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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Z-value: 0.85

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Transcription factors associated with OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

Gene Symbol Gene ID Gene Info
OTP
ENSG00000171540.6 orthopedia homeobox
PHOX2B
ENSG00000109132.5 paired like homeobox 2B
LHX1
ENSG00000132130.7 LIM homeobox 1
LMX1A
ENSG00000162761.10 LIM homeobox transcription factor 1 alpha
LHX5
ENSG00000089116.3 LIM homeobox 5
HOXC4
ENSG00000198353.6 homeobox C4
HOXC4
ENSG00000273266.1 homeobox C4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
LHX5hg19_v2_chr12_-_113909877_1139098770.187.2e-03Click!
PHOX2Bhg19_v2_chr4_-_41750922_417509870.152.3e-02Click!
HOXC4hg19_v2_chr12_+_54447637_54447661-0.045.9e-01Click!
LHX1hg19_v2_chr17_+_35294075_35294102-0.037.1e-01Click!

Activity profile of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Sorted Z-values of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_327537 18.14 ENST00000602735.1
IFITM3
interferon induced transmembrane protein 3
chr17_+_1674982 17.99 ENST00000572048.1
ENST00000573763.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr19_+_50016610 17.42 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_50016411 13.59 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr4_+_169418195 11.94 ENST00000261509.6
ENST00000335742.7
PALLD
palladin, cytoskeletal associated protein
chr9_+_125132803 9.59 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr9_+_125133315 6.67 ENST00000223423.4
ENST00000362012.2
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr2_-_89327228 6.65 ENST00000483158.1
IGKV3-11
immunoglobulin kappa variable 3-11
chr1_-_92952433 6.61 ENST00000294702.5
GFI1
growth factor independent 1 transcription repressor
chr18_-_47018769 6.47 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr18_-_47018869 6.24 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr10_+_94451574 6.18 ENST00000492654.2
HHEX
hematopoietically expressed homeobox
chr2_+_90077680 6.12 ENST00000390270.2
IGKV3D-20
immunoglobulin kappa variable 3D-20
chr11_+_5710919 6.10 ENST00000379965.3
ENST00000425490.1
TRIM22
tripartite motif containing 22
chr11_+_114168085 6.09 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chrX_+_43515467 6.05 ENST00000338702.3
ENST00000542639.1
MAOA
monoamine oxidase A
chr2_+_90273679 6.01 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr12_-_10022735 5.93 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr18_-_47018897 5.59 ENST00000418495.1
RPL17
ribosomal protein L17
chr12_+_4385230 5.25 ENST00000536537.1
CCND2
cyclin D2
chr3_+_157154578 5.23 ENST00000295927.3
PTX3
pentraxin 3, long
chr6_+_26440700 5.20 ENST00000494393.1
ENST00000482451.1
ENST00000244519.2
ENST00000339789.4
ENST00000471353.1
ENST00000361232.3
ENST00000487627.1
ENST00000496719.1
ENST00000490254.1
ENST00000487272.1
BTN3A3
butyrophilin, subfamily 3, member A3
chr1_-_92371839 5.19 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chrX_+_1710484 5.01 ENST00000313871.3
ENST00000381261.3
AKAP17A
A kinase (PRKA) anchor protein 17A
chr2_-_89385283 4.84 ENST00000390252.2
IGKV3-15
immunoglobulin kappa variable 3-15
chr9_-_99540328 4.79 ENST00000223428.4
ENST00000375231.1
ENST00000374641.3
ZNF510
zinc finger protein 510
chr2_+_90211643 4.72 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr2_+_103089756 4.71 ENST00000295269.4
SLC9A4
solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4
chr8_-_90769422 4.52 ENST00000524190.1
ENST00000523859.1
RP11-37B2.1
RP11-37B2.1
chr6_+_26402465 4.27 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr7_-_150020578 4.12 ENST00000478393.1
ACTR3C
ARP3 actin-related protein 3 homolog C (yeast)
chr12_-_7655329 4.11 ENST00000541972.1
CD163
CD163 molecule
chr10_-_28571015 4.10 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr16_+_28565230 3.70 ENST00000317058.3
CCDC101
coiled-coil domain containing 101
chr5_+_66300446 3.66 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr15_-_20193370 3.59 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr16_-_28937027 3.51 ENST00000358201.4
RABEP2
rabaptin, RAB GTPase binding effector protein 2
chr2_+_68961934 3.39 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr12_-_15114603 3.31 ENST00000228945.4
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_+_68961905 3.29 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr7_+_150020363 3.15 ENST00000359623.4
ENST00000493307.1
LRRC61
leucine rich repeat containing 61
chr7_+_150020329 3.13 ENST00000323078.7
LRRC61
leucine rich repeat containing 61
chr6_-_32157947 3.04 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr7_+_134528635 3.00 ENST00000445569.2
CALD1
caldesmon 1
chr12_-_15114492 2.81 ENST00000541546.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr12_+_26348582 2.71 ENST00000535504.1
SSPN
sarcospan
chr7_+_115862858 2.67 ENST00000393481.2
TES
testis derived transcript (3 LIM domains)
chr2_+_152214098 2.64 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr6_-_144385698 2.59 ENST00000444202.1
ENST00000437412.1
PLAGL1
pleiomorphic adenoma gene-like 1
chr4_+_169418255 2.50 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr12_-_10282836 2.46 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr3_-_141747950 2.46 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_+_45927994 2.46 ENST00000357632.2
ENST00000395963.2
CCR9
chemokine (C-C motif) receptor 9
chr12_+_75784850 2.36 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr12_+_104337515 2.32 ENST00000550595.1
HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_-_153518270 2.21 ENST00000354332.4
ENST00000368716.4
S100A4
S100 calcium binding protein A4
chr4_-_185275104 2.12 ENST00000317596.3
RP11-290F5.2
RP11-290F5.2
chr2_-_241497390 2.07 ENST00000272972.3
ENST00000401804.1
ENST00000361678.4
ENST00000405523.3
ANKMY1
ankyrin repeat and MYND domain containing 1
chr2_-_241497374 2.02 ENST00000373318.2
ENST00000406958.1
ENST00000391987.1
ENST00000373320.4
ANKMY1
ankyrin repeat and MYND domain containing 1
chr4_+_155484155 1.93 ENST00000509493.1
FGB
fibrinogen beta chain
chr19_-_14064114 1.88 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
PODNL1
podocan-like 1
chr7_-_144435985 1.81 ENST00000549981.1
TPK1
thiamin pyrophosphokinase 1
chr19_+_54466179 1.79 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr6_+_42584847 1.77 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr2_+_68962014 1.70 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr14_-_51027838 1.65 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5
chr2_-_136678123 1.63 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr13_-_38172863 1.62 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
POSTN
periostin, osteoblast specific factor
chr7_-_87342564 1.60 ENST00000265724.3
ENST00000416177.1
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr12_+_59989918 1.57 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr4_+_155484103 1.57 ENST00000302068.4
FGB
fibrinogen beta chain
chr12_+_26348246 1.57 ENST00000422622.2
SSPN
sarcospan
chr2_-_25391507 1.54 ENST00000380794.1
POMC
proopiomelanocortin
chr7_-_38305279 1.53 ENST00000443402.2
TRGC1
T cell receptor gamma constant 1
chr16_-_28634874 1.52 ENST00000395609.1
ENST00000350842.4
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr7_+_102553430 1.49 ENST00000339431.4
ENST00000249377.4
LRRC17
leucine rich repeat containing 17
chr12_+_25205666 1.45 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr2_-_25391772 1.39 ENST00000405623.1
POMC
proopiomelanocortin
chr12_-_9913489 1.35 ENST00000228434.3
ENST00000536709.1
CD69
CD69 molecule
chr13_-_99910673 1.32 ENST00000397473.2
ENST00000397470.2
GPR18
G protein-coupled receptor 18
chr3_-_114477787 1.31 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr17_-_53800217 1.27 ENST00000424486.2
TMEM100
transmembrane protein 100
chr2_-_25391468 1.27 ENST00000395826.2
POMC
proopiomelanocortin
chr15_+_75970672 1.26 ENST00000435356.1
AC105020.1
Uncharacterized protein; cDNA FLJ12988 fis, clone NT2RP3000080
chrX_-_100872911 1.26 ENST00000361910.4
ENST00000539247.1
ENST00000538627.1
ARMCX6
armadillo repeat containing, X-linked 6
chr3_-_114477962 1.24 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr20_-_18477862 1.22 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr15_+_64680003 1.22 ENST00000261884.3
TRIP4
thyroid hormone receptor interactor 4
chr12_-_112123524 1.21 ENST00000327551.6
BRAP
BRCA1 associated protein
chr6_+_114178512 1.18 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr2_-_25391425 1.14 ENST00000264708.3
ENST00000449220.1
POMC
proopiomelanocortin
chr12_-_22063787 1.14 ENST00000544039.1
ABCC9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
chr2_-_163008903 1.10 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr16_+_31271274 1.09 ENST00000287497.8
ENST00000544665.3
ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr10_-_75415825 1.04 ENST00000394810.2
SYNPO2L
synaptopodin 2-like
chr7_-_107642348 1.03 ENST00000393561.1
LAMB1
laminin, beta 1
chr6_+_26365443 1.00 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2
chr5_+_81575281 0.99 ENST00000380167.4
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr6_+_26402517 0.97 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chrX_+_107288239 0.95 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr14_+_55595762 0.95 ENST00000254301.9
LGALS3
lectin, galactoside-binding, soluble, 3
chr4_-_120243545 0.94 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr19_-_58326267 0.93 ENST00000391701.1
ZNF552
zinc finger protein 552
chr7_-_140482926 0.91 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr1_-_211307404 0.87 ENST00000367007.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr13_+_53602894 0.86 ENST00000219022.2
OLFM4
olfactomedin 4
chrX_-_18690210 0.85 ENST00000379984.3
RS1
retinoschisin 1
chr12_+_26348429 0.85 ENST00000242729.2
SSPN
sarcospan
chr17_+_74463650 0.84 ENST00000392492.3
AANAT
aralkylamine N-acetyltransferase
chr15_+_93443419 0.81 ENST00000557381.1
ENST00000420239.2
CHD2
chromodomain helicase DNA binding protein 2
chr2_-_79386786 0.80 ENST00000393878.1
ENST00000305165.2
ENST00000409839.3
REG3A
regenerating islet-derived 3 alpha
chr4_+_80584903 0.75 ENST00000506460.1
RP11-452C8.1
RP11-452C8.1
chr2_+_234826016 0.75 ENST00000324695.4
ENST00000433712.2
TRPM8
transient receptor potential cation channel, subfamily M, member 8
chr8_-_86253888 0.74 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr1_+_157963063 0.73 ENST00000360089.4
ENST00000368173.3
ENST00000392272.2
KIRREL
kin of IRRE like (Drosophila)
chr20_+_55904815 0.72 ENST00000371263.3
ENST00000345868.4
ENST00000371260.4
ENST00000418127.1
SPO11
SPO11 meiotic protein covalently bound to DSB
chr14_+_103851712 0.72 ENST00000440884.3
ENST00000416682.2
ENST00000429436.2
ENST00000303622.9
MARK3
MAP/microtubule affinity-regulating kinase 3
chr19_+_48949030 0.72 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr6_-_29527702 0.71 ENST00000377050.4
UBD
ubiquitin D
chr19_+_21264980 0.71 ENST00000596053.1
ENST00000597086.1
ENST00000596143.1
ENST00000596367.1
ENST00000601416.1
ZNF714
zinc finger protein 714
chr9_+_34652164 0.68 ENST00000441545.2
ENST00000553620.1
IL11RA
interleukin 11 receptor, alpha
chr18_-_53177984 0.67 ENST00000543082.1
TCF4
transcription factor 4
chr19_+_21324827 0.66 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431
zinc finger protein 431
chr17_-_64225508 0.64 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr17_-_39093672 0.64 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr9_-_77567743 0.63 ENST00000376854.5
C9orf40
chromosome 9 open reading frame 40
chr18_-_52989217 0.63 ENST00000570287.2
TCF4
transcription factor 4
chr14_-_106552755 0.63 ENST00000390600.2
IGHV3-9
immunoglobulin heavy variable 3-9
chr18_-_51750948 0.62 ENST00000583046.1
ENST00000398398.2
MBD2
methyl-CpG binding domain protein 2
chr20_-_33735070 0.57 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr16_-_66583701 0.55 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
TK2
thymidine kinase 2, mitochondrial
chr6_-_10838736 0.54 ENST00000536370.1
ENST00000474039.1
MAK
male germ cell-associated kinase
chr22_+_40297079 0.53 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr5_-_70316737 0.53 ENST00000194097.4
NAIP
NLR family, apoptosis inhibitory protein
chr4_-_170948361 0.52 ENST00000393702.3
MFAP3L
microfibrillar-associated protein 3-like
chr6_-_10838710 0.52 ENST00000313243.2
MAK
male germ cell-associated kinase
chr1_+_180601139 0.52 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr22_+_40297105 0.51 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr10_-_102989551 0.51 ENST00000370193.2
LBX1
ladybird homeobox 1
chr16_-_66584059 0.50 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
TK2
thymidine kinase 2, mitochondrial
chrX_+_77166172 0.50 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr14_-_106668095 0.49 ENST00000390606.2
IGHV3-20
immunoglobulin heavy variable 3-20
chrX_+_47696275 0.49 ENST00000376954.1
ENST00000338637.7
ZNF81
zinc finger protein 81
chr16_+_12059091 0.47 ENST00000562385.1
TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr1_-_57045228 0.45 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr18_-_51751132 0.45 ENST00000256429.3
MBD2
methyl-CpG binding domain protein 2
chr5_-_149829244 0.45 ENST00000312037.5
RPS14
ribosomal protein S14
chr7_-_102283238 0.44 ENST00000340457.8
UPK3BL
uroplakin 3B-like
chr4_-_39979576 0.43 ENST00000303538.8
ENST00000503396.1
PDS5A
PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr10_-_115904361 0.43 ENST00000428953.1
ENST00000543782.1
C10orf118
chromosome 10 open reading frame 118
chr3_+_12329397 0.43 ENST00000397015.2
PPARG
peroxisome proliferator-activated receptor gamma
chr8_-_57123815 0.43 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr1_+_168250194 0.43 ENST00000367821.3
TBX19
T-box 19
chr6_-_7313381 0.42 ENST00000489567.1
ENST00000479365.1
ENST00000462112.1
ENST00000397511.2
ENST00000534851.1
ENST00000474597.1
ENST00000244763.4
SSR1
signal sequence receptor, alpha
chr18_-_52989525 0.39 ENST00000457482.3
TCF4
transcription factor 4
chr17_-_72772462 0.39 ENST00000582870.1
ENST00000581136.1
ENST00000357814.3
ENST00000579218.1
ENST00000583476.1
ENST00000580301.1
ENST00000583757.1
ENST00000582524.1
NAT9
N-acetyltransferase 9 (GCN5-related, putative)
chr19_+_23945768 0.38 ENST00000486528.1
ENST00000496398.1
RPSAP58
ribosomal protein SA pseudogene 58
chrX_+_55744228 0.37 ENST00000262850.7
RRAGB
Ras-related GTP binding B
chr13_-_36050819 0.36 ENST00000379919.4
MAB21L1
mab-21-like 1 (C. elegans)
chr9_+_90112590 0.36 ENST00000472284.1
DAPK1
death-associated protein kinase 1
chr20_-_56265680 0.35 ENST00000414037.1
PMEPA1
prostate transmembrane protein, androgen induced 1
chr2_+_109237717 0.34 ENST00000409441.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr8_+_121137333 0.33 ENST00000309791.4
ENST00000297848.3
ENST00000247781.3
COL14A1
collagen, type XIV, alpha 1
chrX_+_107288197 0.33 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr10_-_105845674 0.33 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr3_+_149191723 0.33 ENST00000305354.4
TM4SF4
transmembrane 4 L six family member 4
chr6_-_112115074 0.32 ENST00000368667.2
FYN
FYN oncogene related to SRC, FGR, YES
chr5_+_95066823 0.32 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr4_-_119759795 0.32 ENST00000419654.2
SEC24D
SEC24 family member D
chr2_+_102953608 0.30 ENST00000311734.2
ENST00000409584.1
IL1RL1
interleukin 1 receptor-like 1
chr3_+_39424828 0.30 ENST00000273158.4
ENST00000431510.1
SLC25A38
solute carrier family 25, member 38
chr4_-_122854612 0.30 ENST00000264811.5
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr8_-_49833978 0.30 ENST00000020945.1
SNAI2
snail family zinc finger 2
chr12_+_122688090 0.29 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr3_-_141719195 0.29 ENST00000397991.4
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr3_+_12329358 0.29 ENST00000309576.6
PPARG
peroxisome proliferator-activated receptor gamma
chr21_-_31538971 0.29 ENST00000286808.3
CLDN17
claudin 17
chr14_+_102276192 0.28 ENST00000557714.1
PPP2R5C
protein phosphatase 2, regulatory subunit B', gamma
chr6_-_109702885 0.28 ENST00000504373.1
CD164
CD164 molecule, sialomucin
chr4_-_76944621 0.26 ENST00000306602.1
CXCL10
chemokine (C-X-C motif) ligand 10
chr3_+_141106643 0.26 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr16_-_30122717 0.26 ENST00000566613.1
GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr12_-_117319236 0.26 ENST00000257572.5
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr12_-_117318788 0.25 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr7_-_22862448 0.25 ENST00000358435.4
TOMM7
translocase of outer mitochondrial membrane 7 homolog (yeast)
chr3_-_99569821 0.21 ENST00000487087.1
FILIP1L
filamin A interacting protein 1-like
chr1_+_81771806 0.20 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
LPHN2
latrophilin 2
chr19_-_19887185 0.20 ENST00000590092.1
ENST00000589910.1
ENST00000589508.1
ENST00000586645.1
ENST00000586816.1
ENST00000588223.1
ENST00000586885.1
LINC00663
long intergenic non-protein coding RNA 663
chr9_+_90112767 0.20 ENST00000408954.3
DAPK1
death-associated protein kinase 1
chr6_+_25754927 0.20 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr5_-_88119580 0.19 ENST00000539796.1
MEF2C
myocyte enhancer factor 2C
chr4_+_5527117 0.19 ENST00000505296.1
C4orf6
chromosome 4 open reading frame 6
chr12_-_25348007 0.17 ENST00000354189.5
ENST00000545133.1
ENST00000554347.1
ENST00000395987.3
ENST00000320267.9
ENST00000395990.2
ENST00000537577.1
CASC1
cancer susceptibility candidate 1
chr9_-_26947453 0.17 ENST00000397292.3
PLAA
phospholipase A2-activating protein
chr7_+_138145076 0.16 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr6_-_133035185 0.16 ENST00000367928.4
VNN1
vanin 1
chr8_-_49834299 0.16 ENST00000396822.1
SNAI2
snail family zinc finger 2
chr2_+_102615416 0.15 ENST00000393414.2
IL1R2
interleukin 1 receptor, type II
chr4_-_39033963 0.15 ENST00000381938.3
TMEM156
transmembrane protein 156
chr1_-_114414316 0.14 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Network of associatons between targets according to the STRING database.

First level regulatory network of OTP_PHOX2B_LHX1_LMX1A_LHX5_HOXC4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.4 31.0 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
3.7 18.5 GO:0071279 cellular response to cobalt ion(GO:0071279)
2.2 6.6 GO:0070105 positive regulation of interleukin-6-mediated signaling pathway(GO:0070105)
2.1 6.2 GO:0010621 negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
1.7 5.2 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
1.5 6.1 GO:0071461 cellular response to redox state(GO:0071461)
1.0 5.2 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.9 16.3 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.7 18.1 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.7 5.3 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.6 14.4 GO:0003334 keratinocyte development(GO:0003334)
0.6 6.1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.6 4.1 GO:0071896 protein localization to adherens junction(GO:0071896)
0.5 1.6 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.5 1.6 GO:1990523 bone regeneration(GO:1990523)
0.5 1.8 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.4 6.1 GO:0042420 dopamine catabolic process(GO:0042420)
0.4 3.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 3.8 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.3 0.9 GO:2000521 negative regulation of immunological synapse formation(GO:2000521)
0.3 1.5 GO:0048539 bone marrow development(GO:0048539)
0.3 1.8 GO:0071233 cellular response to leucine(GO:0071233)
0.3 4.7 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 0.9 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.3 0.8 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.3 5.3 GO:0071481 cellular response to X-ray(GO:0071481)
0.3 1.1 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.3 1.0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.3 6.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.2 1.6 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.2 1.6 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.2 0.6 GO:0036511 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 0.9 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.2 1.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.2 0.7 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.2 2.3 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)
0.2 0.5 GO:1990253 cellular response to leucine starvation(GO:1990253)
0.2 1.1 GO:1902856 negative regulation of nonmotile primary cilium assembly(GO:1902856)
0.2 0.5 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.1 0.7 GO:0050955 thermoception(GO:0050955)
0.1 22.2 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 0.7 GO:0070842 aggresome assembly(GO:0070842)
0.1 2.6 GO:0006910 phagocytosis, recognition(GO:0006910) carbohydrate mediated signaling(GO:0009756)
0.1 0.9 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.1 0.9 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 0.7 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 18.8 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 6.1 GO:0070206 protein trimerization(GO:0070206)
0.1 0.6 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.1 0.8 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 0.3 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 3.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.1 2.6 GO:0030728 ovulation(GO:0030728)
0.1 2.0 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.1 4.1 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 1.1 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.1 0.5 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.5 GO:0051923 sulfation(GO:0051923)
0.1 1.1 GO:0006346 methylation-dependent chromatin silencing(GO:0006346)
0.1 0.9 GO:0009642 response to light intensity(GO:0009642)
0.1 0.4 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.1 0.7 GO:0045141 meiotic telomere clustering(GO:0045141) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.1 2.8 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 1.3 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.1 0.5 GO:0048664 neuron fate determination(GO:0048664)
0.1 9.8 GO:0002377 immunoglobulin production(GO:0002377)
0.1 0.3 GO:0002826 negative regulation of T-helper 1 type immune response(GO:0002826)
0.1 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 4.9 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 1.2 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.3 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.0 0.3 GO:0010615 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.0 3.2 GO:0006953 acute-phase response(GO:0006953)
0.0 0.6 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.1 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.0 0.5 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.0 2.5 GO:0032760 positive regulation of interleukin-6 production(GO:0032755) positive regulation of tumor necrosis factor production(GO:0032760)
0.0 0.3 GO:0015816 glycine transport(GO:0015816)
0.0 0.1 GO:0050712 negative regulation of interleukin-1 alpha production(GO:0032690) negative regulation of interleukin-1 alpha secretion(GO:0050712)
0.0 1.2 GO:0007265 Ras protein signal transduction(GO:0007265)
0.0 0.7 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 2.6 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977) signal transduction involved in mitotic G1 DNA damage checkpoint(GO:0072431) intracellular signal transduction involved in G1 DNA damage checkpoint(GO:1902400)
0.0 0.2 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.0 0.3 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 1.9 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0 5.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.5 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0 1.1 GO:0010107 potassium ion import(GO:0010107)
0.0 1.0 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 0.1 GO:0002428 antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476)
0.0 0.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.4 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.0 1.2 GO:1901998 toxin transport(GO:1901998)
0.0 1.2 GO:0042127 regulation of cell proliferation(GO:0042127)
0.0 1.4 GO:0035690 cellular response to drug(GO:0035690)
0.0 1.8 GO:0031295 T cell costimulation(GO:0031295)
0.0 0.1 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.0 0.3 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 0.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.7 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 0.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 0.7 GO:0007566 embryo implantation(GO:0007566)
0.0 1.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.0 0.1 GO:0035878 nail development(GO:0035878)
0.0 0.1 GO:0032218 riboflavin transport(GO:0032218)
0.0 0.1 GO:0071798 response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0 0.2 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 18.0 GO:0043203 axon hillock(GO:0043203)
1.3 5.2 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.9 5.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.4 1.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.3 1.0 GO:0005607 laminin-2 complex(GO:0005607)
0.3 4.1 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.3 3.0 GO:0030478 actin cap(GO:0030478)
0.3 3.5 GO:0005577 fibrinogen complex(GO:0005577)
0.3 14.4 GO:0002102 podosome(GO:0002102)
0.2 4.1 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 1.1 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.2 17.3 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 5.1 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 16.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 18.1 GO:0031902 late endosome membrane(GO:0031902)
0.1 2.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 8.7 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 5.8 GO:0015030 Cajal body(GO:0015030)
0.1 4.1 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.5 GO:0034448 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 1.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.0 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 11.6 GO:0072562 blood microparticle(GO:0072562)
0.1 1.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 0.9 GO:0043073 germ cell nucleus(GO:0043073)
0.0 0.6 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.3 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 7.6 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.2 GO:0005726 perichromatin fibrils(GO:0005726)
0.0 5.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.6 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 1.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 5.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.1 GO:0016363 nuclear matrix(GO:0016363)
0.0 3.5 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 3.2 GO:0043204 perikaryon(GO:0043204)
0.0 27.0 GO:0005615 extracellular space(GO:0005615)
0.0 0.3 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 1.0 GO:0030018 Z disc(GO:0030018)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 3.7 GO:0016324 apical plasma membrane(GO:0016324)
0.0 0.6 GO:0015629 actin cytoskeleton(GO:0015629)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 31.0 GO:0019770 IgG receptor activity(GO:0019770)
4.1 16.3 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
1.5 6.1 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
1.3 5.3 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.8 6.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.7 7.5 GO:0046790 virion binding(GO:0046790)
0.6 14.4 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.6 6.1 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.5 5.2 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.5 4.7 GO:0015386 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.4 6.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 1.6 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.4 1.8 GO:0070728 leucine binding(GO:0070728)
0.4 1.1 GO:0004797 thymidine kinase activity(GO:0004797)
0.3 1.6 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.3 1.6 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.2 0.7 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.2 1.8 GO:0016778 diphosphotransferase activity(GO:0016778)
0.2 1.5 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.2 0.8 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.2 0.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 16.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.9 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.1 2.5 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.1 31.0 GO:0003823 antigen binding(GO:0003823)
0.1 1.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.6 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.1 0.9 GO:0019863 IgE binding(GO:0019863)
0.1 2.2 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 1.1 GO:0001851 complement component C3b binding(GO:0001851)
0.1 3.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.1 GO:0003696 satellite DNA binding(GO:0003696)
0.1 0.3 GO:0002113 interleukin-33 binding(GO:0002113)
0.1 0.3 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 2.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1 0.7 GO:0004064 arylesterase activity(GO:0004064)
0.1 0.7 GO:0050692 DBD domain binding(GO:0050692)
0.1 4.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.9 GO:0070492 phosphatidylinositol-5-phosphate binding(GO:0010314) oligosaccharide binding(GO:0070492)
0.1 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.4 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.1 3.9 GO:0051018 protein kinase A binding(GO:0051018)
0.1 13.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.3 GO:0042610 CD8 receptor binding(GO:0042610)
0.1 0.3 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 0.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.0 0.3 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.0 8.5 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 1.2 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.1 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.0 0.9 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.0 4.1 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.7 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 1.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0004958 prostaglandin F receptor activity(GO:0004958)
0.0 0.2 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 3.5 GO:0051087 chaperone binding(GO:0051087)
0.0 1.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.1 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 0.1 GO:0046978 peptide antigen-transporting ATPase activity(GO:0015433) TAP binding(GO:0046977) TAP1 binding(GO:0046978)
0.0 0.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 1.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.9 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 4.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.3 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
0.0 5.6 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 3.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 8.7 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.1 GO:0032217 riboflavin transporter activity(GO:0032217)
0.0 5.8 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 1.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.1 GO:0030280 structural constituent of epidermis(GO:0030280)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.7 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 5.2 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1 5.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 4.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 6.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 0.9 ST G ALPHA S PATHWAY G alpha s Pathway
0.1 0.7 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 1.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 15.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 10.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 6.6 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 4.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 1.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 2.6 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.2 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 0.7 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 1.6 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.6 PID IFNG PATHWAY IFN-gamma pathway
0.0 3.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.5 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.8 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.3 PID CXCR3 PATHWAY CXCR3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.3 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.3 6.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 3.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.2 15.8 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.2 16.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 2.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.2 1.7 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 18.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 1.2 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 1.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 0.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.1 14.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 4.8 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 7.0 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 0.9 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling
0.0 0.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 3.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.6 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 2.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.0 0.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.0 4.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.6 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.8 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.1 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.0 1.4 REACTOME CD28 CO STIMULATION Genes involved in CD28 co-stimulation
0.0 0.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.0 1.1 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 0.4 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.5 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.3 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.6 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.2 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 3.9 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway