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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SOX10_SOX15
Z-value: 1.00
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Transcription factors associated with SOX10_SOX15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX15 | hg19_v2_chr17_-_7493390_7493488 | -0.39 | 3.2e-09 | Click! |
| SOX10 | hg19_v2_chr22_-_38380543_38380569 | -0.28 | 3.7e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX10_SOX15
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.0 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 6.2 | 18.5 | GO:0051086 | chaperone mediated protein folding independent of cofactor(GO:0051086) |
| 0.2 | 17.1 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
| 0.1 | 16.9 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.6 | 16.5 | GO:0050860 | negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 2.2 | 15.7 | GO:2000483 | negative regulation of interleukin-8 secretion(GO:2000483) |
| 0.1 | 15.2 | GO:1902036 | regulation of hematopoietic stem cell differentiation(GO:1902036) |
| 2.9 | 14.3 | GO:0071895 | odontoblast differentiation(GO:0071895) |
| 2.6 | 13.1 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.5 | 11.8 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.4 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.0 | 27.4 | GO:0005654 | nucleoplasm(GO:0005654) |
| 2.0 | 22.0 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 21.0 | GO:0000785 | chromatin(GO:0000785) |
| 1.4 | 18.5 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 0.7 | 17.1 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.2 | 14.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.2 | 13.6 | GO:0005871 | kinesin complex(GO:0005871) |
| 1.7 | 13.5 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 13.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.7 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 1.0 | 21.0 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 20.7 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.9 | 19.3 | GO:0035497 | cAMP response element binding(GO:0035497) |
| 0.5 | 18.5 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.0 | 16.8 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.4 | 15.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 15.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 4.7 | 14.1 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.5 | 13.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.4 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.2 | 23.8 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.2 | 19.6 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.7 | 17.9 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.2 | 17.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.8 | 15.0 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 13.4 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.2 | 11.6 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 9.2 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.1 | 8.4 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 22.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.4 | 20.4 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 16.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.3 | 15.9 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.8 | 14.4 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 14.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.4 | 11.8 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.5 | 10.2 | REACTOME SOS MEDIATED SIGNALLING | Genes involved in SOS-mediated signalling |
| 0.4 | 9.9 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.1 | 9.5 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |