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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX17

Z-value: 1.47

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Transcription factors associated with SOX17

Gene Symbol Gene ID Gene Info
ENSG00000164736.5 SRY-box transcription factor 17

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX17hg19_v2_chr8_+_55370487_553705030.127.7e-02Click!

Activity profile of SOX17 motif

Sorted Z-values of SOX17 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_89399845 24.74 ENST00000479981.1
immunoglobulin kappa variable 1-16
chr2_+_90139056 20.18 ENST00000492446.1
immunoglobulin kappa variable 1D-16
chr19_+_58095501 18.82 ENST00000536878.2
ENST00000597850.1
ENST00000597219.1
ENST00000598689.1
ENST00000599456.1
ENST00000307468.4
zinc finger protein interacting with K protein 1
chr19_-_10764509 17.61 ENST00000591501.1
ILF3 antisense RNA 1 (head to head)
chrX_+_49216659 15.09 ENST00000415752.1
G antigen 12I
chr6_-_32920794 14.76 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chrX_+_49178536 14.46 ENST00000442437.2
G antigen 12J
chr2_-_100939195 12.70 ENST00000393437.3
LON peptidase N-terminal domain and ring finger 2
chr15_-_20193370 12.59 ENST00000558565.2
immunoglobulin heavy variable 3/OR15-7 (pseudogene)
chrX_+_49235708 12.53 ENST00000381725.1
G antigen 2B
chr17_-_5138099 12.28 ENST00000571800.1
ENST00000574081.1
ENST00000399600.4
ENST00000574297.1
SLP adaptor and CSK interacting membrane protein
chr15_-_47426320 12.16 ENST00000557832.1
FKSG62
chr6_-_52710893 12.05 ENST00000284562.2
glutathione S-transferase alpha 5
chr2_-_89278535 11.94 ENST00000390247.2
immunoglobulin kappa variable 3-7 (non-functional)
chr19_+_6135646 11.89 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
acyl-CoA synthetase bubblegum family member 2
chr2_-_89417335 11.88 ENST00000490686.1
immunoglobulin kappa variable 1-17
chrX_+_8432871 11.63 ENST00000381032.1
ENST00000453306.1
ENST00000444481.1
variable charge, X-linked 3B
chrY_+_2709906 11.44 ENST00000430575.1
ribosomal protein S4, Y-linked 1
chrX_-_6453159 11.23 ENST00000381089.3
ENST00000398729.1
variable charge, X-linked 3A
chr3_-_123710199 10.92 ENST00000184183.4
rhophilin associated tail protein 1
chr6_-_52628271 10.84 ENST00000493422.1
glutathione S-transferase alpha 2
chr4_+_128554081 10.60 ENST00000335251.6
ENST00000296461.5
inturned planar cell polarity protein
chr3_+_125687987 10.33 ENST00000514116.1
ENST00000251776.4
ENST00000504401.1
ENST00000513830.1
ENST00000508088.1
rhophilin associated tail protein 1B
chr12_-_71533055 10.04 ENST00000552128.1
tetraspanin 8
chr6_+_32605195 9.98 ENST00000374949.2
major histocompatibility complex, class II, DQ alpha 1
chr1_+_158901329 9.96 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
pyrin and HIN domain family, member 1
chrX_+_49197607 9.51 ENST00000402590.3
G antigen 2E
chr1_-_48937821 9.17 ENST00000396199.3
spermatogenesis associated 6
chr13_-_46756351 9.10 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr5_+_49962772 9.06 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
poly (ADP-ribose) polymerase family, member 8
chr6_-_49755019 8.80 ENST00000304801.3
phosphoglycerate kinase 2
chr16_+_2867228 8.79 ENST00000005995.3
ENST00000574813.1
protease, serine, 21 (testisin)
chr14_+_77882741 8.77 ENST00000595520.1
FKSG61
chr3_-_123710893 8.76 ENST00000467907.1
ENST00000459660.1
ENST00000495093.1
ENST00000460743.1
ENST00000405845.3
ENST00000484329.1
ENST00000479867.1
ENST00000496145.1
rhophilin associated tail protein 1
chr12_+_69742121 8.72 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
lysozyme
chr2_+_48844973 8.65 ENST00000403751.3
general transcription factor IIA, 1-like
chr12_+_25205568 8.59 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr12_+_25205666 8.43 ENST00000547044.1
lymphoid-restricted membrane protein
chr12_-_11463353 8.40 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
proline-rich protein BstNI subfamily 4
chr16_-_70239683 8.35 ENST00000601706.1
Uncharacterized protein
chr3_+_46412345 8.30 ENST00000292303.4
chemokine (C-C motif) receptor 5 (gene/pseudogene)
chrX_-_8139308 8.25 ENST00000317103.4
variable charge, X-linked 2
chr2_+_48844937 8.24 ENST00000448460.1
ENST00000437125.1
ENST00000430487.2
general transcription factor IIA, 1-like
chr11_+_125365110 8.14 ENST00000527818.1
AP000708.1
chr12_+_25205446 7.99 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr2_-_90538397 7.80 ENST00000443397.3
Uncharacterized protein
chr1_+_174844645 7.72 ENST00000486220.1
RAB GTPase activating protein 1-like
chr15_+_93749295 7.69 ENST00000599897.1
AC112693.2
chr15_-_28778117 7.61 ENST00000525590.2
ENST00000329523.6
golgin A8 family, member G
chr12_+_9822331 7.45 ENST00000545918.1
ENST00000543300.1
ENST00000261339.6
ENST00000466035.2
C-type lectin domain family 2, member D
chr1_+_24969755 7.26 ENST00000447431.2
ENST00000374389.4
serine/arginine repetitive matrix 1
chr6_-_52668605 7.23 ENST00000334575.5
glutathione S-transferase alpha 1
chr19_-_58514129 7.22 ENST00000552184.1
ENST00000546715.1
ENST00000536132.1
ENST00000547828.1
ENST00000547121.1
ENST00000551380.1
zinc finger protein 606
chrX_+_129473859 7.20 ENST00000424447.1
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr2_-_157198860 7.18 ENST00000409572.1
nuclear receptor subfamily 4, group A, member 2
chr15_+_101459420 7.13 ENST00000388948.3
ENST00000284395.5
ENST00000534045.1
ENST00000532029.2
leucine-rich repeat kinase 1
chr12_-_11036844 7.13 ENST00000428168.2
proline-rich protein HaeIII subfamily 1
chr7_+_16828866 7.12 ENST00000597084.1
Uncharacterized protein
chr1_-_48937838 7.11 ENST00000371847.3
spermatogenesis associated 6
chrX_+_49363665 7.10 ENST00000381700.6
G antigen 1
chrX_-_38186811 7.05 ENST00000318842.7
retinitis pigmentosa GTPase regulator
chr11_-_85565906 7.02 ENST00000544076.1
CDNA FLJ26432 fis, clone KDN01418; Uncharacterized protein
chr2_-_89327228 6.92 ENST00000483158.1
immunoglobulin kappa variable 3-11
chr6_+_32605134 6.74 ENST00000343139.5
ENST00000395363.1
ENST00000496318.1
major histocompatibility complex, class II, DQ alpha 1
chr11_-_7695437 6.59 ENST00000533558.1
ENST00000527542.1
ENST00000531096.1
cytochrome b5 reductase 2
chr7_+_139025875 6.49 ENST00000297534.6
chromosome 7 open reading frame 55
chr8_+_133931648 6.48 ENST00000519178.1
ENST00000542445.1
thyroglobulin
chr2_+_90121477 6.47 ENST00000483379.1
immunoglobulin kappa variable 1D-17
chr2_+_71357744 6.42 ENST00000498451.2
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr16_-_15187865 6.37 ENST00000327307.7
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr10_+_76871353 6.27 ENST00000542569.1
sterile alpha motif domain containing 8
chr19_+_48248779 6.25 ENST00000246802.5
glioma tumor suppressor candidate region gene 2
chr6_+_126240442 6.14 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
nuclear receptor coactivator 7
chr17_-_58042075 6.10 ENST00000305783.8
ENST00000589113.1
ENST00000442346.2
ring finger protein, transmembrane 1
chr3_+_39093481 6.02 ENST00000302313.5
ENST00000544962.1
ENST00000396258.3
ENST00000418020.1
WD repeat domain 48
chr12_+_11081828 5.99 ENST00000381847.3
ENST00000396400.3
proline-rich protein HaeIII subfamily 2
chr8_+_27631903 5.97 ENST00000305188.8
establishment of sister chromatid cohesion N-acetyltransferase 2
chr19_+_10764937 5.92 ENST00000449870.1
ENST00000318511.3
ENST00000420083.1
interleukin enhancer binding factor 3, 90kDa
chr2_+_89184868 5.65 ENST00000390243.2
immunoglobulin kappa variable 4-1
chr1_+_45805728 5.65 ENST00000539779.1
target of EGR1, member 1 (nuclear)
chr6_+_142468361 5.64 ENST00000367630.4
vesicle (multivesicular body) trafficking 1
chr14_-_107219365 5.50 ENST00000424969.2
immunoglobulin heavy variable 3-74
chr7_-_91808845 5.50 ENST00000343318.5
leucine-rich repeats and death domain containing 1
chr19_+_15852203 5.49 ENST00000305892.1
olfactory receptor, family 10, subfamily H, member 3
chr9_-_35650900 5.48 ENST00000259608.3
signaling threshold regulating transmembrane adaptor 1
chr9_-_115818951 5.45 ENST00000553380.1
ENST00000374227.3
ZFP37 zinc finger protein
chr8_-_66474884 5.43 ENST00000520902.1
CTD-3025N20.2
chr6_-_39902185 5.40 ENST00000373195.3
ENST00000308559.7
ENST00000373188.2
molybdenum cofactor synthesis 1
chr9_+_100174232 5.29 ENST00000355295.4
tudor domain containing 7
chr6_-_25042231 5.17 ENST00000510784.2
family with sequence similarity 65, member B
chr2_+_86668464 5.04 ENST00000409064.1
lysine (K)-specific demethylase 3A
chr5_-_10308125 4.93 ENST00000296658.3
carboxymethylenebutenolidase homolog (Pseudomonas)
chr14_-_107283278 4.90 ENST00000390639.2
immunoglobulin heavy variable 7-81 (non-functional)
chr16_+_2867164 4.82 ENST00000455114.1
ENST00000450020.3
protease, serine, 21 (testisin)
chr15_-_81616446 4.78 ENST00000302824.6
StAR-related lipid transfer (START) domain containing 5
chr19_-_44809121 4.72 ENST00000591609.1
ENST00000589799.1
ENST00000291182.4
ENST00000589248.1
zinc finger protein 235
chr5_-_132166579 4.64 ENST00000378679.3
shroom family member 1
chr22_-_32766972 4.62 ENST00000382084.4
ENST00000382086.2
RFPL3 antisense
chr8_-_95220775 4.57 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
cadherin 17, LI cadherin (liver-intestine)
chr7_-_29186008 4.53 ENST00000396276.3
ENST00000265394.5
carboxypeptidase, vitellogenic-like
chr6_-_52705641 4.49 ENST00000370989.2
glutathione S-transferase alpha 5
chr14_+_22293618 4.47 ENST00000390432.2
T cell receptor alpha variable 10
chr6_-_45345597 4.44 ENST00000371460.1
ENST00000371459.1
suppressor of Ty 3 homolog (S. cerevisiae)
chr3_-_105588231 4.44 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr7_-_102257139 4.43 ENST00000521076.1
ENST00000462172.1
ENST00000522801.1
ENST00000449970.2
ENST00000262940.7
RAS p21 protein activator 4
chr19_-_19887185 4.41 ENST00000590092.1
ENST00000589910.1
ENST00000589508.1
ENST00000586645.1
ENST00000586816.1
ENST00000588223.1
ENST00000586885.1
long intergenic non-protein coding RNA 663
chr14_-_107013465 4.40 ENST00000390625.2
immunoglobulin heavy variable 3-49
chr1_+_171217622 4.39 ENST00000433267.1
ENST00000367750.3
flavin containing monooxygenase 1
chr2_+_103035102 4.25 ENST00000264260.2
interleukin 18 receptor accessory protein
chr10_-_27389392 4.25 ENST00000376087.4
ankyrin repeat domain 26
chr20_-_43883197 4.20 ENST00000338380.2
secretory leukocyte peptidase inhibitor
chr19_+_10765003 4.15 ENST00000407004.3
ENST00000589998.1
ENST00000589600.1
interleukin enhancer binding factor 3, 90kDa
chr17_+_41132564 4.07 ENST00000361677.1
ENST00000589705.1
RUN domain containing 1
chr15_+_34310428 4.02 ENST00000557872.1
cholinergic receptor, muscarinic 5
chr14_-_106518922 3.98 ENST00000390598.2
immunoglobulin heavy variable 3-7
chr17_+_57297807 3.95 ENST00000284116.4
ENST00000581140.1
ENST00000581276.1
glycerophosphodiester phosphodiesterase domain containing 1
chr2_-_158300556 3.95 ENST00000264192.3
cytohesin 1 interacting protein
chr1_+_13641973 3.87 ENST00000330087.5
PRAME family member 15
chrY_-_19992098 3.86 ENST00000544303.1
ENST00000382867.3
chromodomain protein, Y-linked, 2B
chr3_+_111260954 3.85 ENST00000283285.5
CD96 molecule
chr1_+_22333943 3.84 ENST00000400271.2
chymotrypsin-like elastase family, member 3A
chr11_-_116708302 3.83 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
apolipoprotein A-I
chr19_+_3933085 3.82 ENST00000168977.2
ENST00000599576.1
nicotinamide riboside kinase 2
chr12_-_96794143 3.82 ENST00000543119.2
cyclin-dependent kinase 17
chr3_-_164875850 3.70 ENST00000472120.1
RP11-747D18.1
chr6_+_27107053 3.70 ENST00000354348.2
histone cluster 1, H4i
chr6_-_152958521 3.69 ENST00000367255.5
ENST00000265368.4
ENST00000448038.1
ENST00000341594.5
spectrin repeat containing, nuclear envelope 1
chr4_+_71063641 3.63 ENST00000514097.1
odontogenic, ameloblast asssociated
chr4_+_155665123 3.63 ENST00000336356.3
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
chr10_-_91295304 3.63 ENST00000341233.4
ENST00000371790.4
solute carrier family 16, member 12
chr2_+_231090433 3.55 ENST00000486687.2
ENST00000350136.5
ENST00000392045.3
ENST00000417495.3
ENST00000343805.6
ENST00000420434.3
SP140 nuclear body protein
chr4_+_156588249 3.50 ENST00000393832.3
guanylate cyclase 1, soluble, alpha 3
chr4_+_2794750 3.49 ENST00000452765.2
ENST00000389838.2
SH3-domain binding protein 2
chr14_-_106610852 3.47 ENST00000390603.2
immunoglobulin heavy variable 3-15
chr1_-_160492994 3.37 ENST00000368055.1
ENST00000368057.3
ENST00000368059.3
SLAM family member 6
chr9_-_115819039 3.34 ENST00000555206.1
ZFP37 zinc finger protein
chr4_-_170897045 3.33 ENST00000508313.1
RP11-205M3.3
chr1_-_45805667 3.33 ENST00000488731.2
ENST00000435155.1
mutY homolog
chr16_+_33629600 3.32 ENST00000562905.2
immunoglobulin heavy variable 3/OR16-13 (non-functional)
chr22_+_32754139 3.31 ENST00000382088.3
ret finger protein-like 3
chr3_+_111260856 3.29 ENST00000352690.4
CD96 molecule
chr6_+_136172820 3.28 ENST00000308191.6
phosphodiesterase 7B
chr18_+_5238055 3.25 ENST00000582363.1
ENST00000582008.1
ENST00000580082.1
long intergenic non-protein coding RNA 667
chr1_-_45805607 3.23 ENST00000372104.1
ENST00000448481.1
ENST00000483127.1
ENST00000528013.2
ENST00000456914.2
mutY homolog
chrY_+_20137667 3.21 ENST00000250838.4
ENST00000426790.1
chromodomain protein, Y-linked, 2A
chr18_-_24283586 3.20 ENST00000579458.1
Small nucleolar RNA U3
chr11_-_59950622 3.17 ENST00000323961.3
ENST00000412309.2
membrane-spanning 4-domains, subfamily A, member 6A
chr1_-_12946025 3.15 ENST00000235349.5
PRAME family member 4
chr3_-_45838011 3.08 ENST00000358525.4
ENST00000413781.1
solute carrier family 6 (proline IMINO transporter), member 20
chr3_+_98451275 3.01 ENST00000265261.6
ENST00000497008.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
chr16_+_28770025 3.00 ENST00000435324.2
nuclear pore complex interacting protein family, member B9
chr20_+_61448376 3.00 ENST00000343916.3
collagen, type IX, alpha 3
chr10_-_72362515 2.97 ENST00000373209.2
ENST00000441259.1
perforin 1 (pore forming protein)
chr1_+_158801095 2.95 ENST00000368141.4
myeloid cell nuclear differentiation antigen
chr13_+_25338290 2.95 ENST00000255324.5
ENST00000381921.1
ENST00000255325.6
ring finger protein 17
chr2_+_113816215 2.95 ENST00000346807.3
interleukin 36 receptor antagonist
chr3_-_58200398 2.94 ENST00000318316.3
ENST00000460422.1
ENST00000483681.1
deoxyribonuclease I-like 3
chr5_+_54398463 2.93 ENST00000274306.6
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr19_+_7011509 2.90 ENST00000377296.3
Uncharacterized protein
chr6_+_28109703 2.90 ENST00000457389.2
ENST00000330236.6
zinc finger with KRAB and SCAN domains 8
chr12_-_498620 2.88 ENST00000399788.2
ENST00000382815.4
lysine (K)-specific demethylase 5A
chrY_+_27768264 2.84 ENST00000361963.2
ENST00000306609.4
chromodomain protein, Y-linked, 1
chr22_+_32753854 2.82 ENST00000249007.4
ret finger protein-like 3
chr19_-_48753104 2.81 ENST00000447740.2
caspase recruitment domain family, member 8
chr4_-_100212132 2.79 ENST00000209668.2
alcohol dehydrogenase 1A (class I), alpha polypeptide
chr4_+_170581213 2.77 ENST00000507875.1
chloride channel, voltage-sensitive 3
chr16_+_71560023 2.76 ENST00000572450.1
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr1_+_45805342 2.76 ENST00000372090.5
target of EGR1, member 1 (nuclear)
chr6_-_119256311 2.69 ENST00000316316.6
minichromosome maintenance complex component 9
chr17_-_55038375 2.68 ENST00000240316.4
coilin
chr19_+_34745442 2.67 ENST00000299505.6
ENST00000588470.1
ENST00000589583.1
ENST00000588338.2
KIAA0355
chr19_-_19843900 2.59 ENST00000344099.3
zinc finger protein 14
chr2_+_157330081 2.56 ENST00000409674.1
glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
chr12_+_52668394 2.55 ENST00000423955.2
keratin 86
chr15_-_45815005 2.55 ENST00000261867.4
solute carrier family 30 (zinc transporter), member 4
chr8_-_7309887 2.44 ENST00000458665.1
ENST00000528168.1
sperm associated antigen 11B
chr7_-_115608304 2.43 ENST00000457268.1
transcription factor EC
chr4_-_122791583 2.40 ENST00000506636.1
ENST00000264499.4
Bardet-Biedl syndrome 7
chr1_+_20959943 2.38 ENST00000321556.4
PTEN induced putative kinase 1
chr6_+_84569359 2.35 ENST00000369681.5
ENST00000369679.4
cytochrome b5 reductase 4
chr19_-_21776784 2.31 ENST00000594927.1
RP11-678G14.4
chr7_+_95115210 2.29 ENST00000428113.1
ENST00000325885.5
ankyrin repeat and SOCS box containing 4
chr1_+_156589051 2.27 ENST00000255039.1
hyaluronan and proteoglycan link protein 2
chr19_-_48752812 2.27 ENST00000359009.4
caspase recruitment domain family, member 8
chr1_+_13359819 2.23 ENST00000376168.1
PRAME family member 5
chr12_+_32260085 2.23 ENST00000548411.1
ENST00000281474.5
ENST00000551086.1
bicaudal D homolog 1 (Drosophila)
chr10_-_95209 2.22 ENST00000332708.5
ENST00000309812.4
tubulin, beta 8 class VIII
chr19_-_45909585 2.21 ENST00000593226.1
ENST00000418234.2
protein phosphatase 1, regulatory subunit 13 like
chr15_-_33360085 2.18 ENST00000334528.9
formin 1
chr16_-_71523236 2.16 ENST00000288177.5
ENST00000569072.1
zinc finger protein 19
chr1_-_13007420 2.14 ENST00000376189.1
PRAME family member 6
chr5_+_135468516 2.11 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD family member 5
chr6_-_42690312 2.11 ENST00000230381.5
peripherin 2 (retinal degeneration, slow)
chr1_+_171283331 2.08 ENST00000367749.3
flavin containing monooxygenase 4
chr2_+_33661382 2.06 ENST00000402538.3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr17_-_39041479 2.05 ENST00000167588.3
keratin 20
chr9_-_100935043 2.01 ENST00000343933.5
coronin, actin binding protein, 2A
chr8_+_39442097 2.00 ENST00000265707.5
ENST00000379866.1
ENST00000520772.1
ENST00000541111.1
ADAM metallopeptidase domain 18
chr5_-_41213607 1.99 ENST00000337836.5
ENST00000433294.1
complement component 6
chr12_-_7655329 1.96 ENST00000541972.1
CD163 molecule

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX17

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 14.8 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
2.4 7.2 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
2.4 7.1 GO:0002370 natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
1.7 8.7 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.7 5.0 GO:0007290 spermatid nucleus elongation(GO:0007290)
1.6 4.7 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
1.2 8.3 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.1 4.6 GO:0002314 germinal center B cell differentiation(GO:0002314)
1.0 26.9 GO:0044458 motile cilium assembly(GO:0044458)
1.0 3.8 GO:0010903 negative regulation of very-low-density lipoprotein particle remodeling(GO:0010903)
0.9 6.6 GO:0045007 depurination(GO:0045007)
0.9 6.4 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.9 3.6 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.8 4.0 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.8 2.4 GO:0036482 neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036482) positive regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902958) regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903383) negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway(GO:1903384)
0.8 6.3 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.8 6.0 GO:1902525 regulation of protein monoubiquitination(GO:1902525)
0.7 2.2 GO:0072092 ureteric bud invasion(GO:0072092)
0.7 106.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 6.5 GO:0015705 iodide transport(GO:0015705)
0.7 2.9 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.7 4.8 GO:0015824 proline transport(GO:0015824)
0.7 5.4 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.6 10.3 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.6 5.0 GO:0070995 NADPH oxidation(GO:0070995)
0.6 1.8 GO:0019605 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.6 2.9 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.6 3.5 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
0.6 9.1 GO:0051639 actin filament network formation(GO:0051639)
0.6 5.1 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.6 7.2 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.6 2.8 GO:0048388 endosomal lumen acidification(GO:0048388)
0.5 2.6 GO:0006127 glycerophosphate shuttle(GO:0006127)
0.5 2.5 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.5 1.5 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.5 11.9 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.5 1.5 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.5 1.8 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.5 2.3 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.4 2.2 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.4 2.2 GO:0007056 spindle assembly involved in female meiosis(GO:0007056)
0.4 4.8 GO:0070508 sterol import(GO:0035376) cholesterol import(GO:0070508)
0.4 5.6 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.4 1.2 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.4 1.6 GO:0035627 ceramide transport(GO:0035627)
0.4 3.1 GO:0016926 protein desumoylation(GO:0016926)
0.4 6.1 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.4 4.4 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.4 3.7 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.4 1.1 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
0.4 2.1 GO:0001880 Mullerian duct regression(GO:0001880)
0.3 3.9 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 0.9 GO:0051552 flavone metabolic process(GO:0051552)
0.3 2.8 GO:0006477 protein sulfation(GO:0006477)
0.3 2.1 GO:0060041 retina development in camera-type eye(GO:0060041)
0.3 2.9 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.3 5.5 GO:0045199 maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)
0.3 2.8 GO:0006069 ethanol oxidation(GO:0006069)
0.3 1.6 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 2.6 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.3 7.1 GO:0036035 osteoclast development(GO:0036035)
0.2 3.0 GO:0051712 positive regulation of killing of cells of other organism(GO:0051712)
0.2 8.8 GO:0030317 sperm motility(GO:0030317)
0.2 5.7 GO:0009435 NAD biosynthetic process(GO:0009435)
0.2 0.6 GO:1902896 terminal web assembly(GO:1902896)
0.2 1.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.2 1.7 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)
0.2 23.5 GO:0007338 single fertilization(GO:0007338)
0.2 3.4 GO:0001787 natural killer cell proliferation(GO:0001787)
0.2 14.2 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.2 5.3 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.2 1.5 GO:0015980 glycogen metabolic process(GO:0005977) cellular glucan metabolic process(GO:0006073) energy reserve metabolic process(GO:0006112) energy derivation by oxidation of organic compounds(GO:0015980) glucan metabolic process(GO:0044042)
0.2 2.3 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 0.9 GO:0034334 adherens junction maintenance(GO:0034334)
0.2 14.3 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.2 9.6 GO:0015701 bicarbonate transport(GO:0015701)
0.2 4.4 GO:0016578 histone deubiquitination(GO:0016578)
0.2 0.5 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
0.2 1.4 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.2 2.9 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.1 1.0 GO:0034378 chylomicron assembly(GO:0034378)
0.1 5.5 GO:0043029 T cell homeostasis(GO:0043029)
0.1 0.9 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 10.8 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 11.4 GO:0006968 cellular defense response(GO:0006968)
0.1 16.7 GO:0031295 T cell costimulation(GO:0031295)
0.1 0.7 GO:0010519 negative regulation of phospholipase activity(GO:0010519)
0.1 7.1 GO:0042073 intraciliary transport(GO:0042073)
0.1 2.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.4 GO:1990502 dense core granule maturation(GO:1990502)
0.1 13.2 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.1 13.0 GO:0007127 meiosis I(GO:0007127)
0.1 1.5 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.1 1.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 9.5 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 5.6 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.1 3.6 GO:0071354 cellular response to interleukin-6(GO:0071354)
0.1 3.6 GO:0072337 modified amino acid transport(GO:0072337)
0.1 2.2 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
0.1 0.9 GO:0070166 enamel mineralization(GO:0070166)
0.1 0.5 GO:0001836 release of cytochrome c from mitochondria(GO:0001836) regulation of release of cytochrome c from mitochondria(GO:0090199) positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 1.3 GO:1901750 leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750)
0.1 2.0 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.5 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.1 5.7 GO:0009060 aerobic respiration(GO:0009060)
0.1 4.7 GO:0030195 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.1 0.6 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.1 0.9 GO:0043691 reverse cholesterol transport(GO:0043691)
0.1 1.2 GO:0042737 drug catabolic process(GO:0042737)
0.1 3.3 GO:0006198 cAMP catabolic process(GO:0006198)
0.1 4.4 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 0.2 GO:0071676 negative regulation of mononuclear cell migration(GO:0071676)
0.1 16.9 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.1 1.9 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 7.3 GO:0002377 immunoglobulin production(GO:0002377)
0.1 2.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.1 1.1 GO:0030539 male genitalia development(GO:0030539)
0.1 7.3 GO:0031124 mRNA 3'-end processing(GO:0031124)
0.0 1.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 3.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 1.2 GO:0000038 very long-chain fatty acid metabolic process(GO:0000038)
0.0 0.3 GO:0006293 nucleotide-excision repair, preincision complex stabilization(GO:0006293) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0 2.2 GO:0016266 O-glycan processing(GO:0016266)
0.0 1.0 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.0 1.4 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 4.0 GO:0042439 ethanolamine-containing compound metabolic process(GO:0042439)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 2.0 GO:0035556 intracellular signal transduction(GO:0035556)
0.0 1.0 GO:0046825 regulation of protein export from nucleus(GO:0046825)
0.0 0.3 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 2.4 GO:0008585 female gonad development(GO:0008585)
0.0 6.0 GO:0006473 protein acetylation(GO:0006473)
0.0 1.0 GO:0006897 endocytosis(GO:0006897)
0.0 0.3 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 1.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.0 0.0 GO:0002086 diaphragm contraction(GO:0002086)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.7 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.8 GO:0045616 regulation of keratinocyte differentiation(GO:0045616)
0.0 0.5 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.6 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 0.8 GO:0007292 female gamete generation(GO:0007292)
0.0 0.5 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.9 GO:0007049 cell cycle(GO:0007049)
0.0 0.6 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.0 1.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 2.2 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.3 GO:0097224 sperm connecting piece(GO:0097224)
2.1 16.9 GO:0005672 transcription factor TFIIA complex(GO:0005672)
1.8 5.4 GO:0019008 molybdopterin synthase complex(GO:0019008)
1.5 31.5 GO:0042613 MHC class II protein complex(GO:0042613)
1.3 3.8 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.2 12.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.8 8.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.7 3.5 GO:0034457 Mpp10 complex(GO:0034457)
0.7 34.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.6 3.0 GO:0005594 collagen type IX trimer(GO:0005594)
0.5 5.3 GO:0033391 chromatoid body(GO:0033391)
0.5 1.8 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.5 9.1 GO:0001891 phagocytic cup(GO:0001891)
0.4 2.2 GO:0033648 host cell cytoplasm(GO:0030430) host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648) host cell cytoplasm part(GO:0033655) tubulin complex(GO:0045298)
0.4 6.0 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.4 2.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 3.1 GO:0034464 BBSome(GO:0034464)
0.3 2.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.3 25.0 GO:0035577 azurophil granule membrane(GO:0035577)
0.3 3.0 GO:0044194 cytolytic granule(GO:0044194)
0.3 2.9 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.3 4.4 GO:0000124 SAGA complex(GO:0000124)
0.3 0.9 GO:0097058 CRLF-CLCF1 complex(GO:0097058) CNTFR-CLCF1 complex(GO:0097059)
0.3 3.7 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 2.2 GO:0072687 meiotic spindle(GO:0072687)
0.2 4.4 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 2.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.2 1.6 GO:0097209 epidermal lamellar body(GO:0097209)
0.2 2.0 GO:0005579 membrane attack complex(GO:0005579)
0.2 9.0 GO:0031228 intrinsic component of Golgi membrane(GO:0031228)
0.2 11.4 GO:0005844 polysome(GO:0005844)
0.2 15.8 GO:0036064 ciliary basal body(GO:0036064)
0.2 2.3 GO:0031462 Cul2-RING ubiquitin ligase complex(GO:0031462)
0.2 2.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 11.1 GO:0015030 Cajal body(GO:0015030)
0.1 3.5 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 11.2 GO:0035580 specific granule lumen(GO:0035580)
0.1 1.7 GO:0097512 cardiac myofibril(GO:0097512)
0.1 2.1 GO:0071141 SMAD protein complex(GO:0071141)
0.1 14.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 3.6 GO:0005771 multivesicular body(GO:0005771)
0.1 3.8 GO:0016460 myosin II complex(GO:0016460)
0.1 1.6 GO:0031528 microvillus membrane(GO:0031528)
0.1 0.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 4.4 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 11.2 GO:0072562 blood microparticle(GO:0072562)
0.1 2.5 GO:0045095 keratin filament(GO:0045095)
0.1 4.7 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 2.9 GO:0001772 immunological synapse(GO:0001772)
0.0 5.7 GO:0031514 motile cilium(GO:0031514)
0.0 0.6 GO:0032433 filopodium tip(GO:0032433)
0.0 9.2 GO:0005770 late endosome(GO:0005770)
0.0 2.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 3.0 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 5.7 GO:0010008 endosome membrane(GO:0010008)
0.0 2.1 GO:0005796 Golgi lumen(GO:0005796)
0.0 6.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 6.9 GO:0005769 early endosome(GO:0005769)
0.0 11.8 GO:0009986 cell surface(GO:0009986)
0.0 0.0 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 1.4 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 1.3 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.9 GO:0016605 PML body(GO:0016605)
0.0 3.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.5 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 8.8 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
2.1 6.4 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
2.1 6.3 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
1.7 5.1 GO:0032089 NACHT domain binding(GO:0032089)
1.6 6.6 GO:0032406 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
1.6 4.7 GO:0001861 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
1.5 8.7 GO:0003796 lysozyme activity(GO:0003796)
1.4 5.7 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
1.4 16.3 GO:0032027 myosin light chain binding(GO:0032027)
1.2 6.0 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.2 16.7 GO:0032395 MHC class II receptor activity(GO:0032395)
1.1 4.6 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.0 3.8 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.9 13.1 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.9 3.6 GO:0052798 beta-galactoside alpha-2,3-sialyltransferase activity(GO:0052798)
0.8 4.0 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.8 7.1 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.8 3.1 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.8 8.3 GO:0019957 C-C chemokine binding(GO:0019957)
0.7 8.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.7 2.9 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.6 2.6 GO:0052591 sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591)
0.6 34.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.6 3.6 GO:0016416 O-palmitoyltransferase activity(GO:0016416)
0.6 2.9 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.6 28.0 GO:0004364 glutathione transferase activity(GO:0004364)
0.6 2.2 GO:0031871 proteinase activated receptor binding(GO:0031871)
0.6 97.9 GO:0003823 antigen binding(GO:0003823)
0.5 2.8 GO:0004024 alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.5 2.8 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 3.0 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.4 1.6 GO:0034040 lipid-transporting ATPase activity(GO:0034040)
0.4 2.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.4 2.8 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.4 7.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.4 3.4 GO:0004969 histamine receptor activity(GO:0004969)
0.4 1.5 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.4 12.7 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.3 1.3 GO:0004980 melanocyte-stimulating hormone receptor activity(GO:0004980)
0.3 5.5 GO:0042169 SH2 domain binding(GO:0042169)
0.3 5.0 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 1.2 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.3 5.5 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993)
0.3 1.5 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.3 10.3 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.3 7.2 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.3 9.1 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 4.5 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.3 4.8 GO:0017127 cholesterol transporter activity(GO:0017127) bile acid binding(GO:0032052)
0.3 1.4 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.2 1.2 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.2 5.0 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.2 2.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.2 3.6 GO:0072349 modified amino acid transmembrane transporter activity(GO:0072349)
0.2 1.8 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.2 1.4 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.2 4.7 GO:0005521 lamin binding(GO:0005521)
0.2 0.6 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.2 4.0 GO:0004622 lysophospholipase activity(GO:0004622)
0.2 0.5 GO:0004914 interleukin-5 receptor activity(GO:0004914)
0.1 10.5 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 3.5 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 7.9 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 2.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 3.0 GO:0022829 wide pore channel activity(GO:0022829)
0.1 2.9 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.1 2.1 GO:0019992 diacylglycerol binding(GO:0019992)
0.1 0.7 GO:0005119 smoothened binding(GO:0005119)
0.1 5.4 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.6 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.7 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.2 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.1 1.3 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 10.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 3.3 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 0.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 4.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.1 1.9 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.1 0.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 17.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 7.3 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.1 2.3 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 0.3 GO:0000405 bubble DNA binding(GO:0000405)
0.1 1.6 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 4.7 GO:0019843 rRNA binding(GO:0019843)
0.1 0.6 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.1 0.8 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 3.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 20.1 GO:0005096 GTPase activator activity(GO:0005096)
0.1 18.1 GO:0003713 transcription coactivator activity(GO:0003713)
0.0 1.1 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.0 0.5 GO:0031432 titin binding(GO:0031432)
0.0 1.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 4.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 5.3 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.7 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.2 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.3 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 2.2 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.0 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.0 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 21.1 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.0 0.2 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696) BMP receptor binding(GO:0070700)
0.0 0.9 GO:0005319 lipid transporter activity(GO:0005319)
0.0 0.8 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 0.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.7 GO:0051117 ATPase binding(GO:0051117)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 16.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.2 3.6 PID CONE PATHWAY Visual signal transduction: Cones
0.1 6.5 PID RAS PATHWAY Regulation of Ras family activation
0.1 2.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.1 PID ALK2 PATHWAY ALK2 signaling events
0.1 1.7 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 5.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 5.3 PID AURORA A PATHWAY Aurora A signaling
0.1 4.4 PID MYC PATHWAY C-MYC pathway
0.1 6.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.6 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.1 2.2 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.1 1.8 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 4.4 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 9.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 3.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 0.5 PID IL5 PATHWAY IL5-mediated signaling events
0.1 3.5 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 3.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 2.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.0 3.9 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 7.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.4 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.0 0.8 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.3 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.8 16.7 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.7 25.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.4 6.6 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 2.8 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.3 5.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 2.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.2 5.0 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.2 5.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 8.4 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.2 16.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 7.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 3.6 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 6.4 REACTOME RNA POL I TRANSCRIPTION INITIATION Genes involved in RNA Polymerase I Transcription Initiation
0.1 6.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 6.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.1 8.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 14.3 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 43.6 REACTOME GENERIC TRANSCRIPTION PATHWAY Genes involved in Generic Transcription Pathway
0.1 8.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.9 REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE Genes involved in Nitric oxide stimulates guanylate cyclase
0.1 2.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.1 4.4 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 3.9 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 5.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.7 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 1.5 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 1.9 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.0 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.1 1.4 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 1.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 0.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 1.2 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 3.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events
0.0 1.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.5 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 2.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling