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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SIX6

Z-value: 0.93

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Transcription factors associated with SIX6

Gene Symbol Gene ID Gene Info
SIX6
ENSG00000184302.6 SIX homeobox 6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX6hg19_v2_chr14_+_60975644_609756730.385.9e-09Click!

Activity profile of SIX6 motif

Sorted Z-values of SIX6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_64708615 21.90 ENST00000338957.4
ENST00000423889.3
ZC3H12B
zinc finger CCCH-type containing 12B
chr8_+_84824920 16.88 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr18_+_74240610 16.40 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
LINC00908
long intergenic non-protein coding RNA 908
chr4_+_113739244 10.31 ENST00000503271.1
ENST00000503423.1
ENST00000506722.1
ANK2
ankyrin 2, neuronal
chrX_+_8433376 8.57 ENST00000440654.2
ENST00000381029.4
VCX3B
variable charge, X-linked 3B
chr2_-_100939195 8.25 ENST00000393437.3
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr1_+_21880560 7.06 ENST00000425315.2
ALPL
alkaline phosphatase, liver/bone/kidney
chr3_+_8543533 6.73 ENST00000454244.1
LMCD1
LIM and cysteine-rich domains 1
chrY_-_16098393 6.54 ENST00000250825.4
VCY
variable charge, Y-linked
chr2_-_88427568 6.50 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr9_-_21142144 6.06 ENST00000380229.2
IFNW1
interferon, omega 1
chr11_+_74699942 6.02 ENST00000526068.1
ENST00000532963.1
ENST00000531619.1
ENST00000534628.1
ENST00000545272.1
NEU3
sialidase 3 (membrane sialidase)
chrY_+_16168097 5.73 ENST00000250823.4
VCY1B
variable charge, Y-linked 1B
chr12_-_122018859 5.60 ENST00000536437.1
ENST00000377071.4
ENST00000538046.2
KDM2B
lysine (K)-specific demethylase 2B
chr1_-_67142710 5.50 ENST00000502413.2
AL139147.1
Uncharacterized protein
chr11_+_74699703 5.29 ENST00000529024.1
ENST00000544263.1
NEU3
sialidase 3 (membrane sialidase)
chr1_+_160709055 5.22 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr3_+_151531810 4.99 ENST00000232892.7
AADAC
arylacetamide deacetylase
chrX_-_55020511 4.79 ENST00000375006.3
ENST00000374992.2
PFKFB1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr1_-_36235559 4.71 ENST00000251195.5
CLSPN
claspin
chrX_-_53350522 4.64 ENST00000396435.3
ENST00000375368.5
IQSEC2
IQ motif and Sec7 domain 2
chr1_+_160709029 4.39 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr1_-_150669604 4.37 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr6_+_26204825 4.35 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr7_-_44530479 4.35 ENST00000355451.7
NUDCD3
NudC domain containing 3
chr3_+_125694347 4.17 ENST00000505382.1
ENST00000511082.1
ROPN1B
rhophilin associated tail protein 1B
chr9_-_23821842 4.15 ENST00000544538.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr1_+_86934526 4.06 ENST00000394711.1
CLCA1
chloride channel accessory 1
chrX_-_18238999 3.94 ENST00000380033.4
ENST00000380030.3
BEND2
BEN domain containing 2
chr16_+_19467772 3.87 ENST00000219821.5
ENST00000561503.1
ENST00000564959.1
TMC5
transmembrane channel-like 5
chr5_-_177207634 3.79 ENST00000513554.1
ENST00000440605.3
FAM153A
family with sequence similarity 153, member A
chr13_+_73629107 3.71 ENST00000539231.1
KLF5
Kruppel-like factor 5 (intestinal)
chr1_-_13673511 3.61 ENST00000344998.3
ENST00000334600.6
PRAMEF14
PRAME family member 14
chr1_+_53308398 3.48 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr2_-_208989225 3.45 ENST00000264376.4
CRYGD
crystallin, gamma D
chr1_+_160709076 3.43 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr3_+_8543561 3.42 ENST00000397386.3
LMCD1
LIM and cysteine-rich domains 1
chr16_-_29517141 3.41 ENST00000550665.1
RP11-231C14.4
Uncharacterized protein
chr10_+_91061712 3.32 ENST00000371826.3
IFIT2
interferon-induced protein with tetratricopeptide repeats 2
chr16_-_20364122 3.30 ENST00000396138.4
ENST00000577168.1
UMOD
uromodulin
chr11_-_45307817 3.29 ENST00000020926.3
SYT13
synaptotagmin XIII
chr7_+_117251671 3.24 ENST00000468795.1
CFTR
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
chr3_-_9994021 3.21 ENST00000411976.2
ENST00000412055.1
PRRT3
proline-rich transmembrane protein 3
chr2_-_62081148 3.20 ENST00000404929.1
FAM161A
family with sequence similarity 161, member A
chr6_-_26189304 3.17 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr9_-_21351377 3.15 ENST00000380210.1
IFNA6
interferon, alpha 6
chr11_+_33902189 3.14 ENST00000330381.2
AC132216.1
HCG1785179; PRO1787; Uncharacterized protein
chr16_-_20364030 2.98 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD
uromodulin
chr6_+_146348782 2.96 ENST00000361719.2
ENST00000392299.2
GRM1
glutamate receptor, metabotropic 1
chr10_-_61720640 2.88 ENST00000521074.1
ENST00000444900.1
C10orf40
chromosome 10 open reading frame 40
chr19_-_16008880 2.72 ENST00000011989.7
ENST00000221700.6
CYP4F2
cytochrome P450, family 4, subfamily F, polypeptide 2
chr5_+_40909354 2.70 ENST00000313164.9
C7
complement component 7
chr1_+_156119798 2.61 ENST00000355014.2
SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr4_-_70826725 2.61 ENST00000353151.3
CSN2
casein beta
chr17_-_42327236 2.58 ENST00000399246.2
AC003102.1
AC003102.1
chr1_-_20446020 2.56 ENST00000375105.3
PLA2G2D
phospholipase A2, group IID
chr21_-_19775973 2.56 ENST00000284885.3
TMPRSS15
transmembrane protease, serine 15
chr6_-_26018007 2.41 ENST00000244573.3
HIST1H1A
histone cluster 1, H1a
chr8_+_101170257 2.31 ENST00000251809.3
SPAG1
sperm associated antigen 1
chr17_+_60501228 2.25 ENST00000311506.5
METTL2A
methyltransferase like 2A
chr4_-_155511887 2.24 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr16_-_87350970 2.24 ENST00000567970.1
C16orf95
chromosome 16 open reading frame 95
chr19_+_55235969 2.23 ENST00000402254.2
ENST00000538269.1
ENST00000541392.1
ENST00000291860.1
ENST00000396284.2
KIR3DL1
KIR3DL3
KIR2DL4
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
chr16_+_72090053 2.19 ENST00000576168.2
ENST00000567185.3
ENST00000567612.2
HP
haptoglobin
chr6_+_80816342 2.16 ENST00000369760.4
ENST00000356489.5
ENST00000320393.6
BCKDHB
branched chain keto acid dehydrogenase E1, beta polypeptide
chr15_-_51397473 2.10 ENST00000327536.5
TNFAIP8L3
tumor necrosis factor, alpha-induced protein 8-like 3
chr14_+_22948510 2.06 ENST00000390483.1
TRAJ56
T cell receptor alpha joining 56
chr12_-_121477039 2.01 ENST00000257570.5
OASL
2'-5'-oligoadenylate synthetase-like
chr22_-_17302589 2.01 ENST00000331428.5
XKR3
XK, Kell blood group complex subunit-related family, member 3
chr18_+_55018044 1.95 ENST00000324000.3
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chr1_-_161193349 1.91 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2
apolipoprotein A-II
chr14_+_21152259 1.89 ENST00000555835.1
ENST00000336811.6
RNASE4
ANG
ribonuclease, RNase A family, 4
angiogenin, ribonuclease, RNase A family, 5
chr12_-_121476959 1.74 ENST00000339275.5
OASL
2'-5'-oligoadenylate synthetase-like
chr9_-_100684845 1.68 ENST00000375119.3
C9orf156
chromosome 9 open reading frame 156
chr2_-_228497888 1.65 ENST00000264387.4
ENST00000409066.1
C2orf83
chromosome 2 open reading frame 83
chr10_-_79397479 1.65 ENST00000404771.3
KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr6_-_26043885 1.64 ENST00000357905.2
HIST1H2BB
histone cluster 1, H2bb
chr16_-_21436459 1.58 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
NPIPB3
nuclear pore complex interacting protein family, member B3
chr6_+_146348810 1.52 ENST00000492807.2
GRM1
glutamate receptor, metabotropic 1
chr5_+_175490540 1.51 ENST00000515817.1
FAM153B
family with sequence similarity 153, member B
chr20_+_54987305 1.48 ENST00000371336.3
ENST00000434344.1
CASS4
Cas scaffolding protein family member 4
chr22_-_19137796 1.48 ENST00000086933.2
GSC2
goosecoid homeobox 2
chr20_+_54987168 1.46 ENST00000360314.3
CASS4
Cas scaffolding protein family member 4
chr21_-_43735446 1.41 ENST00000398431.2
TFF3
trefoil factor 3 (intestinal)
chr6_+_52051171 1.32 ENST00000340057.1
IL17A
interleukin 17A
chrY_-_24038660 1.30 ENST00000382677.3
RBMY1D
RNA binding motif protein, Y-linked, family 1, member D
chr3_-_53916202 1.20 ENST00000335754.3
ACTR8
ARP8 actin-related protein 8 homolog (yeast)
chr12_-_11091862 1.18 ENST00000537503.1
TAS2R14
taste receptor, type 2, member 14
chrX_-_118699325 1.18 ENST00000320339.4
ENST00000371594.4
ENST00000536133.1
CXorf56
chromosome X open reading frame 56
chr2_-_77749474 1.11 ENST00000409093.1
ENST00000409088.3
LRRTM4
leucine rich repeat transmembrane neuronal 4
chr1_+_159557607 1.11 ENST00000255040.2
APCS
amyloid P component, serum
chr12_-_28123206 1.07 ENST00000542963.1
ENST00000535992.1
PTHLH
parathyroid hormone-like hormone
chr12_-_10978957 1.07 ENST00000240619.2
TAS2R10
taste receptor, type 2, member 10
chr5_+_140201183 1.05 ENST00000529619.1
ENST00000529859.1
ENST00000378126.3
PCDHA5
protocadherin alpha 5
chr8_+_1993152 1.04 ENST00000262113.4
MYOM2
myomesin 2
chr9_-_99382065 1.01 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
CDC14B
cell division cycle 14B
chrY_+_23698778 0.94 ENST00000303902.5
RBMY1A1
RNA binding motif protein, Y-linked, family 1, member A1
chr16_+_28648975 0.90 ENST00000529716.1
NPIPB8
nuclear pore complex interacting protein family, member B8
chr10_+_52094298 0.81 ENST00000595931.1
AC069547.1
HCG1745369; PRO3073; Uncharacterized protein
chr21_-_43735628 0.77 ENST00000291525.10
ENST00000518498.1
TFF3
trefoil factor 3 (intestinal)
chr13_-_46679185 0.75 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr13_-_46679144 0.75 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr4_-_123377880 0.74 ENST00000226730.4
IL2
interleukin 2
chr16_+_22524844 0.67 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr4_-_13546632 0.66 ENST00000382438.5
NKX3-2
NK3 homeobox 2
chr20_-_4990931 0.62 ENST00000379333.1
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr1_+_63063152 0.59 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr12_-_121476750 0.59 ENST00000543677.1
OASL
2'-5'-oligoadenylate synthetase-like
chr8_+_24241969 0.58 ENST00000522298.1
ADAMDEC1
ADAM-like, decysin 1
chr16_-_21868978 0.57 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
NPIPB4
nuclear pore complex interacting protein family, member B4
chr19_+_3136115 0.49 ENST00000262958.3
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr8_+_24241789 0.37 ENST00000256412.4
ENST00000538205.1
ADAMDEC1
ADAM-like, decysin 1
chr8_+_1993173 0.33 ENST00000523438.1
MYOM2
myomesin 2
chr11_+_30253410 0.32 ENST00000533718.1
FSHB
follicle stimulating hormone, beta polypeptide
chr19_-_1650666 0.26 ENST00000588136.1
TCF3
transcription factor 3
chr8_+_32579341 0.19 ENST00000519240.1
ENST00000539990.1
NRG1
neuregulin 1
chr16_-_21868739 0.18 ENST00000415645.2
NPIPB4
nuclear pore complex interacting protein family, member B4
chr2_+_177134201 0.18 ENST00000452865.1
MTX2
metaxin 2
chr3_-_111314230 0.14 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr4_+_74301880 0.03 ENST00000395792.2
ENST00000226359.2
AFP
alpha-fetoprotein

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.3 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.4 7.1 GO:0071529 cementum mineralization(GO:0071529)
1.9 5.6 GO:0021678 midbrain-hindbrain boundary morphogenesis(GO:0021555) fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
1.4 11.3 GO:0006689 ganglioside catabolic process(GO:0006689)
1.3 6.3 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
1.1 3.2 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.9 4.7 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 2.7 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.9 2.6 GO:1903487 regulation of lactation(GO:1903487)
0.8 4.8 GO:1903301 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.7 2.2 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.6 6.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.6 1.9 GO:0060620 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.6 4.5 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.5 1.6 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.5 2.6 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.5 5.0 GO:0010898 positive regulation of triglyceride catabolic process(GO:0010898)
0.5 9.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.4 3.7 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 1.9 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.4 1.5 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.4 4.4 GO:0048194 Golgi vesicle budding(GO:0048194)
0.3 1.3 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.3 7.7 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.3 3.3 GO:0035457 cellular response to interferon-alpha(GO:0035457)
0.2 0.7 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.2 4.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.2 1.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.2 4.2 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.2 2.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.1 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.2 14.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 1.4 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.1 1.6 GO:0034465 response to carbon monoxide(GO:0034465)
0.1 2.7 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.1 2.3 GO:0070286 axonemal dynein complex assembly(GO:0070286)
0.1 3.9 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.1 0.6 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.1 0.6 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 2.3 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.1 2.3 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.5 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.1 3.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 3.4 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 2.6 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.1 2.2 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.1 8.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 1.0 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.3 GO:0002326 B cell lineage commitment(GO:0002326)
0.1 0.7 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.1 4.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 0.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 16.7 GO:0090305 nucleic acid phosphodiester bond hydrolysis(GO:0090305)
0.0 2.4 GO:0048260 positive regulation of receptor-mediated endocytosis(GO:0048260)
0.0 1.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 2.1 GO:0015914 phospholipid transport(GO:0015914)
0.0 4.1 GO:1902476 chloride transmembrane transport(GO:1902476)
0.0 6.0 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 3.5 GO:0051438 regulation of ubiquitin-protein transferase activity(GO:0051438)
0.0 1.1 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 14.8 GO:0007420 brain development(GO:0007420)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.6 GO:0006334 nucleosome assembly(GO:0006334)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 7.1 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
1.1 4.5 GO:0038038 G-protein coupled receptor homodimeric complex(GO:0038038)
0.8 6.5 GO:0045179 apical cortex(GO:0045179)
0.6 3.2 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205)
0.5 2.2 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.4 2.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.3 1.9 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.3 2.7 GO:0005579 membrane attack complex(GO:0005579)
0.2 4.1 GO:0042589 zymogen granule membrane(GO:0042589)
0.2 11.7 GO:0031430 M band(GO:0031430)
0.2 2.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 4.3 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.9 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 5.6 GO:0031519 PcG protein complex(GO:0031519)
0.1 3.2 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 4.1 GO:0000786 nucleosome(GO:0000786)
0.1 6.3 GO:0060170 ciliary membrane(GO:0060170)
0.1 1.2 GO:0033202 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0 4.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 2.6 GO:0005903 brush border(GO:0005903)
0.0 0.6 GO:0009925 basal plasma membrane(GO:0009925)
0.0 10.1 GO:0031012 extracellular matrix(GO:0031012)
0.0 1.6 GO:0005901 caveola(GO:0005901)
0.0 1.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.7 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.0 GO:0072686 mitotic spindle(GO:0072686)
0.0 49.1 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.3 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.1 3.2 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
1.0 7.1 GO:0004035 alkaline phosphatase activity(GO:0004035)
1.0 4.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.9 6.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.9 2.7 GO:0097258 tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871) 20-hydroxy-leukotriene B4 omega oxidase activity(GO:0097258) 20-aldehyde-leukotriene B4 20-monooxygenase activity(GO:0097259)
0.8 4.7 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.7 2.2 GO:0003863 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.7 5.6 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.7 9.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.6 4.5 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)
0.5 1.6 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.5 1.9 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.5 2.3 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.4 4.3 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.4 2.2 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.4 2.2 GO:0030492 hemoglobin binding(GO:0030492)
0.3 6.3 GO:0019864 IgG binding(GO:0019864)
0.3 1.9 GO:0004522 ribonuclease A activity(GO:0004522)
0.3 1.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.3 4.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 8.2 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 1.6 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.2 2.1 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.2 10.3 GO:0030507 spectrin binding(GO:0030507)
0.2 0.6 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.2 2.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.2 5.0 GO:0004806 triglyceride lipase activity(GO:0004806)
0.2 4.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 21.9 GO:0004519 endonuclease activity(GO:0004519)
0.2 2.6 GO:0038191 neuropilin binding(GO:0038191)
0.1 0.7 GO:0005134 interleukin-2 receptor binding(GO:0005134)
0.1 2.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 4.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 3.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 2.6 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.8 GO:0046790 virion binding(GO:0046790)
0.1 4.3 GO:0051082 unfolded protein binding(GO:0051082)
0.1 3.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 1.4 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.1 0.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 1.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 2.6 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 4.1 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.0 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 1.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.5 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 0.2 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 2.4 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.7 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.1 PID IL27 PATHWAY IL27-mediated signaling events
0.0 2.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 3.2 PID CD8 TCR DOWNSTREAM PATHWAY Downstream signaling in naïve CD8+ T cells
0.0 0.5 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 2.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 2.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 6.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 2.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 3.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.5 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 11.3 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 2.6 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.1 2.2 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 6.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.4 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 10.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 3.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.6 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 4.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 3.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 1.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 1.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 2.4 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 2.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 6.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 2.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 3.8 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.3 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 1.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell