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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX6

Z-value: 1.10

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Transcription factors associated with SOX6

Gene Symbol Gene ID Gene Info
ENSG00000110693.11 SRY-box transcription factor 6

Activity profile of SOX6 motif

Sorted Z-values of SOX6 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_37899323 15.74 ENST00000295324.3
ENST00000457889.1
CDC42 effector protein (Rho GTPase binding) 3
chr2_+_232573222 15.58 ENST00000341369.7
ENST00000409683.1
prothymosin, alpha
chr11_-_102323489 14.96 ENST00000361236.3
transmembrane protein 123
chr12_+_69979446 14.35 ENST00000543146.2
chaperonin containing TCP1, subunit 2 (beta)
chr11_-_102323740 14.14 ENST00000398136.2
transmembrane protein 123
chr2_+_10262857 13.99 ENST00000304567.5
ribonucleotide reductase M2
chr2_+_232573208 13.11 ENST00000409115.3
prothymosin, alpha
chr12_-_58146048 12.87 ENST00000547281.1
ENST00000546489.1
ENST00000552388.1
ENST00000540325.1
ENST00000312990.6
cyclin-dependent kinase 4
chr16_+_33605231 11.52 ENST00000570121.2
immunoglobulin heavy variable 3/OR16-12 (non-functional)
chr16_-_29466285 11.23 ENST00000330978.3
bolA family member 2
chr3_-_57583052 10.87 ENST00000496292.1
ENST00000489843.1
ADP-ribosylation factor 4
chr8_-_102218292 10.39 ENST00000518336.1
ENST00000520454.1
zinc finger protein 706
chr16_+_14980632 10.07 ENST00000565655.1
NODAL modulator 1
chr12_-_53320245 9.82 ENST00000552150.1
keratin 8
chr3_-_57583130 9.62 ENST00000303436.6
ADP-ribosylation factor 4
chr21_-_40720995 9.53 ENST00000380749.5
high mobility group nucleosome binding domain 1
chr4_-_71705027 9.43 ENST00000545193.1
G-rich RNA sequence binding factor 1
chr4_-_71705060 9.36 ENST00000514161.1
G-rich RNA sequence binding factor 1
chr10_-_33247124 8.86 ENST00000414670.1
ENST00000302278.3
ENST00000374956.4
ENST00000488494.1
ENST00000417122.2
ENST00000474568.1
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
chr1_+_68150744 8.80 ENST00000370986.4
ENST00000370985.3
growth arrest and DNA-damage-inducible, alpha
chr12_-_58146128 8.76 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
cyclin-dependent kinase 4
chr19_+_5681153 8.60 ENST00000579559.1
ENST00000577222.1
hydroxysteroid (11-beta) dehydrogenase 1-like
ribosomal protein L36
chr14_-_106725723 8.59 ENST00000390609.2
immunoglobulin heavy variable 3-23
chr1_-_32801825 8.58 ENST00000329421.7
MARCKS-like 1
chr1_-_26233423 8.41 ENST00000357865.2
stathmin 1
chr15_+_77224045 8.41 ENST00000320963.5
ENST00000394883.3
reticulocalbin 2, EF-hand calcium binding domain
chr17_-_40288449 8.28 ENST00000552162.1
ENST00000550504.1
RAB5C, member RAS oncogene family
chr22_-_42336209 8.06 ENST00000472374.2
centromere protein M
chr18_+_3449821 8.01 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGFB-induced factor homeobox 1
chr7_-_148725733 7.95 ENST00000286091.4
protein disulfide isomerase family A, member 4
chr21_-_40720974 7.85 ENST00000380748.1
high mobility group nucleosome binding domain 1
chr14_-_106926724 7.74 ENST00000434710.1
immunoglobulin heavy variable 3-43
chr2_-_85641162 7.70 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
capping protein (actin filament), gelsolin-like
chr18_+_3451646 7.56 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGFB-induced factor homeobox 1
chr12_+_104359576 7.50 ENST00000392872.3
ENST00000436021.2
thymine-DNA glycosylase
chrX_-_153599578 7.43 ENST00000360319.4
ENST00000344736.4
filamin A, alpha
chr4_+_41614720 7.40 ENST00000509277.1
LIM and calponin homology domains 1
chr2_-_86790593 7.40 ENST00000263856.4
ENST00000409225.2
charged multivesicular body protein 3
chr13_-_24007815 7.39 ENST00000382298.3
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr17_+_75283973 7.24 ENST00000431235.2
ENST00000449803.2
septin 9
chr12_+_69633372 7.02 ENST00000456847.3
ENST00000266679.8
cleavage and polyadenylation specific factor 6, 68kDa
chr3_+_52719936 6.93 ENST00000418458.1
ENST00000394799.2
guanine nucleotide binding protein-like 3 (nucleolar)
chr15_+_77223960 6.91 ENST00000394885.3
reticulocalbin 2, EF-hand calcium binding domain
chr12_+_104359641 6.90 ENST00000537100.1
thymine-DNA glycosylase
chr6_-_134639180 6.85 ENST00000367858.5
serum/glucocorticoid regulated kinase 1
chr1_-_26232951 6.70 ENST00000426559.2
ENST00000455785.2
stathmin 1
chr8_+_126442563 6.60 ENST00000311922.3
tribbles pseudokinase 1
chr13_-_41593425 6.58 ENST00000239882.3
E74-like factor 1 (ets domain transcription factor)
chr15_+_52311398 6.46 ENST00000261845.5
mitogen-activated protein kinase 6
chr14_-_106845789 6.42 ENST00000390617.2
immunoglobulin heavy variable 3-35 (non-functional)
chrX_+_12993336 6.38 ENST00000380635.1
thymosin beta 4, X-linked
chr7_+_134464414 6.35 ENST00000361901.2
caldesmon 1
chr11_+_63754294 6.34 ENST00000543988.1
OTU domain, ubiquitin aldehyde binding 1
chr11_-_64013663 6.33 ENST00000392210.2
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr7_+_99006232 6.23 ENST00000403633.2
BUD31 homolog (S. cerevisiae)
chr14_-_71107921 6.13 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
chr10_-_13390270 6.11 ENST00000378614.4
ENST00000545675.1
ENST00000327347.5
selenophosphate synthetase 1
chr1_-_212004090 6.07 ENST00000366997.4
lysophosphatidylglycerol acyltransferase 1
chr14_-_35344093 6.05 ENST00000382422.2
bromodomain adjacent to zinc finger domain, 1A
chr13_+_100153665 6.00 ENST00000376387.4
transmembrane 9 superfamily member 2
chr3_+_151986709 5.96 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr13_-_95131923 5.88 ENST00000377028.5
ENST00000446125.1
dopachrome tautomerase
chr12_+_11081828 5.81 ENST00000381847.3
ENST00000396400.3
proline-rich protein HaeIII subfamily 2
chr12_+_104359614 5.81 ENST00000266775.9
ENST00000544861.1
thymine-DNA glycosylase
chr17_+_75372165 5.76 ENST00000427674.2
septin 9
chr4_+_41614909 5.68 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIM and calponin homology domains 1
chr4_-_143227088 5.66 ENST00000511838.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr12_-_11036844 5.60 ENST00000428168.2
proline-rich protein HaeIII subfamily 1
chr10_+_104535994 5.59 ENST00000369889.4
WW domain binding protein 1-like
chr19_+_47105309 5.57 ENST00000599839.1
ENST00000596362.1
calmodulin 3 (phosphorylase kinase, delta)
chr17_-_1588101 5.57 ENST00000577001.1
ENST00000572621.1
ENST00000304992.6
pre-mRNA processing factor 8
chr16_-_67970990 5.53 ENST00000358514.4
proteasome (prosome, macropain) subunit, beta type, 10
chr16_+_56970567 5.49 ENST00000563911.1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr9_-_86595105 5.45 ENST00000457156.1
ENST00000360384.5
ENST00000376263.3
heterogeneous nuclear ribonucleoprotein K
chr14_+_23791159 5.15 ENST00000557702.1
poly(A) binding protein, nuclear 1
chr12_-_49582593 5.11 ENST00000295766.5
tubulin, alpha 1a
chr7_+_134464376 5.08 ENST00000454108.1
ENST00000361675.2
caldesmon 1
chr12_+_69633407 5.00 ENST00000551516.1
cleavage and polyadenylation specific factor 6, 68kDa
chr5_-_39425068 4.96 ENST00000515700.1
ENST00000339788.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chrX_+_70503433 4.94 ENST00000276079.8
ENST00000373856.3
ENST00000373841.1
ENST00000420903.1
non-POU domain containing, octamer-binding
chr17_+_52978156 4.85 ENST00000348161.4
target of myb1 (chicken)-like 1
chr3_-_195270162 4.80 ENST00000438848.1
ENST00000328432.3
protein phosphatase 1, regulatory (inhibitor) subunit 2
chr7_-_107643674 4.79 ENST00000222399.6
laminin, beta 1
chr5_-_16936340 4.67 ENST00000507288.1
ENST00000513610.1
myosin X
chr2_+_54683419 4.64 ENST00000356805.4
spectrin, beta, non-erythrocytic 1
chr5_-_157002775 4.53 ENST00000257527.4
ADAM metallopeptidase domain 19
chr7_-_99699538 4.53 ENST00000343023.6
ENST00000303887.5
minichromosome maintenance complex component 7
chr1_-_89357179 4.47 ENST00000448623.1
ENST00000418217.1
ENST00000370500.5
general transcription factor IIB
chr9_-_74979420 4.45 ENST00000343431.2
ENST00000376956.3
zinc finger, AN1-type domain 5
chr6_+_114178512 4.41 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr12_-_49582978 4.29 ENST00000301071.7
tubulin, alpha 1a
chr16_-_15736881 4.22 ENST00000540441.2
KIAA0430
chr7_+_69064300 4.19 ENST00000342771.4
autism susceptibility candidate 2
chr4_+_70861647 4.19 ENST00000246895.4
ENST00000381060.2
statherin
chr8_+_11660120 4.19 ENST00000220584.4
farnesyl-diphosphate farnesyltransferase 1
chr11_+_19798964 4.18 ENST00000527559.2
neuron navigator 2
chr11_+_64949899 4.18 ENST00000531068.1
ENST00000527699.1
ENST00000533909.1
ENST00000527323.1
calpain 1, (mu/I) large subunit
chr6_-_24877490 4.14 ENST00000540914.1
ENST00000378023.4
family with sequence similarity 65, member B
chr1_+_40505891 4.10 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr4_+_70916119 4.05 ENST00000246896.3
ENST00000511674.1
histatin 1
chr18_+_7946941 3.98 ENST00000444013.1
protein tyrosine phosphatase, receptor type, M
chr4_-_109090106 3.97 ENST00000379951.2
lymphoid enhancer-binding factor 1
chr17_-_56065484 3.92 ENST00000581208.1
vascular endothelial zinc finger 1
chr11_+_19799327 3.90 ENST00000540292.1
neuron navigator 2
chr1_+_166808692 3.80 ENST00000367876.4
pogo transposable element with KRAB domain
chr10_+_22605374 3.79 ENST00000448361.1
COMM domain containing 3
chr8_+_11660227 3.78 ENST00000443614.2
ENST00000525900.1
farnesyl-diphosphate farnesyltransferase 1
chr5_-_39425222 3.73 ENST00000320816.6
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr7_+_23146271 3.72 ENST00000545771.1
kelch-like family member 7
chr4_-_143226979 3.71 ENST00000514525.1
inositol polyphosphate-4-phosphatase, type II, 105kDa
chr9_+_108463234 3.67 ENST00000374688.1
transmembrane protein 38B
chr5_-_176900610 3.67 ENST00000477391.2
ENST00000393565.1
ENST00000309007.5
drebrin 1
chr5_+_134094461 3.63 ENST00000452510.2
ENST00000354283.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
chr2_-_55276320 3.62 ENST00000357376.3
reticulon 4
chr11_+_64949343 3.60 ENST00000279247.6
ENST00000532285.1
ENST00000534373.1
calpain 1, (mu/I) large subunit
chr5_-_39425290 3.56 ENST00000545653.1
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr15_+_64388166 3.53 ENST00000353874.4
ENST00000261889.5
ENST00000559844.1
ENST00000561026.1
ENST00000558040.1
sorting nexin 1
chr4_-_105416039 3.50 ENST00000394767.2
CXXC finger protein 4
chr12_+_22778009 3.47 ENST00000266517.4
ENST00000335148.3
ethanolamine kinase 1
chr1_-_26232522 3.44 ENST00000399728.1
stathmin 1
chr13_-_110959478 3.40 ENST00000543140.1
ENST00000375820.4
collagen, type IV, alpha 1
chr8_-_141810634 3.38 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
protein tyrosine kinase 2
chr21_-_16437126 3.36 ENST00000318948.4
nuclear receptor interacting protein 1
chr8_-_30515693 3.27 ENST00000355904.4
general transcription factor IIE, polypeptide 2, beta 34kDa
chr8_+_107738240 3.25 ENST00000449762.2
ENST00000297447.6
oxidation resistance 1
chr11_+_125496619 3.20 ENST00000532669.1
ENST00000278916.3
checkpoint kinase 1
chr10_+_22605304 3.19 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1 readthrough
COMM domain containing 3
chrX_+_12993202 3.11 ENST00000451311.2
ENST00000380636.1
thymosin beta 4, X-linked
chr14_-_106518922 3.09 ENST00000390598.2
immunoglobulin heavy variable 3-7
chr17_-_79479789 3.03 ENST00000571691.1
ENST00000571721.1
ENST00000573283.1
ENST00000575842.1
ENST00000575087.1
ENST00000570382.1
ENST00000331925.2
actin, gamma 1
chr1_-_155880672 3.00 ENST00000609492.1
ENST00000368322.3
Ras-like without CAAX 1
chr14_+_50234827 2.99 ENST00000554589.1
ENST00000557247.1
kelch domain containing 2
chr19_+_50354462 2.86 ENST00000601675.1
prostate tumor overexpressed 1
chr5_-_176836577 2.85 ENST00000253496.3
coagulation factor XII (Hageman factor)
chr17_-_49124230 2.80 ENST00000510283.1
ENST00000510855.1
sperm associated antigen 9
chr11_-_62414070 2.77 ENST00000540933.1
ENST00000346178.4
ENST00000356638.3
ENST00000534779.1
ENST00000525994.1
glucosidase, alpha; neutral AB
chr6_-_132834184 2.76 ENST00000367941.2
ENST00000367937.4
syntaxin 7
chr6_-_128841503 2.75 ENST00000368215.3
ENST00000532331.1
ENST00000368213.5
ENST00000368207.3
ENST00000525459.1
ENST00000368210.3
ENST00000368226.4
ENST00000368227.3
protein tyrosine phosphatase, receptor type, K
chr16_+_89989687 2.65 ENST00000315491.7
ENST00000555576.1
ENST00000554336.1
ENST00000553967.1
Tubulin beta-3 chain
chr6_-_109777128 2.55 ENST00000358807.3
ENST00000358577.3
microtubule associated monooxygenase, calponin and LIM domain containing 1
chr19_+_50354430 2.53 ENST00000599732.1
prostate tumor overexpressed 1
chr2_+_120517174 2.52 ENST00000263708.2
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chrX_+_80457442 2.46 ENST00000373212.5
SH3 domain binding glutamic acid-rich protein like
chr1_+_172502336 2.45 ENST00000263688.3
SUN domain containing ossification factor
chr13_+_111767650 2.42 ENST00000449979.1
ENST00000370623.3
Rho guanine nucleotide exchange factor (GEF) 7
chr12_-_8815215 2.39 ENST00000544889.1
ENST00000543369.1
microfibrillar associated protein 5
chr17_-_53046058 2.36 ENST00000571584.1
ENST00000299335.3
cytochrome c oxidase assembly homolog 11 (yeast)
chr21_-_16437255 2.36 ENST00000400199.1
ENST00000400202.1
nuclear receptor interacting protein 1
chr15_+_79166065 2.35 ENST00000559690.1
ENST00000559158.1
mortality factor 4 like 1
chr1_+_24286287 2.29 ENST00000334351.7
ENST00000374468.1
proline-rich nuclear receptor coactivator 2
chr16_-_29478016 2.28 ENST00000549858.1
ENST00000551411.1
Uncharacterized protein
chr1_+_150039369 2.24 ENST00000369130.3
ENST00000369128.5
vacuolar protein sorting 45 homolog (S. cerevisiae)
chr12_-_8815299 2.19 ENST00000535336.1
microfibrillar associated protein 5
chr7_+_107224364 2.18 ENST00000491150.1
B-cell receptor-associated protein 29
chr20_-_43150601 2.15 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
serine incorporator 3
chr15_+_85923797 2.11 ENST00000559362.1
A kinase (PRKA) anchor protein 13
chr11_+_46402583 2.09 ENST00000359803.3
midkine (neurite growth-promoting factor 2)
chr20_-_39317868 1.93 ENST00000373313.2
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
chr14_-_106791536 1.88 ENST00000390613.2
immunoglobulin heavy variable 3-30
chr20_+_60718785 1.87 ENST00000421564.1
ENST00000450482.1
ENST00000331758.3
synovial sarcoma translocation gene on chromosome 18-like 1
chr15_-_73076030 1.86 ENST00000311669.8
ADP-dependent glucokinase
chr1_-_21503337 1.83 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
eukaryotic translation initiation factor 4 gamma, 3
chr11_+_63706444 1.74 ENST00000377793.4
ENST00000456907.2
ENST00000539656.1
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr11_+_60691924 1.73 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
transmembrane protein 132A
chr17_-_19648916 1.73 ENST00000444455.1
ENST00000439102.2
aldehyde dehydrogenase 3 family, member A1
chr6_+_64282447 1.68 ENST00000370650.2
ENST00000578299.1
protein tyrosine phosphatase type IVA, member 1
chr2_-_1748214 1.68 ENST00000433670.1
ENST00000425171.1
ENST00000252804.4
peroxidasin homolog (Drosophila)
chr19_+_49468558 1.63 ENST00000331825.6
ferritin, light polypeptide
chr11_+_65339820 1.61 ENST00000316409.2
ENST00000449319.2
ENST00000530349.1
family with sequence similarity 89, member B
chr17_-_19648683 1.60 ENST00000573368.1
ENST00000457500.2
aldehyde dehydrogenase 3 family, member A1
chr11_+_63753883 1.59 ENST00000538426.1
ENST00000543004.1
OTU domain, ubiquitin aldehyde binding 1
chr1_-_93645818 1.59 ENST00000370280.1
ENST00000479918.1
transmembrane emp24 protein transport domain containing 5
chr3_-_18466026 1.55 ENST00000417717.2
SATB homeobox 1
chr4_+_26585686 1.48 ENST00000505206.1
ENST00000511789.1
TBC1 domain family, member 19
chr14_-_106866934 1.47 ENST00000390618.2
immunoglobulin heavy variable 3-38 (non-functional)
chr16_+_30205754 1.37 ENST00000354723.6
ENST00000355544.5
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr14_-_55878538 1.37 ENST00000247178.5
autophagy related 14
chr2_-_39348137 1.36 ENST00000426016.1
son of sevenless homolog 1 (Drosophila)
chr17_+_9066252 1.32 ENST00000436734.1
netrin 1
chr4_+_88896819 1.32 ENST00000237623.7
ENST00000395080.3
ENST00000508233.1
ENST00000360804.4
secreted phosphoprotein 1
chr1_+_182808474 1.31 ENST00000367549.3
DEAH (Asp-Glu-Ala-His) box helicase 9
chr16_-_22385901 1.28 ENST00000268383.2
cerebellar degeneration-related protein 2, 62kDa
chr17_-_76719807 1.18 ENST00000589297.1
cytohesin 1
chr8_+_23104130 1.18 ENST00000313219.7
ENST00000519984.1
charged multivesicular body protein 7
chr15_+_89631381 1.17 ENST00000352732.5
abhydrolase domain containing 2
chr12_+_25205666 1.17 ENST00000547044.1
lymphoid-restricted membrane protein
chr7_+_73868439 1.11 ENST00000424337.2
GTF2I repeat domain containing 1
chr3_-_65583561 1.11 ENST00000460329.2
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr15_+_63335899 1.11 ENST00000561266.1
tropomyosin 1 (alpha)
chr13_+_49684445 1.09 ENST00000398316.3
fibronectin type III domain containing 3A
chr8_+_42195972 1.09 ENST00000532157.1
ENST00000265421.4
ENST00000520008.1
polymerase (DNA directed), beta
chr11_+_46402744 1.06 ENST00000533952.1
midkine (neurite growth-promoting factor 2)
chr16_+_3704822 1.06 ENST00000414110.2
deoxyribonuclease I
chr18_+_13611763 1.00 ENST00000585931.1
low density lipoprotein receptor class A domain containing 4
chr2_-_231989808 1.00 ENST00000258400.3
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr12_-_11463353 0.97 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
proline-rich protein BstNI subfamily 4
chr6_+_13272904 0.97 ENST00000379335.3
ENST00000379329.1
phosphatase and actin regulator 1
chr22_+_39052632 0.97 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
chibby homolog 1 (Drosophila)
chr11_-_69633792 0.84 ENST00000334134.2
fibroblast growth factor 3
chr21_+_38445539 0.82 ENST00000418766.1
ENST00000450533.1
ENST00000438055.1
ENST00000355666.1
ENST00000540756.1
ENST00000399010.1
tetratricopeptide repeat domain 3

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 20.2 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
4.8 14.4 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
4.3 21.6 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
3.9 19.3 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
3.1 12.3 GO:0035026 leading edge cell differentiation(GO:0035026)
2.8 11.2 GO:0044571 [2Fe-2S] cluster assembly(GO:0044571)
2.3 21.0 GO:0021943 formation of radial glial scaffolds(GO:0021943)
2.2 6.6 GO:0045659 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
2.1 29.1 GO:0045793 positive regulation of cell size(GO:0045793)
2.0 6.1 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
2.0 8.1 GO:0021564 vagus nerve development(GO:0021564)
1.9 20.5 GO:0031584 activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176)
1.7 5.2 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
1.6 8.0 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
1.4 5.4 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
1.4 9.5 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
1.2 4.8 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.2 4.6 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
1.1 7.9 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.1 13.7 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
1.0 4.2 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.0 10.4 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
1.0 6.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
1.0 6.9 GO:0070294 renal sodium ion absorption(GO:0070294)
0.9 2.8 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.9 7.4 GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.9 2.6 GO:0019417 sulfur oxidation(GO:0019417)
0.9 3.4 GO:0061304 retinal blood vessel morphogenesis(GO:0061304)
0.8 5.9 GO:0021847 ventricular zone neuroblast division(GO:0021847)
0.8 4.9 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.7 4.5 GO:1904798 positive regulation of core promoter binding(GO:1904798)
0.7 9.8 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.7 1.3 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.6 1.9 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.6 1.9 GO:0021571 rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.6 8.3 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.6 13.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.6 3.7 GO:0010643 cell communication by chemical coupling(GO:0010643)
0.6 14.0 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
0.6 17.4 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
0.6 2.4 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.6 3.5 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.5 3.2 GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010767) histone H3-T11 phosphorylation(GO:0035407)
0.5 3.2 GO:0030421 defecation(GO:0030421)
0.5 35.7 GO:0006910 phagocytosis, recognition(GO:0006910)
0.5 8.8 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.5 7.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.5 6.9 GO:0033235 positive regulation of protein sumoylation(GO:0033235) positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.5 4.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.5 6.8 GO:0097264 self proteolysis(GO:0097264)
0.4 1.3 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.4 1.3 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.4 23.7 GO:0006378 mRNA polyadenylation(GO:0006378)
0.4 7.7 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 3.6 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.4 1.6 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.4 2.8 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.4 5.5 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.4 4.2 GO:0046541 saliva secretion(GO:0046541)
0.4 5.7 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.4 3.4 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.4 1.1 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.4 6.1 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.3 5.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 4.9 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.3 2.2 GO:0009597 detection of virus(GO:0009597)
0.3 2.8 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
0.3 2.3 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.3 1.1 GO:0070997 neuron death(GO:0070997)
0.3 1.4 GO:0016240 autophagosome docking(GO:0016240)
0.3 1.4 GO:1904693 midbrain morphogenesis(GO:1904693)
0.3 2.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.3 3.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.3 8.1 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.3 4.4 GO:0051764 actin crosslink formation(GO:0051764)
0.3 3.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.2 6.6 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.2 1.6 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.2 1.1 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.2 1.0 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.2 1.4 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.2 2.8 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 2.4 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.2 0.8 GO:0006581 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.2 3.5 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.2 1.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.2 4.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 4.0 GO:0010842 retina layer formation(GO:0010842)
0.1 0.4 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 1.1 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065) negative regulation of vascular associated smooth muscle cell migration(GO:1904753)
0.1 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.5 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 4.4 GO:0003016 respiratory system process(GO:0003016)
0.1 4.7 GO:0060216 definitive hemopoiesis(GO:0060216)
0.1 0.5 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 1.6 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.2 GO:0039702 viral budding via host ESCRT complex(GO:0039702)
0.1 4.8 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 0.7 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.1 0.6 GO:0042476 odontogenesis(GO:0042476)
0.1 4.1 GO:0050832 defense response to fungus(GO:0050832)
0.1 7.9 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 6.5 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 4.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 6.5 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 1.9 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 1.6 GO:0090161 Golgi ribbon formation(GO:0090161)
0.1 4.1 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.1 0.4 GO:1990834 response to odorant(GO:1990834)
0.1 2.5 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.1 1.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.8 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 8.6 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 3.6 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 0.4 GO:0046549 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.1 3.0 GO:0045214 sarcomere organization(GO:0045214)
0.1 1.1 GO:0060009 Sertoli cell development(GO:0060009)
0.1 6.0 GO:0045445 myoblast differentiation(GO:0045445)
0.1 5.5 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.1 0.4 GO:1901475 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.1 GO:0048240 sperm capacitation(GO:0048240)
0.1 3.9 GO:0006968 cellular defense response(GO:0006968)
0.1 0.6 GO:0051601 exocyst localization(GO:0051601)
0.0 5.0 GO:0006958 complement activation, classical pathway(GO:0006958)
0.0 9.4 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 6.2 GO:0006338 chromatin remodeling(GO:0006338)
0.0 2.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 8.0 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 3.3 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0 1.9 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.7 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 2.6 GO:0006081 cellular aldehyde metabolic process(GO:0006081)
0.0 1.7 GO:0001960 negative regulation of cytokine-mediated signaling pathway(GO:0001960)
0.0 1.8 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.1 GO:0006308 DNA catabolic process(GO:0006308)
0.0 1.6 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.2 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 9.5 GO:0042493 response to drug(GO:0042493)
0.0 0.1 GO:0003105 negative regulation of glomerular filtration(GO:0003105) filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060) negative regulation of retinal ganglion cell axon guidance(GO:0090260)
0.0 0.7 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.0 1.0 GO:0051289 protein homotetramerization(GO:0051289)
0.0 1.2 GO:0006906 vesicle fusion(GO:0006906)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 21.6 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
3.5 14.0 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
3.0 8.9 GO:0034680 integrin alpha1-beta1 complex(GO:0034665) integrin alpha3-beta1 complex(GO:0034667) integrin alpha8-beta1 complex(GO:0034678) integrin alpha10-beta1 complex(GO:0034680)
2.5 7.4 GO:0031523 Myb complex(GO:0031523)
2.1 17.0 GO:0042382 paraspeckles(GO:0042382)
1.6 4.8 GO:0005607 laminin-2 complex(GO:0005607)
1.4 12.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
1.1 7.4 GO:0070852 cell body fiber(GO:0070852)
0.9 5.5 GO:1990037 Lewy body core(GO:1990037)
0.9 11.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.9 20.0 GO:0032156 septin cytoskeleton(GO:0032156)
0.8 11.4 GO:0030478 actin cap(GO:0030478)
0.7 8.1 GO:0005614 interstitial matrix(GO:0005614)
0.7 35.7 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.7 5.5 GO:1990111 spermatoproteasome complex(GO:1990111)
0.7 4.6 GO:0032437 cuticular plate(GO:0032437)
0.7 8.6 GO:0000815 ESCRT III complex(GO:0000815)
0.6 3.5 GO:0030905 retromer, tubulation complex(GO:0030905)
0.6 6.1 GO:0031010 ISWI-type complex(GO:0031010)
0.6 7.7 GO:0090543 Flemming body(GO:0090543)
0.5 1.4 GO:1903349 omegasome membrane(GO:1903349)
0.4 4.7 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.4 3.4 GO:0005587 collagen type IV trimer(GO:0005587)
0.4 1.6 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
0.4 4.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.3 4.5 GO:0042555 MCM complex(GO:0042555)
0.3 5.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.3 18.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.3 5.9 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.3 2.4 GO:0000322 storage vacuole(GO:0000322)
0.3 2.1 GO:0097165 nuclear stress granule(GO:0097165)
0.3 9.8 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 4.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.3 4.4 GO:0043073 germ cell nucleus(GO:0043073)
0.2 4.7 GO:0032433 filopodium tip(GO:0032433)
0.2 3.0 GO:0097433 dense body(GO:0097433)
0.2 4.7 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 5.6 GO:0005682 U5 snRNP(GO:0005682)
0.2 21.8 GO:0016605 PML body(GO:0016605)
0.2 0.8 GO:0005594 collagen type IX trimer(GO:0005594)
0.1 21.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 5.6 GO:0002102 podosome(GO:0002102)
0.1 9.4 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 7.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.4 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.3 GO:0016580 Sin3 complex(GO:0016580)
0.1 9.9 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 27.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 0.5 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.1 0.2 GO:0071564 npBAF complex(GO:0071564)
0.1 6.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 2.5 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 14.8 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.1 1.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.1 1.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 6.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.1 9.5 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 9.5 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 8.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 3.3 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 3.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 4.1 GO:0015030 Cajal body(GO:0015030)
0.1 1.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 4.4 GO:0000922 spindle pole(GO:0000922)
0.1 0.8 GO:0043083 synaptic cleft(GO:0043083)
0.1 5.4 GO:0042641 actomyosin(GO:0042641)
0.1 3.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 13.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 3.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 15.6 GO:0005874 microtubule(GO:0005874)
0.0 4.0 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.6 GO:0000145 exocyst(GO:0000145)
0.0 13.9 GO:0016607 nuclear speck(GO:0016607)
0.0 2.6 GO:0043195 terminal bouton(GO:0043195)
0.0 4.7 GO:0005681 spliceosomal complex(GO:0005681)
0.0 2.8 GO:0031256 leading edge membrane(GO:0031256)
0.0 8.9 GO:0016604 nuclear body(GO:0016604)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 1.3 GO:0016363 nuclear matrix(GO:0016363)
0.0 1.8 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.3 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 1.9 GO:0005884 actin filament(GO:0005884)
0.0 9.2 GO:0000785 chromatin(GO:0000785)
0.0 1.7 GO:0005819 spindle(GO:0005819)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.2 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
3.5 14.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
2.0 6.1 GO:0004756 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
2.0 8.0 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
2.0 6.0 GO:0001069 regulatory region RNA binding(GO:0001069)
1.9 9.4 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
1.9 7.4 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.9 5.6 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
1.8 8.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
1.4 4.2 GO:0046848 hydroxyapatite binding(GO:0046848)
1.0 5.9 GO:0004167 dopachrome isomerase activity(GO:0004167)
0.9 15.7 GO:0017049 GTP-Rho binding(GO:0017049)
0.9 22.1 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.8 3.2 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.8 7.9 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.7 3.5 GO:1990460 leptin receptor binding(GO:1990460)
0.7 35.7 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.7 3.3 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.6 4.8 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.6 12.3 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.5 15.6 GO:0070410 co-SMAD binding(GO:0070410)
0.5 21.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.5 4.7 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.4 3.4 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.4 7.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.4 6.9 GO:0070628 proteasome binding(GO:0070628)
0.4 4.7 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.4 6.6 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.4 14.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.4 3.5 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.4 9.6 GO:0017081 chloride channel regulator activity(GO:0017081)
0.4 7.9 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 7.5 GO:0045295 gamma-catenin binding(GO:0045295)
0.4 10.4 GO:0005523 tropomyosin binding(GO:0005523)
0.4 17.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.3 1.7 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.3 2.8 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 1.7 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.3 1.3 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.3 3.4 GO:0008432 JUN kinase binding(GO:0008432)
0.3 27.8 GO:0033613 activating transcription factor binding(GO:0033613)
0.3 1.1 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.3 4.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 1.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.2 5.3 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.4 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.2 0.7 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.2 9.5 GO:0003785 actin monomer binding(GO:0003785)
0.2 1.9 GO:0016773 phosphotransferase activity, alcohol group as acceptor(GO:0016773)
0.2 7.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 6.9 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 2.7 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 7.3 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 5.5 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 4.6 GO:0030506 ankyrin binding(GO:0030506)
0.2 2.8 GO:0051787 misfolded protein binding(GO:0051787)
0.2 3.0 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.6 GO:0008199 ferric iron binding(GO:0008199)
0.1 3.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 1.8 GO:0000339 RNA cap binding(GO:0000339)
0.1 30.8 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 4.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 0.4 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.1 0.8 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.1 4.5 GO:0017025 TBP-class protein binding(GO:0017025)
0.1 6.1 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 8.3 GO:0019003 GDP binding(GO:0019003)
0.1 1.9 GO:0005522 profilin binding(GO:0005522)
0.1 4.4 GO:0005080 protein kinase C binding(GO:0005080)
0.1 7.5 GO:0097110 scaffold protein binding(GO:0097110)
0.1 5.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 2.6 GO:0071949 FAD binding(GO:0071949)
0.1 2.3 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 4.9 GO:0030276 clathrin binding(GO:0030276)
0.1 1.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 7.1 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 1.1 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.1 1.0 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 2.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 1.0 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 11.1 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 21.3 GO:0003924 GTPase activity(GO:0003924)
0.1 0.8 GO:0017091 AU-rich element binding(GO:0017091)
0.1 7.4 GO:0004386 helicase activity(GO:0004386)
0.1 3.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 5.4 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 8.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 1.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 1.1 GO:0051393 alpha-actinin binding(GO:0051393)
0.0 0.5 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 0.8 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 1.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 5.0 GO:0003823 antigen binding(GO:0003823)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0 0.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 4.4 GO:0015631 tubulin binding(GO:0015631)
0.0 3.7 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.2 GO:0051015 actin filament binding(GO:0051015)
0.0 2.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.2 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 18.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.7 16.4 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 10.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 8.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.3 8.8 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 18.3 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 4.8 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 9.4 PID NETRIN PATHWAY Netrin-mediated signaling events
0.2 28.7 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 11.7 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.2 11.3 PID FOXO PATHWAY FoxO family signaling
0.2 14.0 PID E2F PATHWAY E2F transcription factor network
0.2 8.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2 9.8 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.2 9.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.2 17.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 6.6 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 4.0 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 7.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 4.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 11.5 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 6.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 5.5 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
0.1 7.9 PID INTEGRIN1 PATHWAY Beta1 integrin cell surface interactions
0.1 3.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 2.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 4.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.4 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.1 1.6 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 4.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 2.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.6 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.4 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 21.3 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.8 26.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.7 12.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.6 9.4 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.5 8.9 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.5 14.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.4 6.1 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.4 4.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 15.6 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.4 21.6 REACTOME G1 PHASE Genes involved in G1 Phase
0.3 8.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.3 1.4 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.3 4.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 12.0 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.3 5.2 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.3 5.6 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.3 8.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 7.7 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 4.6 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.2 2.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.2 4.7 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 10.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.2 3.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.2 5.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.2 3.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.2 5.5 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.2 2.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.2 3.0 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 27.4 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.1 4.7 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 9.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 4.1 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 2.8 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 9.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 8.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 9.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.5 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.1 1.0 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.0 1.4 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.8 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.0 1.9 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 2.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.6 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 1.6 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 2.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.4 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.7 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type