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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PAX5
Z-value: 2.27
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Transcription factors associated with PAX5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PAX5 | hg19_v2_chr9_-_37034028_37034157 | 0.55 | 1.6e-18 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PAX5
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 400.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 4.6 | 83.2 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 4.0 | 59.7 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.5 | 58.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.1 | 48.8 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 6.4 | 38.1 | GO:0070560 | protein secretion by platelet(GO:0070560) |
| 0.5 | 37.6 | GO:0010923 | negative regulation of phosphatase activity(GO:0010923) |
| 7.2 | 36.1 | GO:0071279 | cellular response to cobalt ion(GO:0071279) |
| 2.1 | 35.3 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 1.3 | 34.4 | GO:2000369 | regulation of clathrin-mediated endocytosis(GO:2000369) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 133.6 | GO:0019814 | immunoglobulin complex(GO:0019814) |
| 0.6 | 89.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 3.7 | 78.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.8 | 77.3 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.3 | 73.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.5 | 66.0 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 64.0 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 53.8 | GO:0005796 | Golgi lumen(GO:0005796) |
| 2.5 | 52.8 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 3.6 | 43.5 | GO:0043203 | axon hillock(GO:0043203) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 252.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 201.2 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 3.0 | 167.1 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 24.3 | 97.0 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
| 0.4 | 81.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.7 | 71.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 4.8 | 62.7 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.5 | 57.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 52.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 3.4 | 48.1 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 129.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 94.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 79.5 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.4 | 73.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.4 | 58.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 1.0 | 55.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.8 | 47.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 1.8 | 41.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.9 | 37.9 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.6 | 36.1 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 121.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.3 | 105.3 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.6 | 78.9 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.9 | 55.1 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 1.2 | 49.8 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 2.5 | 44.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 1.0 | 44.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.5 | 38.7 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.5 | 38.3 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.7 | 37.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |