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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU3F2
Z-value: 2.29
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Transcription factors associated with POU3F2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU3F2 | hg19_v2_chr6_+_99282570_99282591 | -0.40 | 7.9e-10 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU3F2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 125.8 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 1.1 | 111.9 | GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418) |
| 2.2 | 97.5 | GO:0045143 | homologous chromosome segregation(GO:0045143) |
| 1.7 | 81.8 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 1.6 | 80.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 2.3 | 57.8 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.6 | 54.6 | GO:0051225 | spindle assembly(GO:0051225) |
| 3.0 | 53.9 | GO:2000774 | positive regulation of cellular senescence(GO:2000774) |
| 6.2 | 49.4 | GO:0010767 | regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767) |
| 6.1 | 48.8 | GO:0090166 | Golgi disassembly(GO:0090166) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 89.4 | GO:0005819 | spindle(GO:0005819) |
| 1.4 | 86.5 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.1 | 66.6 | GO:0005730 | nucleolus(GO:0005730) |
| 0.2 | 66.0 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.8 | 59.7 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 4.6 | 55.5 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 50.7 | GO:0005925 | focal adhesion(GO:0005925) |
| 1.6 | 48.0 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 11.9 | 47.4 | GO:0070985 | TFIIK complex(GO:0070985) |
| 5.8 | 46.2 | GO:0034715 | pICln-Sm protein complex(GO:0034715) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 122.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.2 | 119.2 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 1.5 | 79.2 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) |
| 0.1 | 78.8 | GO:0003723 | RNA binding(GO:0003723) |
| 3.1 | 73.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.8 | 65.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 1.3 | 64.7 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 1.3 | 64.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 3.4 | 57.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 5.0 | 55.5 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 112.9 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 1.4 | 87.1 | PID ATR PATHWAY | ATR signaling pathway |
| 1.1 | 46.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.8 | 45.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.5 | 36.9 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.7 | 35.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.5 | 30.7 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 28.9 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 1.0 | 28.2 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.6 | 27.0 | PID AURORA A PATHWAY | Aurora A signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 244.6 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.8 | 151.0 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 4.2 | 112.4 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 1.6 | 107.0 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 2.4 | 85.9 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.8 | 70.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.2 | 62.6 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.6 | 60.5 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 1.0 | 56.1 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 2.7 | 54.7 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |