ISMARA results: SMAD4

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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SMAD4

Z-value: 1.93

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Transcription factors associated with SMAD4

Gene Symbol	Gene ID	Gene Info
SMAD4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000141646.9	SMAD family member 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SMAD4	hg19_v2_chr18_+_48494361_48494426	0.54	4.3e-18	Click!

Activity profile of SMAD4 motif

Sorted Z-values of SMAD4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_117070037 Show fit	34.46	ENST00000392951.4 ENST00000525531.1 ENST00000278968.6	TAGLN Ensembl NCBI GeneCards UniProt NextProt Show fit	transgelin
chr22_+_23247030 Show fit	33.92	ENST00000390324.2	IGLJ3 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda joining 3
chr11_-_111794446 Show fit	27.73	ENST00000527950.1	CRYAB Ensembl NCBI GeneCards UniProt NextProt Show fit	crystallin, alpha B
chr14_-_106209368 Show fit	22.50	ENST00000390548.2 ENST00000390549.2 ENST00000390542.2	IGHG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin heavy constant gamma 1 (G1m marker)
chr6_-_33048483 Show fit	21.03	ENST00000419277.1	HLA-DPA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	major histocompatibility complex, class II, DP alpha 1
chr2_+_113033164 Show fit	19.41	ENST00000409871.1 ENST00000343936.4	ZC3H6 Ensembl NCBI GeneCards UniProt NextProt Show fit	zinc finger CCCH-type containing 6
chr11_-_5248294 Show fit	18.98	ENST00000335295.4	HBB Ensembl NCBI GeneCards UniProt NextProt Show fit	hemoglobin, beta
chr7_+_94023873 Show fit	18.83	ENST00000297268.6	COL1A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	collagen, type I, alpha 2
chr22_-_27620603 Show fit	18.76	ENST00000418271.1 ENST00000444114.1	RP5-1172A22.1 Ensembl NCBI GeneCards UniProt NextProt Show fit	RP5-1172A22.1
chr22_+_30752606 Show fit	17.76	ENST00000399824.2 ENST00000405659.1 ENST00000338306.3	CCDC157 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 157

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	198.7	GO:0006958	complement activation, classical pathway(GO:0006958)
3.9	70.4	GO:0007021	tubulin complex assembly(GO:0007021)
0.4	55.7	GO:0002377	immunoglobulin production(GO:0002377)
0.5	34.9	GO:0032729	positive regulation of interferon-gamma production(GO:0032729)
5.1	30.7	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
1.4	29.3	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
5.0	24.8	GO:0044858	plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
6.1	24.5	GO:0071461	cellular response to redox state(GO:0071461)
3.1	24.5	GO:0002774	Fc receptor mediated inhibitory signaling pathway(GO:0002774)
7.7	23.0	GO:2001190	positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)

Showing 1 to 10 of 440 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	189.9	GO:0005615	extracellular space(GO:0005615)
0.1	108.4	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
1.7	85.9	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
3.9	82.0	GO:0042613	MHC class II protein complex(GO:0042613)
4.4	70.4	GO:0097512	cardiac myofibril(GO:0097512)
0.3	40.9	GO:0072562	blood microparticle(GO:0072562)
0.5	32.0	GO:0005581	collagen trimer(GO:0005581)
0.3	30.7	GO:0005604	basement membrane(GO:0005604)
0.3	27.0	GO:0070821	tertiary granule membrane(GO:0070821)
0.2	24.7	GO:0031225	anchored component of membrane(GO:0031225)

Showing 1 to 10 of 171 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	182.3	GO:0003823	antigen binding(GO:0003823)
1.4	75.2	GO:0034987	immunoglobulin receptor binding(GO:0034987)
2.3	70.7	GO:0005212	structural constituent of eye lens(GO:0005212)
3.5	46.0	GO:0032395	MHC class II receptor activity(GO:0032395)
0.2	37.4	GO:0051015	actin filament binding(GO:0051015)
2.5	27.0	GO:0008430	selenium binding(GO:0008430)
1.1	25.1	GO:0048018	receptor agonist activity(GO:0048018)
2.1	24.8	GO:0045159	myosin II binding(GO:0045159)
3.1	24.5	GO:0032396	inhibitory MHC class I receptor activity(GO:0032396)
2.3	23.4	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)

Showing 1 to 10 of 285 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	79.7	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.6	64.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.3	48.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	42.9	NABA CORE MATRISOME	Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.5	33.7	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.6	31.3	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.7	23.5	PID ERBB1 RECEPTOR PROXIMAL PATHWAY	EGF receptor (ErbB1) signaling pathway
0.3	20.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.4	15.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	14.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Showing 1 to 10 of 66 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	50.2	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.6	48.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.4	34.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.4	27.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.2	26.6	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
1.5	25.6	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.1	24.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.7	22.6	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.6	21.5	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.5	19.1	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport

Showing 1 to 10 of 104 entries

Results for SMAD4

Z-value: 1.93

Motif logo

Transcription factors associated with SMAD4

Activity-expression correlation:

Activity profile of SMAD4 motif

Sorted Z-values of SMAD4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: