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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for PLAGL1
Z-value: 2.84
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Transcription factors associated with PLAGL1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PLAGL1 | hg19_v2_chr6_-_144385698_144385742 | -0.02 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of PLAGL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 202.2 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 7.0 | 112.0 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 2.9 | 100.0 | GO:0009214 | cyclic nucleotide catabolic process(GO:0009214) |
| 2.6 | 96.3 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 6.2 | 92.3 | GO:0015669 | gas transport(GO:0015669) oxygen transport(GO:0015671) |
| 5.4 | 91.2 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
| 2.3 | 90.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 13.9 | 83.2 | GO:0061517 | macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 3.4 | 81.5 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 20.3 | 81.2 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 545.3 | GO:0031224 | intrinsic component of membrane(GO:0031224) |
| 0.3 | 281.6 | GO:0005615 | extracellular space(GO:0005615) |
| 4.0 | 190.2 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 1.9 | 188.1 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 2.2 | 166.2 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.5 | 121.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 4.7 | 116.5 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 4.2 | 114.0 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
| 5.3 | 111.3 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
| 0.9 | 102.1 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 451.2 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 1.0 | 260.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.8 | 245.5 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 4.1 | 225.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 1.3 | 133.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.8 | 118.0 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 4.7 | 116.5 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 2.9 | 116.1 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 4.3 | 111.6 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
| 6.1 | 110.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 290.3 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.7 | 172.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.5 | 145.8 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.5 | 128.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.6 | 108.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 2.2 | 107.6 | PID RAS PATHWAY | Regulation of Ras family activation |
| 2.8 | 99.2 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 1.1 | 95.6 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 1.0 | 67.8 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.9 | 59.2 | PID IL4 2PATHWAY | IL4-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 375.9 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 3.7 | 179.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 1.1 | 179.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.4 | 150.3 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 2.7 | 148.8 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 3.4 | 147.4 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.2 | 113.8 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 3.3 | 102.3 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 3.0 | 95.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.9 | 81.5 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |