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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU2F2_POU3F1
Z-value: 2.71
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Transcription factors associated with POU2F2_POU3F1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F2 | hg19_v2_chr19_-_42636543_42636607 | 0.50 | 3.6e-15 | Click! |
| POU3F1 | hg19_v2_chr1_-_38512450_38512474 | 0.31 | 2.8e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr16_+_33605231 Show fit | 85.76 |
ENST00000570121.2
|
immunoglobulin heavy variable 3/OR16-12 (non-functional) |
|
| chr14_-_106573756 Show fit | 75.03 |
ENST00000390601.2
|
immunoglobulin heavy variable 3-11 (gene/pseudogene) |
|
| chr14_-_106994333 Show fit | 74.28 |
ENST00000390624.2
|
immunoglobulin heavy variable 3-48 |
|
| chr2_-_89399845 Show fit | 71.07 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr14_-_107114267 Show fit | 68.34 |
ENST00000454421.2
|
immunoglobulin heavy variable 3-64 |
|
| chr14_-_106692191 Show fit | 68.04 |
ENST00000390607.2
|
immunoglobulin heavy variable 3-21 |
|
| chr14_-_106926724 Show fit | 67.27 |
ENST00000434710.1
|
immunoglobulin heavy variable 3-43 |
|
| chr16_+_32077386 Show fit | 66.96 |
ENST00000354689.6
|
immunoglobulin heavy variable 3/OR16-9 (non-functional) |
|
| chr2_+_90248739 Show fit | 64.54 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr14_-_106552755 Show fit | 59.97 |
ENST00000390600.2
|
immunoglobulin heavy variable 3-9 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU2F2_POU3F1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.7 | 1750.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.3 | 565.1 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 1.4 | 127.5 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.2 | 49.4 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 16.1 | 48.2 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 14.8 | 44.4 | GO:0070666 | positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668) |
| 1.9 | 34.0 | GO:0002227 | innate immune response in mucosa(GO:0002227) |
| 2.2 | 24.5 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
| 0.2 | 23.6 | GO:0051591 | response to cAMP(GO:0051591) |
| 2.7 | 21.8 | GO:0070235 | regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.0 | 801.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.4 | 621.9 | GO:0005615 | extracellular space(GO:0005615) |
| 1.8 | 315.7 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 288.3 | GO:0005576 | extracellular region(GO:0005576) |
| 3.5 | 198.1 | GO:0000786 | nucleosome(GO:0000786) |
| 8.9 | 44.4 | GO:0034666 | integrin alpha2-beta1 complex(GO:0034666) |
| 0.3 | 41.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.5 | 17.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 4.0 | 15.9 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.1 | 14.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.4 | 1385.5 | GO:0003823 | antigen binding(GO:0003823) |
| 14.6 | 801.9 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 120.7 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 16.1 | 48.2 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 3.5 | 45.9 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 6.2 | 43.3 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 1.7 | 24.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 1.2 | 22.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 2.4 | 21.8 | GO:0043426 | MRF binding(GO:0043426) |
| 1.3 | 18.7 | GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 70.4 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 2.2 | 47.5 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.3 | 39.7 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.9 | 22.3 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.4 | 15.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.2 | 10.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 9.6 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.1 | SIG BCR SIGNALING PATHWAY | Members of the BCR signaling pathway |
| 0.1 | 5.6 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.1 | 5.3 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 210.1 | REACTOME PACKAGING OF TELOMERE ENDS | Genes involved in Packaging Of Telomere Ends |
| 0.9 | 48.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 2.6 | 44.4 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 1.5 | 43.1 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.7 | 22.3 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.1 | 17.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.4 | 15.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.2 | 13.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.5 | 11.9 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 0.1 | 10.5 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |