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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for POU5F1_POU2F3
Z-value: 3.90
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Transcription factors associated with POU5F1_POU2F3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| POU2F3 | hg19_v2_chr11_+_120107344_120107351 | 0.30 | 5.3e-06 | Click! |
| POU5F1 | hg19_v2_chr6_-_31138439_31138475 | 0.20 | 3.0e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90060377 Show fit | 91.79 |
ENST00000436451.2
|
immunoglobulin kappa variable 6D-21 (non-functional) |
|
| chr2_+_90248739 Show fit | 83.44 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr2_+_90139056 Show fit | 83.06 |
ENST00000492446.1
|
immunoglobulin kappa variable 1D-16 |
|
| chr2_-_89399845 Show fit | 82.87 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr2_+_90108504 Show fit | 78.23 |
ENST00000390271.2
|
immunoglobulin kappa variable 6D-41 (non-functional) |
|
| chr2_+_90077680 Show fit | 75.77 |
ENST00000390270.2
|
immunoglobulin kappa variable 3D-20 |
|
| chr14_-_107049312 Show fit | 72.79 |
ENST00000390627.2
|
immunoglobulin heavy variable 3-53 |
|
| chr2_+_89998789 Show fit | 69.92 |
ENST00000453166.2
|
immunoglobulin kappa variable 2D-28 |
|
| chr2_-_89340242 Show fit | 66.20 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr2_+_90121477 Show fit | 64.87 |
ENST00000483379.1
|
immunoglobulin kappa variable 1D-17 |
Network of associatons between targets according to the STRING database.
First level regulatory network of POU5F1_POU2F3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.9 | 2692.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 6.5 | 1120.7 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 10.4 | 124.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.3 | 74.4 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 23.7 | 71.2 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 1.3 | 64.9 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 12.1 | 60.6 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 0.6 | 57.6 | GO:0030183 | B cell differentiation(GO:0030183) |
| 1.5 | 56.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
| 0.9 | 54.6 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 1451.5 | GO:0005615 | extracellular space(GO:0005615) |
| 16.8 | 790.4 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 614.5 | GO:0005886 | plasma membrane(GO:0005886) |
| 2.9 | 529.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 8.9 | 124.6 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 4.2 | 88.4 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.8 | 77.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 1.2 | 65.0 | GO:0001533 | cornified envelope(GO:0001533) |
| 19.8 | 59.4 | GO:0071745 | IgA immunoglobulin complex(GO:0071745) IgA immunoglobulin complex, circulating(GO:0071746) monomeric IgA immunoglobulin complex(GO:0071748) polymeric IgA immunoglobulin complex(GO:0071749) secretory IgA immunoglobulin complex(GO:0071751) |
| 7.1 | 49.9 | GO:0019815 | B cell receptor complex(GO:0019815) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.6 | 3668.9 | GO:0003823 | antigen binding(GO:0003823) |
| 10.4 | 135.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.8 | 124.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.2 | 80.2 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 23.7 | 71.2 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 18.5 | 55.4 | GO:0003835 | beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835) |
| 0.2 | 54.1 | GO:0005085 | guanyl-nucleotide exchange factor activity(GO:0005085) |
| 2.7 | 48.6 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 13.0 | 39.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 4.9 | 34.4 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 136.8 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 5.2 | 131.2 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 2.2 | 123.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 2.7 | 106.8 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 1.2 | 103.9 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 1.7 | 98.2 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.5 | 61.2 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 1.2 | 35.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 2.9 | 31.9 | ST PAC1 RECEPTOR PATHWAY | PAC1 Receptor Pathway |
| 0.9 | 30.1 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 131.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 4.8 | 129.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 3.0 | 106.8 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 3.4 | 94.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.3 | 64.6 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 2.9 | 55.4 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 1.3 | 40.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 1.2 | 34.2 | REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS | Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis |
| 0.8 | 32.6 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 1.7 | 30.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |