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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SIX4

Z-value: 0.52

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
SIX4
ENSG00000100625.8 SIX homeobox 4

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr14_-_106406090 8.98 ENST00000390593.2
IGHV6-1
immunoglobulin heavy variable 6-1
chr1_+_117297007 4.42 ENST00000369478.3
ENST00000369477.1
CD2
CD2 molecule
chr15_-_20193370 4.07 ENST00000558565.2
IGHV3OR15-7
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chr6_+_41040678 3.87 ENST00000341376.6
ENST00000353205.5
NFYA
nuclear transcription factor Y, alpha
chr11_-_64511575 3.65 ENST00000431822.1
ENST00000377486.3
ENST00000394432.3
RASGRP2
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_-_10282836 3.56 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A
C-type lectin domain family 7, member A
chr16_+_640201 3.33 ENST00000563109.1
RAB40C
RAB40C, member RAS oncogene family
chr14_-_107083690 2.84 ENST00000455737.1
ENST00000390629.2
IGHV4-59
immunoglobulin heavy variable 4-59
chr5_-_1295104 2.77 ENST00000334602.6
ENST00000508104.2
ENST00000310581.5
ENST00000296820.5
TERT
telomerase reverse transcriptase
chr6_-_41040268 2.69 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr7_+_69064300 2.56 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr20_-_52687059 2.53 ENST00000371435.2
ENST00000395961.3
BCAS1
breast carcinoma amplified sequence 1
chr11_-_2906979 2.49 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr12_+_30948865 2.48 ENST00000547804.1
LINC00941
long intergenic non-protein coding RNA 941
chr14_-_106692191 2.37 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chrY_+_22737678 2.35 ENST00000382772.3
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr6_-_41040195 2.23 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
OARD1
O-acyl-ADP-ribose deacylase 1
chr7_+_97361218 2.11 ENST00000319273.5
TAC1
tachykinin, precursor 1
chr9_+_132427883 2.09 ENST00000372469.4
PRRX2
paired related homeobox 2
chr11_+_117947782 2.06 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4
transmembrane protease, serine 4
chr11_+_117947724 1.98 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr1_+_160097462 1.96 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr12_-_10282742 1.93 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A
C-type lectin domain family 7, member A
chr11_+_117049910 1.91 ENST00000431081.2
ENST00000524842.1
SIDT2
SID1 transmembrane family, member 2
chr3_+_183967409 1.91 ENST00000324557.4
ENST00000402825.3
ECE2
endothelin converting enzyme 2
chrY_+_22737604 1.90 ENST00000361365.2
EIF1AY
eukaryotic translation initiation factor 1A, Y-linked
chr11_+_117049445 1.84 ENST00000324225.4
ENST00000532960.1
SIDT2
SID1 transmembrane family, member 2
chr7_+_97361388 1.78 ENST00000350485.4
ENST00000346867.4
TAC1
tachykinin, precursor 1
chr12_+_133757995 1.76 ENST00000536435.2
ENST00000228289.5
ENST00000541211.2
ENST00000500625.3
ENST00000539248.2
ENST00000542711.2
ENST00000536899.2
ENST00000542986.2
ENST00000537565.1
ENST00000541975.2
ZNF268
zinc finger protein 268
chr19_+_55235969 1.75 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
KIR3DL1
KIR3DL3
KIR2DL4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
chr11_+_117049854 1.72 ENST00000278951.7
SIDT2
SID1 transmembrane family, member 2
chr3_-_49158218 1.59 ENST00000417901.1
ENST00000306026.5
ENST00000434032.2
USP19
ubiquitin specific peptidase 19
chr3_-_52488048 1.48 ENST00000232975.3
TNNC1
troponin C type 1 (slow)
chr1_-_207119738 1.46 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr19_+_55249969 1.43 ENST00000342376.3
ENST00000434419.2
KIR2DL3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
chr6_-_27840099 1.41 ENST00000328488.2
HIST1H3I
histone cluster 1, H3i
chrX_+_108780347 1.40 ENST00000372103.1
NXT2
nuclear transport factor 2-like export factor 2
chr1_-_247335269 1.37 ENST00000543802.2
ENST00000491356.1
ENST00000472531.1
ENST00000340684.6
ZNF124
zinc finger protein 124
chr12_-_4488872 1.27 ENST00000237837.1
FGF23
fibroblast growth factor 23
chr9_-_95298314 1.26 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr20_+_57875658 1.24 ENST00000371025.3
EDN3
endothelin 3
chr1_+_26737292 1.23 ENST00000254231.4
LIN28A
lin-28 homolog A (C. elegans)
chr2_+_85811525 1.20 ENST00000306384.4
VAMP5
vesicle-associated membrane protein 5
chr15_-_73661605 1.18 ENST00000261917.3
HCN4
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr20_+_57875457 1.11 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
EDN3
endothelin 3
chr12_+_4829507 1.10 ENST00000252318.2
GALNT8
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr7_-_113559104 1.01 ENST00000284601.3
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chr2_+_120687335 1.00 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr1_+_156611960 0.99 ENST00000361588.5
BCAN
brevican
chr16_-_15180257 0.95 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chrX_+_56100757 0.94 ENST00000433279.1
AL353698.1
Uncharacterized protein
chr12_+_133758115 0.93 ENST00000541009.2
ENST00000592241.1
ZNF268
zinc finger protein 268
chr8_+_56014949 0.92 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr17_-_61523622 0.90 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561
cytochrome b561
chr3_+_32147997 0.88 ENST00000282541.5
GPD1L
glycerol-3-phosphate dehydrogenase 1-like
chr11_+_46958248 0.83 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
C11orf49
chromosome 11 open reading frame 49
chr12_+_8975061 0.81 ENST00000299698.7
A2ML1
alpha-2-macroglobulin-like 1
chr10_+_26505594 0.81 ENST00000259271.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr1_+_26737253 0.81 ENST00000326279.6
LIN28A
lin-28 homolog A (C. elegans)
chr5_-_175788758 0.81 ENST00000510164.1
ENST00000533553.1
ENST00000504688.1
ENST00000393725.2
ENST00000503082.1
ENST00000506983.1
KIAA1191
KIAA1191
chr4_+_90823130 0.79 ENST00000508372.1
MMRN1
multimerin 1
chr11_+_33279850 0.76 ENST00000531504.1
ENST00000456517.1
HIPK3
homeodomain interacting protein kinase 3
chr1_-_114414316 0.75 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
PTPN22
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr15_+_41245160 0.73 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr1_+_156611704 0.66 ENST00000329117.5
BCAN
brevican
chr7_-_14880892 0.63 ENST00000406247.3
ENST00000399322.3
ENST00000258767.5
DGKB
diacylglycerol kinase, beta 90kDa
chr1_-_173176452 0.61 ENST00000281834.3
TNFSF4
tumor necrosis factor (ligand) superfamily, member 4
chr13_+_33160553 0.59 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr2_-_74710078 0.58 ENST00000290418.4
CCDC142
coiled-coil domain containing 142
chr4_-_170897045 0.53 ENST00000508313.1
RP11-205M3.3
RP11-205M3.3
chr1_+_226250379 0.53 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr19_-_47128294 0.49 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
PTGIR
prostaglandin I2 (prostacyclin) receptor (IP)
chr11_-_46615498 0.48 ENST00000533727.1
ENST00000534300.1
ENST00000528950.1
ENST00000526606.1
AMBRA1
autophagy/beclin-1 regulator 1
chr3_-_87325612 0.47 ENST00000561167.1
ENST00000560656.1
ENST00000344265.3
POU1F1
POU class 1 homeobox 1
chr19_+_50887585 0.44 ENST00000440232.2
ENST00000601098.1
ENST00000599857.1
ENST00000593887.1
POLD1
polymerase (DNA directed), delta 1, catalytic subunit
chr2_+_74710194 0.44 ENST00000410003.1
ENST00000442235.2
ENST00000233623.5
TTC31
tetratricopeptide repeat domain 31
chr11_-_35547572 0.41 ENST00000378880.2
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr10_+_26505179 0.39 ENST00000376261.3
GAD2
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr5_+_149569520 0.39 ENST00000230671.2
ENST00000524041.1
SLC6A7
solute carrier family 6 (neurotransmitter transporter), member 7
chr1_+_38022572 0.39 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chrX_+_41583408 0.30 ENST00000302548.4
GPR82
G protein-coupled receptor 82
chr12_-_58135903 0.30 ENST00000257897.3
AGAP2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
chr6_+_52051171 0.24 ENST00000340057.1
IL17A
interleukin 17A
chr13_-_78492955 0.24 ENST00000446573.1
EDNRB
endothelin receptor type B
chr19_+_13135386 0.22 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr15_+_59279851 0.21 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
RNF111
ring finger protein 111
chr4_-_13546632 0.21 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr10_+_89622870 0.18 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr4_-_84255935 0.17 ENST00000513463.1
HPSE
heparanase
chr22_-_39268308 0.17 ENST00000407418.3
CBX6
chromobox homolog 6
chr19_+_13134772 0.10 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chrX_+_54466829 0.08 ENST00000375151.4
TSR2
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr9_-_136084628 0.06 ENST00000372034.3
ENST00000372032.2
OBP2B
odorant binding protein 2B
chr22_-_39268192 0.04 ENST00000216083.6
CBX6
chromobox homolog 6
chr1_-_42800860 0.02 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
FOXJ3
forkhead box J3

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.9 2.8 GO:1900369 transcription, RNA-templated(GO:0001172) regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369) positive regulation of protein localization to nucleolus(GO:1904751)
0.9 2.7 GO:0045897 positive regulation of transcription during mitosis(GO:0045897)
0.7 5.2 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.6 2.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
0.6 2.3 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.5 5.5 GO:0033227 dsRNA transport(GO:0033227)
0.4 1.3 GO:0042369 vitamin D catabolic process(GO:0042369)
0.4 2.0 GO:0010587 miRNA catabolic process(GO:0010587)
0.4 2.0 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.4 1.5 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.4 2.5 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.3 1.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.3 20.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 0.9 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072) negative regulation of protein kinase C signaling(GO:0090038)
0.2 0.6 GO:2000523 regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.2 1.2 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.2 1.2 GO:0071321 cellular response to cGMP(GO:0071321)
0.1 0.9 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.1 0.5 GO:0060623 regulation of chromosome condensation(GO:0060623)
0.1 0.5 GO:0060133 somatotropin secreting cell development(GO:0060133)
0.1 1.9 GO:0010002 cardioblast differentiation(GO:0010002)
0.1 1.6 GO:1900037 negative regulation of skeletal muscle tissue development(GO:0048642) regulation of cellular response to hypoxia(GO:1900037)
0.1 0.4 GO:0035524 proline transmembrane transport(GO:0035524)
0.1 0.4 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 1.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 3.3 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 3.9 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.1 0.5 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.0 0.7 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.2 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.0 0.2 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 3.7 GO:0071277 cellular response to calcium ion(GO:0071277)
0.0 0.8 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.0 0.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.0 1.2 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.6 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 2.8 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 1.7 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.5 GO:0098780 response to mitochondrial depolarisation(GO:0098780)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.0 4.2 GO:0006413 translational initiation(GO:0006413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.8 GO:0000333 telomerase catalytic core complex(GO:0000333)
0.4 3.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.3 14.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.2 1.5 GO:1990584 cardiac Troponin complex(GO:1990584)
0.1 0.9 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1 4.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.3 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.1 1.2 GO:0060077 inhibitory synapse(GO:0060077)
0.1 0.5 GO:0001740 Barr body(GO:0001740)
0.0 3.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 2.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 2.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 3.3 GO:0008021 synaptic vesicle(GO:0008021)
0.0 1.2 GO:0031201 SNARE complex(GO:0031201)
0.0 1.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 6.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.3 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 1.2 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.8 GO:0003968 RNA-directed RNA polymerase activity(GO:0003968)
0.9 5.5 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.5 2.3 GO:0031708 endothelin B receptor binding(GO:0031708)
0.4 1.3 GO:0070052 collagen V binding(GO:0070052)
0.3 1.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.3 0.9 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.3 1.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.3 1.7 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.3 14.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.2 0.9 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.2 5.5 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.2 3.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 2.0 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.2 1.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.2 1.2 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.2 1.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.1 2.5 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 1.5 GO:0031013 troponin I binding(GO:0031013)
0.1 3.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 4.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.4 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.1 1.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.0 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 4.9 GO:0019213 deacetylase activity(GO:0019213)
0.1 0.2 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.7 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.1 4.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.2 GO:0030305 beta-glucuronidase activity(GO:0004566) heparanase activity(GO:0030305)
0.0 3.3 GO:0019003 GDP binding(GO:0019003)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.4 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296)
0.0 0.5 GO:0004955 prostaglandin receptor activity(GO:0004955)
0.0 1.2 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.3 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0004962 endothelin receptor activity(GO:0004962)
0.0 3.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.9 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.7 GO:0003823 antigen binding(GO:0003823)
0.0 0.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 PID RAS PATHWAY Regulation of Ras family activation
0.0 2.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 5.5 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 2.4 PID ENDOTHELIN PATHWAY Endothelins
0.0 3.9 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.5 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 0.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 1.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.9 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 4.3 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.3 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 3.2 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 1.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.5 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 1.2 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 6.3 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 4.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.0 1.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.9 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.0 0.4 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.2 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 1.6 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 1.2 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.5 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins