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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SHOX

Z-value: 0.74

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Transcription factors associated with SHOX

Gene Symbol Gene ID Gene Info
SHOX
ENSG00000185960.8 short stature homeobox
SHOX
ENSGR0000185960.8 short stature homeobox

Activity profile of SHOX motif

Sorted Z-values of SHOX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_117748138 23.84 ENST00000527717.1
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_117747607 23.45 ENST00000540359.1
ENST00000539526.1
FXYD6
FXYD domain containing ion transport regulator 6
chrX_-_13835147 23.17 ENST00000493677.1
ENST00000355135.2
GPM6B
glycoprotein M6B
chr11_-_117747434 23.07 ENST00000529335.2
ENST00000530956.1
ENST00000260282.4
FXYD6
FXYD domain containing ion transport regulator 6
chr11_-_111794446 14.61 ENST00000527950.1
CRYAB
crystallin, alpha B
chr12_-_16761007 13.03 ENST00000354662.1
ENST00000441439.2
LMO3
LIM domain only 3 (rhombotin-like 2)
chr3_+_111718036 9.34 ENST00000455401.2
TAGLN3
transgelin 3
chr3_+_111718173 9.33 ENST00000494932.1
TAGLN3
transgelin 3
chr13_-_36429763 8.92 ENST00000379893.1
DCLK1
doublecortin-like kinase 1
chr3_+_111717600 8.80 ENST00000273368.4
TAGLN3
transgelin 3
chr3_+_111717511 8.57 ENST00000478951.1
ENST00000393917.2
TAGLN3
transgelin 3
chr3_+_115342349 8.18 ENST00000393780.3
GAP43
growth associated protein 43
chr12_-_16759711 7.87 ENST00000447609.1
LMO3
LIM domain only 3 (rhombotin-like 2)
chr4_-_57547870 7.78 ENST00000381260.3
ENST00000420433.1
ENST00000554144.1
ENST00000557328.1
HOPX
HOP homeobox
chr4_-_57547454 7.40 ENST00000556376.2
HOPX
HOP homeobox
chr2_-_224467093 6.04 ENST00000305409.2
SCG2
secretogranin II
chr17_-_9929581 5.52 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr5_-_24645078 5.50 ENST00000264463.4
CDH10
cadherin 10, type 2 (T2-cadherin)
chr11_-_129062093 5.45 ENST00000310343.9
ARHGAP32
Rho GTPase activating protein 32
chr12_-_10282836 5.29 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr18_-_21977748 5.16 ENST00000399441.4
ENST00000319481.3
OSBPL1A
oxysterol binding protein-like 1A
chr12_-_16758059 5.03 ENST00000261169.6
LMO3
LIM domain only 3 (rhombotin-like 2)
chr17_-_78450398 4.84 ENST00000306773.4
NPTX1
neuronal pentraxin I
chr7_-_37488834 4.53 ENST00000310758.4
ELMO1
engulfment and cell motility 1
chr8_-_102803163 4.34 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr1_-_45956822 4.32 ENST00000372086.3
ENST00000341771.6
TESK2
testis-specific kinase 2
chr13_-_67802549 4.31 ENST00000328454.5
ENST00000377865.2
PCDH9
protocadherin 9
chr1_+_153747746 4.27 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr16_-_29910853 4.23 ENST00000308713.5
SEZ6L2
seizure related 6 homolog (mouse)-like 2
chr1_+_66458072 4.19 ENST00000423207.2
PDE4B
phosphodiesterase 4B, cAMP-specific
chr10_+_111765562 4.15 ENST00000360162.3
ADD3
adducin 3 (gamma)
chr19_+_50016610 3.61 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_39693111 3.57 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
KIF6
kinesin family member 6
chr16_-_4852915 3.56 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr1_+_180601139 3.55 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1
chr1_+_153746683 3.53 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr7_-_137028534 3.50 ENST00000348225.2
PTN
pleiotrophin
chr7_+_154002189 3.41 ENST00000332007.3
DPP6
dipeptidyl-peptidase 6
chr12_+_26348246 3.40 ENST00000422622.2
SSPN
sarcospan
chr8_+_107738240 3.40 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr7_-_137028498 3.38 ENST00000393083.2
PTN
pleiotrophin
chr8_-_17533838 3.37 ENST00000400046.1
MTUS1
microtubule associated tumor suppressor 1
chr12_-_6233828 3.33 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr4_+_114214125 3.29 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr7_+_97361218 3.27 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr1_+_50569575 3.23 ENST00000371827.1
ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr3_+_69985792 3.06 ENST00000531774.1
MITF
microphthalmia-associated transcription factor
chr1_+_183774240 3.05 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr2_-_50201327 3.00 ENST00000412315.1
NRXN1
neurexin 1
chr8_-_33457453 2.98 ENST00000523956.1
ENST00000256261.4
DUSP26
dual specificity phosphatase 26 (putative)
chr12_-_89746173 2.89 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr1_-_68698222 2.86 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
WLS
wntless Wnt ligand secretion mediator
chr7_+_97361388 2.83 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr19_-_7968427 2.83 ENST00000539278.1
AC010336.1
Uncharacterized protein
chr10_-_50970322 2.80 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr2_-_50574856 2.79 ENST00000342183.5
NRXN1
neurexin 1
chr2_+_68962014 2.73 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr2_-_74618964 2.71 ENST00000417090.1
ENST00000409868.1
DCTN1
dynactin 1
chr19_+_50016411 2.65 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr9_+_12693336 2.61 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chr3_+_69985734 2.45 ENST00000314557.6
ENST00000394351.3
MITF
microphthalmia-associated transcription factor
chr12_-_10282742 2.37 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr7_+_100136811 2.35 ENST00000300176.4
ENST00000262935.4
AGFG2
ArfGAP with FG repeats 2
chr2_+_90248739 2.35 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chr1_-_45956800 2.34 ENST00000538496.1
TESK2
testis-specific kinase 2
chr3_-_33686743 2.33 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr1_-_152386732 2.33 ENST00000271835.3
CRNN
cornulin
chr3_+_173116225 2.31 ENST00000457714.1
NLGN1
neuroligin 1
chr17_-_77924627 2.28 ENST00000572862.1
ENST00000573782.1
ENST00000574427.1
ENST00000570373.1
ENST00000340848.7
ENST00000576768.1
TBC1D16
TBC1 domain family, member 16
chr9_+_5890802 2.26 ENST00000381477.3
ENST00000381476.1
ENST00000381471.1
MLANA
melan-A
chr2_-_74619152 2.21 ENST00000440727.1
ENST00000409240.1
DCTN1
dynactin 1
chr10_-_50970382 2.12 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr4_+_72204755 2.10 ENST00000512686.1
ENST00000340595.3
SLC4A4
solute carrier family 4 (sodium bicarbonate cotransporter), member 4
chrX_-_19988382 2.05 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23
chromosome X open reading frame 23
chr14_+_29236269 2.02 ENST00000313071.4
FOXG1
forkhead box G1
chr11_-_128894053 2.01 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr10_+_18629628 2.01 ENST00000377329.4
CACNB2
calcium channel, voltage-dependent, beta 2 subunit
chr12_+_26348429 2.00 ENST00000242729.2
SSPN
sarcospan
chr9_+_82186872 1.98 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr19_-_53758094 1.96 ENST00000601828.1
ENST00000598513.1
ENST00000599012.1
ENST00000333952.4
ENST00000598806.1
ZNF677
zinc finger protein 677
chr7_-_14026063 1.88 ENST00000443608.1
ENST00000438956.1
ETV1
ets variant 1
chrX_+_107288239 1.80 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr6_-_32908792 1.79 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_153552455 1.78 ENST00000392385.2
AL590867.1
Uncharacterized protein; cDNA FLJ59044, highly similar to LINE-1 reverse transcriptase homolog
chr8_+_105235572 1.78 ENST00000523362.1
RIMS2
regulating synaptic membrane exocytosis 2
chr8_-_18541603 1.78 ENST00000428502.2
PSD3
pleckstrin and Sec7 domain containing 3
chr1_-_150738261 1.77 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr5_-_20575959 1.75 ENST00000507958.1
CDH18
cadherin 18, type 2
chr2_-_145277569 1.74 ENST00000303660.4
ZEB2
zinc finger E-box binding homeobox 2
chr3_-_114790179 1.71 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr9_+_470288 1.70 ENST00000382303.1
KANK1
KN motif and ankyrin repeat domains 1
chr11_-_108093329 1.69 ENST00000278612.8
NPAT
nuclear protein, ataxia-telangiectasia locus
chr12_+_12938541 1.69 ENST00000356591.4
APOLD1
apolipoprotein L domain containing 1
chr12_+_7014126 1.67 ENST00000415834.1
ENST00000436789.1
LRRC23
leucine rich repeat containing 23
chr12_+_7014064 1.65 ENST00000443597.2
LRRC23
leucine rich repeat containing 23
chr12_-_118797475 1.63 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAOK3
TAO kinase 3
chr2_+_103035102 1.63 ENST00000264260.2
IL18RAP
interleukin 18 receptor accessory protein
chr10_+_74451883 1.62 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr7_+_49813255 1.62 ENST00000340652.4
VWC2
von Willebrand factor C domain containing 2
chr7_-_22233442 1.62 ENST00000401957.2
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr13_-_88323218 1.61 ENST00000436290.2
ENST00000453832.2
ENST00000606590.1
MIR4500HG
MIR4500 host gene (non-protein coding)
chr13_-_95131923 1.58 ENST00000377028.5
ENST00000446125.1
DCT
dopachrome tautomerase
chr19_-_51522955 1.56 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr9_-_215744 1.56 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr19_+_54641444 1.51 ENST00000221232.5
ENST00000358389.3
CNOT3
CCR4-NOT transcription complex, subunit 3
chr3_-_114477962 1.48 ENST00000471418.1
ZBTB20
zinc finger and BTB domain containing 20
chr17_+_41363854 1.48 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A
transmembrane protein 106A
chr2_+_68961934 1.48 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chrX_+_107288197 1.43 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr7_-_14026123 1.43 ENST00000420159.2
ENST00000399357.3
ENST00000403527.1
ETV1
ets variant 1
chr12_-_118796910 1.42 ENST00000541186.1
ENST00000539872.1
TAOK3
TAO kinase 3
chr4_+_88754069 1.42 ENST00000395102.4
ENST00000497649.2
MEPE
matrix extracellular phosphoglycoprotein
chr19_+_34287751 1.41 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr3_-_114477787 1.41 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr4_-_41884620 1.40 ENST00000504870.1
LINC00682
long intergenic non-protein coding RNA 682
chr18_+_32556892 1.39 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr18_-_500692 1.39 ENST00000400256.3
COLEC12
collectin sub-family member 12
chr2_+_68961905 1.39 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chr2_-_111334678 1.38 ENST00000329516.3
ENST00000330331.5
ENST00000446930.1
RGPD6
RANBP2-like and GRIP domain containing 6
chr17_+_47448102 1.38 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr5_+_66300446 1.38 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr20_+_18488137 1.37 ENST00000450074.1
ENST00000262544.2
ENST00000336714.3
ENST00000377475.3
SEC23B
Sec23 homolog B (S. cerevisiae)
chr12_+_7013897 1.37 ENST00000007969.8
ENST00000323702.5
LRRC23
leucine rich repeat containing 23
chr1_-_151762943 1.36 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
TDRKH
tudor and KH domain containing
chr9_-_21351377 1.35 ENST00000380210.1
IFNA6
interferon, alpha 6
chr8_+_119294456 1.31 ENST00000366457.2
AC023590.1
Uncharacterized protein
chr4_-_74486347 1.31 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr12_-_10022735 1.29 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr4_+_3388057 1.29 ENST00000538395.1
RGS12
regulator of G-protein signaling 12
chr3_+_69928256 1.28 ENST00000394355.2
MITF
microphthalmia-associated transcription factor
chr18_-_53253323 1.27 ENST00000540999.1
ENST00000563888.2
TCF4
transcription factor 4
chr7_-_14029515 1.26 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr4_+_41614909 1.26 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIMCH1
LIM and calponin homology domains 1
chr2_-_145278475 1.26 ENST00000558170.2
ZEB2
zinc finger E-box binding homeobox 2
chr5_+_69321074 1.25 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
SERF1B
small EDRK-rich factor 1B (centromeric)
chr8_+_9953061 1.23 ENST00000522907.1
ENST00000528246.1
MSRA
methionine sulfoxide reductase A
chr8_+_101170563 1.23 ENST00000520508.1
ENST00000388798.2
SPAG1
sperm associated antigen 1
chr7_+_138943265 1.22 ENST00000483726.1
UBN2
ubinuclein 2
chr7_-_151217001 1.19 ENST00000262187.5
RHEB
Ras homolog enriched in brain
chr18_-_53253112 1.19 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4
transcription factor 4
chr7_-_14029283 1.18 ENST00000433547.1
ENST00000405192.2
ETV1
ets variant 1
chr8_+_117950422 1.18 ENST00000378279.3
AARD
alanine and arginine rich domain containing protein
chr8_+_9953214 1.14 ENST00000382490.5
MSRA
methionine sulfoxide reductase A
chr14_-_82000140 1.14 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr7_-_83278322 1.13 ENST00000307792.3
SEMA3E
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
chr12_+_81110684 1.10 ENST00000228644.3
MYF5
myogenic factor 5
chr1_+_160160283 1.09 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr2_+_171034646 1.08 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr7_-_14028488 1.07 ENST00000405358.4
ETV1
ets variant 1
chr6_+_72922590 1.06 ENST00000523963.1
RIMS1
regulating synaptic membrane exocytosis 1
chr2_-_166930131 1.03 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr14_-_98444386 1.01 ENST00000556462.1
ENST00000556138.1
C14orf64
chromosome 14 open reading frame 64
chr2_+_90211643 0.99 ENST00000390277.2
IGKV3D-11
immunoglobulin kappa variable 3D-11
chr4_-_170897045 0.98 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr11_-_102576537 0.96 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr17_+_72427477 0.95 ENST00000342648.5
ENST00000481232.1
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr2_-_28113965 0.95 ENST00000302188.3
RBKS
ribokinase
chr14_-_92413727 0.94 ENST00000267620.10
FBLN5
fibulin 5
chr1_+_226013047 0.93 ENST00000366837.4
EPHX1
epoxide hydrolase 1, microsomal (xenobiotic)
chr6_+_72922505 0.93 ENST00000401910.3
RIMS1
regulating synaptic membrane exocytosis 1
chr10_+_119301928 0.91 ENST00000553456.3
EMX2
empty spiracles homeobox 2
chr4_+_88754113 0.90 ENST00000560249.1
ENST00000540395.1
ENST00000511670.1
ENST00000361056.3
MEPE
matrix extracellular phosphoglycoprotein
chr2_-_208031943 0.90 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr6_+_26402465 0.89 ENST00000476549.2
ENST00000289361.6
ENST00000450085.2
ENST00000425234.2
ENST00000427334.1
ENST00000506698.1
BTN3A1
butyrophilin, subfamily 3, member A1
chr18_+_46065393 0.89 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr2_+_210444142 0.88 ENST00000360351.4
ENST00000361559.4
MAP2
microtubule-associated protein 2
chr10_+_13628933 0.88 ENST00000417658.1
ENST00000320054.4
PRPF18
pre-mRNA processing factor 18
chr12_-_23737534 0.87 ENST00000396007.2
SOX5
SRY (sex determining region Y)-box 5
chr8_-_87755878 0.86 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr6_-_91296602 0.86 ENST00000369325.3
ENST00000369327.3
MAP3K7
mitogen-activated protein kinase kinase kinase 7
chr8_+_28748765 0.86 ENST00000355231.5
HMBOX1
homeobox containing 1
chr10_+_102222798 0.84 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr12_-_58135903 0.82 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr20_+_2276639 0.82 ENST00000381458.5
TGM3
transglutaminase 3
chr6_-_22297730 0.81 ENST00000306482.1
PRL
prolactin
chr6_+_26402517 0.79 ENST00000414912.2
BTN3A1
butyrophilin, subfamily 3, member A1
chr10_-_71169031 0.79 ENST00000373307.1
TACR2
tachykinin receptor 2
chr19_-_51523275 0.78 ENST00000309958.3
KLK10
kallikrein-related peptidase 10
chr6_-_138539627 0.77 ENST00000527246.2
PBOV1
prostate and breast cancer overexpressed 1
chr6_-_136788001 0.76 ENST00000544465.1
MAP7
microtubule-associated protein 7
chr7_-_104909435 0.76 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr6_-_100912785 0.75 ENST00000369208.3
SIM1
single-minded family bHLH transcription factor 1
chr5_-_159827033 0.75 ENST00000523213.1
C5orf54
chromosome 5 open reading frame 54
chr2_+_90273679 0.75 ENST00000423080.2
IGKV3D-7
immunoglobulin kappa variable 3D-7
chr16_+_89334512 0.74 ENST00000602042.1
AC137932.1
AC137932.1
chr12_-_51422017 0.74 ENST00000394904.3
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr1_-_101360331 0.73 ENST00000416479.1
ENST00000370113.3
EXTL2
exostosin-like glycosyltransferase 2
chr12_+_18414446 0.73 ENST00000433979.1
PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr7_-_22234381 0.73 ENST00000458533.1
RAPGEF5
Rap guanine nucleotide exchange factor (GEF) 5
chr8_-_72274467 0.72 ENST00000340726.3
EYA1
eyes absent homolog 1 (Drosophila)
chr13_-_99630233 0.72 ENST00000376460.1
ENST00000442173.1
DOCK9
dedicator of cytokinesis 9
chr2_-_30144432 0.72 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chr4_-_74486217 0.71 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr5_+_59783941 0.71 ENST00000506884.1
ENST00000504876.2
PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr12_-_10605929 0.70 ENST00000347831.5
ENST00000359151.3
KLRC1
killer cell lectin-like receptor subfamily C, member 1
chr14_+_74034310 0.69 ENST00000538782.1
ACOT2
acyl-CoA thioesterase 2
chr20_-_21494654 0.69 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chrX_+_105937068 0.67 ENST00000324342.3
RNF128
ring finger protein 128, E3 ubiquitin protein ligase
chr19_+_45458503 0.65 ENST00000337392.5
ENST00000591304.1
CLPTM1
cleft lip and palate associated transmembrane protein 1
chr5_+_125758813 0.64 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3

Network of associatons between targets according to the STRING database.

First level regulatory network of SHOX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 25.9 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
2.3 23.2 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
2.3 6.9 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
2.0 6.1 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
1.2 2.3 GO:0098923 retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
1.1 3.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.0 3.0 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.9 6.3 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.8 65.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.8 8.4 GO:0016198 axon choice point recognition(GO:0016198)
0.8 14.6 GO:0007021 tubulin complex assembly(GO:0007021)
0.8 17.3 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.7 3.0 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.7 5.8 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.7 2.9 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.7 2.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.6 4.9 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.6 1.8 GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.6 1.7 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.5 2.6 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.5 9.0 GO:0009756 carbohydrate mediated signaling(GO:0009756)
0.4 6.0 GO:0048245 eosinophil chemotaxis(GO:0048245)
0.4 8.9 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.4 6.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.4 3.7 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.3 4.2 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.3 3.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 1.7 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.3 2.0 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.3 0.9 GO:0006014 D-ribose metabolic process(GO:0006014)
0.3 0.9 GO:0071030 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
0.3 2.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.3 1.7 GO:0072502 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.3 0.8 GO:0045229 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.3 1.6 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.3 2.4 GO:0030091 protein repair(GO:0030091)
0.3 0.8 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
0.2 1.2 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.2 0.7 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.2 0.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.2 1.6 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.2 3.8 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.2 0.6 GO:2000007 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm development(GO:0048389) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) regulation of transcription from RNA polymerase II promoter involved in kidney development(GO:0060994) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) pattern specification involved in mesonephros development(GO:0061227) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in kidney development(GO:0072098) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter urothelium development(GO:0072190) ureter epithelial cell differentiation(GO:0072192) ureter morphogenesis(GO:0072197) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.2 0.6 GO:0002384 hepatic immune response(GO:0002384)
0.2 0.6 GO:0042109 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.2 0.5 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 0.7 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.2 0.5 GO:0071284 cellular response to lead ion(GO:0071284)
0.2 0.7 GO:0036269 swimming behavior(GO:0036269)
0.2 3.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 1.4 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.6 GO:1904383 response to sodium phosphate(GO:1904383)
0.2 0.8 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.7 GO:0015692 lead ion transport(GO:0015692)
0.1 0.9 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.1 1.7 GO:0042118 endothelial cell activation(GO:0042118)
0.1 5.2 GO:0016601 Rac protein signal transduction(GO:0016601)
0.1 6.8 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 1.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 2.3 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 0.8 GO:0048263 determination of dorsal identity(GO:0048263)
0.1 2.3 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 1.9 GO:0042693 muscle cell fate commitment(GO:0042693)
0.1 0.9 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.1 0.2 GO:0002456 T cell mediated immunity(GO:0002456)
0.1 0.3 GO:0097052 tryptophan catabolic process to acetyl-CoA(GO:0019442) L-kynurenine metabolic process(GO:0097052)
0.1 1.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 2.1 GO:0072643 interferon-gamma secretion(GO:0072643)
0.1 4.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.3 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.1 1.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.1 1.8 GO:2001259 positive regulation of cation channel activity(GO:2001259)
0.1 0.7 GO:1904352 positive regulation of protein catabolic process in the vacuole(GO:1904352)
0.1 1.4 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 2.5 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.1 3.1 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.1 1.2 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 0.4 GO:0035898 parathyroid hormone secretion(GO:0035898) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.1 0.3 GO:0060605 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.1 9.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 2.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 0.5 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.1 2.3 GO:0001919 regulation of receptor recycling(GO:0001919)
0.0 1.1 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
0.0 0.1 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0 0.9 GO:0042340 keratan sulfate catabolic process(GO:0042340)
0.0 0.5 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
0.0 0.3 GO:0044245 polysaccharide digestion(GO:0044245)
0.0 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 1.1 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 1.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.0 5.4 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.0 0.3 GO:1903961 positive regulation of anion transmembrane transport(GO:1903961)
0.0 0.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.3 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.0 0.2 GO:0050955 thermoception(GO:0050955)
0.0 1.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 4.3 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 0.5 GO:0032196 transposition(GO:0032196)
0.0 11.5 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.0 3.8 GO:0007045 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0 0.8 GO:0001823 ureteric bud development(GO:0001657) mesonephros development(GO:0001823) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164)
0.0 0.8 GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0 0.3 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 1.4 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 1.6 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.6 GO:0033081 regulation of T cell differentiation in thymus(GO:0033081) regulation of thymocyte aggregation(GO:2000398)
0.0 0.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.7 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.0 1.8 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.0 GO:0048867 stem cell fate determination(GO:0048867)
0.0 2.5 GO:0035725 sodium ion transmembrane transport(GO:0035725)
0.0 0.3 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.0 0.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 4.5 GO:0007264 small GTPase mediated signal transduction(GO:0007264)
0.0 0.3 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 3.6 GO:0007018 microtubule-based movement(GO:0007018)
0.0 0.3 GO:0042135 neurotransmitter catabolic process(GO:0042135)
0.0 3.0 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.0 GO:0030574 collagen catabolic process(GO:0030574)
0.0 1.3 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.0 0.4 GO:0009060 aerobic respiration(GO:0009060)
0.0 0.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0001778 plasma membrane repair(GO:0001778)
0.0 0.1 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.5 GO:0002763 positive regulation of myeloid leukocyte differentiation(GO:0002763)
0.0 1.8 GO:0009408 response to heat(GO:0009408)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 8.2 GO:0032584 growth cone membrane(GO:0032584)
0.9 14.6 GO:0097512 cardiac myofibril(GO:0097512)
0.7 4.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.6 3.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.4 1.6 GO:1990246 uniplex complex(GO:1990246)
0.4 4.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.3 4.9 GO:0005869 dynactin complex(GO:0005869)
0.3 6.0 GO:0031045 dense core granule(GO:0031045)
0.3 0.9 GO:0071020 post-spliceosomal complex(GO:0071020)
0.3 4.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.3 1.4 GO:0071546 pi-body(GO:0071546)
0.3 3.6 GO:0001673 male germ cell nucleus(GO:0001673)
0.3 1.8 GO:0036021 endolysosome lumen(GO:0036021)
0.2 2.3 GO:0045180 basal cortex(GO:0045180)
0.2 1.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.2 1.7 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.2 1.7 GO:0014802 terminal cisterna(GO:0014802)
0.2 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 5.3 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 4.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.0 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.2 1.5 GO:0030015 CCR4-NOT core complex(GO:0030015)
0.1 1.6 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:0070826 paraferritin complex(GO:0070826)
0.1 0.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.1 0.6 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 2.5 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.1 36.2 GO:0043209 myelin sheath(GO:0043209)
0.1 1.4 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 2.3 GO:0032433 filopodium tip(GO:0032433)
0.1 8.4 GO:0044291 cell-cell contact zone(GO:0044291)
0.1 9.6 GO:0042734 presynaptic membrane(GO:0042734)
0.1 0.3 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.1 6.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 1.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 2.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.1 21.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 1.4 GO:0035371 microtubule plus-end(GO:0035371)
0.1 0.4 GO:0033268 node of Ranvier(GO:0033268)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 16.2 GO:0045121 membrane raft(GO:0045121)
0.0 0.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 3.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 0.8 GO:0031904 endosome lumen(GO:0031904)
0.0 0.7 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.3 GO:0005579 membrane attack complex(GO:0005579)
0.0 59.4 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
0.0 0.5 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 5.4 GO:0005770 late endosome(GO:0005770)
0.0 0.9 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.0 0.1 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0 1.8 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.3 GO:0030133 transport vesicle(GO:0030133)
0.0 1.2 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 6.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
1.6 6.3 GO:0019770 IgG receptor activity(GO:0019770)
1.2 68.7 GO:0017080 sodium channel regulator activity(GO:0017080)
1.0 3.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
1.0 2.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
1.0 4.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.9 3.5 GO:0000822 inositol hexakisphosphate binding(GO:0000822)
0.8 7.9 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.6 3.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.6 7.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.5 2.4 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.5 14.6 GO:0005212 structural constituent of eye lens(GO:0005212)
0.5 2.3 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.4 5.8 GO:0097109 neuroligin family protein binding(GO:0097109)
0.3 9.0 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.3 1.2 GO:0015265 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.3 0.9 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
0.3 0.8 GO:0005148 prolactin receptor binding(GO:0005148)
0.3 1.6 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.3 2.0 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.2 0.6 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.2 1.3 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.2 2.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 0.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.2 8.5 GO:0070888 E-box binding(GO:0070888)
0.2 2.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 4.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.2 2.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 0.5 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.2 6.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 0.8 GO:0004995 tachykinin receptor activity(GO:0004995)
0.2 3.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 5.2 GO:0015248 sterol transporter activity(GO:0015248)
0.1 6.6 GO:0042056 chemoattractant activity(GO:0042056)
0.1 0.7 GO:0015086 cadmium ion transmembrane transporter activity(GO:0015086) cobalt ion transmembrane transporter activity(GO:0015087) lead ion transmembrane transporter activity(GO:0015094) ferrous iron uptake transmembrane transporter activity(GO:0015639)
0.1 0.7 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.1 4.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 4.2 GO:0043015 gamma-tubulin binding(GO:0043015)
0.1 0.7 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.1 3.2 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.9 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.1 3.3 GO:0019865 immunoglobulin binding(GO:0019865)
0.1 2.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.5 GO:0004803 transposase activity(GO:0004803)
0.1 4.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.3 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
0.1 0.7 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.4 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.1 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 24.1 GO:0051015 actin filament binding(GO:0051015)
0.1 6.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 3.2 GO:0017091 AU-rich element binding(GO:0017091)
0.1 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.9 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.1 0.3 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
0.1 3.3 GO:0030507 spectrin binding(GO:0030507)
0.1 1.8 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.5 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.1 1.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 0.6 GO:0004000 adenosine deaminase activity(GO:0004000)
0.1 0.3 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.1 1.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.3 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1 0.8 GO:0003774 motor activity(GO:0003774)
0.1 0.7 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.1 3.1 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.1 8.8 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 1.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.0 0.5 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 16.1 GO:0005096 GTPase activator activity(GO:0005096)
0.0 3.6 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0005174 CD40 receptor binding(GO:0005174)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
0.0 4.3 GO:0044325 ion channel binding(GO:0044325)
0.0 0.3 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0 0.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 4.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 0.9 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.0 0.8 GO:0005109 frizzled binding(GO:0005109)
0.0 1.6 GO:0005507 copper ion binding(GO:0005507)
0.0 2.1 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 3.1 GO:0003823 antigen binding(GO:0003823)
0.0 1.3 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.4 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 7.7 GO:0005509 calcium ion binding(GO:0005509)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 13.1 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 6.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 3.1 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 5.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 7.1 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 3.0 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.4 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.1 6.0 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 10.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.6 ST STAT3 PATHWAY STAT3 Pathway
0.0 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.6 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.9 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.0 1.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.0 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 5.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 3.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 0.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.9 PID MTOR 4PATHWAY mTOR signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.3 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 1.8 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 4.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.6 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.1 1.4 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.1 2.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 2.0 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.1 4.2 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 4.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.2 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.1 0.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 11.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 2.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 0.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 0.4 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.1 1.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 0.9 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.0 1.1 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.5 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.0 1.4 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 1.5 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.7 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 6.9 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 5.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.3 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.0 0.7 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.2 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.5 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 0.3 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels