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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PAX3

Z-value: 1.37

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Transcription factors associated with PAX3

Gene Symbol Gene ID Gene Info
PAX3
ENSG00000135903.14 paired box 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PAX3hg19_v2_chr2_-_223163465_2231637300.252.1e-04Click!

Activity profile of PAX3 motif

Sorted Z-values of PAX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_44258360 50.17 ENST00000330884.4
ENST00000249130.5
SULT4A1
sulfotransferase family 4A, member 1
chrX_+_38420783 47.37 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chrX_+_38420623 41.84 ENST00000378482.2
TSPAN7
tetraspanin 7
chr11_+_73358594 27.60 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chrX_-_13835461 24.28 ENST00000316715.4
ENST00000356942.5
GPM6B
glycoprotein M6B
chr1_+_50513686 20.66 ENST00000448907.2
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr3_-_58572760 19.04 ENST00000447756.2
FAM107A
family with sequence similarity 107, member A
chr15_+_99791567 18.34 ENST00000558879.1
ENST00000301981.3
ENST00000422500.2
ENST00000447360.2
ENST00000442993.2
LRRC28
leucine rich repeat containing 28
chr1_+_99729813 15.84 ENST00000457765.1
LPPR4
Lipid phosphate phosphatase-related protein type 4
chr9_-_91793675 15.38 ENST00000375835.4
ENST00000375830.1
SHC3
SHC (Src homology 2 domain containing) transforming protein 3
chr16_+_23847339 13.64 ENST00000303531.7
PRKCB
protein kinase C, beta
chr15_-_52861157 13.10 ENST00000564163.1
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr1_+_84630053 12.86 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr11_+_31391381 12.07 ENST00000465995.1
ENST00000536040.1
DNAJC24
DnaJ (Hsp40) homolog, subfamily C, member 24
chr4_+_156680153 12.07 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr19_+_52693259 10.75 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chr2_-_44588624 10.72 ENST00000438314.1
ENST00000409936.1
PREPL
prolyl endopeptidase-like
chr7_-_103629963 10.44 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
RELN
reelin
chr1_+_202830876 10.32 ENST00000456105.2
RP11-480I12.7
RP11-480I12.7
chr18_+_23806437 10.17 ENST00000578121.1
TAF4B
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
chr2_-_44588694 10.14 ENST00000409957.1
PREPL
prolyl endopeptidase-like
chr19_+_37407212 9.93 ENST00000427117.1
ENST00000587130.1
ENST00000333987.7
ENST00000415168.1
ENST00000444991.1
ZNF568
zinc finger protein 568
chr2_-_44588679 9.79 ENST00000409411.1
PREPL
prolyl endopeptidase-like
chr4_+_156680143 9.26 ENST00000505154.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr8_+_117950422 9.17 ENST00000378279.3
AARD
alanine and arginine rich domain containing protein
chr15_+_51973680 9.15 ENST00000542355.2
SCG3
secretogranin III
chr19_-_57183114 9.10 ENST00000537055.2
ENST00000601659.1
ZNF835
zinc finger protein 835
chr2_-_44588893 8.76 ENST00000409272.1
ENST00000410081.1
ENST00000541738.1
PREPL
prolyl endopeptidase-like
chr15_+_51973550 8.68 ENST00000220478.3
SCG3
secretogranin III
chr6_+_89674246 8.55 ENST00000369474.1
AL079342.1
Uncharacterized protein; cDNA FLJ27030 fis, clone SLV07741
chr15_-_52861323 8.43 ENST00000569723.1
ENST00000249822.4
ENST00000567669.1
ENST00000569281.2
ENST00000563566.1
ENST00000567830.1
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr6_-_32908765 8.02 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr19_+_2841433 7.76 ENST00000334241.4
ENST00000585966.1
ENST00000591539.1
ZNF555
zinc finger protein 555
chr15_-_42783303 7.58 ENST00000565380.1
ENST00000564754.1
ZNF106
zinc finger protein 106
chr7_+_29519486 7.42 ENST00000409041.4
CHN2
chimerin 2
chr5_+_177457525 7.27 ENST00000511856.1
ENST00000511189.1
FAM153C
family with sequence similarity 153, member C
chr14_+_24583836 7.07 ENST00000559115.1
ENST00000558215.1
ENST00000557810.1
ENST00000561375.1
ENST00000446197.3
ENST00000559796.1
ENST00000560713.1
ENST00000560901.1
ENST00000559382.1
DCAF11
DDB1 and CUL4 associated factor 11
chr10_-_75226166 6.91 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr6_+_127587755 6.88 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
RNF146
ring finger protein 146
chr22_+_18593507 6.68 ENST00000330423.3
TUBA8
tubulin, alpha 8
chr19_+_35168567 6.43 ENST00000457781.2
ENST00000505163.1
ENST00000505242.1
ENST00000423823.2
ENST00000507959.1
ENST00000446502.2
ZNF302
zinc finger protein 302
chr10_+_96162242 6.32 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr9_+_104161123 6.31 ENST00000374861.3
ENST00000339664.2
ENST00000259395.4
ZNF189
zinc finger protein 189
chr15_+_90808919 6.21 ENST00000379095.3
NGRN
neugrin, neurite outgrowth associated
chrX_-_48931648 6.19 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr8_-_145159083 6.12 ENST00000398712.2
SHARPIN
SHANK-associated RH domain interactor
chr16_-_18468926 6.09 ENST00000545114.1
RP11-1212A22.4
LOC339047 protein; Nuclear pore complex-interacting protein family member A3; Nuclear pore complex-interacting protein family member A5; Protein PKD1P1
chrX_+_103217207 5.86 ENST00000563257.1
ENST00000540220.1
ENST00000436583.1
ENST00000567181.1
ENST00000569577.1
TMSB15B
thymosin beta 15B
chr16_-_21849091 5.67 ENST00000537951.1
NPIPB4
nuclear pore complex interacting protein family, member B4
chr14_+_22964877 5.63 ENST00000390494.1
TRAJ43
T cell receptor alpha joining 43
chr10_-_104178857 5.56 ENST00000020673.5
PSD
pleckstrin and Sec7 domain containing
chr19_+_35168633 5.44 ENST00000505365.2
ZNF302
zinc finger protein 302
chr6_+_14117872 5.43 ENST00000379153.3
CD83
CD83 molecule
chr7_+_99816859 5.39 ENST00000317271.2
PVRIG
poliovirus receptor related immunoglobulin domain containing
chr9_-_73029540 5.17 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr13_+_96085847 5.08 ENST00000376873.3
CLDN10
claudin 10
chr19_-_46296011 4.93 ENST00000377735.3
ENST00000270223.6
DMWD
dystrophia myotonica, WD repeat containing
chr10_+_91087651 4.85 ENST00000371818.4
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr14_-_24711806 4.81 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr6_+_127588020 4.76 ENST00000309649.3
ENST00000610162.1
ENST00000610153.1
ENST00000608991.1
ENST00000480444.1
RNF146
ring finger protein 146
chr14_-_24584138 4.72 ENST00000558280.1
ENST00000561028.1
NRL
neural retina leucine zipper
chr16_-_21416640 4.71 ENST00000542817.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr19_+_10527449 4.59 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chrX_+_70364667 4.50 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr2_-_128051670 4.48 ENST00000493187.2
ERCC3
excision repair cross-complementing rodent repair deficiency, complementation group 3
chr6_-_30815936 4.40 ENST00000442852.1
XXbac-BPG27H4.8
XXbac-BPG27H4.8
chr12_+_112563303 4.09 ENST00000412615.2
TRAFD1
TRAF-type zinc finger domain containing 1
chr16_+_27214802 4.02 ENST00000380948.2
ENST00000286096.4
KDM8
lysine (K)-specific demethylase 8
chr16_-_71523236 4.01 ENST00000288177.5
ENST00000569072.1
ZNF19
zinc finger protein 19
chr2_-_11810284 3.85 ENST00000306928.5
NTSR2
neurotensin receptor 2
chr15_-_52861394 3.76 ENST00000563277.1
ENST00000566423.1
ARPP19
cAMP-regulated phosphoprotein, 19kDa
chr12_-_53594227 3.65 ENST00000550743.2
ITGB7
integrin, beta 7
chr2_-_128051708 3.61 ENST00000285398.2
ERCC3
excision repair cross-complementing rodent repair deficiency, complementation group 3
chr5_-_180688105 3.60 ENST00000327767.4
TRIM52
tripartite motif containing 52
chr16_-_75018968 3.48 ENST00000262144.6
WDR59
WD repeat domain 59
chr12_+_112563335 3.42 ENST00000549358.1
ENST00000257604.5
ENST00000548092.1
ENST00000552896.1
TRAFD1
TRAF-type zinc finger domain containing 1
chr14_+_24584508 3.42 ENST00000559354.1
ENST00000560459.1
ENST00000559593.1
ENST00000396941.4
ENST00000396936.1
DCAF11
DDB1 and CUL4 associated factor 11
chr12_-_89919965 3.41 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr19_+_7968728 3.33 ENST00000397981.3
ENST00000545011.1
ENST00000397983.3
ENST00000397979.3
MAP2K7
mitogen-activated protein kinase kinase 7
chr19_-_2783363 3.30 ENST00000221566.2
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr17_-_3461092 3.29 ENST00000301365.4
ENST00000572519.1
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr18_-_59854203 3.27 ENST00000589339.1
ENST00000357637.5
ENST00000585458.1
ENST00000400334.3
ENST00000587134.1
ENST00000585923.1
ENST00000590765.1
ENST00000589720.1
ENST00000588571.1
ENST00000585344.1
PIGN
phosphatidylinositol glycan anchor biosynthesis, class N
chr1_-_7913089 3.18 ENST00000361696.5
UTS2
urotensin 2
chr5_+_49961727 3.18 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8
poly (ADP-ribose) polymerase family, member 8
chr12_-_89920030 2.93 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr2_+_171034646 2.92 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr10_-_102289611 2.90 ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
ENST00000535773.1
NDUFB8
SEC31B
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa
SEC31 homolog B (S. cerevisiae)
chr1_+_171283331 2.77 ENST00000367749.3
FMO4
flavin containing monooxygenase 4
chr10_+_118305435 2.63 ENST00000369221.2
PNLIP
pancreatic lipase
chr3_-_119379427 2.54 ENST00000264231.3
ENST00000468801.1
ENST00000538678.1
POPDC2
popeye domain containing 2
chr2_+_44589036 2.53 ENST00000402247.1
ENST00000407131.1
ENST00000403853.3
ENST00000378494.3
CAMKMT
calmodulin-lysine N-methyltransferase
chr19_-_54784353 2.53 ENST00000391746.1
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr12_+_10460417 2.50 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr1_+_1222489 2.46 ENST00000379099.3
SCNN1D
sodium channel, non-voltage-gated 1, delta subunit
chr19_-_40596828 2.44 ENST00000414720.2
ENST00000455521.1
ENST00000340963.5
ENST00000595773.1
ZNF780A
zinc finger protein 780A
chr9_-_21239978 2.36 ENST00000380222.2
IFNA14
interferon, alpha 14
chr2_-_114514181 2.30 ENST00000409342.1
SLC35F5
solute carrier family 35, member F5
chr9_+_131549483 2.26 ENST00000372648.5
ENST00000539497.1
TBC1D13
TBC1 domain family, member 13
chr9_-_35650900 2.20 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr8_+_107670064 2.18 ENST00000312046.6
OXR1
oxidation resistance 1
chr21_-_30365136 2.09 ENST00000361371.5
ENST00000389194.2
ENST00000389195.2
LTN1
listerin E3 ubiquitin protein ligase 1
chrX_+_102883620 2.08 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chrX_-_118699325 2.04 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
CXorf56
chromosome X open reading frame 56
chr17_+_3118915 2.01 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr19_-_41388657 1.99 ENST00000301146.4
ENST00000291764.3
CYP2A7
cytochrome P450, family 2, subfamily A, polypeptide 7
chr1_-_205180664 1.94 ENST00000367161.3
ENST00000367162.3
ENST00000367160.4
DSTYK
dual serine/threonine and tyrosine protein kinase
chrX_-_15872914 1.80 ENST00000380291.1
ENST00000545766.1
ENST00000421527.2
ENST00000329235.2
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr11_-_104972158 1.77 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr2_-_219524193 1.76 ENST00000450560.1
ENST00000449707.1
ENST00000432460.1
ENST00000411696.2
ZNF142
zinc finger protein 142
chr9_-_13175823 1.70 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chr1_-_52344471 1.66 ENST00000352171.7
ENST00000354831.7
NRD1
nardilysin (N-arginine dibasic convertase)
chr6_+_35227449 1.62 ENST00000373953.3
ENST00000440666.2
ENST00000339411.5
ZNF76
zinc finger protein 76
chr20_-_23807358 1.61 ENST00000304725.2
CST2
cystatin SA
chr15_+_81591757 1.56 ENST00000558332.1
IL16
interleukin 16
chr4_-_168155730 1.56 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr4_-_170924888 1.52 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chrX_+_102883887 1.40 ENST00000372625.3
ENST00000372624.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr5_-_157079428 1.37 ENST00000265007.6
SOX30
SRY (sex determining region Y)-box 30
chr11_+_112038088 1.35 ENST00000530752.1
ENST00000280358.4
TEX12
testis expressed 12
chr12_-_57400227 1.29 ENST00000300101.2
ZBTB39
zinc finger and BTB domain containing 39
chr12_+_10460549 1.29 ENST00000543420.1
ENST00000543777.1
KLRD1
killer cell lectin-like receptor subfamily D, member 1
chr4_-_168155700 1.26 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr17_-_59668550 1.18 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr12_+_9142131 1.15 ENST00000356986.3
ENST00000266551.4
KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr3_+_49726932 1.15 ENST00000327697.6
ENST00000432042.1
ENST00000454491.1
RNF123
ring finger protein 123
chr6_-_169654139 1.13 ENST00000366787.3
THBS2
thrombospondin 2
chr9_+_131549610 1.08 ENST00000223865.8
TBC1D13
TBC1 domain family, member 13
chr19_+_55105085 1.06 ENST00000251372.3
ENST00000453777.1
LILRA1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
chr15_-_43622736 1.01 ENST00000544735.1
ENST00000567039.1
ENST00000305641.5
LCMT2
leucine carboxyl methyltransferase 2
chrX_+_37850026 0.89 ENST00000341016.3
CXorf27
chromosome X open reading frame 27
chr2_-_68479614 0.63 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr1_+_158323486 0.57 ENST00000444681.2
ENST00000368167.3
CD1E
CD1e molecule
chr1_+_158323244 0.57 ENST00000434258.1
CD1E
CD1e molecule
chrX_+_135230712 0.56 ENST00000535737.1
FHL1
four and a half LIM domains 1
chr4_-_168155577 0.50 ENST00000541354.1
ENST00000509854.1
ENST00000512681.1
ENST00000421836.2
ENST00000510741.1
ENST00000510403.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr20_-_17511962 0.44 ENST00000377873.3
BFSP1
beaded filament structural protein 1, filensin
chr11_-_615942 0.40 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
IRF7
interferon regulatory factor 7
chr15_-_80263506 0.31 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr6_-_32908792 0.29 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chrX_+_47077632 0.26 ENST00000457458.2
CDK16
cyclin-dependent kinase 16
chrX_+_1734051 0.24 ENST00000381229.4
ENST00000381233.3
ASMT
acetylserotonin O-methyltransferase
chr1_+_154244987 0.20 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chrX_+_68725084 0.06 ENST00000252338.4
FAM155B
family with sequence similarity 155, member B
chr12_-_57352103 0.05 ENST00000398138.3
RDH16
retinol dehydrogenase 16 (all-trans)

Network of associatons between targets according to the STRING database.

First level regulatory network of PAX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.1 21.3 GO:0038060 nitric oxide-cGMP-mediated signaling pathway(GO:0038060)
4.5 13.6 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
3.7 14.9 GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
2.8 8.3 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
2.7 10.8 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
2.6 12.9 GO:0097338 response to clozapine(GO:0097338)
2.4 24.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.1 25.3 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
1.6 3.2 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
1.5 12.1 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
1.4 50.2 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
1.2 4.7 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
1.1 3.3 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
1.0 6.1 GO:2000348 regulation of CD40 signaling pathway(GO:2000348)
0.9 3.6 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.9 39.4 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.8 4.8 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.7 5.2 GO:0051414 response to cortisol(GO:0051414)
0.6 2.5 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.6 5.4 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.6 6.9 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 4.0 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.5 3.3 GO:0042636 negative regulation of hair cycle(GO:0042636)
0.4 1.8 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.4 3.3 GO:0035897 proteolysis in other organism(GO:0035897)
0.4 30.1 GO:0007602 phototransduction(GO:0007602)
0.4 8.1 GO:0009650 UV protection(GO:0009650)
0.4 4.8 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.3 1.9 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.3 5.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 13.7 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 6.3 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.2 6.2 GO:0015813 L-glutamate transport(GO:0015813)
0.2 10.2 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.2 5.1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 2.8 GO:0042737 drug catabolic process(GO:0042737)
0.2 15.4 GO:0035249 synaptic transmission, glutamatergic(GO:0035249)
0.2 7.5 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.2 2.6 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.2 3.3 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 4.6 GO:0043949 regulation of cAMP-mediated signaling(GO:0043949)
0.1 2.2 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 1.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.1 2.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 2.0 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.1 3.5 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 2.0 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 1.1 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.2 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 3.6 GO:0051092 positive regulation of NF-kappaB transcription factor activity(GO:0051092)
0.1 1.4 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.1 4.1 GO:0050909 sensory perception of taste(GO:0050909)
0.1 1.6 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854) positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 2.2 GO:0043029 T cell homeostasis(GO:0043029)
0.1 2.9 GO:0016266 O-glycan processing(GO:0016266)
0.0 2.9 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 3.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 7.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 1.1 GO:2000181 negative regulation of angiogenesis(GO:0016525) negative regulation of vasculature development(GO:1901343) negative regulation of blood vessel morphogenesis(GO:2000181)
0.0 3.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 9.2 GO:0030324 lung development(GO:0030324)
0.0 2.0 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 6.1 GO:0016579 protein deubiquitination(GO:0016579)
0.0 7.3 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 18.4 GO:0001558 regulation of cell growth(GO:0001558)
0.0 0.3 GO:0030252 growth hormone secretion(GO:0030252)
0.0 4.0 GO:0030335 positive regulation of cell migration(GO:0030335)
0.0 1.7 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 7.4 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 2.9 GO:0007601 visual perception(GO:0007601)
0.0 59.1 GO:0007166 cell surface receptor signaling pathway(GO:0007166)
0.0 2.4 GO:0002027 regulation of heart rate(GO:0002027)
0.0 9.6 GO:0016567 protein ubiquitination(GO:0016567)
0.0 3.4 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 6.1 GO:0071797 LUBAC complex(GO:0071797)
1.0 4.8 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.9 3.6 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.8 7.5 GO:0005955 calcineurin complex(GO:0005955)
0.8 8.1 GO:0000439 core TFIIH complex(GO:0000439)
0.7 17.3 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 12.9 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 3.5 GO:0061700 GATOR2 complex(GO:0061700)
0.4 8.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.4 1.8 GO:0097179 protease inhibitor complex(GO:0097179)
0.3 10.5 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 10.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.3 1.4 GO:0000801 central element(GO:0000801)
0.2 10.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.2 1.2 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.1 20.7 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 1.7 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 5.6 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 6.3 GO:0005776 autophagosome(GO:0005776)
0.1 23.8 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 15.3 GO:0005856 cytoskeleton(GO:0005856)
0.0 95.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 5.1 GO:0005923 bicellular tight junction(GO:0005923)
0.0 4.6 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.9 GO:0016459 myosin complex(GO:0016459)
0.0 24.8 GO:0005794 Golgi apparatus(GO:0005794)
0.0 9.6 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 35.7 GO:0005829 cytosol(GO:0005829)
0.0 51.0 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.2 GO:0016529 sarcoplasmic reticulum(GO:0016529)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 13.6 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
3.5 10.4 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
2.2 50.2 GO:0004062 aryl sulfotransferase activity(GO:0004062)
1.7 39.4 GO:0070008 serine-type exopeptidase activity(GO:0070008)
1.3 8.1 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
1.1 3.3 GO:1904288 BAT3 complex binding(GO:1904288)
1.1 3.3 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.8 12.9 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.8 3.8 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.7 10.2 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.7 17.3 GO:0004383 guanylate cyclase activity(GO:0004383)
0.7 6.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.6 25.3 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.6 20.7 GO:0017091 AU-rich element binding(GO:0017091)
0.5 4.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.3 4.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 12.1 GO:0001671 ATPase activator activity(GO:0001671)
0.3 8.3 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.3 2.5 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.3 2.8 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.3 4.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 5.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 2.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 15.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.2 2.5 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.2 2.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 0.6 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 1.8 GO:0089720 caspase binding(GO:0089720)
0.1 10.8 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 5.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 4.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 2.2 GO:0042169 SH2 domain binding(GO:0042169)
0.1 3.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.1 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 2.0 GO:0070330 aromatase activity(GO:0070330)
0.1 3.8 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 4.8 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 4.7 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 2.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 3.2 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.1 1.6 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 3.5 GO:0050699 WW domain binding(GO:0050699)
0.1 2.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 7.6 GO:0017124 SH3 domain binding(GO:0017124)
0.1 7.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 9.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 13.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 2.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 1.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 7.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.0 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 1.0 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.0 3.6 GO:0001618 virus receptor activity(GO:0001618)
0.0 0.2 GO:0008172 S-methyltransferase activity(GO:0008172)
0.0 44.0 GO:0001071 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.3 GO:0051400 BH domain binding(GO:0051400)
0.0 3.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 2.5 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 5.4 GO:0060089 receptor activity(GO:0004872) molecular transducer activity(GO:0060089)
0.0 3.2 GO:0005179 hormone activity(GO:0005179)
0.0 4.6 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 15.2 GO:0004871 signal transducer activity(GO:0004871)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 13.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 13.8 PID REELIN PATHWAY Reelin signaling pathway
0.3 12.9 PID IL3 PATHWAY IL3-mediated signaling events
0.2 10.8 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
0.2 15.4 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.2 7.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.1 7.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 3.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.1 10.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 1.8 PID IFNG PATHWAY IFN-gamma pathway
0.1 2.4 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.1 4.8 PID TELOMERASE PATHWAY Regulation of Telomerase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 50.2 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.8 10.8 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.7 15.4 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.4 12.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.4 21.2 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.4 10.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.3 18.3 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 7.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 3.3 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 5.1 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 4.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.8 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.9 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 8.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 5.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 7.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 16.1 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.0 2.0 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 2.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 6.5 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.1 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF