Project

averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation
Downloads

Results for PRRX1_ALX4_PHOX2A

Z-value: 0.95

Motif logo

logo of logo of logo of

Transcription factors associated with PRRX1_ALX4_PHOX2A

Gene Symbol Gene ID Gene Info
PRRX1
ENSG00000116132.7 paired related homeobox 1
ALX4
ENSG00000052850.5 ALX homeobox 4
PHOX2A
ENSG00000165462.5 paired like homeobox 2A

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ALX4hg19_v2_chr11_-_44331679_443317160.282.1e-05Click!
PRRX1hg19_v2_chr1_+_170633047_1706330840.238.1e-04Click!
PHOX2Ahg19_v2_chr11_-_71955210_71955227,
hg19_v2_chr11_-_71952236_71952319		0.045.7e-01Click!

Activity profile of PRRX1_ALX4_PHOX2A motif

Sorted Z-values of PRRX1_ALX4_PHOX2A motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_195310802 36.22 ENST00000421243.1
ENST00000453131.1
APOD
apolipoprotein D
chr4_-_176733897 29.27 ENST00000393658.2
GPM6A
glycoprotein M6A
chr1_+_92632542 25.97 ENST00000409154.4
ENST00000370378.4
KIAA1107
KIAA1107
chr5_+_140743859 16.94 ENST00000518069.1
PCDHGA5
protocadherin gamma subfamily A, 5
chr1_+_50569575 16.52 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr4_-_174320687 16.05 ENST00000296506.3
SCRG1
stimulator of chondrogenesis 1
chr18_-_21891460 15.45 ENST00000357041.4
OSBPL1A
oxysterol binding protein-like 1A
chr12_+_14572070 13.81 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
ATF7IP
activating transcription factor 7 interacting protein
chr15_+_66874502 12.90 ENST00000558797.1
RP11-321F6.1
HCG2003567; Uncharacterized protein
chr14_+_95078714 12.48 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr14_-_101036119 12.21 ENST00000355173.2
BEGAIN
brain-enriched guanylate kinase-associated
chr6_-_134639180 12.19 ENST00000367858.5
SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_16761007 12.07 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_87028478 10.93 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr2_+_166150541 9.86 ENST00000283256.6
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr2_-_175711133 9.83 ENST00000409597.1
ENST00000413882.1
CHN1
chimerin 1
chr12_-_91546926 9.79 ENST00000550758.1
DCN
decorin
chr5_+_140762268 9.57 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr7_-_82792215 9.46 ENST00000333891.9
ENST00000423517.2
PCLO
piccolo presynaptic cytomatrix protein
chr1_+_183774240 9.18 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr12_-_118796910 9.18 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr2_+_196313239 9.17 ENST00000413290.1
AC064834.1
AC064834.1
chr18_-_52989217 8.86 ENST00000570287.2
TCF4
transcription factor 4
chr5_-_11588907 8.70 ENST00000513598.1
ENST00000503622.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr5_-_11589131 8.48 ENST00000511377.1
CTNND2
catenin (cadherin-associated protein), delta 2
chr2_-_145275228 8.42 ENST00000427902.1
ENST00000409487.3
ENST00000470879.1
ENST00000435831.1
ZEB2
zinc finger E-box binding homeobox 2
chr3_+_153839149 8.09 ENST00000465093.1
ENST00000465817.1
ARHGEF26
Rho guanine nucleotide exchange factor (GEF) 26
chr20_+_31823792 7.51 ENST00000375413.4
ENST00000354297.4
ENST00000375422.2
BPIFA1
BPI fold containing family A, member 1
chr7_+_55980331 7.25 ENST00000429591.2
ZNF713
zinc finger protein 713
chr1_+_12976450 7.05 ENST00000361079.2
PRAMEF7
PRAME family member 7
chr11_+_55029628 6.97 ENST00000417545.2
TRIM48
tripartite motif containing 48
chr3_-_9291063 6.70 ENST00000383836.3
SRGAP3
SLIT-ROBO Rho GTPase activating protein 3
chr12_-_91573249 6.53 ENST00000550099.1
ENST00000546391.1
ENST00000551354.1
DCN
decorin
chr5_-_160279207 6.40 ENST00000327245.5
ATP10B
ATPase, class V, type 10B
chrX_+_107288239 6.31 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr15_+_80733570 6.13 ENST00000533983.1
ENST00000527771.1
ENST00000525103.1
ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr1_+_50459990 6.12 ENST00000448346.1
AL645730.2
AL645730.2
chr1_-_92371839 5.95 ENST00000370399.2
TGFBR3
transforming growth factor, beta receptor III
chr3_-_33759699 5.74 ENST00000399362.4
ENST00000359576.5
ENST00000307312.7
CLASP2
cytoplasmic linker associated protein 2
chr18_-_52989525 5.67 ENST00000457482.3
TCF4
transcription factor 4
chr1_+_180601139 5.65 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr6_+_121756809 5.55 ENST00000282561.3
GJA1
gap junction protein, alpha 1, 43kDa
chr3_-_164914640 5.50 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr11_+_49050504 5.43 ENST00000332682.7
TRIM49B
tripartite motif containing 49B
chr17_+_53342311 5.27 ENST00000226067.5
HLF
hepatic leukemia factor
chrX_+_77166172 5.01 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr2_+_223725652 4.91 ENST00000357430.3
ENST00000392066.3
ACSL3
acyl-CoA synthetase long-chain family member 3
chr13_-_47471155 4.88 ENST00000543956.1
ENST00000542664.1
HTR2A
5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
chr3_+_69985792 4.76 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr1_-_13452656 4.72 ENST00000376132.3
PRAMEF13
PRAME family member 13
chr8_-_86253888 4.46 ENST00000522389.1
ENST00000432364.2
ENST00000517618.1
CA1
carbonic anhydrase I
chr12_-_91573132 4.44 ENST00000550563.1
ENST00000546370.1
DCN
decorin
chr7_+_90338712 4.43 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chrX_+_107288197 4.43 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr16_+_6533380 4.39 ENST00000552089.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr12_+_12878829 4.28 ENST00000326765.6
APOLD1
apolipoprotein L domain containing 1
chr5_+_173472607 4.24 ENST00000303177.3
ENST00000519867.1
NSG2
Neuron-specific protein family member 2
chr5_-_115872142 3.98 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr6_+_25992884 3.92 ENST00000606723.2
U91328.19
U91328.19
chr12_-_91573316 3.92 ENST00000393155.1
DCN
decorin
chr3_+_40518599 3.86 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
ZNF619
zinc finger protein 619
chr8_-_102803163 3.85 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr6_+_26087646 3.76 ENST00000309234.6
HFE
hemochromatosis
chr6_-_27835357 3.75 ENST00000331442.3
HIST1H1B
histone cluster 1, H1b
chr21_-_27423339 3.74 ENST00000415997.1
APP
amyloid beta (A4) precursor protein
chr16_+_7382745 3.70 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_-_13390765 3.44 ENST00000357367.2
PRAMEF8
PRAME family member 8
chr5_+_140227048 3.43 ENST00000532602.1
PCDHA9
protocadherin alpha 9
chr12_+_19358228 3.42 ENST00000424268.1
ENST00000543806.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr15_+_42066632 3.39 ENST00000457542.2
ENST00000221214.6
ENST00000260357.7
ENST00000456763.2
MAPKBP1
mitogen-activated protein kinase binding protein 1
chr10_+_18689637 3.31 ENST00000377315.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr1_-_68698222 3.31 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr10_+_13142225 3.19 ENST00000378747.3
OPTN
optineurin
chr3_+_69985734 3.18 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chrX_-_68385354 3.18 ENST00000361478.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr16_+_6533729 3.12 ENST00000551752.1
RBFOX1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr13_+_53602894 3.09 ENST00000219022.2
OLFM4
olfactomedin 4
chr1_-_94147385 2.93 ENST00000260502.6
BCAR3
breast cancer anti-estrogen resistance 3
chr7_-_152373216 2.89 ENST00000359321.1
XRCC2
X-ray repair complementing defective repair in Chinese hamster cells 2
chr11_+_18433840 2.85 ENST00000541669.1
ENST00000280704.4
LDHC
lactate dehydrogenase C
chr17_+_3118915 2.81 ENST00000304094.1
OR1A1
olfactory receptor, family 1, subfamily A, member 1
chr19_-_49149553 2.81 ENST00000084798.4
CA11
carbonic anhydrase XI
chr12_+_122688090 2.73 ENST00000324189.4
ENST00000546192.1
B3GNT4
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr8_-_26724784 2.69 ENST00000380573.3
ADRA1A
adrenoceptor alpha 1A
chrX_-_48858667 2.68 ENST00000376423.4
ENST00000376441.1
GRIPAP1
GRIP1 associated protein 1
chr2_-_183291741 2.64 ENST00000351439.5
ENST00000409365.1
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr2_+_54683419 2.61 ENST00000356805.4
SPTBN1
spectrin, beta, non-erythrocytic 1
chr14_+_65453432 2.60 ENST00000246166.2
FNTB
farnesyltransferase, CAAX box, beta
chr11_+_66276550 2.54 ENST00000419755.3
CTD-3074O7.11
Bardet-Biedl syndrome 1 protein
chr5_+_40909354 2.52 ENST00000313164.9
C7
complement component 7
chr12_-_10151773 2.41 ENST00000298527.6
ENST00000348658.4
CLEC1B
C-type lectin domain family 1, member B
chr12_+_72080253 2.34 ENST00000549735.1
TMEM19
transmembrane protein 19
chr12_-_25150373 2.32 ENST00000549828.1
C12orf77
chromosome 12 open reading frame 77
chr4_+_155484155 2.31 ENST00000509493.1
FGB
fibrinogen beta chain
chr6_+_153552455 2.31 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr9_-_95298314 2.23 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr2_-_175629164 2.20 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr10_+_53806501 2.12 ENST00000373975.2
PRKG1
protein kinase, cGMP-dependent, type I
chr15_-_26874230 2.10 ENST00000400188.3
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr1_-_165414414 2.10 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr12_-_81992111 2.10 ENST00000443686.3
ENST00000407050.4
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr3_-_149293990 2.08 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chrX_+_11311533 2.08 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
AMELX
amelogenin, X-linked
chr6_+_45296391 2.07 ENST00000371436.6
ENST00000576263.1
RUNX2
runt-related transcription factor 2
chr4_-_170897045 2.01 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr1_+_12916941 1.99 ENST00000240189.2
PRAMEF2
PRAME family member 2
chr6_-_32908765 1.98 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr9_-_21351377 1.91 ENST00000380210.1
IFNA6
interferon, alpha 6
chr19_-_51920835 1.84 ENST00000442846.3
ENST00000530476.1
SIGLEC10
sialic acid binding Ig-like lectin 10
chr16_+_89334512 1.83 ENST00000602042.1
AC137932.1
AC137932.1
chr9_-_215744 1.81 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr3_-_48956818 1.77 ENST00000408959.2
ARIH2OS
ariadne homolog 2 opposite strand
chr5_-_137475071 1.77 ENST00000265191.2
NME5
NME/NM23 family member 5
chr10_-_61900762 1.76 ENST00000355288.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr8_+_107738240 1.75 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr2_-_166930131 1.72 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr4_+_88571429 1.68 ENST00000339673.6
ENST00000282479.7
DMP1
dentin matrix acidic phosphoprotein 1
chrY_-_6742068 1.66 ENST00000215479.5
AMELY
amelogenin, Y-linked
chr10_-_75226166 1.65 ENST00000544628.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_-_23737534 1.61 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr12_+_8975061 1.60 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr7_-_140482926 1.58 ENST00000496384.2
BRAF
v-raf murine sarcoma viral oncogene homolog B
chr12_+_120105558 1.55 ENST00000229328.5
ENST00000541640.1
PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr12_-_11463353 1.53 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
PRB4
proline-rich protein BstNI subfamily 4
chr14_+_88851874 1.51 ENST00000393545.4
ENST00000356583.5
ENST00000555401.1
ENST00000553885.1
SPATA7
spermatogenesis associated 7
chrX_-_68385274 1.50 ENST00000374584.3
ENST00000590146.1
PJA1
praja ring finger 1, E3 ubiquitin protein ligase
chr3_+_155860751 1.48 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr10_+_71075552 1.47 ENST00000298649.3
HK1
hexokinase 1
chr12_+_20968608 1.42 ENST00000381541.3
ENST00000540229.1
ENST00000553473.1
ENST00000554957.1
LST3
SLCO1B3
SLCO1B7
Putative solute carrier organic anion transporter family member 1B7; Uncharacterized protein
solute carrier organic anion transporter family, member 1B3
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr12_+_18414446 1.42 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr21_-_43346790 1.41 ENST00000329623.7
C2CD2
C2 calcium-dependent domain containing 2
chr10_+_89420706 1.41 ENST00000427144.2
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr21_-_35899113 1.39 ENST00000492600.1
ENST00000481448.1
ENST00000381132.2
RCAN1
regulator of calcineurin 1
chr1_+_67632083 1.38 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr10_+_35464513 1.36 ENST00000494479.1
ENST00000463314.1
ENST00000342105.3
ENST00000495301.1
ENST00000463960.1
CREM
cAMP responsive element modulator
chr3_+_111697843 1.31 ENST00000534857.1
ENST00000273359.3
ENST00000494817.1
ABHD10
abhydrolase domain containing 10
chr18_-_64271363 1.31 ENST00000262150.2
CDH19
cadherin 19, type 2
chr12_-_112123524 1.27 ENST00000327551.6
BRAP
BRCA1 associated protein
chr10_+_13141585 1.26 ENST00000378764.2
OPTN
optineurin
chr5_-_111312622 1.24 ENST00000395634.3
NREP
neuronal regeneration related protein
chr3_-_101039402 1.18 ENST00000193391.7
IMPG2
interphotoreceptor matrix proteoglycan 2
chr5_+_140227357 1.18 ENST00000378122.3
PCDHA9
protocadherin alpha 9
chr8_+_38677850 1.17 ENST00000518809.1
ENST00000520611.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr5_+_66254698 1.17 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr19_+_8455077 1.16 ENST00000328024.6
RAB11B
RAB11B, member RAS oncogene family
chr12_+_26348246 1.15 ENST00000422622.2
SSPN
sarcospan
chr1_+_52682052 1.14 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr1_-_241799232 1.13 ENST00000366553.1
CHML
choroideremia-like (Rab escort protein 2)
chr7_-_6866401 1.13 ENST00000316731.8
CCZ1B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr5_-_55412774 1.10 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr2_+_101437487 1.06 ENST00000427413.1
ENST00000542504.1
NPAS2
neuronal PAS domain protein 2
chr21_+_48055527 1.06 ENST00000397638.2
ENST00000458387.2
ENST00000451211.2
ENST00000291705.6
ENST00000397637.1
ENST00000334494.4
ENST00000397628.1
ENST00000440086.1
PRMT2
protein arginine methyltransferase 2
chr1_+_84630645 1.05 ENST00000394839.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chrY_-_6740649 1.05 ENST00000383036.1
ENST00000383037.4
AMELY
amelogenin, Y-linked
chr10_+_57358750 1.04 ENST00000512524.2
MTRNR2L5
MT-RNR2-like 5
chr1_+_109756523 1.04 ENST00000234677.2
ENST00000369923.4
SARS
seryl-tRNA synthetase
chr21_-_36421401 1.03 ENST00000486278.2
RUNX1
runt-related transcription factor 1
chr1_+_158323755 1.01 ENST00000368157.1
ENST00000368156.1
ENST00000368155.3
ENST00000368154.1
ENST00000368160.3
ENST00000368161.3
CD1E
CD1e molecule
chr9_-_21305312 0.99 ENST00000259555.4
IFNA5
interferon, alpha 5
chr19_+_42580274 0.95 ENST00000359044.4
ZNF574
zinc finger protein 574
chr14_+_21467414 0.92 ENST00000554422.1
ENST00000298681.4
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr11_-_89653576 0.92 ENST00000420869.1
TRIM49D1
tripartite motif containing 49D1
chr4_-_122854612 0.91 ENST00000264811.5
TRPC3
transient receptor potential cation channel, subfamily C, member 3
chr12_-_9360966 0.91 ENST00000261336.2
PZP
pregnancy-zone protein
chr1_-_242162375 0.90 ENST00000357246.3
MAP1LC3C
microtubule-associated protein 1 light chain 3 gamma
chr12_-_10978957 0.89 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr10_-_111713633 0.88 ENST00000538668.1
ENST00000369657.1
ENST00000369655.1
RP11-451M19.3
Uncharacterized protein
chrX_-_138724994 0.88 ENST00000536274.1
MCF2
MCF.2 cell line derived transforming sequence
chr15_-_37393406 0.87 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
MEIS2
Meis homeobox 2
chr12_+_75784850 0.84 ENST00000550916.1
ENST00000435775.1
ENST00000378689.2
ENST00000378692.3
ENST00000320460.4
ENST00000547164.1
GLIPR1L2
GLI pathogenesis-related 1 like 2
chr2_-_58468437 0.83 ENST00000403676.1
ENST00000427708.2
ENST00000403295.3
ENST00000446381.1
ENST00000417361.1
ENST00000233741.4
ENST00000402135.3
ENST00000540646.1
ENST00000449070.1
FANCL
Fanconi anemia, complementation group L
chr11_-_89540388 0.79 ENST00000532501.2
TRIM49
tripartite motif containing 49
chr2_-_175629135 0.77 ENST00000409542.1
ENST00000409219.1
CHRNA1
cholinergic receptor, nicotinic, alpha 1 (muscle)
chr13_-_26795840 0.76 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr17_+_71228740 0.76 ENST00000268942.8
ENST00000359042.2
C17orf80
chromosome 17 open reading frame 80
chr10_+_13141441 0.75 ENST00000263036.5
OPTN
optineurin
chr21_-_31588365 0.74 ENST00000399899.1
CLDN8
claudin 8
chr17_+_71228793 0.73 ENST00000426147.2
C17orf80
chromosome 17 open reading frame 80
chr2_+_152214098 0.73 ENST00000243347.3
TNFAIP6
tumor necrosis factor, alpha-induced protein 6
chr2_+_157330081 0.73 ENST00000409674.1
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr9_-_14314566 0.69 ENST00000397579.2
NFIB
nuclear factor I/B
chr22_-_22337204 0.68 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr11_-_82708435 0.67 ENST00000525117.1
ENST00000532548.1
RAB30
RAB30, member RAS oncogene family
chr7_-_93520191 0.65 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr9_+_12693336 0.63 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr14_+_20811722 0.62 ENST00000429687.3
PARP2
poly (ADP-ribose) polymerase 2
chr2_-_172967621 0.61 ENST00000234198.4
ENST00000466293.2
DLX2
distal-less homeobox 2
chr21_-_43816052 0.59 ENST00000398405.1
TMPRSS3
transmembrane protease, serine 3
chr20_-_18477862 0.59 ENST00000337227.4
RBBP9
retinoblastoma binding protein 9
chr11_+_118938485 0.58 ENST00000300793.6
VPS11
vacuolar protein sorting 11 homolog (S. cerevisiae)
chr5_+_36152179 0.56 ENST00000508514.1
ENST00000513151.1
ENST00000546211.1
SKP2
S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
chr9_-_14314518 0.55 ENST00000397581.2
NFIB
nuclear factor I/B
chr4_+_71263599 0.53 ENST00000399575.2
PROL1
proline rich, lacrimal 1
chr6_+_108487245 0.53 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr2_+_44001172 0.53 ENST00000260605.8
ENST00000406852.3
ENST00000443170.3
ENST00000398823.2
ENST00000605786.1
DYNC2LI1
dynein, cytoplasmic 2, light intermediate chain 1
chr11_+_8040739 0.51 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr6_-_152639479 0.51 ENST00000356820.4
SYNE1
spectrin repeat containing, nuclear envelope 1
chr11_+_24518723 0.50 ENST00000336930.6
ENST00000529015.1
ENST00000533227.1
LUZP2
leucine zipper protein 2
chr11_+_12766583 0.50 ENST00000361985.2
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr13_-_52980263 0.49 ENST00000258613.4
ENST00000544466.1
THSD1
thrombospondin, type I, domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of PRRX1_ALX4_PHOX2A

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.1 36.2 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
2.1 24.7 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
2.0 12.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.0 5.9 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
1.9 7.5 GO:0044010 biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
1.8 8.8 GO:0034759 regulation of iron ion transport(GO:0034756) regulation of iron ion transmembrane transport(GO:0034759)
1.7 12.2 GO:0070294 renal sodium ion absorption(GO:0070294)
1.7 6.8 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
1.6 4.9 GO:2001245 regulation of phosphatidylcholine biosynthetic process(GO:2001245)
1.4 5.5 GO:0010652 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
1.4 10.9 GO:0007258 JUN phosphorylation(GO:0007258)
1.2 23.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
1.0 4.9 GO:0071073 positive regulation of phospholipid biosynthetic process(GO:0071073)
0.9 2.7 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.9 2.7 GO:0003099 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback(GO:0001978) baroreceptor response to increased systemic arterial blood pressure(GO:0001983) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.8 3.4 GO:1900425 negative regulation of defense response to bacterium(GO:1900425)
0.8 5.7 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.8 9.9 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.7 3.7 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.7 5.7 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 27.9 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.7 2.7 GO:1905244 regulation of modification of synaptic structure(GO:1905244)
0.7 2.6 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.6 1.9 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.6 7.0 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.6 3.3 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.5 1.6 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.5 5.2 GO:1904415 regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.5 2.9 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.5 2.9 GO:0019249 lactate biosynthetic process(GO:0019249)
0.4 3.1 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.4 1.8 GO:0072658 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 2.6 GO:0018343 protein farnesylation(GO:0018343)
0.4 13.8 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.4 4.3 GO:0042118 endothelial cell activation(GO:0042118)
0.4 3.8 GO:0070166 enamel mineralization(GO:0070166)
0.4 3.0 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.4 15.9 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.4 1.4 GO:0000103 sulfate assimilation(GO:0000103)
0.3 1.0 GO:0097056 seryl-tRNA aminoacylation(GO:0006434) selenocysteinyl-tRNA(Sec) biosynthetic process(GO:0097056)
0.3 1.4 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.3 0.6 GO:1900378 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.3 7.9 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.3 9.8 GO:0008045 motor neuron axon guidance(GO:0008045)
0.3 3.7 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.3 1.6 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.3 2.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.3 0.8 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.3 17.2 GO:0060997 dendritic spine morphogenesis(GO:0060997)
0.2 6.4 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 1.1 GO:0097338 response to clozapine(GO:0097338)
0.2 0.6 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.2 2.1 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.2 0.6 GO:0046533 negative regulation of photoreceptor cell differentiation(GO:0046533) regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.2 2.0 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.2 1.8 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 11.2 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.2 30.6 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 1.0 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734) negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.2 1.3 GO:0016139 glycoside catabolic process(GO:0016139)
0.2 1.1 GO:0018342 protein prenylation(GO:0018342) protein geranylgeranylation(GO:0018344) prenylation(GO:0097354)
0.2 1.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 2.6 GO:0046069 cGMP catabolic process(GO:0046069)
0.2 1.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.9 GO:1903244 positive regulation of cardiac muscle adaptation(GO:0010615) positive regulation of cardiac muscle hypertrophy in response to stress(GO:1903244)
0.2 2.9 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.2 4.2 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 9.5 GO:0035418 protein localization to synapse(GO:0035418)
0.2 1.7 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 1.8 GO:0006228 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.1 1.5 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
0.1 0.7 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.1 2.1 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.1 0.1 GO:0061153 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.1 3.1 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 1.5 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.1 0.4 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.1 1.6 GO:0035878 nail development(GO:0035878)
0.1 0.4 GO:0021558 trochlear nerve development(GO:0021558)
0.1 1.2 GO:0045054 constitutive secretory pathway(GO:0045054)
0.1 5.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 1.7 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1 1.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 2.1 GO:0071420 cellular response to histamine(GO:0071420)
0.1 1.4 GO:0034505 tooth mineralization(GO:0034505)
0.1 2.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.4 GO:0030220 platelet formation(GO:0030220)
0.1 0.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.3 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 0.3 GO:0019442 tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.1 0.6 GO:0015824 proline transport(GO:0015824)
0.1 5.4 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.1 1.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 4.7 GO:0015701 bicarbonate transport(GO:0015701)
0.1 1.1 GO:0051775 response to redox state(GO:0051775)
0.1 2.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.1 0.5 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.6 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 0.7 GO:0006265 DNA topological change(GO:0006265)
0.1 1.0 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.0 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.1 0.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.1 1.4 GO:0039694 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.1 1.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.1 0.9 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 0.5 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.3 GO:0072205 metanephric collecting duct development(GO:0072205)
0.0 0.5 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.0 2.4 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.1 GO:0009726 detection of endogenous stimulus(GO:0009726)
0.0 1.1 GO:0007183 SMAD protein complex assembly(GO:0007183)
0.0 0.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.9 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 9.4 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 1.4 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 5.7 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 0.2 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 1.4 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 2.1 GO:0014047 glutamate secretion(GO:0014047)
0.0 0.6 GO:0042127 regulation of cell proliferation(GO:0042127)
0.0 0.2 GO:0009597 detection of virus(GO:0009597)
0.0 0.3 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.0 0.1 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
0.0 0.7 GO:0030728 ovulation(GO:0030728)
0.0 1.0 GO:0022610 cell adhesion(GO:0007155) biological adhesion(GO:0022610)
0.0 0.5 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.8 GO:0008542 visual learning(GO:0008542)
0.0 1.1 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 0.4 GO:0051497 negative regulation of actin filament bundle assembly(GO:0032232) negative regulation of stress fiber assembly(GO:0051497)
0.0 2.3 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.2 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.0 0.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 3.4 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.0 0.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 0.4 GO:0019433 triglyceride catabolic process(GO:0019433)
0.0 1.1 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 24.7 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
1.5 5.9 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
1.5 4.4 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
1.3 29.3 GO:0044295 axonal growth cone(GO:0044295)
0.7 4.9 GO:0070852 cell body fiber(GO:0070852)
0.7 11.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.6 2.6 GO:0005965 protein farnesyltransferase complex(GO:0005965)
0.6 3.8 GO:1990357 terminal web(GO:1990357)
0.6 5.7 GO:0045180 basal cortex(GO:0045180)
0.5 2.7 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.5 2.9 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.4 3.7 GO:1990761 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
0.4 2.6 GO:0032437 cuticular plate(GO:0032437)
0.4 5.5 GO:0005916 fascia adherens(GO:0005916)
0.4 1.1 GO:0035189 Rb-E2F complex(GO:0035189)
0.3 1.4 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.3 3.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.3 1.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.3 2.5 GO:0005579 membrane attack complex(GO:0005579)
0.3 9.5 GO:0099738 cell cortex region(GO:0099738)
0.3 3.8 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 3.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 5.0 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.2 1.5 GO:1990635 proximal dendrite(GO:1990635)
0.2 2.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 4.2 GO:0032585 multivesicular body membrane(GO:0032585)
0.2 1.7 GO:0005955 calcineurin complex(GO:0005955)
0.1 1.2 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.8 GO:0043194 axon initial segment(GO:0043194)
0.1 3.0 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 0.7 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 14.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 0.8 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.0 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 1.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 16.2 GO:0043204 perikaryon(GO:0043204)
0.1 15.5 GO:0044306 neuron projection terminus(GO:0044306)
0.1 0.5 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.1 6.4 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 1.4 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 31.8 GO:0043025 neuronal cell body(GO:0043025)
0.1 1.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 1.6 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 2.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 2.1 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.6 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1 4.9 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 1.5 GO:0097228 sperm principal piece(GO:0097228)
0.1 2.7 GO:0030315 T-tubule(GO:0030315)
0.1 3.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 11.5 GO:0005802 trans-Golgi network(GO:0005802)
0.0 5.1 GO:0031514 motile cilium(GO:0031514)
0.0 0.6 GO:0030897 HOPS complex(GO:0030897)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 8.9 GO:0032993 protein-DNA complex(GO:0032993)
0.0 8.1 GO:0001726 ruffle(GO:0001726)
0.0 0.5 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 0.9 GO:0000421 autophagosome membrane(GO:0000421)
0.0 5.2 GO:0005770 late endosome(GO:0005770)
0.0 1.5 GO:0005930 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.1 GO:0016235 aggresome(GO:0016235)
0.0 1.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 4.7 GO:0030424 axon(GO:0030424)
0.0 1.6 GO:0044297 cell body(GO:0044297)
0.0 1.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.0 GO:0043005 neuron projection(GO:0043005)
0.0 4.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 10.8 GO:0005789 endoplasmic reticulum membrane(GO:0005789)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.1 9.2 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.8 10.9 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.7 5.0 GO:0032767 copper-dependent protein binding(GO:0032767)
1.4 5.7 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
1.2 15.4 GO:0015248 sterol transporter activity(GO:0015248)
1.1 14.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.9 5.5 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.9 2.7 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.9 2.7 GO:0004937 alpha1-adrenergic receptor activity(GO:0004937)
0.7 2.2 GO:0070052 collagen V binding(GO:0070052)
0.7 2.1 GO:0046848 hydroxyapatite binding(GO:0046848)
0.7 36.4 GO:0015485 cholesterol binding(GO:0015485)
0.6 2.6 GO:0004660 protein farnesyltransferase activity(GO:0004660)
0.6 5.9 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.6 4.5 GO:0004064 arylesterase activity(GO:0004064)
0.5 2.7 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.5 9.5 GO:0005522 profilin binding(GO:0005522)
0.5 2.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.5 12.2 GO:0017081 chloride channel regulator activity(GO:0017081)
0.5 11.6 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.5 3.3 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.5 4.2 GO:0032051 clathrin light chain binding(GO:0032051)
0.5 1.4 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.5 16.5 GO:0017091 AU-rich element binding(GO:0017091)
0.4 6.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.4 2.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.4 2.9 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.4 4.9 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.4 2.6 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.4 3.7 GO:0051425 PTB domain binding(GO:0051425)
0.4 26.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.3 1.0 GO:0004828 serine-tRNA ligase activity(GO:0004828)
0.3 1.4 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.3 3.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.3 3.8 GO:0039706 co-receptor binding(GO:0039706)
0.3 5.7 GO:0002162 dystroglycan binding(GO:0002162)
0.3 4.9 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.3 6.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 2.9 GO:0000150 recombinase activity(GO:0000150)
0.3 30.2 GO:0005262 calcium channel activity(GO:0005262)
0.3 5.2 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 1.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.2 0.6 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.2 2.9 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 9.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.2 1.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.2 2.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 1.5 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.2 0.7 GO:0052590 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.2 1.7 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2 2.1 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 16.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.0 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 1.9 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 6.8 GO:0070412 R-SMAD binding(GO:0070412)
0.1 3.8 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 1.1 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.1 14.0 GO:0008013 beta-catenin binding(GO:0008013)
0.1 0.4 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 4.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.7 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.6 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.1 2.6 GO:0030506 ankyrin binding(GO:0030506)
0.1 4.4 GO:0030332 cyclin binding(GO:0030332)
0.1 1.0 GO:0030882 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 1.1 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.1 0.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 0.3 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.1 0.5 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.1 1.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 2.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.1 1.8 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.1 8.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.1 1.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.6 GO:0031489 myosin V binding(GO:0031489)
0.1 1.5 GO:0070402 NADPH binding(GO:0070402)
0.1 2.5 GO:0070888 E-box binding(GO:0070888)
0.0 1.1 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.4 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 2.4 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.2 GO:0030507 spectrin binding(GO:0030507)
0.0 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 2.4 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0008422 beta-glucosidase activity(GO:0008422)
0.0 10.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 4.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.0 1.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.6 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.5 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.5 GO:0045504 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569) dynein heavy chain binding(GO:0045504)
0.0 8.5 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.1 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.0 19.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.5 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.5 GO:0005521 lamin binding(GO:0005521)
0.0 0.2 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0 1.5 GO:0051087 chaperone binding(GO:0051087)
0.0 1.5 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 1.3 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 3.6 GO:0008289 lipid binding(GO:0008289)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.6 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.5 GO:0005507 copper ion binding(GO:0005507)
0.0 0.4 GO:0005504 fatty acid binding(GO:0005504)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.3 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 21.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 20.1 PID FOXO PATHWAY FoxO family signaling
0.2 10.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 19.5 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 5.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 2.9 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 2.4 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 4.6 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.1 3.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 0.4 PID IL5 PATHWAY IL5-mediated signaling events
0.1 2.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 1.6 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.1 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.1 3.4 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 1.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.1 14.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 3.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.1 PID IL3 PATHWAY IL3-mediated signaling events
0.0 6.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.4 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 8.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.4 PID IL23 PATHWAY IL23-mediated signaling events
0.0 2.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.2 PID AURORA A PATHWAY Aurora A signaling
0.0 1.6 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.5 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 0.8 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.4 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 24.7 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.5 10.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.4 14.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.4 4.9 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.3 5.5 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 4.5 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 4.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.2 11.0 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 3.7 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 3.7 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 9.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.2 3.0 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.2 4.0 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 3.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 1.1 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 5.2 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.2 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 1.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.9 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 1.6 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.1 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 1.6 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.1 0.9 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 1.8 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 0.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 6.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 3.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.4 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 1.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.3 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.2 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 1.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 1.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.8 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.6 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 3.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters