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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for PITX2

Z-value: 0.47

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Transcription factors associated with PITX2

Gene Symbol Gene ID Gene Info
PITX2
ENSG00000164093.11 paired like homeodomain 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
PITX2hg19_v2_chr4_-_111544254_111544270,
hg19_v2_chr4_-_111563076_111563172,
hg19_v2_chr4_-_111558135_111558198		0.152.5e-02Click!

Activity profile of PITX2 motif

Sorted Z-values of PITX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_5248294 17.07 ENST00000335295.4
HBB
hemoglobin, beta
chr8_-_27462822 11.24 ENST00000522098.1
CLU
clusterin
chr13_-_36429763 8.27 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chrX_-_54384425 4.73 ENST00000375169.3
ENST00000354646.2
WNK3
WNK lysine deficient protein kinase 3
chr17_-_40021656 3.86 ENST00000319121.3
KLHL11
kelch-like family member 11
chrX_+_15767971 3.74 ENST00000479740.1
ENST00000454127.2
CA5B
carbonic anhydrase VB, mitochondrial
chr5_-_64920115 3.46 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr16_-_5116025 3.06 ENST00000472572.3
ENST00000315997.5
ENST00000422873.1
ENST00000350219.4
C16orf89
chromosome 16 open reading frame 89
chr5_+_64920543 2.30 ENST00000399438.3
ENST00000510585.2
TRAPPC13
CTC-534A2.2
trafficking protein particle complex 13
CDNA FLJ26957 fis, clone SLV00486; Uncharacterized protein
chr2_+_120770645 2.25 ENST00000443902.2
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr19_+_2476116 2.24 ENST00000215631.4
ENST00000587345.1
GADD45B
growth arrest and DNA-damage-inducible, beta
chr2_+_120770581 2.12 ENST00000263713.5
EPB41L5
erythrocyte membrane protein band 4.1 like 5
chr1_+_22303503 1.88 ENST00000337107.6
CELA3B
chymotrypsin-like elastase family, member 3B
chr10_-_61900762 1.87 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr14_+_75988851 1.76 ENST00000555504.1
BATF
basic leucine zipper transcription factor, ATF-like
chr6_-_53013620 1.74 ENST00000259803.7
GCM1
glial cells missing homolog 1 (Drosophila)
chr1_-_31230650 1.47 ENST00000294507.3
LAPTM5
lysosomal protein transmembrane 5
chr16_-_68014732 1.46 ENST00000268793.4
DPEP3
dipeptidase 3
chr12_+_7941989 1.41 ENST00000229307.4
NANOG
Nanog homeobox
chr9_+_8858102 1.40 ENST00000447950.1
ENST00000430766.1
RP11-75C9.1
RP11-75C9.1
chr15_-_89764929 1.39 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1
chr9_+_34458771 1.35 ENST00000437363.1
ENST00000242317.4
DNAI1
dynein, axonemal, intermediate chain 1
chr7_-_128415844 1.24 ENST00000249389.2
OPN1SW
opsin 1 (cone pigments), short-wave-sensitive
chr9_-_95166841 1.06 ENST00000262551.4
OGN
osteoglycin
chr1_+_92417716 1.06 ENST00000402388.1
BRDT
bromodomain, testis-specific
chrX_-_6146876 1.05 ENST00000381095.3
NLGN4X
neuroligin 4, X-linked
chr11_+_61522844 1.05 ENST00000265460.5
MYRF
myelin regulatory factor
chr6_+_35310391 1.01 ENST00000337400.2
ENST00000311565.4
ENST00000540939.1
PPARD
peroxisome proliferator-activated receptor delta
chr11_-_36619771 0.93 ENST00000311485.3
ENST00000527033.1
ENST00000532616.1
RAG2
recombination activating gene 2
chrX_-_48931648 0.92 ENST00000376386.3
ENST00000376390.4
PRAF2
PRA1 domain family, member 2
chr21_-_19775973 0.88 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr8_-_133123406 0.87 ENST00000434736.2
HHLA1
HERV-H LTR-associating 1
chr6_+_35310312 0.86 ENST00000448077.2
ENST00000360694.3
ENST00000418635.2
ENST00000444397.1
PPARD
peroxisome proliferator-activated receptor delta
chr21_-_34915147 0.78 ENST00000381831.3
ENST00000381839.3
GART
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chrX_+_107069063 0.74 ENST00000262843.6
MID2
midline 2
chr1_-_165414414 0.70 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr4_+_70916119 0.70 ENST00000246896.3
ENST00000511674.1
HTN1
histatin 1
chr4_-_76912070 0.68 ENST00000395711.4
ENST00000356260.5
SDAD1
SDA1 domain containing 1
chr18_-_3880051 0.67 ENST00000584874.1
DLGAP1
discs, large (Drosophila) homolog-associated protein 1
chr4_-_68620053 0.65 ENST00000420975.2
ENST00000226413.4
GNRHR
gonadotropin-releasing hormone receptor
chr1_+_22328144 0.64 ENST00000290122.3
ENST00000374663.1
CELA3A
chymotrypsin-like elastase family, member 3A
chr1_+_2407754 0.51 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr13_+_73632897 0.35 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr4_+_126237554 0.32 ENST00000394329.3
FAT4
FAT atypical cadherin 4
chr9_-_110251836 0.22 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr17_+_79495397 0.15 ENST00000417245.2
ENST00000334850.7
FSCN2
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr1_+_201979645 0.13 ENST00000367284.5
ENST00000367283.3
ELF3
E74-like factor 3 (ets domain transcription factor, epithelial-specific )
chr12_-_323689 0.08 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr14_+_75988768 0.06 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like

Network of associatons between targets according to the STRING database.

First level regulatory network of PITX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 17.1 GO:0030185 nitric oxide transport(GO:0030185)
1.9 11.2 GO:0061517 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.5 4.4 GO:0003383 apical constriction(GO:0003383) mesoderm migration involved in gastrulation(GO:0007509)
1.2 4.7 GO:2000686 regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.6 1.7 GO:0060018 astrocyte fate commitment(GO:0060018)
0.5 1.9 GO:1900827 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.1 GO:0051039 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
0.3 8.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.3 3.3 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 1.1 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.2 1.4 GO:0001714 endodermal cell fate specification(GO:0001714)
0.2 0.9 GO:0002329 pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.2 1.8 GO:0003360 brainstem development(GO:0003360)
0.2 0.6 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.1 1.3 GO:0036158 outer dynein arm assembly(GO:0036158)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 2.2 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 1.8 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.1 0.7 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 1.2 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.2 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.1 3.7 GO:0006730 one-carbon metabolic process(GO:0006730) bicarbonate transport(GO:0015701)
0.1 0.7 GO:0035372 protein localization to microtubule(GO:0035372)
0.1 1.1 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 1.5 GO:0007140 male meiosis(GO:0007140)
0.0 0.9 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.7 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 2.5 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 1.5 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 17.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.7 11.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.2 1.3 GO:0036157 outer dynein arm(GO:0036157)
0.1 1.9 GO:0043194 axon initial segment(GO:0043194)
0.1 3.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 1.2 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 4.4 GO:0032587 ruffle membrane(GO:0032587)
0.0 9.8 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 4.7 GO:0005923 bicellular tight junction(GO:0005923)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 17.1 GO:0030492 hemoglobin binding(GO:0030492)
0.6 11.2 GO:0051787 misfolded protein binding(GO:0051787)
0.4 4.7 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.3 1.4 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 3.7 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.8 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 1.2 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 1.1 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 1.9 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.1 1.3 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.0 3.5 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 2.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.6 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 0.9 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 8.3 GO:0005057 receptor signaling protein activity(GO:0005057)
0.0 6.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 1.7 GO:0042826 histone deacetylase binding(GO:0042826)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 11.0 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 2.6 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 2.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 1.2 REACTOME OPSINS Genes involved in Opsins
0.1 17.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 11.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.1 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.1 1.9 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.6 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 2.6 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin