.4
ENST00000539681.1
MMP10
matrix metallopeptidase 10 (stromelysin 2)
chr4_+_71588372 0.11 ENST00000536664.1
RUFY3
RUN and FYVE domain containing 3
chr4_+_169418255 0.10 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr2_+_170440844 0.09 ENST00000260970.3
ENST00000433207.1
ENST00000409714.3
ENST00000462903.1
PPIG
peptidylprolyl isomerase G (cyclophilin G)
chr3_-_170744498 0.07 ENST00000382808.4
ENST00000314251.3
SLC2A2
solute carrier family 2 (facilitated glucose transporter), member 2
chr8_+_77593474 0.02 ENST00000455469.2
ENST00000050961.6
ZFHX4
zinc finger homeobox 4
chr12_+_41831485 0.01 ENST00000539469.2
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4

Network of associatons between targets according to the STRING database.

First level regulatory network of ONECUT2_ONECUT3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.7 GO:0090149 synaptic vesicle recycling via endosome(GO:0036466) mitochondrial membrane fission(GO:0090149)
2.3 7.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.6 4.8 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
1.3 6.5 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
1.2 6.0 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
1.2 6.0 GO:0035063 nuclear speck organization(GO:0035063)
1.1 10.1 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
1.1 9.5 GO:0045916 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
1.0 4.9 GO:0070370 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
0.9 4.3 GO:0048539 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
0.8 5.9 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.8 2.5 GO:0008050 female courtship behavior(GO:0008050)
0.8 4.7 GO:0044211 CTP salvage(GO:0044211)
0.6 3.9 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.6 7.9 GO:0051382 kinetochore assembly(GO:0051382)
0.6 2.3 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780) uroporphyrinogen III metabolic process(GO:0046502)
0.6 13.0 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.5 3.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.4 2.7 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.4 1.3 GO:0002232 leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.4 1.9 GO:0080009 mRNA methylation(GO:0080009)
0.4 2.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)
0.3 9.2 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.3 2.7 GO:0060633 negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633)
0.3 14.7 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 12.0 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 1.5 GO:0035881 amacrine cell differentiation(GO:0035881)
0.2 4.2 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.2 1.6 GO:0048014 Tie signaling pathway(GO:0048014)
0.2 3.6 GO:0000338 protein deneddylation(GO:0000338)
0.2 1.1 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
0.2 1.3 GO:0072564 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.2 4.5 GO:0051764 actin crosslink formation(GO:0051764)
0.2 3.3 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.2 1.6 GO:0015816 glycine transport(GO:0015816)
0.2 0.7 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 3.6 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.2 7.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.2 20.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.2 1.4 GO:0008228 opsonization(GO:0008228)
0.2 1.9 GO:0002903 negative regulation of B cell apoptotic process(GO:0002903)
0.2 0.8 GO:1904693 midbrain morphogenesis(GO:1904693)
0.2 12.0 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.2 1.1 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 7.8 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.2 2.9 GO:0071481 cellular response to X-ray(GO:0071481)
0.1 1.2 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.1 14.7 GO:0051225 spindle assembly(GO:0051225)
0.1 2.6 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.1 3.3 GO:0072600 establishment of protein localization to Golgi(GO:0072600)
0.1 4.5 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.1 2.9 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.6 GO:0090308 cytidine to uridine editing(GO:0016554) DNA cytosine deamination(GO:0070383) regulation of methylation-dependent chromatin silencing(GO:0090308)
0.1 3.3 GO:0021522 spinal cord motor neuron differentiation(GO:0021522)
0.1 2.1 GO:0007635 chemosensory behavior(GO:0007635)
0.1 1.8 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 1.5 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.1 7.4 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.1 3.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 1.4 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 2.2 GO:0016577 histone demethylation(GO:0016577)
0.1 0.2 GO:0060460 subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung development(GO:0060459) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.1 1.9 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.1 3.9 GO:0010507 negative regulation of autophagy(GO:0010507)
0.1 3.6 GO:0008542 visual learning(GO:0008542)
0.0 0.8 GO:0002820 negative regulation of adaptive immune response(GO:0002820)
0.0 0.9 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.5 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 1.0 GO:0006833 water transport(GO:0006833)
0.0 0.4 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 4.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:0005984 disaccharide metabolic process(GO:0005984) oligosaccharide catabolic process(GO:0009313)
0.0 0.6 GO:0006828 manganese ion transport(GO:0006828)
0.0 4.6 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 1.0 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 1.6 GO:0007569 cell aging(GO:0007569)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.9 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.0 4.6 GO:0016050 vesicle organization(GO:0016050)
0.0 2.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 5.0 GO:0001501 skeletal system development(GO:0001501)
0.0 2.2 GO:0010976 positive regulation of neuron projection development(GO:0010976)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0002079 inner acrosomal membrane(GO:0002079)
1.6 14.7 GO:0070652 HAUS complex(GO:0070652)
0.8 7.0 GO:0005955 calcineurin complex(GO:0005955)
0.7 14.4 GO:0000974 Prp19 complex(GO:0000974)
0.6 1.9 GO:0030689 Noc complex(GO:0030689)
0.5 2.9 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.4 5.9 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.3 3.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 1.0 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
0.2 5.9 GO:0035861 site of double-strand break(GO:0035861)
0.2 4.9 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 3.9 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 1.9 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 9.7 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 10.1 GO:0044216 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.1 1.2 GO:0043073 germ cell nucleus(GO:0043073)
0.1 5.2 GO:0015030 Cajal body(GO:0015030)
0.1 3.6 GO:0008180 COP9 signalosome(GO:0008180)
0.1 4.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.3 GO:0031941 filamentous actin(GO:0031941)
0.0 14.7 GO:0010008 endosome membrane(GO:0010008)
0.0 15.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 1.3 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.3 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.0 3.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 14.9 GO:0005769 early endosome(GO:0005769)
0.0 6.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.1 GO:0030673 axolemma(GO:0030673)
0.0 9.6 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 6.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.0 1.0 GO:0045177 apical part of cell(GO:0045177)
0.0 4.2 GO:0043197 dendritic spine(GO:0043197) neuron spine(GO:0044309)
0.0 1.6 GO:0005902 microvillus(GO:0005902)
0.0 4.7 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 11.6 GO:0005925 focal adhesion(GO:0005925)
0.0 1.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 4.5 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 6.5 GO:0005874 microtubule(GO:0005874)
0.0 2.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 2.9 GO:0030054 cell junction(GO:0030054)
0.0 7.0 GO:0000139 Golgi membrane(GO:0000139)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 20.7 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
1.6 13.0 GO:0004111 creatine kinase activity(GO:0004111)
1.6 4.8 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
1.0 3.9 GO:0004998 transferrin receptor activity(GO:0004998)
0.7 7.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.7 4.7 GO:0004849 uridine kinase activity(GO:0004849)
0.7 6.0 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 2.7 GO:0061665 SUMO ligase activity(GO:0061665)
0.5 9.7 GO:0051400 BH domain binding(GO:0051400)
0.4 3.3 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.4 1.9 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.4 1.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.3 3.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.3 9.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.3 9.2 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 15.1 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.3 10.6 GO:0001848 complement binding(GO:0001848)
0.3 1.6 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.3 2.5 GO:0070324 thyroid hormone binding(GO:0070324)
0.2 1.9 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 7.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 1.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.2 2.1 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 6.0 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 5.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 4.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 4.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 4.4 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 0.3 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity(GO:0047223)
0.1 3.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 4.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.1 0.6 GO:0004126 cytidine deaminase activity(GO:0004126)
0.1 6.1 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 2.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 1.7 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 2.2 GO:0032452 histone demethylase activity(GO:0032452)
0.1 0.7 GO:0043422 protein kinase B binding(GO:0043422)
0.1 1.0 GO:0015250 water channel activity(GO:0015250)
0.1 3.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 0.6 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 1.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.9 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.0 2.6 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.8 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 7.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 12.1 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 1.2 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.5 GO:0030371 translation repressor activity(GO:0030371)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 1.6 GO:0016836 hydro-lyase activity(GO:0016836)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 1.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.0 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 10.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 6.5 GO:0015631 tubulin binding(GO:0015631)
0.0 0.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 3.3 GO:0003924 GTPase activity(GO:0003924)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 20.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.4 6.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 14.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.2 15.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.2 4.8 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 17.9 PID E2F PATHWAY E2F transcription factor network
0.2 8.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 9.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 5.2 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 3.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 7.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.3 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.1 2.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 4.9 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.4 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 2.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 1.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.6 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 4.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 19.6 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.5 19.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 7.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 3.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 4.2 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.2 4.3 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 2.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.1 1.4 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.1 7.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 3.3 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 1.4 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 2.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 4.9 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 8.4 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 1.6 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.1 1.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 4.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.9 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 7.8 REACTOME DIABETES PATHWAYS Genes involved in Diabetes pathways
0.0 3.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 3.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 5.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 6.0 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.4 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 1.3 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.0 5.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.6 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.0 1.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis