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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SOX7

Z-value: 0.77

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.6 SRY-box transcription factor 7
SOX7
ENSG00000258724.1 SRY-box transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg19_v2_chr8_-_10588010_105880300.695.5e-32Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_66951474 17.47 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr21_+_34144411 14.58 ENST00000382375.4
ENST00000453404.1
ENST00000382378.1
ENST00000477513.1
C21orf49
chromosome 21 open reading frame 49
chr18_+_32820990 8.44 ENST00000601719.1
ENST00000591206.1
ENST00000330501.7
ENST00000261333.6
ENST00000355632.4
ENST00000585800.1
ZNF397
zinc finger protein 397
chr8_-_82359662 8.00 ENST00000519260.1
ENST00000256103.2
PMP2
peripheral myelin protein 2
chr16_-_20364122 7.83 ENST00000396138.4
ENST00000577168.1
UMOD
uromodulin
chr11_-_62474803 7.34 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr22_+_23101182 7.04 ENST00000390312.2
IGLV2-14
immunoglobulin lambda variable 2-14
chr16_+_33020496 6.88 ENST00000565407.2
IGHV3OR16-8
immunoglobulin heavy variable 3/OR16-8 (non-functional)
chr10_+_5005445 6.87 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr16_-_20364030 6.30 ENST00000396134.2
ENST00000573567.1
ENST00000570757.1
ENST00000424589.1
ENST00000302509.4
ENST00000571174.1
ENST00000576688.1
UMOD
uromodulin
chr1_+_156698708 5.89 ENST00000519086.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr1_+_100598691 5.72 ENST00000370143.1
ENST00000370141.2
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr10_-_71169031 5.69 ENST00000373307.1
TACR2
tachykinin receptor 2
chr15_+_25068773 5.69 ENST00000400100.1
ENST00000400098.1
SNRPN
small nuclear ribonucleoprotein polypeptide N
chr16_-_279405 5.63 ENST00000430864.1
ENST00000293872.8
ENST00000337351.4
ENST00000397783.1
LUC7L
LUC7-like (S. cerevisiae)
chr11_+_3011093 5.57 ENST00000332881.2
AC131971.1
HCG1782999; PRO0943; Uncharacterized protein
chr5_+_175511859 5.57 ENST00000503724.2
ENST00000253490.4
FAM153B
family with sequence similarity 153, member B
chr1_+_158901329 5.41 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr9_+_105757590 5.39 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2
chr16_-_33647696 5.32 ENST00000558425.1
ENST00000569103.2
RP11-812E19.9
Uncharacterized protein
chr1_+_11724167 4.81 ENST00000376753.4
FBXO6
F-box protein 6
chr10_-_5046042 4.69 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr8_-_102803163 4.19 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr8_-_19459993 4.18 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr6_+_150690133 3.79 ENST00000392255.3
ENST00000500320.3
IYD
iodotyrosine deiodinase
chr5_+_161494521 3.62 ENST00000356592.3
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr4_-_47983519 3.48 ENST00000358519.4
ENST00000544810.1
ENST00000402813.3
CNGA1
cyclic nucleotide gated channel alpha 1
chr6_+_150690028 3.37 ENST00000229447.5
ENST00000344419.3
IYD
iodotyrosine deiodinase
chr10_+_96162242 3.31 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr6_+_29555683 3.21 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr6_+_131894284 3.12 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr3_-_123411191 3.00 ENST00000354792.5
ENST00000508240.1
MYLK
myosin light chain kinase
chr8_+_12803176 2.81 ENST00000524591.2
KIAA1456
KIAA1456
chr5_+_161494770 2.77 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chr7_-_143966381 2.69 ENST00000487179.1
CTAGE8
CTAGE family, member 8
chr2_+_3705785 2.65 ENST00000252505.3
ALLC
allantoicase
chr19_-_2783363 2.50 ENST00000221566.2
SGTA
small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
chr14_+_50291993 2.49 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr1_+_10509971 2.23 ENST00000320498.4
CORT
cortistatin
chr2_-_166930131 2.11 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr4_+_76995855 1.88 ENST00000355810.4
ENST00000349321.3
ART3
ADP-ribosyltransferase 3
chr6_-_46048116 1.65 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr13_-_37633567 1.17 ENST00000464744.1
SUPT20H
suppressor of Ty 20 homolog (S. cerevisiae)
chr19_-_22379753 1.09 ENST00000397121.2
ZNF676
zinc finger protein 676
chr17_-_39623681 0.79 ENST00000225899.3
KRT32
keratin 32
chrY_+_14813160 0.70 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr8_+_77593448 0.64 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr10_-_17243579 0.59 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr12_-_58027138 0.56 ENST00000341156.4
B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr14_-_106573756 0.54 ENST00000390601.2
IGHV3-11
immunoglobulin heavy variable 3-11 (gene/pseudogene)
chrX_+_69353284 0.20 ENST00000342206.6
ENST00000356413.4
IGBP1
immunoglobulin (CD79A) binding protein 1
chr15_+_59439899 0.13 ENST00000599727.1
C15ORF31
C15ORF31
chr11_+_7618413 0.12 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 14.1 GO:0072233 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
1.9 5.7 GO:0014057 positive regulation of acetylcholine secretion, neurotransmission(GO:0014057)
1.7 11.6 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.6 17.5 GO:0042908 xenobiotic transport(GO:0042908)
1.0 4.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.9 2.6 GO:0043605 cellular amide catabolic process(GO:0043605)
0.8 2.5 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
0.6 3.1 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.6 7.2 GO:0006570 tyrosine metabolic process(GO:0006570)
0.4 5.9 GO:0031167 rRNA methylation(GO:0031167)
0.4 3.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 9.1 GO:0030488 tRNA methylation(GO:0030488)
0.3 6.4 GO:0071420 cellular response to histamine(GO:0071420)
0.3 7.3 GO:0034389 lipid particle organization(GO:0034389)
0.3 4.8 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.2 2.2 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.2 2.1 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 1.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 5.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.6 GO:0030259 lipid glycosylation(GO:0030259)
0.1 3.3 GO:2000785 regulation of autophagosome assembly(GO:2000785)
0.1 6.9 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 3.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.1 7.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 3.2 GO:0007618 mating(GO:0007618)
0.0 1.9 GO:0006471 protein ADP-ribosylation(GO:0006471)
0.0 4.2 GO:0003073 regulation of systemic arterial blood pressure(GO:0003073)
0.0 5.7 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.2 GO:0060632 regulation of microtubule-based movement(GO:0060632)
0.0 4.9 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 5.4 GO:0033150 perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.5 11.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.3 2.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.3 4.2 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 3.5 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.2 6.4 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 14.1 GO:0060170 ciliary membrane(GO:0060170)
0.1 4.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.1 6.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 4.7 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 2.1 GO:0043194 voltage-gated sodium channel complex(GO:0001518) axon initial segment(GO:0043194)
0.1 1.2 GO:0000124 SAGA complex(GO:0000124)
0.0 7.3 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 3.0 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 8.0 GO:0043209 myelin sheath(GO:0043209)
0.0 1.6 GO:0034707 chloride channel complex(GO:0034707)
0.0 3.1 GO:0035580 specific granule lumen(GO:0035580)
0.0 17.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.3 GO:0005776 autophagosome(GO:0005776)
0.0 1.9 GO:0031225 anchored component of membrane(GO:0031225)
0.0 5.4 GO:0016607 nuclear speck(GO:0016607)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 17.5 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
1.9 11.6 GO:0047115 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
1.4 4.2 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
1.2 7.2 GO:0004447 iodide peroxidase activity(GO:0004447)
1.2 5.9 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
1.1 5.7 GO:0004995 tachykinin receptor activity(GO:0004995)
0.8 2.5 GO:1904288 BAT3 complex binding(GO:1904288)
0.8 5.6 GO:0050733 RS domain binding(GO:0050733)
0.8 14.1 GO:0019864 IgG binding(GO:0019864)
0.6 3.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.6 2.8 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.5 6.4 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.4 5.8 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.4 1.9 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.3 6.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 3.5 GO:0043855 intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.2 8.0 GO:0015485 cholesterol binding(GO:0015485)
0.1 6.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 4.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.1 2.1 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.1 3.2 GO:0004984 olfactory receptor activity(GO:0004984)
0.1 2.2 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 7.6 GO:0003823 antigen binding(GO:0003823)
0.0 1.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 5.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.6 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.0 4.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 3.3 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.5 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.1 3.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 3.1 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 17.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.3 7.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.2 6.4 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 4.2 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 4.8 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 4.2 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 3.0 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 5.7 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 3.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives