ISMARA results: RUNX3

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for RUNX3_BCL11A

Z-value: 1.68

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Transcription factors associated with RUNX3_BCL11A

Gene Symbol	Gene ID	Gene Info
RUNX3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000020633.14	RUNX family transcription factor 3
BCL11A Ensembl NCBI GeneCards UniProt NextProt	ENSG00000119866.16	BAF chromatin remodeling complex subunit BCL11A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
RUNX3	hg19_v2_chr1_-_25291475_25291511	0.62	1.4e-24	Click!
BCL11A	hg19_v2_chr2_-_60780536_60780541	-0.14	4.6e-02	Click!

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_25291475 Show fit	34.47	ENST00000338888.3 ENST00000399916.1	RUNX3 Ensembl NCBI GeneCards UniProt NextProt Show fit	runt-related transcription factor 3
chr10_+_17272608 Show fit	33.26	ENST00000421459.2	VIM Ensembl NCBI GeneCards UniProt NextProt Show fit	vimentin
chr2_-_158300556 Show fit	31.12	ENST00000264192.3	CYTIP Ensembl NCBI GeneCards UniProt NextProt Show fit	cytohesin 1 interacting protein
chr11_-_58345569 Show fit	30.52	ENST00000528954.1 ENST00000528489.1	LPXN Ensembl NCBI GeneCards UniProt NextProt Show fit	leupaxin
chr4_-_84035905 Show fit	26.00	ENST00000311507.4	PLAC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	placenta-specific 8
chr4_-_84035868 Show fit	24.80	ENST00000426923.2 ENST00000509973.1	PLAC8 Ensembl NCBI GeneCards UniProt NextProt Show fit	placenta-specific 8
chr5_+_35856951 Show fit	23.64	ENST00000303115.3 ENST00000343305.4 ENST00000506850.1 ENST00000511982.1	IL7R Ensembl NCBI GeneCards UniProt NextProt Show fit	interleukin 7 receptor
chr5_+_54398463 Show fit	22.83	ENST00000274306.6	GZMA Ensembl NCBI GeneCards UniProt NextProt Show fit	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr9_+_75766652 Show fit	22.06	ENST00000257497.6	ANXA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	annexin A1
chr5_+_156607829 Show fit	20.99	ENST00000422843.3	ITK Ensembl NCBI GeneCards UniProt NextProt Show fit	IL2-inducible T-cell kinase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	56.5	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
4.8	52.4	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
2.4	51.1	GO:0097320	membrane tubulation(GO:0097320)
0.5	44.0	GO:0038083	peptidyl-tyrosine autophosphorylation(GO:0038083)
3.8	30.5	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.2	27.5	GO:0050680	negative regulation of epithelial cell proliferation(GO:0050680)
2.0	27.4	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
3.5	24.4	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
2.3	22.8	GO:0032074	negative regulation of nuclease activity(GO:0032074)
2.3	22.7	GO:0033089	positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)

Showing 1 to 10 of 169 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	94.3	GO:0001772	immunological synapse(GO:0001772)
4.7	93.1	GO:0001891	phagocytic cup(GO:0001891)
0.5	56.6	GO:0005882	intermediate filament(GO:0005882)
0.3	54.8	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5	50.8	GO:0035578	azurophil granule lumen(GO:0035578)
0.2	46.5	GO:0009897	external side of plasma membrane(GO:0009897)
0.1	36.8	GO:0005769	early endosome(GO:0005769)
0.6	27.8	GO:0002102	podosome(GO:0002102)
0.3	25.5	GO:0005884	actin filament(GO:0005884)
0.3	25.5	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)

Showing 1 to 10 of 93 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	64.9	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
8.7	52.4	GO:1990254	keratin filament binding(GO:1990254)
0.2	48.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	25.9	GO:0005543	phospholipid binding(GO:0005543)
4.3	25.5	GO:0042610	CD8 receptor binding(GO:0042610)
7.9	23.6	GO:0004917	interleukin-7 receptor activity(GO:0004917)
1.1	22.4	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5	22.3	GO:0050699	WW domain binding(GO:0050699)
2.8	22.2	GO:0071933	Arp2/3 complex binding(GO:0071933)
3.7	22.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)

Showing 1 to 10 of 137 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	97.4	PID TCR PATHWAY	TCR signaling in naïve CD4+ T cells
0.9	94.4	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.6	49.7	PID IL12 2PATHWAY	IL12-mediated signaling events
1.1	28.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.7	26.9	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	25.3	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.5	23.7	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.5	23.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.1	17.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	16.8	PID BCR 5PATHWAY	BCR signaling pathway

Showing 1 to 10 of 46 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	107.3	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.4	49.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5	48.3	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.6	37.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.2	33.2	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
1.3	24.7	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.5	24.4	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
1.1	23.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.2	22.9	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.8	20.8	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing

Showing 1 to 10 of 54 entries

Results for RUNX3_BCL11A

Z-value: 1.68

Motif logo

Transcription factors associated with RUNX3_BCL11A

Activity-expression correlation:

Activity profile of RUNX3_BCL11A motif

Sorted Z-values of RUNX3_BCL11A motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of RUNX3_BCL11A

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: