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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RBPJ

Z-value: 1.10

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Transcription factors associated with RBPJ

Gene Symbol Gene ID Gene Info
RBPJ
ENSG00000168214.16 recombination signal binding protein for immunoglobulin kappa J region

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RBPJhg19_v2_chr4_+_26322185_26322334-0.321.3e-06Click!

Activity profile of RBPJ motif

Sorted Z-values of RBPJ motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_-_80680078 18.81 ENST00000337919.5
ENST00000354724.3
HEY1
hes-related family bHLH transcription factor with YRPW motif 1
chr17_-_56606664 16.34 ENST00000580844.1
SEPT4
septin 4
chr17_-_56606705 16.10 ENST00000317268.3
SEPT4
septin 4
chr17_-_56606639 15.48 ENST00000579371.1
SEPT4
septin 4
chr3_+_32726774 15.15 ENST00000538368.1
CNOT10
CCR4-NOT transcription complex, subunit 10
chr16_-_70719925 14.83 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr4_-_176733897 13.01 ENST00000393658.2
GPM6A
glycoprotein M6A
chr19_+_50706866 12.89 ENST00000440075.2
ENST00000376970.2
ENST00000425460.1
ENST00000599920.1
ENST00000601313.1
MYH14
myosin, heavy chain 14, non-muscle
chr12_-_16759711 12.09 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_73935409 11.76 ENST00000507544.2
ENST00000295890.4
COX18
COX18 cytochrome C oxidase assembly factor
chr8_-_22089845 11.64 ENST00000454243.2
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chrX_-_153236819 11.49 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr6_+_126070726 11.28 ENST00000368364.3
HEY2
hes-related family bHLH transcription factor with YRPW motif 2
chr8_-_22089533 11.25 ENST00000321613.3
PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein
chr19_-_39390440 11.14 ENST00000249396.7
ENST00000414941.1
ENST00000392081.2
SIRT2
sirtuin 2
chr17_-_34257731 10.64 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
RDM1
RAD52 motif 1
chr5_-_139943830 10.63 ENST00000412920.3
ENST00000511201.2
ENST00000356738.2
ENST00000354402.5
ENST00000358580.5
ENST00000508496.2
APBB3
amyloid beta (A4) precursor protein-binding, family B, member 3
chr12_+_4918342 10.59 ENST00000280684.3
ENST00000433855.1
KCNA6
potassium voltage-gated channel, shaker-related subfamily, member 6
chr19_-_39390350 9.93 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
SIRT2
sirtuin 2
chr19_-_55690758 9.77 ENST00000590851.1
SYT5
synaptotagmin V
chr19_-_46296011 9.14 ENST00000377735.3
ENST00000270223.6
DMWD
dystrophia myotonica, WD repeat containing
chr12_+_12938541 9.10 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr16_-_30102547 8.82 ENST00000279386.2
TBX6
T-box 6
chr1_+_36690011 8.74 ENST00000354618.5
ENST00000469141.2
ENST00000478853.1
THRAP3
thyroid hormone receptor associated protein 3
chr10_-_38146510 8.44 ENST00000395867.3
ZNF248
zinc finger protein 248
chr19_+_56652686 8.21 ENST00000592949.1
ZNF444
zinc finger protein 444
chr1_+_15272271 8.20 ENST00000400797.3
KAZN
kazrin, periplakin interacting protein
chr9_-_35665165 8.09 ENST00000343259.3
ENST00000378387.3
ARHGEF39
Rho guanine nucleotide exchange factor (GEF) 39
chr1_-_223536679 7.68 ENST00000608996.1
SUSD4
sushi domain containing 4
chr14_+_29234870 7.47 ENST00000382535.3
FOXG1
forkhead box G1
chr19_-_36870087 7.34 ENST00000270001.7
ZFP14
ZFP14 zinc finger protein
chr14_-_53258314 7.12 ENST00000216410.3
ENST00000557604.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr22_-_38245304 7.07 ENST00000609454.1
ANKRD54
ankyrin repeat domain 54
chr3_+_142442841 7.01 ENST00000476941.1
ENST00000273482.6
TRPC1
transient receptor potential cation channel, subfamily C, member 1
chr2_+_219824357 6.96 ENST00000302625.4
CDK5R2
cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr11_+_112832202 6.82 ENST00000534015.1
NCAM1
neural cell adhesion molecule 1
chrX_-_40594755 6.74 ENST00000324817.1
MED14
mediator complex subunit 14
chr1_-_146644036 6.73 ENST00000425272.2
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr5_-_137514617 6.69 ENST00000254900.5
BRD8
bromodomain containing 8
chr18_-_52989217 6.64 ENST00000570287.2
TCF4
transcription factor 4
chrX_-_153236620 6.63 ENST00000369984.4
HCFC1
host cell factor C1 (VP16-accessory protein)
chr14_-_53258180 6.56 ENST00000554230.1
GNPNAT1
glucosamine-phosphate N-acetyltransferase 1
chr5_-_115872142 6.51 ENST00000510263.1
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr10_-_51371321 6.46 ENST00000602930.1
AGAP8
ArfGAP with GTPase domain, ankyrin repeat and PH domain 8
chr17_+_2699697 6.24 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr1_-_223537401 6.21 ENST00000343846.3
ENST00000454695.2
ENST00000484758.2
SUSD4
sushi domain containing 4
chr19_+_56652556 6.08 ENST00000337080.3
ZNF444
zinc finger protein 444
chr10_+_112836779 5.91 ENST00000280155.2
ADRA2A
adrenoceptor alpha 2A
chrX_+_122993827 5.75 ENST00000371199.3
XIAP
X-linked inhibitor of apoptosis
chr5_+_178368186 5.69 ENST00000320129.3
ENST00000519564.1
ZNF454
zinc finger protein 454
chr11_+_112832090 5.66 ENST00000533760.1
NCAM1
neural cell adhesion molecule 1
chr17_-_71410794 5.65 ENST00000424778.1
SDK2
sidekick cell adhesion molecule 2
chr12_+_175930 5.65 ENST00000538872.1
ENST00000326261.4
IQSEC3
IQ motif and Sec7 domain 3
chr19_+_42746927 5.46 ENST00000378108.1
AC006486.1
AC006486.1
chr13_-_25496926 5.34 ENST00000545981.1
ENST00000381884.4
CENPJ
centromere protein J
chr11_-_790060 5.31 ENST00000330106.4
CEND1
cell cycle exit and neuronal differentiation 1
chrX_+_16141667 5.13 ENST00000380289.2
GRPR
gastrin-releasing peptide receptor
chr14_-_93214915 5.10 ENST00000553918.1
ENST00000555699.1
ENST00000553802.1
ENST00000554397.1
ENST00000554919.1
ENST00000554080.1
ENST00000553371.1
LGMN
legumain
chr12_-_49259643 5.07 ENST00000309739.5
RND1
Rho family GTPase 1
chr11_-_32452357 5.02 ENST00000379079.2
ENST00000530998.1
WT1
Wilms tumor 1
chr10_+_74927875 4.76 ENST00000242505.6
FAM149B1
family with sequence similarity 149, member B1
chr17_+_29421987 4.75 ENST00000431387.4
NF1
neurofibromin 1
chr3_+_171561127 4.69 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr11_-_64512273 4.56 ENST00000377497.3
ENST00000377487.1
ENST00000430645.1
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr14_-_93214988 4.50 ENST00000557434.1
ENST00000393218.2
ENST00000334869.4
LGMN
legumain
chr1_+_50571949 4.34 ENST00000357083.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr20_+_43211149 4.34 ENST00000372886.1
PKIG
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr9_+_102584128 4.34 ENST00000338488.4
ENST00000395097.2
NR4A3
nuclear receptor subfamily 4, group A, member 3
chr5_+_140792614 4.26 ENST00000398610.2
PCDHGA10
protocadherin gamma subfamily A, 10
chr5_+_178322893 4.13 ENST00000361362.2
ENST00000520660.1
ENST00000520805.1
ZFP2
ZFP2 zinc finger protein
chr2_+_3642545 4.07 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
COLEC11
collectin sub-family member 11
chr16_-_10276611 4.04 ENST00000396573.2
GRIN2A
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
chr3_+_46449049 4.02 ENST00000357392.4
ENST00000400880.3
ENST00000433848.1
CCRL2
chemokine (C-C motif) receptor-like 2
chr1_-_146644122 4.00 ENST00000254101.3
PRKAB2
protein kinase, AMP-activated, beta 2 non-catalytic subunit
chr1_+_43855560 3.90 ENST00000562955.1
SZT2
seizure threshold 2 homolog (mouse)
chr10_+_118305435 3.80 ENST00000369221.2
PNLIP
pancreatic lipase
chr10_+_124320156 3.73 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
DMBT1
deleted in malignant brain tumors 1
chr9_-_130712995 3.70 ENST00000373084.4
FAM102A
family with sequence similarity 102, member A
chr2_-_129076151 3.57 ENST00000259241.6
HS6ST1
heparan sulfate 6-O-sulfotransferase 1
chr1_-_150980828 3.49 ENST00000361936.5
ENST00000361738.6
FAM63A
family with sequence similarity 63, member A
chr3_-_183735731 3.48 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr7_+_76090993 3.47 ENST00000425780.1
ENST00000456590.1
ENST00000451769.1
ENST00000324432.5
ENST00000307569.8
ENST00000457529.1
ENST00000446600.1
ENST00000413936.2
ENST00000423646.1
ENST00000438930.1
ENST00000430490.2
DTX2
deltex homolog 2 (Drosophila)
chr3_+_155860751 3.44 ENST00000471742.1
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr11_+_118478313 3.34 ENST00000356063.5
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr1_-_112531777 3.26 ENST00000315987.2
ENST00000302127.4
KCND3
potassium voltage-gated channel, Shal-related subfamily, member 3
chr17_-_39780819 3.23 ENST00000311208.8
KRT17
keratin 17
chr3_+_159570722 3.23 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr10_+_124320195 3.12 ENST00000359586.6
DMBT1
deleted in malignant brain tumors 1
chr16_+_23313591 3.09 ENST00000343070.2
SCNN1B
sodium channel, non-voltage-gated 1, beta subunit
chr17_+_73452545 3.05 ENST00000314256.7
KIAA0195
KIAA0195
chr12_-_4758159 3.04 ENST00000545990.2
AKAP3
A kinase (PRKA) anchor protein 3
chr14_+_22337014 2.99 ENST00000390436.2
TRAV13-1
T cell receptor alpha variable 13-1
chr2_+_48796120 2.98 ENST00000394754.1
STON1-GTF2A1L
STON1-GTF2A1L readthrough
chr11_+_64052692 2.95 ENST00000377702.4
GPR137
G protein-coupled receptor 137
chr16_-_53737795 2.93 ENST00000262135.4
ENST00000564374.1
ENST00000566096.1
RPGRIP1L
RPGRIP1-like
chr14_-_53417732 2.93 ENST00000399304.3
ENST00000395631.2
ENST00000341590.3
ENST00000343279.4
FERMT2
fermitin family member 2
chr9_-_98269481 2.90 ENST00000418258.1
ENST00000553011.1
ENST00000551845.1
PTCH1
patched 1
chr11_+_66512089 2.83 ENST00000524551.1
ENST00000525908.1
ENST00000360962.4
ENST00000346672.4
ENST00000527634.1
ENST00000540737.1
C11orf80
chromosome 11 open reading frame 80
chr16_-_53737722 2.73 ENST00000569716.1
ENST00000562588.1
ENST00000562230.1
ENST00000379925.3
ENST00000563746.1
ENST00000568653.3
RPGRIP1L
RPGRIP1-like
chr21_+_38792602 2.61 ENST00000398960.2
ENST00000398956.2
DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
chr13_-_74708372 2.61 ENST00000377666.4
KLF12
Kruppel-like factor 12
chrX_-_49121165 2.57 ENST00000376207.4
ENST00000376199.2
FOXP3
forkhead box P3
chr7_-_120498357 2.55 ENST00000415871.1
ENST00000222747.3
ENST00000430985.1
TSPAN12
tetraspanin 12
chr19_+_50528971 2.51 ENST00000598809.1
ENST00000595661.1
ENST00000391821.2
ZNF473
zinc finger protein 473
chr17_-_16118835 2.48 ENST00000582357.1
ENST00000436828.1
ENST00000411510.1
ENST00000268712.3
NCOR1
nuclear receptor corepressor 1
chr6_-_76203345 2.44 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr11_+_66512303 2.39 ENST00000532565.2
C11orf80
chromosome 11 open reading frame 80
chr11_-_64512469 2.35 ENST00000377485.1
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr21_-_31538971 2.33 ENST00000286808.3
CLDN17
claudin 17
chr10_-_97200772 2.16 ENST00000371241.1
ENST00000354106.3
ENST00000371239.1
ENST00000361941.3
ENST00000277982.5
ENST00000371245.3
SORBS1
sorbin and SH3 domain containing 1
chr7_+_90338712 2.08 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr19_+_39390587 2.07 ENST00000572515.1
ENST00000392079.3
ENST00000575359.1
ENST00000313582.5
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr22_+_40297105 2.04 ENST00000540310.1
GRAP2
GRB2-related adaptor protein 2
chr20_+_30063067 2.02 ENST00000201979.2
REM1
RAS (RAD and GEM)-like GTP-binding 1
chr3_+_193853927 2.02 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr9_-_14722715 1.94 ENST00000380911.3
CER1
cerberus 1, DAN family BMP antagonist
chr19_+_50529212 1.84 ENST00000270617.3
ENST00000445728.3
ENST00000601364.1
ZNF473
zinc finger protein 473
chr1_-_8000872 1.80 ENST00000377507.3
TNFRSF9
tumor necrosis factor receptor superfamily, member 9
chr12_-_7848364 1.72 ENST00000329913.3
GDF3
growth differentiation factor 3
chr2_+_204193101 1.63 ENST00000430418.1
ENST00000424558.1
ENST00000261016.6
ABI2
abl-interactor 2
chr19_+_39390320 1.60 ENST00000576510.1
NFKBIB
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
chr7_+_90339169 1.58 ENST00000436577.2
CDK14
cyclin-dependent kinase 14
chr11_-_64512803 1.55 ENST00000377489.1
ENST00000354024.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr18_+_10526008 1.51 ENST00000542979.1
ENST00000322897.6
NAPG
N-ethylmaleimide-sensitive factor attachment protein, gamma
chr1_-_40105617 1.50 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr17_+_29421900 1.48 ENST00000358273.4
ENST00000356175.3
NF1
neurofibromin 1
chr17_+_38474489 1.46 ENST00000394089.2
ENST00000425707.3
RARA
retinoic acid receptor, alpha
chr6_-_94129244 1.45 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr8_+_107738240 1.43 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr10_-_33623310 1.39 ENST00000395995.1
ENST00000374823.5
ENST00000374821.5
ENST00000374816.3
NRP1
neuropilin 1
chr7_-_94953878 1.39 ENST00000222381.3
PON1
paraoxonase 1
chr9_-_35691017 1.34 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr1_+_147374915 1.32 ENST00000240986.4
GJA8
gap junction protein, alpha 8, 50kDa
chr7_-_27169801 1.28 ENST00000511914.1
HOXA4
homeobox A4
chr2_-_79315112 1.21 ENST00000305089.3
REG1B
regenerating islet-derived 1 beta
chr22_+_40297079 1.16 ENST00000344138.4
ENST00000543252.1
GRAP2
GRB2-related adaptor protein 2
chr11_+_64053005 1.12 ENST00000538032.1
GPR137
G protein-coupled receptor 137
chr3_-_87325728 1.00 ENST00000350375.2
POU1F1
POU class 1 homeobox 1
chr1_-_85358850 0.98 ENST00000370611.3
LPAR3
lysophosphatidic acid receptor 3
chr7_+_100187196 0.87 ENST00000468962.1
ENST00000427939.2
FBXO24
F-box protein 24
chr11_-_8959758 0.85 ENST00000531618.1
ASCL3
achaete-scute family bHLH transcription factor 3
chr5_+_132009675 0.74 ENST00000231449.2
ENST00000350025.2
IL4
interleukin 4
chr11_+_64052944 0.71 ENST00000535675.1
ENST00000543383.1
GPR137
G protein-coupled receptor 137
chr12_+_6309963 0.68 ENST00000382515.2
CD9
CD9 molecule
chr11_-_83393457 0.63 ENST00000404783.3
DLG2
discs, large homolog 2 (Drosophila)
chr4_+_26321284 0.58 ENST00000506956.1
ENST00000512671.1
ENST00000345843.3
ENST00000342295.1
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr11_-_83393429 0.54 ENST00000426717.2
DLG2
discs, large homolog 2 (Drosophila)
chr1_-_43855479 0.51 ENST00000290663.6
ENST00000372457.4
MED8
mediator complex subunit 8
chr9_+_706842 0.49 ENST00000382293.3
KANK1
KN motif and ankyrin repeat domains 1
chr20_+_44637526 0.49 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr19_+_44100544 0.44 ENST00000391965.2
ENST00000525771.1
ZNF576
zinc finger protein 576
chr19_-_46088068 0.35 ENST00000263275.4
ENST00000323060.3
OPA3
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr15_-_70390191 0.33 ENST00000559191.1
TLE3
transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
chr15_+_40697988 0.18 ENST00000487418.2
ENST00000479013.2
IVD
isovaleryl-CoA dehydrogenase
chr10_-_44144292 0.17 ENST00000374433.2
ZNF32
zinc finger protein 32
chrX_+_19362011 0.16 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr22_-_31885727 0.09 ENST00000330125.5
ENST00000344710.5
ENST00000397518.1
EIF4ENIF1
eukaryotic translation initiation factor 4E nuclear import factor 1
chr13_-_38443860 0.06 ENST00000426868.2
ENST00000379681.3
ENST00000338947.5
ENST00000355779.2
ENST00000358477.2
ENST00000379673.2
TRPC4
transient receptor potential cation channel, subfamily C, member 4
chrX_+_152907913 0.03 ENST00000370167.4
DUSP9
dual specificity phosphatase 9

Network of associatons between targets according to the STRING database.

First level regulatory network of RBPJ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 47.9 GO:0030382 sperm mitochondrion organization(GO:0030382)
7.5 30.1 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
7.0 21.1 GO:2000777 positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
4.5 18.1 GO:0019046 release from viral latency(GO:0019046)
3.2 9.6 GO:0006624 vacuolar protein processing(GO:0006624)
2.7 13.7 GO:0006041 glucosamine metabolic process(GO:0006041)
2.3 7.0 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
2.1 6.2 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
2.0 12.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
1.9 5.8 GO:1902528 regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
1.5 5.9 GO:0035625 negative regulation of epinephrine secretion(GO:0032811) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
1.5 8.8 GO:0014043 negative regulation of neuron maturation(GO:0014043)
1.4 4.3 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
1.3 5.1 GO:0036343 psychomotor behavior(GO:0036343)
1.3 5.0 GO:0072299 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
1.1 5.3 GO:0061511 centriole elongation(GO:0061511)
1.1 5.3 GO:0021699 cerebellum maturation(GO:0021590) cerebellar cortex maturation(GO:0021699)
1.0 2.9 GO:0021997 neural plate axis specification(GO:0021997)
0.9 4.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.9 1.7 GO:0048859 formation of anatomical boundary(GO:0048859)
0.9 2.6 GO:0032829 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.8 9.1 GO:0042118 endothelial cell activation(GO:0042118)
0.7 6.9 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.7 2.0 GO:1901842 negative regulation of high voltage-gated calcium channel activity(GO:1901842)
0.7 2.0 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.6 11.8 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.6 3.9 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.5 6.5 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.5 10.7 GO:0006853 carnitine shuttle(GO:0006853)
0.5 1.5 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.5 1.9 GO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175)
0.5 5.1 GO:0016322 neuron remodeling(GO:0016322)
0.4 4.0 GO:0042428 serotonin metabolic process(GO:0042428)
0.4 5.7 GO:0022038 corpus callosum development(GO:0022038)
0.4 13.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.4 2.5 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.4 8.7 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.4 1.5 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.3 1.4 GO:0034444 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.3 15.3 GO:0097178 ruffle assembly(GO:0097178)
0.3 5.7 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.3 4.1 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.3 3.3 GO:1904261 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.3 1.8 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.3 6.1 GO:0006828 manganese ion transport(GO:0006828)
0.3 3.4 GO:0060539 diaphragm development(GO:0060539)
0.3 5.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 10.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.3 4.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.3 15.1 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.3 3.8 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.2 1.0 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.2 3.5 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.2 0.7 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.2 9.8 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 4.2 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.2 1.6 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 3.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.2 3.2 GO:0051798 positive regulation of hair follicle development(GO:0051798)
0.2 7.1 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 1.5 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 2.6 GO:0090312 positive regulation of protein deacetylation(GO:0090312)
0.1 2.6 GO:0010842 retina layer formation(GO:0010842)
0.1 3.4 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.9 GO:0033622 integrin activation(GO:0033622)
0.1 1.4 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.1 13.9 GO:0030449 regulation of complement activation(GO:0030449)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 3.0 GO:0007340 acrosome reaction(GO:0007340)
0.1 2.2 GO:0045725 positive regulation of glycogen biosynthetic process(GO:0045725)
0.1 2.3 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.1 0.5 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 10.1 GO:0060333 interferon-gamma-mediated signaling pathway(GO:0060333)
0.1 5.8 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 7.6 GO:0070268 cornification(GO:0070268)
0.1 0.7 GO:0009414 response to water deprivation(GO:0009414)
0.1 3.1 GO:0050909 sensory perception of taste(GO:0050909)
0.1 8.1 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 10.6 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 1.2 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 4.7 GO:0030521 androgen receptor signaling pathway(GO:0030521)
0.0 4.0 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 3.2 GO:0031295 T cell costimulation(GO:0031295)
0.0 6.2 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 4.3 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.3 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 1.5 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 3.7 GO:0071222 cellular response to lipopolysaccharide(GO:0071222)
0.0 0.2 GO:0006552 leucine catabolic process(GO:0006552)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 1.3 GO:0033275 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 47.9 GO:0097227 sperm annulus(GO:0097227)
2.6 12.9 GO:0097513 myosin II filament(GO:0097513)
2.3 21.1 GO:0072687 meiotic spindle(GO:0072687)
1.9 5.7 GO:0005879 axonemal microtubule(GO:0005879)
1.7 7.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
1.6 9.8 GO:1990769 proximal neuron projection(GO:1990769)
1.4 18.1 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.4 9.6 GO:0036021 endolysosome lumen(GO:0036021)
1.3 6.7 GO:0070847 core mediator complex(GO:0070847)
1.2 3.7 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
1.1 5.3 GO:0008275 gamma-tubulin small complex(GO:0008275)
0.9 15.1 GO:0030014 CCR4-NOT complex(GO:0030014)
0.7 15.9 GO:0044295 axonal growth cone(GO:0044295)
0.6 3.9 GO:1990130 Iml1 complex(GO:1990130)
0.6 13.8 GO:0016580 Sin3 complex(GO:0016580)
0.5 10.7 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.5 3.4 GO:1990635 proximal dendrite(GO:1990635)
0.5 5.7 GO:0060077 inhibitory synapse(GO:0060077)
0.4 2.2 GO:0005899 insulin receptor complex(GO:0005899)
0.4 11.8 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.4 6.9 GO:0042589 zymogen granule membrane(GO:0042589)
0.3 6.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 3.3 GO:0045180 basal cortex(GO:0045180)
0.3 8.7 GO:0035145 exon-exon junction complex(GO:0035145)
0.3 3.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.3 8.2 GO:0030057 desmosome(GO:0030057)
0.2 15.0 GO:0015030 Cajal body(GO:0015030)
0.2 3.4 GO:0000812 Swr1 complex(GO:0000812)
0.1 14.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 15.0 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 1.6 GO:0031209 SCAR complex(GO:0031209)
0.1 3.1 GO:0034706 sodium channel complex(GO:0034706)
0.1 1.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.1 4.3 GO:0042629 mast cell granule(GO:0042629)
0.1 0.6 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1 2.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 13.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 1.3 GO:0005922 connexon complex(GO:0005922)
0.1 8.9 GO:0032587 ruffle membrane(GO:0032587)
0.1 10.1 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.0 GO:0042734 presynaptic membrane(GO:0042734)
0.0 4.1 GO:0005581 collagen trimer(GO:0005581)
0.0 1.5 GO:0031201 SNARE complex(GO:0031201)
0.0 2.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 9.7 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 25.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.1 GO:0031965 nuclear membrane(GO:0031965)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.9 31.6 GO:0035939 microsatellite binding(GO:0035939)
7.0 21.1 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
2.3 7.0 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
2.0 5.9 GO:0004938 alpha2-adrenergic receptor activity(GO:0004938)
1.5 18.1 GO:0043995 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
1.1 3.4 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.0 5.0 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
1.0 15.5 GO:0042809 vitamin D receptor binding(GO:0042809)
0.8 10.7 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.7 3.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.6 3.2 GO:0042289 MHC class II protein binding(GO:0042289)
0.6 2.9 GO:0097108 hedgehog family protein binding(GO:0097108)
0.6 12.9 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.5 6.6 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.5 6.2 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.5 6.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.5 8.5 GO:0019992 diacylglycerol binding(GO:0019992)
0.5 1.4 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.4 10.6 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 24.6 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.3 3.5 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.3 4.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.3 1.9 GO:0016015 morphogen activity(GO:0016015)
0.3 6.9 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 1.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 1.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 3.6 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.2 2.6 GO:0051525 NFAT protein binding(GO:0051525)
0.2 3.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.2 5.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 4.3 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.2 4.1 GO:0005537 mannose binding(GO:0005537)
0.2 10.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 5.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.2 55.0 GO:0003924 GTPase activity(GO:0003924)
0.2 13.1 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 10.6 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 5.1 GO:0008188 neuropeptide receptor activity(GO:0008188)
0.1 3.8 GO:0004806 triglyceride lipase activity(GO:0004806)
0.1 2.6 GO:0048156 tau protein binding(GO:0048156)
0.1 3.4 GO:0070402 NADPH binding(GO:0070402)
0.1 2.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.1 14.2 GO:0005262 calcium channel activity(GO:0005262)
0.1 4.3 GO:0017091 AU-rich element binding(GO:0017091)
0.1 2.9 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.1 4.0 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.3 GO:0005243 gap junction channel activity(GO:0005243)
0.1 11.9 GO:0008565 protein transporter activity(GO:0008565)
0.1 3.7 GO:0030332 cyclin binding(GO:0030332)
0.1 8.1 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 6.9 GO:0001618 virus receptor activity(GO:0001618)
0.1 1.6 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.1 1.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 0.6 GO:0000150 recombinase activity(GO:0000150)
0.0 2.2 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 3.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 7.1 GO:0019887 protein kinase regulator activity(GO:0019887)
0.0 1.2 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 5.7 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 1.7 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 2.3 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.5 GO:0019905 syntaxin binding(GO:0019905)
0.0 9.1 GO:0008289 lipid binding(GO:0008289)
0.0 1.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.8 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.2 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 21.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.5 29.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 14.7 PID RAS PATHWAY Regulation of Ras family activation
0.2 7.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 3.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 4.3 ST GA12 PATHWAY G alpha 12 Pathway
0.1 2.9 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.1 10.5 PID FGF PATHWAY FGF signaling pathway
0.1 3.7 ST GAQ PATHWAY G alpha q Pathway
0.1 3.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 11.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.4 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 19.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.5 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.0 2.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 1.8 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.7 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.9 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 4.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.3 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 12.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.7 9.6 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.5 10.7 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 31.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.4 15.1 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.4 18.0 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.4 17.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.3 14.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.3 4.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 6.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 5.9 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.2 3.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 3.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 9.8 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.1 7.2 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 3.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 3.8 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.1 2.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 4.0 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 3.5 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.3 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.2 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 1.9 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 2.9 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 5.2 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.6 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix