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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SMAD2

Z-value: 1.15

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.11 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45457478_45457517-0.413.4e-10Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_94241867 42.24 ENST00000598428.1
AC016885.1
Uncharacterized protein
chr16_-_70719925 21.11 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chrX_-_107018969 17.48 ENST00000372383.4
TSC22D3
TSC22 domain family, member 3
chr22_+_24891210 17.18 ENST00000382760.2
UPB1
ureidopropionase, beta
chr2_+_113033164 16.24 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr12_+_53443963 12.52 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr2_-_220173685 12.35 ENST00000423636.2
ENST00000442029.1
ENST00000412847.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chrX_+_38420783 11.79 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr19_+_56186557 11.46 ENST00000270460.6
EPN1
epsin 1
chr19_+_56186606 10.99 ENST00000085079.7
EPN1
epsin 1
chr1_+_160085501 9.91 ENST00000361216.3
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr7_-_102158157 9.82 ENST00000541662.1
ENST00000306682.6
ENST00000465829.1
RASA4B
RAS p21 protein activator 4B
chr2_-_73053126 9.52 ENST00000272427.6
ENST00000410104.1
EXOC6B
exocyst complex component 6B
chrX_+_48660287 9.42 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
HDAC6
histone deacetylase 6
chrX_+_24167828 9.41 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX
zinc finger protein, X-linked
chr12_-_6798616 9.34 ENST00000355772.4
ENST00000417772.3
ENST00000396801.3
ENST00000396799.2
ZNF384
zinc finger protein 384
chr12_-_6798523 8.91 ENST00000319770.3
ZNF384
zinc finger protein 384
chrX_+_38420623 8.88 ENST00000378482.2
TSPAN7
tetraspanin 7
chrX_-_107019181 8.66 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3
chr17_-_15165854 8.65 ENST00000395936.1
ENST00000395938.2
PMP22
peripheral myelin protein 22
chr12_-_6798410 8.55 ENST00000361959.3
ENST00000436774.2
ENST00000544482.1
ZNF384
zinc finger protein 384
chr7_-_130080818 8.42 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41
centrosomal protein 41kDa
chr19_-_6481776 7.97 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chrY_+_2803322 7.90 ENST00000383052.1
ENST00000155093.3
ENST00000449237.1
ENST00000443793.1
ZFY
zinc finger protein, Y-linked
chr4_+_7045042 7.76 ENST00000310074.7
ENST00000512388.1
TADA2B
transcriptional adaptor 2B
chr20_-_48532019 7.44 ENST00000289431.5
SPATA2
spermatogenesis associated 2
chr3_+_52529346 7.38 ENST00000321725.6
STAB1
stabilin 1
chr9_+_15422702 7.37 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr12_-_3982511 7.28 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr12_+_53443680 7.16 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr20_-_23066953 7.03 ENST00000246006.4
CD93
CD93 molecule
chr1_+_160097462 7.00 ENST00000447527.1
ATP1A2
ATPase, Na+/K+ transporting, alpha 2 polypeptide
chr13_-_27334879 6.75 ENST00000405846.3
GPR12
G protein-coupled receptor 12
chr7_-_102257139 6.71 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RASA4
RAS p21 protein activator 4
chr6_+_32132360 6.64 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8
EGF-like-domain, multiple 8
chr1_-_207119738 6.48 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr4_-_5890145 6.17 ENST00000397890.2
CRMP1
collapsin response mediator protein 1
chr9_-_73029540 5.98 ENST00000377126.2
KLF9
Kruppel-like factor 9
chr12_-_10251576 5.94 ENST00000315330.4
CLEC1A
C-type lectin domain family 1, member A
chr15_-_88799384 5.85 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr1_-_235813290 5.82 ENST00000391854.2
GNG4
guanine nucleotide binding protein (G protein), gamma 4
chr17_+_3627185 5.78 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr8_+_144373550 5.73 ENST00000330143.3
ENST00000521537.1
ENST00000518432.1
ENST00000520333.1
ZNF696
zinc finger protein 696
chr16_-_87417351 5.71 ENST00000311635.7
FBXO31
F-box protein 31
chr1_+_28052518 5.69 ENST00000530324.1
ENST00000234549.7
ENST00000373949.1
ENST00000010299.6
FAM76A
family with sequence similarity 76, member A
chr5_-_43412418 5.49 ENST00000537013.1
ENST00000361115.4
CCL28
chemokine (C-C motif) ligand 28
chr12_-_10251603 5.47 ENST00000457018.2
CLEC1A
C-type lectin domain family 1, member A
chr8_-_96281419 5.45 ENST00000286688.5
C8orf37
chromosome 8 open reading frame 37
chr1_+_28052456 5.44 ENST00000373954.6
ENST00000419687.2
FAM76A
family with sequence similarity 76, member A
chr19_+_16999654 5.32 ENST00000248076.3
F2RL3
coagulation factor II (thrombin) receptor-like 3
chr7_-_100493744 5.27 ENST00000428317.1
ENST00000441605.1
ACHE
acetylcholinesterase (Yt blood group)
chr17_-_10017864 5.24 ENST00000323816.4
GAS7
growth arrest-specific 7
chr3_-_15374659 5.13 ENST00000426925.1
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr16_+_58549378 5.13 ENST00000310682.2
ENST00000394266.4
ENST00000219315.4
SETD6
SET domain containing 6
chr22_-_38851205 4.84 ENST00000303592.3
KCNJ4
potassium inwardly-rectifying channel, subfamily J, member 4
chr1_-_151119087 4.83 ENST00000341697.3
ENST00000368914.3
SEMA6C
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
chr20_+_42143053 4.75 ENST00000373135.3
ENST00000444063.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chrX_-_99987088 4.73 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4
chr8_+_11561660 4.59 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr10_+_72972281 4.59 ENST00000335350.6
UNC5B
unc-5 homolog B (C. elegans)
chr6_-_152489484 4.48 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr1_+_36772691 4.47 ENST00000312808.4
ENST00000505871.1
SH3D21
SH3 domain containing 21
chr1_+_159141397 4.45 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
CADM3
cell adhesion molecule 3
chr6_+_6588316 4.27 ENST00000379953.2
LY86
lymphocyte antigen 86
chr16_-_56459354 4.24 ENST00000290649.5
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
chr8_-_20161466 4.20 ENST00000381569.1
LZTS1
leucine zipper, putative tumor suppressor 1
chr19_-_3606838 4.10 ENST00000375190.4
TBXA2R
thromboxane A2 receptor
chr9_-_137809718 4.09 ENST00000371806.3
FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr1_+_36771946 4.06 ENST00000373139.2
ENST00000453908.2
ENST00000426732.2
SH3D21
SH3 domain containing 21
chr21_-_38338773 4.05 ENST00000399120.1
ENST00000419461.1
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr21_+_47401650 4.02 ENST00000361866.3
COL6A1
collagen, type VI, alpha 1
chr16_+_57702099 3.98 ENST00000333493.4
ENST00000327655.6
GPR97
G protein-coupled receptor 97
chr10_-_102989551 3.96 ENST00000370193.2
LBX1
ladybird homeobox 1
chrX_+_24167746 3.88 ENST00000428571.1
ENST00000539115.1
ZFX
zinc finger protein, X-linked
chr19_-_51587502 3.88 ENST00000156499.2
ENST00000391802.1
KLK14
kallikrein-related peptidase 14
chr22_+_29876197 3.88 ENST00000310624.6
NEFH
neurofilament, heavy polypeptide
chr19_-_46105411 3.87 ENST00000323040.4
ENST00000544371.1
GPR4
OPA3
G protein-coupled receptor 4
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr11_-_33913708 3.86 ENST00000257818.2
LMO2
LIM domain only 2 (rhombotin-like 1)
chr12_-_89918522 3.85 ENST00000529983.2
GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
chr16_+_2198604 3.80 ENST00000210187.6
RAB26
RAB26, member RAS oncogene family
chr1_-_201915590 3.74 ENST00000367288.4
LMOD1
leiomodin 1 (smooth muscle)
chr16_+_2286726 3.66 ENST00000382437.4
ENST00000569184.1
DNASE1L2
deoxyribonuclease I-like 2
chr20_-_48532046 3.59 ENST00000543716.1
SPATA2
spermatogenesis associated 2
chr11_+_117857063 3.58 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
IL10RA
interleukin 10 receptor, alpha
chr1_+_100111580 3.55 ENST00000605497.1
PALMD
palmdelphin
chr9_+_71944241 3.54 ENST00000257515.8
FAM189A2
family with sequence similarity 189, member A2
chr19_-_44285401 3.54 ENST00000262888.3
KCNN4
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4
chr12_-_120554534 3.43 ENST00000538903.1
ENST00000534951.1
RAB35
RAB35, member RAS oncogene family
chr19_+_51645556 3.39 ENST00000601682.1
ENST00000317643.6
ENST00000305628.7
ENST00000600577.1
SIGLEC7
sialic acid binding Ig-like lectin 7
chr7_+_102004322 3.38 ENST00000496391.1
PRKRIP1
PRKR interacting protein 1 (IL11 inducible)
chr1_+_15783222 3.35 ENST00000359621.4
CELA2A
chymotrypsin-like elastase family, member 2A
chr1_-_44497118 3.35 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr15_-_88799661 3.32 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr19_-_52150053 3.24 ENST00000599649.1
ENST00000429354.3
ENST00000360844.6
ENST00000222107.4
SIGLEC5
SIGLEC14
SIGLEC5
SIGLEC5
sialic acid binding Ig-like lectin 14
sialic acid binding Ig-like lectin 5
chr2_-_228028829 3.24 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr20_+_44098346 3.07 ENST00000372676.3
WFDC2
WAP four-disulfide core domain 2
chr2_-_220174166 2.98 ENST00000409251.3
ENST00000451506.1
ENST00000295718.2
ENST00000446182.1
PTPRN
protein tyrosine phosphatase, receptor type, N
chr9_+_125137565 2.94 ENST00000373698.5
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr20_+_35974532 2.91 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr6_+_108487245 2.89 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr12_-_53207842 2.85 ENST00000458244.2
KRT4
keratin 4
chr3_+_195447738 2.84 ENST00000447234.2
ENST00000320736.6
ENST00000436408.1
MUC20
mucin 20, cell surface associated
chr22_+_22735135 2.78 ENST00000390297.2
IGLV1-44
immunoglobulin lambda variable 1-44
chr1_+_15802594 2.75 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr7_+_155250824 2.73 ENST00000297375.4
EN2
engrailed homeobox 2
chr1_-_9189229 2.63 ENST00000377411.4
GPR157
G protein-coupled receptor 157
chr1_+_44412577 2.58 ENST00000372343.3
IPO13
importin 13
chr9_+_101867387 2.56 ENST00000374990.2
ENST00000552516.1
TGFBR1
transforming growth factor, beta receptor 1
chr1_+_100111479 2.53 ENST00000263174.4
PALMD
palmdelphin
chr3_+_40547483 2.52 ENST00000420891.1
ENST00000314529.6
ENST00000418905.1
ZNF620
zinc finger protein 620
chr17_-_1389419 2.51 ENST00000575158.1
MYO1C
myosin IC
chr16_-_4987065 2.47 ENST00000590782.2
ENST00000345988.2
PPL
periplakin
chr19_-_18337240 2.46 ENST00000262805.12
PDE4C
phosphodiesterase 4C, cAMP-specific
chr3_-_195603566 2.43 ENST00000424563.1
ENST00000411741.1
TNK2
tyrosine kinase, non-receptor, 2
chr16_-_67997947 2.42 ENST00000537830.2
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chrX_-_47489244 2.42 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP
complement factor properdin
chr12_+_122516626 2.41 ENST00000319080.7
MLXIP
MLX interacting protein
chr16_-_17564738 2.39 ENST00000261381.6
XYLT1
xylosyltransferase I
chr21_-_38639813 2.38 ENST00000309117.6
ENST00000398998.1
DSCR3
Down syndrome critical region gene 3
chr13_-_96705624 2.35 ENST00000376747.3
ENST00000376712.4
ENST00000397618.3
ENST00000376714.3
UGGT2
UDP-glucose glycoprotein glucosyltransferase 2
chr9_-_136006496 2.30 ENST00000372062.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr19_+_13106383 2.28 ENST00000397661.2
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_+_140345820 2.25 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr6_+_39760129 2.24 ENST00000274867.4
DAAM2
dishevelled associated activator of morphogenesis 2
chr17_-_58469474 2.22 ENST00000300896.4
USP32
ubiquitin specific peptidase 32
chr3_+_123813543 2.21 ENST00000360013.3
KALRN
kalirin, RhoGEF kinase
chr5_+_140762268 2.16 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr22_-_24641027 2.16 ENST00000398292.3
ENST00000263112.7
ENST00000418439.2
ENST00000424217.1
ENST00000327365.4
GGT5
gamma-glutamyltransferase 5
chr3_-_49761337 2.15 ENST00000535833.1
ENST00000308388.6
ENST00000480687.1
ENST00000308375.6
AMIGO3
GMPPB
adhesion molecule with Ig-like domain 3
GDP-mannose pyrophosphorylase B
chr14_+_81421355 2.13 ENST00000541158.2
TSHR
thyroid stimulating hormone receptor
chr2_+_168725458 2.12 ENST00000392690.3
B3GALT1
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1
chr1_-_160040038 2.07 ENST00000368089.3
KCNJ10
potassium inwardly-rectifying channel, subfamily J, member 10
chr9_+_101867359 2.03 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr9_-_130829588 2.00 ENST00000373078.4
NAIF1
nuclear apoptosis inducing factor 1
chr7_+_130020180 1.98 ENST00000481342.1
ENST00000011292.3
ENST00000604896.1
CPA1
carboxypeptidase A1 (pancreatic)
chr20_+_44098385 1.98 ENST00000217425.5
ENST00000339946.3
WFDC2
WAP four-disulfide core domain 2
chr19_+_41594377 1.91 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr1_-_59249732 1.91 ENST00000371222.2
JUN
jun proto-oncogene
chr6_+_41010293 1.90 ENST00000373161.1
ENST00000373158.2
ENST00000470917.1
TSPO2
translocator protein 2
chr2_+_5832799 1.89 ENST00000322002.3
SOX11
SRY (sex determining region Y)-box 11
chr8_-_142377367 1.88 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr3_-_49131013 1.86 ENST00000424300.1
QRICH1
glutamine-rich 1
chr2_+_223289208 1.86 ENST00000321276.7
SGPP2
sphingosine-1-phosphate phosphatase 2
chr6_+_6588902 1.83 ENST00000230568.4
LY86
lymphocyte antigen 86
chr4_+_93225550 1.77 ENST00000282020.4
GRID2
glutamate receptor, ionotropic, delta 2
chr5_+_139493665 1.75 ENST00000331327.3
PURA
purine-rich element binding protein A
chr3_-_62359180 1.72 ENST00000283268.3
FEZF2
FEZ family zinc finger 2
chr16_+_28889801 1.71 ENST00000395503.4
ATP2A1
ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
chr11_-_107590383 1.66 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr19_+_10527449 1.59 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr19_-_11688447 1.59 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr12_-_10251539 1.59 ENST00000420265.2
CLEC1A
C-type lectin domain family 1, member A
chr7_+_130020932 1.58 ENST00000484324.1
CPA1
carboxypeptidase A1 (pancreatic)
chr7_-_100493482 1.58 ENST00000411582.1
ENST00000419336.2
ENST00000241069.5
ENST00000302913.4
ACHE
acetylcholinesterase (Yt blood group)
chr20_+_1875942 1.57 ENST00000358771.4
SIRPA
signal-regulatory protein alpha
chr12_+_93965451 1.56 ENST00000548537.1
SOCS2
suppressor of cytokine signaling 2
chr4_+_47033607 1.55 ENST00000538619.1
GABRB1
gamma-aminobutyric acid (GABA) A receptor, beta 1
chr9_+_103790991 1.53 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr2_+_74881398 1.52 ENST00000339773.5
ENST00000434486.1
SEMA4F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chr17_+_68165657 1.51 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr19_+_49128209 1.47 ENST00000599748.1
ENST00000443164.1
ENST00000599029.1
SPHK2
sphingosine kinase 2
chr1_-_234614849 1.38 ENST00000040877.1
TARBP1
TAR (HIV-1) RNA binding protein 1
chr6_+_99282570 1.37 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr4_-_39640700 1.35 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr19_-_54824344 1.27 ENST00000346508.3
ENST00000446712.3
ENST00000432233.3
ENST00000301219.3
LILRA5
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr7_+_107384579 1.27 ENST00000222597.2
ENST00000415884.2
CBLL1
Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
chr13_-_80915059 1.26 ENST00000377104.3
SPRY2
sprouty homolog 2 (Drosophila)
chr19_-_46272462 1.24 ENST00000317578.6
SIX5
SIX homeobox 5
chr7_+_39125365 1.20 ENST00000559001.1
ENST00000464276.2
POU6F2
POU class 6 homeobox 2
chr14_+_81421861 1.18 ENST00000298171.2
TSHR
thyroid stimulating hormone receptor
chr12_-_71003568 1.18 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr6_+_39760783 1.18 ENST00000398904.2
ENST00000538976.1
DAAM2
dishevelled associated activator of morphogenesis 2
chr12_+_3600356 1.12 ENST00000382622.3
PRMT8
protein arginine methyltransferase 8
chr1_-_44482979 1.11 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_+_16693578 1.10 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr4_-_113437328 1.06 ENST00000313341.3
NEUROG2
neurogenin 2
chr4_-_41216619 1.04 ENST00000508676.1
ENST00000506352.1
ENST00000295974.8
APBB2
amyloid beta (A4) precursor protein-binding, family B, member 2
chr5_+_133861339 1.04 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr20_-_56284816 1.03 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr3_+_123813509 0.93 ENST00000460856.1
ENST00000240874.3
KALRN
kalirin, RhoGEF kinase
chr20_+_43343886 0.91 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr17_-_40337470 0.90 ENST00000293330.1
HCRT
hypocretin (orexin) neuropeptide precursor
chr1_+_226411319 0.90 ENST00000542034.1
ENST00000366810.5
MIXL1
Mix paired-like homeobox
chr1_-_149908217 0.87 ENST00000369140.3
MTMR11
myotubularin related protein 11
chrX_-_151143140 0.83 ENST00000393914.3
ENST00000370328.3
ENST00000370325.1
GABRE
gamma-aminobutyric acid (GABA) A receptor, epsilon
chr7_-_105516923 0.76 ENST00000478915.1
ATXN7L1
ataxin 7-like 1
chr6_-_30128657 0.72 ENST00000449742.2
ENST00000376704.3
TRIM10
tripartite motif containing 10
chr1_+_2407754 0.71 ENST00000419816.2
ENST00000378486.3
ENST00000378488.3
ENST00000288766.5
PLCH2
phospholipase C, eta 2
chr2_+_27237615 0.62 ENST00000458529.1
ENST00000402218.1
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr22_+_22764088 0.57 ENST00000390299.2
IGLV1-40
immunoglobulin lambda variable 1-40
chr19_-_14224969 0.57 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr11_-_34535332 0.57 ENST00000257832.2
ENST00000429939.2
ELF5
E74-like factor 5 (ets domain transcription factor)
chr16_+_58059470 0.54 ENST00000219271.3
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr19_-_42636617 0.54 ENST00000529067.1
ENST00000529952.1
ENST00000533720.1
ENST00000389341.5
ENST00000342301.4
POU2F2
POU class 2 homeobox 2
chr12_-_57410304 0.48 ENST00000441881.1
ENST00000458521.2
TAC3
tachykinin 3
chr3_-_88108212 0.48 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr19_+_49977818 0.47 ENST00000594009.1
ENST00000595510.1
FLT3LG
fms-related tyrosine kinase 3 ligand
chr11_-_22647350 0.44 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chr14_+_81421710 0.44 ENST00000342443.6
TSHR
thyroid stimulating hormone receptor
chr1_-_149908710 0.43 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0019482 beta-alanine metabolic process(GO:0019482)
5.1 15.3 GO:1990502 dense core granule maturation(GO:1990502)
3.4 16.9 GO:0051941 regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
3.3 26.1 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
3.1 9.4 GO:0090035 regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
3.1 9.2 GO:0048691 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
2.3 6.9 GO:0032223 negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212)
2.1 2.1 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
2.1 6.2 GO:1904617 negative regulation of actin filament binding(GO:1904530) negative regulation of actin binding(GO:1904617)
1.5 4.6 GO:0003285 septum secundum development(GO:0003285)
1.5 4.6 GO:0003342 proepicardium development(GO:0003342) septum transversum development(GO:0003343)
1.5 4.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
1.4 8.4 GO:0018095 protein polyglutamylation(GO:0018095)
1.4 4.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
1.4 4.1 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
1.4 4.1 GO:0070781 response to biotin(GO:0070781)
1.3 6.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
1.3 3.9 GO:0048936 neurofilament bundle assembly(GO:0033693) peripheral nervous system neuron axonogenesis(GO:0048936)
1.1 5.5 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
1.0 2.9 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.9 3.7 GO:1904588 cellular response to glycoprotein(GO:1904588) cellular response to thyrotropin-releasing hormone(GO:1905229)
0.9 4.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.9 3.7 GO:0003335 corneocyte development(GO:0003335)
0.9 6.0 GO:0051414 response to cortisol(GO:0051414)
0.8 2.4 GO:0097359 UDP-glucosylation(GO:0097359)
0.7 3.0 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.7 2.9 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.7 6.1 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.7 5.3 GO:0060155 platelet dense granule organization(GO:0060155)
0.6 5.7 GO:0048664 neuron fate determination(GO:0048664)
0.6 1.9 GO:0061386 closure of optic fissure(GO:0061386)
0.6 3.1 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.6 3.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.6 1.2 GO:0048867 stem cell fate determination(GO:0048867)
0.6 5.8 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.6 1.7 GO:1901876 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.5 2.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.5 5.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.5 1.5 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.5 1.9 GO:0035026 leading edge cell differentiation(GO:0035026)
0.5 5.7 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.4 4.5 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.4 8.6 GO:0032060 bleb assembly(GO:0032060)
0.4 3.9 GO:0072143 renal interstitial fibroblast development(GO:0072141) mesangial cell development(GO:0072143) glomerular mesangial cell development(GO:0072144)
0.4 5.1 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.4 1.3 GO:0060437 lung growth(GO:0060437)
0.4 2.5 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.4 18.4 GO:0097178 ruffle assembly(GO:0097178)
0.4 3.9 GO:0007320 insemination(GO:0007320)
0.4 22.5 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.4 1.8 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707) positive regulation of long term synaptic depression(GO:1900454)
0.3 3.5 GO:0030322 stabilization of membrane potential(GO:0030322) saliva secretion(GO:0046541)
0.3 1.9 GO:0009804 coumarin metabolic process(GO:0009804)
0.3 1.6 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.3 1.2 GO:0014859 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.3 4.2 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.3 16.5 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.3 3.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.3 4.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.2 2.7 GO:1990403 embryonic brain development(GO:1990403)
0.2 2.4 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.2 2.1 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.2 0.6 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.2 3.2 GO:0032836 glomerular basement membrane development(GO:0032836)
0.2 2.6 GO:0060019 radial glial cell differentiation(GO:0060019)
0.2 10.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 0.9 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 0.9 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.2 1.7 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.2 7.8 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.2 1.4 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 3.9 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.2 2.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 4.2 GO:0016242 negative regulation of macroautophagy(GO:0016242)
0.2 0.5 GO:0090290 positive regulation of osteoclast proliferation(GO:0090290)
0.2 2.2 GO:1901748 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.2 2.4 GO:0006109 regulation of carbohydrate metabolic process(GO:0006109)
0.1 1.9 GO:0006670 sphingosine metabolic process(GO:0006670) diol metabolic process(GO:0034311)
0.1 2.8 GO:0048012 hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.1 1.3 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.1 6.4 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 4.7 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 4.8 GO:0010107 potassium ion import(GO:0010107)
0.1 7.4 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.1 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 2.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.1 1.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.1 2.4 GO:0006884 cell volume homeostasis(GO:0006884)
0.1 0.5 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 4.1 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 1.0 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 2.4 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.1 7.0 GO:0042116 macrophage activation(GO:0042116)
0.1 7.4 GO:0016525 negative regulation of angiogenesis(GO:0016525)
0.1 1.5 GO:0071420 cellular response to histamine(GO:0071420)
0.1 8.6 GO:0070268 cornification(GO:0070268)
0.1 3.9 GO:0016266 O-glycan processing(GO:0016266)
0.1 4.8 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.1 1.4 GO:0031167 rRNA methylation(GO:0031167)
0.1 0.8 GO:2001225 regulation of chloride transport(GO:2001225)
0.1 1.5 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.1 7.3 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 0.3 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0 0.3 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.0 0.7 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 2.2 GO:0016579 protein deubiquitination(GO:0016579)
0.0 4.5 GO:0034332 adherens junction organization(GO:0034332)
0.0 3.4 GO:0003014 renal system process(GO:0003014)
0.0 0.7 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.4 GO:0031424 keratinization(GO:0031424)
0.0 3.4 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.5 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.0 3.8 GO:0007411 axon guidance(GO:0007411)
0.0 2.0 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 0.5 GO:0035987 endodermal cell differentiation(GO:0035987)
0.0 12.9 GO:0016032 viral process(GO:0016032)
0.0 1.2 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.4 GO:0036297 interstrand cross-link repair(GO:0036297)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 16.5 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.8 16.9 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.7 4.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.6 2.5 GO:0045160 myosin I complex(GO:0045160)
0.5 4.6 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.5 6.9 GO:0043083 synaptic cleft(GO:0043083)
0.5 7.8 GO:0030914 STAGA complex(GO:0030914)
0.4 9.5 GO:0000145 exocyst(GO:0000145)
0.4 2.4 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.4 3.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.4 4.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.3 4.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.3 4.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3 8.6 GO:0043218 compact myelin(GO:0043218)
0.3 3.9 GO:0005883 neurofilament(GO:0005883)
0.3 4.1 GO:0005652 nuclear lamina(GO:0005652)
0.3 25.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 1.9 GO:0035976 AP1 complex(GO:0035976)
0.2 21.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.2 9.4 GO:0016235 aggresome(GO:0016235)
0.2 4.7 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 6.0 GO:0097546 ciliary base(GO:0097546)
0.1 11.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 1.7 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 5.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 2.8 GO:0031528 microvillus membrane(GO:0031528)
0.1 6.5 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 19.9 GO:0008021 synaptic vesicle(GO:0008021)
0.1 5.7 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 2.5 GO:0030057 desmosome(GO:0030057)
0.1 2.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 9.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 1.5 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 12.1 GO:0043197 dendritic spine(GO:0043197)
0.1 3.3 GO:0045095 keratin filament(GO:0045095)
0.1 12.1 GO:0001650 fibrillar center(GO:0001650)
0.1 2.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.1 2.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 7.4 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.1 7.3 GO:0005643 nuclear pore(GO:0005643)
0.1 0.4 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 8.0 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 4.1 GO:0001669 acrosomal vesicle(GO:0001669)
0.1 4.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 16.0 GO:0043235 receptor complex(GO:0043235)
0.0 6.8 GO:0030496 midbody(GO:0030496)
0.0 0.5 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 2.3 GO:0005903 brush border(GO:0005903)
0.0 52.5 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 2.8 GO:0032587 ruffle membrane(GO:0032587)
0.0 31.0 GO:0005730 nucleolus(GO:0005730)
0.0 2.4 GO:0035580 specific granule lumen(GO:0035580)
0.0 3.1 GO:0099572 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.3 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.2 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 15.0 GO:0005615 extracellular space(GO:0005615)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 26.1 GO:0043426 MRF binding(GO:0043426)
2.4 9.4 GO:0042903 tubulin deacetylase activity(GO:0042903)
1.7 6.9 GO:0003990 acetylcholinesterase activity(GO:0003990)
1.6 4.7 GO:0032093 SAM domain binding(GO:0032093)
1.4 4.2 GO:1904288 BAT3 complex binding(GO:1904288)
1.4 4.1 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
1.3 5.0 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
1.2 16.9 GO:1990239 steroid hormone binding(GO:1990239)
1.1 4.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.9 5.3 GO:0015057 thrombin receptor activity(GO:0015057)
0.9 7.0 GO:0001849 complement component C1q binding(GO:0001849)
0.8 6.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.8 2.4 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.8 2.4 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.7 2.9 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.7 2.1 GO:0047275 glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity(GO:0047275)
0.7 3.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.7 9.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.6 1.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.5 3.7 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.5 5.8 GO:0035184 histone threonine kinase activity(GO:0035184)
0.5 3.6 GO:0004920 interleukin-10 receptor activity(GO:0004920)
0.5 4.6 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.5 8.4 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.5 1.4 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.5 21.1 GO:0003785 actin monomer binding(GO:0003785)
0.4 2.1 GO:0070568 guanylyltransferase activity(GO:0070568)
0.4 4.6 GO:0051525 NFAT protein binding(GO:0051525)
0.4 4.1 GO:0009374 biotin binding(GO:0009374)
0.4 1.1 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.4 2.9 GO:0071253 connexin binding(GO:0071253)
0.4 5.0 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 7.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.3 15.3 GO:0030507 spectrin binding(GO:0030507)
0.3 6.2 GO:0031005 filamin binding(GO:0031005)
0.3 4.1 GO:0033691 sialic acid binding(GO:0033691)
0.3 4.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 17.2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.3 3.9 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.2 1.5 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.2 7.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 6.7 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 2.4 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.2 2.4 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 4.5 GO:0005521 lamin binding(GO:0005521)
0.2 2.2 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 2.5 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 8.0 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 5.1 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 5.7 GO:0030332 cyclin binding(GO:0030332)
0.1 3.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 3.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 1.6 GO:0008199 ferric iron binding(GO:0008199)
0.1 3.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 9.9 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.1 3.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 5.5 GO:0008009 chemokine activity(GO:0008009)
0.1 2.4 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 4.1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 7.8 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.9 GO:0070330 aromatase activity(GO:0070330)
0.1 1.5 GO:0038191 neuropilin binding(GO:0038191)
0.1 9.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 2.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 19.6 GO:0030246 carbohydrate binding(GO:0030246)
0.1 1.8 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 5.2 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 3.4 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.1 1.9 GO:0015485 cholesterol binding(GO:0015485)
0.0 3.4 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 12.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 5.8 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.3 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 3.7 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 14.1 GO:0030695 GTPase regulator activity(GO:0030695)
0.0 3.2 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 2.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.7 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 2.9 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184) neuropeptide receptor binding(GO:0071855)
0.0 0.5 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.0 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.8 GO:0008017 microtubule binding(GO:0008017)
0.0 10.0 GO:0005509 calcium ion binding(GO:0005509)
0.0 31.9 GO:0003677 DNA binding(GO:0003677)
0.0 0.2 GO:0005520 insulin-like growth factor binding(GO:0005520)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.3 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.2 9.4 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.2 7.3 NABA COLLAGENS Genes encoding collagen proteins
0.2 2.9 ST STAT3 PATHWAY STAT3 Pathway
0.2 4.6 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 6.7 PID RAS PATHWAY Regulation of Ras family activation
0.1 23.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.1 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.1 8.6 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 9.7 PID SHP2 PATHWAY SHP2 signaling
0.1 6.8 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 8.8 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 1.5 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 4.1 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.1 3.7 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 2.7 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 4.3 PID BCR 5PATHWAY BCR signaling pathway
0.0 2.7 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 2.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 9.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.3 PID FGF PATHWAY FGF signaling pathway
0.0 2.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 17.2 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.6 23.7 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.4 14.2 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.4 4.1 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.3 4.6 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 11.6 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.3 8.2 REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.3 4.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.3 6.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 3.7 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.2 4.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 6.2 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.2 4.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 2.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.1 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 1.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 7.3 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 2.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.9 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 3.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 5.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 1.5 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 2.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 1.6 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 1.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 3.5 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 3.0 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 6.1 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 2.9 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.0 3.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 1.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 5.5 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 1.6 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 2.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 0.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix