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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX21

Z-value: 0.73

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_95364389-0.274.6e-05Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_35201826 13.14 ENST00000531873.1
CD44
CD44 molecule (Indian blood group)
chr3_+_37035263 9.88 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chr3_+_37035289 9.47 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chr7_-_86849883 8.55 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr18_-_47018869 7.90 ENST00000583036.1
ENST00000580261.1
RPL17
ribosomal protein L17
chr19_+_42381337 7.85 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr19_+_42381173 7.84 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr3_+_37034823 7.67 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr18_-_47018897 7.53 ENST00000418495.1
RPL17
ribosomal protein L17
chr18_-_47018769 7.18 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr4_-_103746683 6.53 ENST00000504211.1
ENST00000508476.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr4_-_103747011 6.26 ENST00000350435.7
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr7_+_2394445 6.23 ENST00000360876.4
ENST00000413917.1
ENST00000397011.2
EIF3B
eukaryotic translation initiation factor 3, subunit B
chr4_-_103746924 6.04 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr14_-_107170409 5.79 ENST00000390633.2
IGHV1-69
immunoglobulin heavy variable 1-69
chr12_+_69742121 5.78 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr5_-_95158644 5.54 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr3_-_141747439 5.54 ENST00000467667.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr15_-_80263506 4.90 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr6_+_31371337 4.58 ENST00000449934.2
ENST00000421350.1
MICA
MHC class I polypeptide-related sequence A
chr9_-_70465758 3.98 ENST00000489273.1
CBWD5
COBW domain containing 5
chr8_+_26150628 3.97 ENST00000523925.1
ENST00000315985.7
PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr3_-_141747459 3.87 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr5_-_95158375 3.86 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr12_-_89746173 3.30 ENST00000308385.6
DUSP6
dual specificity phosphatase 6
chr10_-_12084770 3.00 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr5_-_179045199 2.83 ENST00000523921.1
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr1_+_203764742 2.73 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A
zinc finger CCCH-type containing 11A
chr12_+_123011776 2.41 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr16_-_15149828 2.33 ENST00000566419.1
ENST00000568320.1
NTAN1
N-terminal asparagine amidase
chr17_+_66245341 2.23 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr19_+_18682531 2.20 ENST00000596304.1
ENST00000430157.2
UBA52
ubiquitin A-52 residue ribosomal protein fusion product 1
chr22_+_23063100 2.08 ENST00000390309.2
IGLV3-19
immunoglobulin lambda variable 3-19
chr6_+_42531798 2.02 ENST00000372903.2
ENST00000372899.1
ENST00000372901.1
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr22_+_39353527 1.97 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr1_+_221051699 1.97 ENST00000366903.6
HLX
H2.0-like homeobox
chr20_+_43343886 1.68 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr3_+_57994127 1.54 ENST00000490882.1
ENST00000295956.4
ENST00000358537.3
ENST00000429972.2
ENST00000348383.5
ENST00000357272.4
FLNB
filamin B, beta
chr1_+_146714291 1.52 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
CHD1L
chromodomain helicase DNA binding protein 1-like
chr4_+_69313145 1.35 ENST00000305363.4
TMPRSS11E
transmembrane protease, serine 11E
chr12_-_7261772 1.18 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
C1RL
complement component 1, r subcomponent-like
chr1_-_54303934 0.98 ENST00000537333.1
NDC1
NDC1 transmembrane nucleoporin
chr6_-_112575912 0.96 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr8_-_143961236 0.92 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
chr19_-_54784937 0.92 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
LILRB2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr20_+_56964253 0.91 ENST00000395802.3
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr2_+_217363559 0.90 ENST00000600880.1
ENST00000446558.1
RPL37A
ribosomal protein L37a
chr3_-_155524049 0.87 ENST00000534941.1
ENST00000340171.2
C3orf33
chromosome 3 open reading frame 33
chr2_+_3705785 0.85 ENST00000252505.3
ALLC
allantoicase
chr1_+_199996733 0.79 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr6_-_112575758 0.77 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
LAMA4
laminin, alpha 4
chr14_-_102771462 0.73 ENST00000522874.1
MOK
MOK protein kinase
chr14_-_92588246 0.57 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr3_-_155572164 0.47 ENST00000392845.3
ENST00000359479.3
SLC33A1
solute carrier family 33 (acetyl-CoA transporter), member 1
chr11_-_8285405 0.45 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr10_-_17243579 0.41 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr14_-_92588013 0.40 ENST00000553514.1
ENST00000605997.1
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr12_+_20522179 0.37 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr12_-_10324716 0.36 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr1_-_217250231 0.22 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr4_+_81951957 0.18 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr11_+_114168085 0.14 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr22_-_40929812 0.14 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr1_-_169455169 0.14 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr8_-_142377367 0.12 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr6_-_112575838 0.10 ENST00000455073.1
LAMA4
laminin, alpha 4
chrY_+_14813160 0.07 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 27.0 GO:0051311 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
1.6 13.1 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
1.2 5.8 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.1 4.6 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.8 3.3 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.8 6.2 GO:0075525 viral translational termination-reinitiation(GO:0075525)
0.5 9.4 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.4 18.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 2.0 GO:0071233 cellular response to leucine(GO:0071233)
0.3 2.0 GO:0070383 DNA cytosine deamination(GO:0070383)
0.3 2.0 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.3 1.0 GO:0071790 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
0.3 0.9 GO:0043605 cellular amide catabolic process(GO:0043605)
0.2 9.4 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.2 4.0 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.2 4.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.2 25.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.2 0.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 0.9 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
0.2 0.9 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.2 0.5 GO:0046013 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013)
0.1 2.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.1 15.7 GO:0042100 B cell proliferation(GO:0042100)
0.1 2.4 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 1.5 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
0.1 0.5 GO:0051182 coenzyme transport(GO:0051182)
0.1 0.4 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.9 GO:0035865 cellular response to potassium ion(GO:0035865)
0.1 9.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.5 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717)
0.0 3.0 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.0 2.3 GO:0008344 adult locomotory behavior(GO:0008344)
0.0 2.8 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.0 0.1 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.4 GO:0001975 response to amphetamine(GO:0001975)
0.0 1.0 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.8 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 0.1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.9 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 27.0 GO:0005715 late recombination nodule(GO:0005715)
2.2 15.7 GO:0019815 B cell receptor complex(GO:0019815)
1.9 13.1 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.7 6.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.6 2.4 GO:1990423 RZZ complex(GO:1990423)
0.3 1.0 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.2 25.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 2.7 GO:0000346 transcription export complex(GO:0000346)
0.1 4.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 3.0 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 5.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 10.2 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.8 GO:0005605 basal lamina(GO:0005605)
0.0 18.8 GO:0010008 endosome membrane(GO:0010008)
0.0 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 2.8 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 4.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.0 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 1.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.5 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 27.0 GO:0032137 guanine/thymine mispair binding(GO:0032137)
1.0 5.8 GO:0003796 lysozyme activity(GO:0003796)
0.9 9.4 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.5 4.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.4 13.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 18.8 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.4 2.0 GO:0070728 leucine binding(GO:0070728)
0.4 2.0 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.3 0.9 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
0.3 0.9 GO:0033149 FFAT motif binding(GO:0033149)
0.2 4.9 GO:0051400 BH domain binding(GO:0051400)
0.2 3.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 4.0 GO:0048156 tau protein binding(GO:0048156)
0.2 0.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 6.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.4 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 2.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 0.9 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
0.1 25.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.4 GO:0016427 tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1 3.0 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.1 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 1.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 1.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 10.4 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.1 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.0 1.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 2.3 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 1.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.0 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.1 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 10.2 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 15.6 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 0.2 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.7 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 18.8 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.4 13.1 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 20.6 PID BCR 5PATHWAY BCR signaling pathway
0.1 27.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 9.4 PID E2F PATHWAY E2F transcription factor network
0.1 3.3 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 5.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 4.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.8 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 1.4 PID IL12 2PATHWAY IL12-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 13.1 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.6 21.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 27.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.3 15.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.3 6.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3 9.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 3.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.2 30.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 5.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.9 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.0 0.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 2.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.5 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules