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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for RCOR1_MTA3
Z-value: 3.15
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Transcription factors associated with RCOR1_MTA3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RCOR1 | hg19_v2_chr14_+_103058948_103059005 | 0.44 | 1.1e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RCOR1_MTA3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.3 | 1764.5 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 20.8 | 1542.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 12.6 | 829.2 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 10.3 | 727.9 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 14.3 | 644.5 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 25.6 | 639.7 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 5.9 | 572.4 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 11.8 | 565.1 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 6.7 | 562.8 | GO:0006901 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) |
| 2.5 | 452.6 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 4244.5 | GO:0070062 | extracellular exosome(GO:0070062) |
| 5.7 | 2797.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 8.8 | 1356.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 9.5 | 1356.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 7.7 | 818.9 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 19.2 | 730.5 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 11.8 | 718.9 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 4.8 | 687.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 25.0 | 675.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 7.8 | 675.0 | GO:0000779 | condensed chromosome, centromeric region(GO:0000779) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.1 | 3084.6 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.6 | 2834.7 | GO:0003723 | RNA binding(GO:0003723) |
| 10.3 | 2110.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 20.9 | 963.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 25.2 | 755.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 14.4 | 748.7 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 5.7 | 740.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 8.4 | 573.9 | GO:0019003 | GDP binding(GO:0019003) |
| 2.8 | 522.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 8.7 | 470.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.0 | 1401.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 12.9 | 724.8 | PID ATR PATHWAY | ATR signaling pathway |
| 12.8 | 676.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 13.8 | 593.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 11.5 | 573.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 11.0 | 562.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 8.1 | 494.0 | PID A6B1 A6B4 INTEGRIN PATHWAY | a6b1 and a6b4 Integrin signaling |
| 7.0 | 468.8 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 5.6 | 452.0 | PID E2F PATHWAY | E2F transcription factor network |
| 12.9 | 411.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.3 | 2294.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 22.8 | 1782.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 14.8 | 1259.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 6.1 | 919.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 25.6 | 872.0 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 23.2 | 720.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 12.7 | 685.3 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 13.4 | 684.2 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 9.5 | 654.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 6.6 | 638.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |