Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RARG
Z-value: 2.02
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Transcription factors associated with RARG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RARG | hg19_v2_chr12_-_53614155_53614197, hg19_v2_chr12_-_53614043_53614154 | 0.05 | 5.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RARG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 81.0 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 9.1 | 64.0 | GO:1903279 | regulation of calcium:sodium antiporter activity(GO:1903279) |
| 1.1 | 63.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 4.5 | 49.3 | GO:2000576 | positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582) |
| 2.9 | 45.6 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 1.9 | 40.5 | GO:0006123 | mitochondrial electron transport, cytochrome c to oxygen(GO:0006123) |
| 13.1 | 39.4 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 7.0 | 35.1 | GO:0030382 | sperm mitochondrion organization(GO:0030382) |
| 0.8 | 34.7 | GO:0021762 | substantia nigra development(GO:0021762) |
| 0.7 | 29.7 | GO:0061718 | NADH regeneration(GO:0006735) glycolytic process through fructose-6-phosphate(GO:0061615) glycolytic process through glucose-6-phosphate(GO:0061620) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 95.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 4.8 | 95.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 5.0 | 79.8 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.8 | 56.2 | GO:0030315 | T-tubule(GO:0030315) |
| 0.9 | 55.1 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.2 | 54.3 | GO:0060076 | excitatory synapse(GO:0060076) |
| 1.6 | 49.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.1 | 49.3 | GO:0005730 | nucleolus(GO:0005730) |
| 0.8 | 35.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 2.5 | 35.1 | GO:0097227 | sperm annulus(GO:0097227) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 83.1 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 2.5 | 77.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 49.3 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.5 | 46.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.6 | 45.2 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.4 | 44.3 | GO:0003774 | motor activity(GO:0003774) |
| 2.1 | 42.9 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 36.3 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.8 | 35.6 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 4.7 | 28.1 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 82.5 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.6 | 50.2 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.7 | 46.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 44.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.6 | 34.6 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 1.4 | 31.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 25.3 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 25.3 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.5 | 21.7 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.5 | 21.3 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 120.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.0 | 92.0 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 1.5 | 83.3 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 2.9 | 51.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.8 | 49.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.6 | 41.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.2 | 31.3 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.6 | 27.0 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.8 | 26.6 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 1.6 | 26.5 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |