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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU4F1_POU4F3
Z-value: 0.85
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Transcription factors associated with POU4F1_POU4F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU4F1 | hg19_v2_chr13_-_79177673_79177701 | 0.30 | 5.7e-06 | Click! |
| POU4F3 | hg19_v2_chr5_+_145718587_145718607 | 0.10 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU4F1_POU4F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 31.9 | GO:0000042 | protein targeting to Golgi(GO:0000042) |
| 2.5 | 29.8 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 3.7 | 14.9 | GO:0042796 | snRNA transcription from RNA polymerase III promoter(GO:0042796) |
| 0.2 | 10.4 | GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502) |
| 0.0 | 10.4 | GO:0048511 | rhythmic process(GO:0048511) |
| 0.6 | 10.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 10.1 | GO:0045773 | positive regulation of axon extension(GO:0045773) |
| 1.7 | 6.8 | GO:2000768 | glomerular parietal epithelial cell differentiation(GO:0072139) positive regulation of nephron tubule epithelial cell differentiation(GO:2000768) |
| 0.0 | 6.1 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 5.9 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 29.8 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 14.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.0 | 8.4 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 7.0 | GO:0009986 | cell surface(GO:0009986) |
| 0.4 | 6.8 | GO:0042622 | photoreceptor outer segment membrane(GO:0042622) |
| 0.1 | 6.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 5.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 5.8 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 5.2 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.6 | 4.9 | GO:0036157 | outer dynein arm(GO:0036157) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 29.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 14.8 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.1 | 11.3 | GO:0019902 | phosphatase binding(GO:0019902) |
| 1.7 | 10.4 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 1.4 | 10.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 9.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.6 | 8.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 6.8 | GO:0042805 | actinin binding(GO:0042805) |
| 0.1 | 6.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.1 | 5.4 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 30.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 11.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 6.6 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 5.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 4.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 4.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 4.0 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.1 | 3.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 3.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 3.4 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 29.8 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.3 | 14.9 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.3 | 10.1 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.2 | 9.8 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 6.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 6.1 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.1 | 5.5 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 4.9 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.1 | 4.1 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.2 | 4.0 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |