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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SP100

Z-value: 1.40

Motif logo

Transcription factors associated with SP100

Gene Symbol Gene ID Gene Info
ENSG00000067066.12 SP100 nuclear antigen

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SP100hg19_v2_chr2_+_231280908_2312809450.306.8e-06Click!

Activity profile of SP100 motif

Sorted Z-values of SP100 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_137514687 33.53 ENST00000394894.3
kinesin family member 20A
chr5_+_72143988 24.14 ENST00000506351.2
transportin 1
chr12_+_104682496 23.25 ENST00000378070.4
thioredoxin reductase 1
chr15_+_66797627 21.78 ENST00000565627.1
ENST00000564179.1
zwilch kinetochore protein
chr15_+_66797455 21.78 ENST00000446801.2
zwilch kinetochore protein
chr12_+_27863706 20.67 ENST00000081029.3
ENST00000538315.1
ENST00000542791.1
mitochondrial ribosomal protein S35
chr5_+_33440802 19.69 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
threonyl-tRNA synthetase
chr16_-_69760409 18.73 ENST00000561500.1
ENST00000439109.2
ENST00000564043.1
ENST00000379046.2
ENST00000379047.3
NAD(P)H dehydrogenase, quinone 1
chr7_+_117824210 18.06 ENST00000422760.1
ENST00000411938.1
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr9_-_113018835 17.86 ENST00000374517.5
thioredoxin
chr5_+_33441053 17.69 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
threonyl-tRNA synthetase
chr11_+_35201826 17.53 ENST00000531873.1
CD44 molecule (Indian blood group)
chr1_+_214776516 16.32 ENST00000366955.3
centromere protein F, 350/400kDa
chr5_+_159848807 16.17 ENST00000352433.5
pituitary tumor-transforming 1
chr12_+_104324112 15.80 ENST00000299767.5
heat shock protein 90kDa beta (Grp94), member 1
chr16_+_74330673 15.79 ENST00000219313.4
ENST00000540379.1
ENST00000567958.1
ENST00000568615.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
chr9_+_33265011 15.45 ENST00000419016.2
charged multivesicular body protein 5
chr7_+_117824086 15.15 ENST00000249299.2
ENST00000424702.1
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chrX_+_77359671 14.31 ENST00000373316.4
phosphoglycerate kinase 1
chr1_-_87380002 14.14 ENST00000331835.5
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr1_-_63988846 14.02 ENST00000283568.8
ENST00000371092.3
ENST00000271002.10
integrin beta 3 binding protein (beta3-endonexin)
chr14_-_102605983 13.92 ENST00000334701.7
heat shock protein 90kDa alpha (cytosolic), class A member 1
chr4_-_170679024 13.76 ENST00000393381.2
chromosome 4 open reading frame 27
chr5_+_137514834 13.70 ENST00000508792.1
ENST00000504621.1
kinesin family member 20A
chr14_+_56127989 13.61 ENST00000555573.1
kinectin 1 (kinesin receptor)
chr2_+_39005336 13.18 ENST00000409566.1
gem (nuclear organelle) associated protein 6
chr1_-_87379785 13.00 ENST00000401030.3
ENST00000370554.1
Homo sapiens 15 kDa selenoprotein (SEP15), transcript variant 2, mRNA.
chr11_+_85955787 13.00 ENST00000528180.1
embryonic ectoderm development
chr2_+_113403434 12.76 ENST00000272542.3
solute carrier family 20 (phosphate transporter), member 1
chrX_+_77359726 12.75 ENST00000442431.1
phosphoglycerate kinase 1
chr10_+_79793518 12.73 ENST00000440692.1
ENST00000435275.1
ENST00000372360.3
ENST00000360830.4
ribosomal protein S24
chr2_-_55496344 12.58 ENST00000403721.1
ENST00000263629.4
mitochondrial translational initiation factor 2
chr13_+_43597269 12.48 ENST00000379221.2
DnaJ (Hsp40) homolog, subfamily C, member 15
chr2_+_201936707 12.45 ENST00000433898.1
ENST00000454214.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr12_-_120884175 12.39 ENST00000546954.1
TP53 regulated inhibitor of apoptosis 1
chr3_+_159557637 12.38 ENST00000445224.2
schwannomin interacting protein 1
chr10_-_27443294 12.30 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1-like 1 ATPase
chr1_+_45205498 12.27 ENST00000372218.4
kinesin family member 2C
chr1_-_108735440 12.11 ENST00000370041.4
solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
chr2_+_201170770 12.08 ENST00000409988.3
ENST00000409385.1
spermatogenesis associated, serine-rich 2-like
chr17_-_57784755 11.94 ENST00000537860.1
ENST00000393038.2
ENST00000409433.2
peptidyl-tRNA hydrolase 2
chr1_-_75198681 11.87 ENST00000370872.3
ENST00000370871.3
ENST00000340866.5
ENST00000370870.1
crystallin, zeta (quinone reductase)
chr11_+_118958689 11.80 ENST00000535253.1
ENST00000392841.1
hydroxymethylbilane synthase
chr9_-_139372141 11.71 ENST00000313050.7
SEC16 homolog A (S. cerevisiae)
chr11_-_6704513 11.64 ENST00000532203.1
ENST00000288937.6
mitochondrial ribosomal protein L17
chr14_-_102552659 11.55 ENST00000441629.2
heat shock protein 90kDa alpha (cytosolic), class A member 1
chrX_-_77225135 11.38 ENST00000458128.1
phosphoglycerate mutase family member 4
chr3_+_62304648 11.34 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
chromosome 3 open reading frame 14
chr2_+_39005325 11.30 ENST00000281950.3
gem (nuclear organelle) associated protein 6
chr2_+_201170596 11.23 ENST00000439084.1
ENST00000409718.1
spermatogenesis associated, serine-rich 2-like
chr3_+_62304712 11.19 ENST00000494481.1
chromosome 3 open reading frame 14
chr3_+_180630090 11.19 ENST00000357559.4
ENST00000305586.7
fragile X mental retardation, autosomal homolog 1
chrX_+_118708493 11.14 ENST00000371558.2
ubiquitin-conjugating enzyme E2A
chr11_+_125496619 10.86 ENST00000532669.1
ENST00000278916.3
checkpoint kinase 1
chr11_+_125496400 10.77 ENST00000524737.1
checkpoint kinase 1
chr8_+_104310661 10.76 ENST00000522566.1
frizzled family receptor 6
chr2_+_201994042 10.72 ENST00000417748.1
CASP8 and FADD-like apoptosis regulator
chr6_-_150067696 10.62 ENST00000340413.2
ENST00000367403.3
nucleoporin 43kDa
chr11_-_33744487 10.52 ENST00000426650.2
CD59 molecule, complement regulatory protein
chr6_+_31371337 10.44 ENST00000449934.2
ENST00000421350.1
MHC class I polypeptide-related sequence A
chr10_-_91174215 10.43 ENST00000371837.1
lipase A, lysosomal acid, cholesterol esterase
chr5_+_32585605 10.17 ENST00000265073.4
ENST00000515355.1
ENST00000502897.1
ENST00000510442.1
SUB1 homolog (S. cerevisiae)
chrX_+_118708517 10.05 ENST00000346330.3
ubiquitin-conjugating enzyme E2A
chr5_-_68665296 10.02 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr5_+_151151504 10.00 ENST00000356245.3
ENST00000507878.2
GTPase activating protein (SH3 domain) binding protein 1
chr19_-_55919087 9.99 ENST00000587845.1
ENST00000589978.1
ENST00000264552.9
ubiquitin-conjugating enzyme E2S
chr15_-_66797172 9.99 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
ribosomal protein L4
chr1_-_94344754 9.92 ENST00000436063.2
deoxynucleotidyltransferase, terminal, interacting protein 2
chrX_-_10588459 9.88 ENST00000380782.2
midline 1 (Opitz/BBB syndrome)
chr11_-_33744256 9.83 ENST00000415002.2
ENST00000437761.2
ENST00000445143.2
CD59 molecule, complement regulatory protein
chr5_+_151151471 9.82 ENST00000394123.3
ENST00000543466.1
GTPase activating protein (SH3 domain) binding protein 1
chr2_+_192109911 9.74 ENST00000418908.1
ENST00000339514.4
ENST00000392318.3
myosin IB
chrX_-_153707246 9.69 ENST00000407062.1
L antigen family, member 3
chr17_+_57784826 9.66 ENST00000262291.4
vacuole membrane protein 1
chr14_-_23504087 9.57 ENST00000493471.2
ENST00000460922.2
proteasome (prosome, macropain) subunit, beta type, 5
chr7_-_91764108 9.55 ENST00000450723.1
cytochrome P450, family 51, subfamily A, polypeptide 1
chr11_-_65626753 9.50 ENST00000526975.1
ENST00000531413.1
cofilin 1 (non-muscle)
chr20_+_47835884 9.45 ENST00000371764.4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
chr10_+_45495898 9.43 ENST00000298299.3
zinc finger protein 22
chr12_+_95867727 9.36 ENST00000323666.5
ENST00000546753.1
methionyl aminopeptidase 2
chr17_-_685559 9.36 ENST00000301329.6
glyoxalase domain containing 4
chr15_+_59397275 9.31 ENST00000288207.2
cyclin B2
chr5_+_172386419 9.30 ENST00000265100.2
ENST00000519239.1
ribosomal protein L26-like 1
chr6_+_44214824 9.27 ENST00000371646.5
ENST00000353801.3
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr9_-_139343294 9.22 ENST00000313084.5
SEC16 homolog A (S. cerevisiae)
chr20_-_31989307 9.17 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
CDK5 regulatory subunit associated protein 1
chr14_-_54908043 9.15 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
cornichon family AMPA receptor auxiliary protein 1
chr11_+_108535752 9.14 ENST00000322536.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
chr4_+_41540160 9.09 ENST00000503057.1
ENST00000511496.1
LIM and calponin homology domains 1
chr5_-_68665084 9.08 ENST00000509462.1
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr2_+_200820269 8.96 ENST00000392290.1
chromosome 2 open reading frame 47
chr21_-_30445886 8.87 ENST00000431234.1
ENST00000540844.1
ENST00000286788.4
chaperonin containing TCP1, subunit 8 (theta)
chr9_+_33264861 8.79 ENST00000223500.8
charged multivesicular body protein 5
chrX_-_15511438 8.73 ENST00000380420.5
pirin (iron-binding nuclear protein)
chr14_-_75530693 8.56 ENST00000555135.1
ENST00000357971.3
ENST00000553302.1
ENST00000555694.1
ENST00000238618.3
acylphosphatase 1, erythrocyte (common) type
chr13_-_36944307 8.55 ENST00000355182.4
spastic paraplegia 20 (Troyer syndrome)
chr2_+_192110199 8.53 ENST00000304164.4
myosin IB
chrX_-_10588595 8.45 ENST00000423614.1
ENST00000317552.4
midline 1 (Opitz/BBB syndrome)
chrX_+_11129388 8.40 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
holocytochrome c synthase
chr1_-_6420737 8.39 ENST00000541130.1
ENST00000377845.3
acyl-CoA thioesterase 7
chr3_-_64009658 8.38 ENST00000394431.2
proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
chr21_+_34602680 8.35 ENST00000447980.1
interferon (alpha, beta and omega) receptor 2
chr1_+_161284047 8.34 ENST00000367975.2
ENST00000342751.4
ENST00000432287.2
ENST00000392169.2
ENST00000513009.1
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
chr6_+_10747986 8.26 ENST00000379542.5
transmembrane protein 14B
chr16_-_30441293 8.25 ENST00000565758.1
ENST00000567983.1
ENST00000319285.4
dCTP pyrophosphatase 1
chr20_-_49575058 8.07 ENST00000371584.4
ENST00000371583.5
ENST00000413082.1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr12_+_4758264 8.05 ENST00000266544.5
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr1_-_95392635 7.88 ENST00000538964.1
ENST00000394202.4
ENST00000370206.4
calponin 3, acidic
chr15_+_59397298 7.83 ENST00000559622.1
cyclin B2
chr5_+_169010638 7.82 ENST00000265295.4
ENST00000506574.1
ENST00000515224.1
ENST00000508247.1
ENST00000513941.1
spindle apparatus coiled-coil protein 1
chr19_+_33072373 7.80 ENST00000586035.1
programmed cell death 5
chr21_+_40759684 7.79 ENST00000380708.1
tryptophan rich basic protein
chr14_-_23504337 7.74 ENST00000361611.6
proteasome (prosome, macropain) subunit, beta type, 5
chr3_-_176914238 7.73 ENST00000430069.1
ENST00000428970.1
transducin (beta)-like 1 X-linked receptor 1
chr8_+_110552337 7.72 ENST00000337573.5
estrogen receptor binding site associated, antigen, 9
chr10_-_74927810 7.55 ENST00000372979.4
ENST00000430082.2
ENST00000454759.2
ENST00000413026.1
ENST00000453402.1
ecdysoneless homolog (Drosophila)
chr1_+_153606532 7.51 ENST00000403433.1
chromatin target of PRMT1
chr2_-_55496174 7.48 ENST00000417363.1
ENST00000412530.1
ENST00000394600.3
ENST00000366137.2
ENST00000420637.1
mitochondrial translational initiation factor 2
chrX_-_20159934 7.47 ENST00000379593.1
ENST00000379607.5
eukaryotic translation initiation factor 1A, X-linked
chr12_+_56435637 7.44 ENST00000356464.5
ENST00000552361.1
ribosomal protein S26
chr9_-_95087604 7.42 ENST00000542613.1
ENST00000542053.1
ENST00000358855.4
ENST00000545558.1
ENST00000432670.2
ENST00000433029.2
ENST00000411621.2
nucleolar protein 8
chr4_+_41937131 7.40 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chrX_-_77395186 7.40 ENST00000341864.5
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr17_+_65713925 7.35 ENST00000253247.4
nucleolar protein 11
chr1_-_193074504 7.32 ENST00000367439.3
glutaredoxin 2
chr19_-_46195029 7.30 ENST00000588599.1
ENST00000585392.1
ENST00000590212.1
ENST00000587367.1
ENST00000391932.3
small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
chr14_+_51706886 7.28 ENST00000457354.2
thioredoxin-related transmembrane protein 1
chrX_+_48755183 7.28 ENST00000376563.1
ENST00000376566.4
polyglutamine binding protein 1
chr2_+_177134134 7.27 ENST00000249442.6
ENST00000392529.2
ENST00000443241.1
metaxin 2
chr13_-_31736027 7.24 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
heat shock 105kDa/110kDa protein 1
chr22_+_24309089 7.23 ENST00000215770.5
D-dopachrome tautomerase-like
chr11_-_47447970 7.21 ENST00000298852.3
ENST00000530912.1
proteasome (prosome, macropain) 26S subunit, ATPase, 3
chr21_-_43346790 7.19 ENST00000329623.7
C2 calcium-dependent domain containing 2
chr8_+_101162812 7.17 ENST00000353107.3
ENST00000522439.1
polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
chr11_-_62439012 7.16 ENST00000532208.1
ENST00000377954.2
ENST00000415855.2
ENST00000431002.2
ENST00000354588.3
chromosome 11 open reading frame 48
chrX_+_77154935 7.09 ENST00000481445.1
cytochrome c oxidase subunit VIIb
chr14_-_23504432 7.08 ENST00000425762.2
proteasome (prosome, macropain) subunit, beta type, 5
chr8_-_74205851 7.04 ENST00000396467.1
ribosomal protein L7
chr1_-_165738072 7.02 ENST00000481278.1
transmembrane and coiled-coil domains 1
chr2_+_122513109 6.99 ENST00000389682.3
ENST00000536142.1
translin
chr19_+_21688366 6.95 ENST00000358491.4
ENST00000597078.1
zinc finger protein 429
chr10_+_51187938 6.90 ENST00000311663.5
family with sequence similarity 21, member D
chr17_-_685493 6.77 ENST00000536578.1
ENST00000301328.5
ENST00000576419.1
glyoxalase domain containing 4
chr1_-_236767779 6.64 ENST00000366579.1
ENST00000366582.3
ENST00000366581.2
HEAT repeat containing 1
chr20_-_36156293 6.63 ENST00000373537.2
ENST00000414542.2
bladder cancer associated protein
chrX_-_23926004 6.61 ENST00000379226.4
ENST00000379220.3
apolipoprotein O
chr5_+_172386517 6.58 ENST00000519522.1
ribosomal protein L26-like 1
chrX_+_48755202 6.55 ENST00000447146.2
ENST00000376548.5
ENST00000247140.4
polyglutamine binding protein 1
chr21_+_40752170 6.53 ENST00000333781.5
ENST00000541890.1
tryptophan rich basic protein
chr17_-_30228678 6.51 ENST00000261708.4
UTP6, small subunit (SSU) processome component, homolog (yeast)
chr8_+_110552831 6.41 ENST00000530629.1
estrogen receptor binding site associated, antigen, 9
chr13_+_48611665 6.40 ENST00000258662.2
nudix (nucleoside diphosphate linked moiety X)-type motif 15
chr2_+_85132749 6.25 ENST00000233143.4
thymosin beta 10
chr2_+_74056147 6.22 ENST00000394070.2
ENST00000536064.1
STAM binding protein
chr1_-_235324772 6.21 ENST00000408888.3
RNA binding motif protein 34
chr3_-_57583185 6.17 ENST00000463880.1
ADP-ribosylation factor 4
chr5_+_6714718 6.16 ENST00000230859.6
ENST00000515721.1
PAP associated domain containing 7
chr1_-_3566627 6.07 ENST00000419924.2
ENST00000270708.7
WD repeat containing, antisense to TP73
chr2_-_70520832 6.06 ENST00000454893.1
ENST00000272348.2
small nuclear ribonucleoprotein polypeptide G
chr12_-_32908809 5.96 ENST00000324868.8
tyrosyl-tRNA synthetase 2, mitochondrial
chr11_-_77790865 5.96 ENST00000534029.1
ENST00000525085.1
ENST00000527806.1
ENST00000528164.1
ENST00000528251.1
ENST00000530054.1
NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa
NDUFC2-KCTD14 readthrough
chrX_-_153707545 5.90 ENST00000357360.4
L antigen family, member 3
chr14_+_55518349 5.89 ENST00000395468.4
mitogen-activated protein kinase 1 interacting protein 1-like
chr15_-_55541227 5.88 ENST00000566877.1
RAB27A, member RAS oncogene family
chr10_-_96122682 5.80 ENST00000371361.3
nucleolar complex associated 3 homolog (S. cerevisiae)
chr20_-_36156125 5.79 ENST00000397135.1
ENST00000397137.1
bladder cancer associated protein
chr11_+_125496124 5.78 ENST00000533778.2
ENST00000534070.1
checkpoint kinase 1
chr2_-_47403642 5.71 ENST00000456319.1
ENST00000409563.1
ENST00000272298.7
calmodulin 2 (phosphorylase kinase, delta)
chr18_+_3247779 5.63 ENST00000578611.1
ENST00000583449.1
myosin, light chain 12A, regulatory, non-sarcomeric
chr6_-_127664475 5.61 ENST00000474289.2
ENST00000534442.1
ENST00000368289.2
ENST00000525745.1
ENST00000430841.2
enoyl CoA hydratase domain containing 1
chr2_+_201994208 5.49 ENST00000440180.1
CASP8 and FADD-like apoptosis regulator
chr5_+_95998746 5.48 ENST00000508608.1
calpastatin
chr3_-_79816965 5.45 ENST00000464233.1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr13_+_50656307 5.39 ENST00000378180.4
deleted in lymphocytic leukemia 1 (non-protein coding)
chr1_-_220220000 5.37 ENST00000366923.3
glutamyl-prolyl-tRNA synthetase
chr15_-_101835414 5.32 ENST00000254193.6
small nuclear ribonucleoprotein polypeptide A'
chr15_-_90777277 5.28 ENST00000328649.6
calcium and integrin binding 1 (calmyrin)
chr16_-_18812746 5.27 ENST00000546206.2
ENST00000562819.1
ENST00000562234.2
ENST00000304414.7
ENST00000567078.2
ADP-ribosylation factor-like 6 interacting protein 1
Uncharacterized protein
chr22_-_32058166 5.25 ENST00000435900.1
ENST00000336566.4
phosphatidylserine decarboxylase
chr2_-_37068530 5.23 ENST00000593798.1
Uncharacterized protein
chr10_+_112327425 5.21 ENST00000361804.4
structural maintenance of chromosomes 3
chr10_-_35379524 5.17 ENST00000374751.3
ENST00000374742.1
ENST00000602371.1
cullin 2
chr7_-_124569991 5.06 ENST00000446993.1
ENST00000357628.3
ENST00000393329.1
protection of telomeres 1
chr17_-_15587602 5.05 ENST00000416464.2
ENST00000578237.1
ENST00000581200.1
tripartite motif containing 16
chr3_-_11685345 5.02 ENST00000430365.2
vestigial like 4 (Drosophila)
chr10_+_115439282 5.01 ENST00000369321.2
ENST00000345633.4
caspase 7, apoptosis-related cysteine peptidase
chr8_+_59465728 4.96 ENST00000260130.4
ENST00000422546.2
ENST00000447182.2
ENST00000413219.2
ENST00000424270.2
ENST00000523483.1
ENST00000520168.1
syndecan binding protein (syntenin)
chr8_-_117768023 4.92 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
eukaryotic translation initiation factor 3, subunit H
chr11_-_62607036 4.90 ENST00000311713.7
ENST00000278856.4
WD repeat domain 74
chr20_-_34252759 4.89 ENST00000414711.1
ENST00000416778.1
ENST00000397442.1
ENST00000440240.1
ENST00000412056.1
ENST00000352393.4
ENST00000458038.1
ENST00000420363.1
ENST00000434795.1
ENST00000437100.1
ENST00000414664.1
ENST00000359646.1
ENST00000424458.1
ENST00000374104.3
ENST00000374114.3
copine I
RNA binding motif protein 12
chr11_-_111741994 4.88 ENST00000398006.2
ALG9, alpha-1,2-mannosyltransferase
chr17_-_62502022 4.86 ENST00000578804.1
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr8_-_59572301 4.86 ENST00000038176.3
neutral sphingomyelinase (N-SMase) activation associated factor
chr3_+_142720366 4.85 ENST00000493782.1
ENST00000397933.2
ENST00000473835.2
ENST00000493598.2
U2 snRNP-associated SURP domain containing
chr20_-_49575081 4.80 ENST00000371588.5
ENST00000371582.4
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chrX_-_99891796 4.78 ENST00000373020.4
tetraspanin 6
chr11_+_10772534 4.62 ENST00000361367.2
CTR9, Paf1/RNA polymerase II complex component
chr22_-_29107919 4.62 ENST00000434810.1
ENST00000456369.1
checkpoint kinase 2
chr8_-_95487331 4.61 ENST00000336148.5
RAD54 homolog B (S. cerevisiae)
chr11_+_125495862 4.60 ENST00000428830.2
ENST00000544373.1
ENST00000527013.1
ENST00000526937.1
ENST00000534685.1
checkpoint kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of SP100

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 37.4 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
6.4 25.5 GO:0043335 protein unfolding(GO:0043335)
5.3 32.0 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
5.1 20.3 GO:0001971 negative regulation of activation of membrane attack complex(GO:0001971)
4.0 71.5 GO:0000920 cell separation after cytokinesis(GO:0000920)
3.3 10.0 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
2.8 11.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
2.8 8.3 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
2.7 10.8 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
2.6 10.4 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
2.6 54.5 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
2.6 23.3 GO:0001887 selenium compound metabolic process(GO:0001887)
2.6 12.9 GO:0019348 dolichol metabolic process(GO:0019348)
2.5 20.1 GO:0032790 ribosome disassembly(GO:0032790)
2.5 7.4 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
2.4 14.3 GO:0071816 tail-anchored membrane protein insertion into ER membrane(GO:0071816)
2.3 13.8 GO:1902957 negative regulation of mitochondrial electron transport, NADH to ubiquinone(GO:1902957)
2.2 6.6 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
2.2 22.0 GO:0042262 DNA protection(GO:0042262)
2.1 8.6 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
2.1 8.4 GO:0036116 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
2.0 12.3 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
2.0 10.0 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
2.0 8.0 GO:1903660 negative regulation of complement-dependent cytotoxicity(GO:1903660)
2.0 17.9 GO:0030091 protein repair(GO:0030091)
1.9 7.8 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
1.8 9.2 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
1.8 5.5 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
1.8 26.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.8 5.3 GO:0038163 endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163)
1.6 13.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
1.6 14.1 GO:0051503 ATP transport(GO:0015867) adenine nucleotide transport(GO:0051503)
1.5 4.6 GO:2001160 regulation of genetic imprinting(GO:2000653) regulation of histone H3-K79 methylation(GO:2001160) positive regulation of histone H3-K79 methylation(GO:2001162)
1.5 4.6 GO:1903925 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
1.5 4.6 GO:1901420 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
1.5 11.9 GO:2000210 positive regulation of anoikis(GO:2000210)
1.5 8.9 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.5 14.6 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.4 4.3 GO:0000412 histone peptidyl-prolyl isomerization(GO:0000412)
1.4 4.3 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
1.4 18.3 GO:0035372 protein localization to microtubule(GO:0035372)
1.4 4.2 GO:0006059 hexitol metabolic process(GO:0006059) response to methylglyoxal(GO:0051595)
1.4 16.7 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.3 12.8 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
1.3 12.6 GO:0051096 positive regulation of helicase activity(GO:0051096)
1.3 16.3 GO:0051382 kinetochore assembly(GO:0051382)
1.2 3.7 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
1.2 5.0 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
1.2 12.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.2 3.6 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.2 3.6 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
1.2 18.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
1.1 4.6 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
1.1 3.4 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
1.1 3.4 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
1.1 8.9 GO:1903750 positive regulation of MHC class I biosynthetic process(GO:0045345) negative regulation of establishment of protein localization to mitochondrion(GO:1903748) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
1.1 4.4 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
1.1 4.2 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
1.0 3.1 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.0 5.2 GO:0044791 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
1.0 8.1 GO:0006983 ER overload response(GO:0006983)
1.0 4.0 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
1.0 6.0 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
1.0 7.8 GO:0034501 protein localization to kinetochore(GO:0034501)
0.9 7.4 GO:1902570 protein localization to nucleolus(GO:1902570)
0.9 11.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.9 25.1 GO:0031639 plasminogen activation(GO:0031639)
0.9 42.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.9 4.3 GO:0009256 10-formyltetrahydrofolate metabolic process(GO:0009256)
0.9 35.9 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.8 2.5 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.8 3.3 GO:1903826 arginine transmembrane transport(GO:1903826)
0.8 80.5 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.8 9.4 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.8 20.6 GO:2000637 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.7 4.3 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.7 2.2 GO:0072709 cellular response to sorbitol(GO:0072709)
0.7 2.9 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.7 5.0 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.7 4.3 GO:0032596 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
0.7 5.5 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 3.4 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.7 8.9 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.7 2.7 GO:0045218 zonula adherens maintenance(GO:0045218)
0.7 2.0 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.7 3.9 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.6 6.2 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.6 21.2 GO:0033522 histone H2A ubiquitination(GO:0033522)
0.6 6.2 GO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.6 4.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.6 7.3 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.6 4.3 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.6 71.9 GO:0007062 sister chromatid cohesion(GO:0007062)
0.6 11.9 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.6 7.0 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.6 19.8 GO:0033048 negative regulation of sister chromatid segregation(GO:0033046) negative regulation of mitotic sister chromatid segregation(GO:0033048) negative regulation of mitotic sister chromatid separation(GO:2000816)
0.6 2.3 GO:0051030 snRNA export from nucleus(GO:0006408) snRNA transport(GO:0051030)
0.6 5.0 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.6 6.2 GO:0031584 activation of phospholipase D activity(GO:0031584) apical protein localization(GO:0045176)
0.5 10.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.5 17.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.5 7.7 GO:0050872 white fat cell differentiation(GO:0050872)
0.5 6.1 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.5 4.5 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.5 29.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.5 3.9 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.5 5.7 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
0.5 21.4 GO:0007077 mitotic nuclear envelope disassembly(GO:0007077)
0.5 36.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.5 1.8 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.4 1.8 GO:0002326 B cell lineage commitment(GO:0002326)
0.4 11.6 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.4 5.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.4 2.1 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.4 4.9 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.4 4.0 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 7.9 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 2.4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.4 1.2 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.4 23.0 GO:0032508 DNA duplex unwinding(GO:0032508)
0.4 6.4 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.3 4.9 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.3 8.3 GO:0035455 response to interferon-alpha(GO:0035455)
0.3 4.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 15.2 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.3 3.3 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
0.3 6.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 12.4 GO:0030262 apoptotic nuclear changes(GO:0030262)
0.3 2.1 GO:1990564 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.3 1.1 GO:0061643 chemorepulsion of dopaminergic neuron axon(GO:0036518) chemorepulsion of axon(GO:0061643)
0.3 10.4 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.3 4.6 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 2.5 GO:0032808 lacrimal gland development(GO:0032808)
0.2 3.7 GO:0002227 innate immune response in mucosa(GO:0002227)
0.2 8.8 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.2 4.1 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.2 1.7 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.2 1.3 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.2 1.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.2 7.4 GO:0033119 negative regulation of RNA splicing(GO:0033119)
0.2 7.2 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.2 1.0 GO:0035721 intraciliary retrograde transport(GO:0035721)
0.2 1.9 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 0.8 GO:0035425 autocrine signaling(GO:0035425)
0.2 0.4 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.2 3.1 GO:2000009 negative regulation of protein localization to cell surface(GO:2000009)
0.2 11.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.2 2.8 GO:0018126 protein hydroxylation(GO:0018126)
0.2 15.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.2 3.7 GO:0003334 keratinocyte development(GO:0003334)
0.2 4.2 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.2 6.4 GO:0030224 monocyte differentiation(GO:0030224)
0.2 1.2 GO:0015816 glycine transport(GO:0015816)
0.2 1.2 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.1 1.2 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 5.5 GO:0042407 cristae formation(GO:0042407)
0.1 7.0 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 0.8 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.1 9.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.1 GO:0070374 positive regulation of ERK1 and ERK2 cascade(GO:0070374)
0.1 8.2 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 3.8 GO:0000291 nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 6.0 GO:0043038 amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039)
0.1 1.8 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.1 2.4 GO:0044764 multi-organism cellular process(GO:0044764)
0.1 1.0 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.1 3.3 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.1 3.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.1 3.7 GO:0045661 regulation of myoblast differentiation(GO:0045661)
0.1 7.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.1 0.3 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.1 4.2 GO:0090114 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114)
0.1 12.8 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.1 6.5 GO:0042476 odontogenesis(GO:0042476)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.5 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0 1.2 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.0 1.0 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 6.5 GO:0045444 fat cell differentiation(GO:0045444)
0.0 4.9 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 1.2 GO:0000060 protein import into nucleus, translocation(GO:0000060)
0.0 1.2 GO:0033146 regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 1.2 GO:0043086 negative regulation of catalytic activity(GO:0043086)
0.0 2.4 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 2.1 GO:0008033 tRNA processing(GO:0008033)
0.0 2.2 GO:0006413 translational initiation(GO:0006413)
0.0 1.8 GO:0019827 stem cell population maintenance(GO:0019827) maintenance of cell number(GO:0098727)
0.0 2.3 GO:0048013 ephrin receptor signaling pathway(GO:0048013)
0.0 0.5 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 1.4 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 0.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.0 0.9 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 0.3 GO:0051591 response to cAMP(GO:0051591)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 1.3 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 0.6 GO:0060395 SMAD protein signal transduction(GO:0060395)
0.0 1.2 GO:0050871 positive regulation of B cell activation(GO:0050871)
0.0 0.2 GO:0052695 cellular glucuronidation(GO:0052695)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 43.6 GO:1990423 RZZ complex(GO:1990423)
8.3 33.2 GO:0031417 NatC complex(GO:0031417)
4.7 14.0 GO:0034455 t-UTP complex(GO:0034455)
4.3 12.9 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
4.2 21.2 GO:0033503 HULC complex(GO:0033503)
3.5 13.8 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
3.1 15.6 GO:0000408 EKC/KEOPS complex(GO:0000408)
3.1 24.5 GO:0097504 Gemini of coiled bodies(GO:0097504)
2.5 17.5 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
2.4 19.1 GO:0070761 pre-snoRNP complex(GO:0070761)
2.4 28.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
2.3 9.3 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
2.1 8.3 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
1.8 17.6 GO:0034719 SMN-Sm protein complex(GO:0034719)
1.7 5.2 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
1.7 27.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
1.3 6.5 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
1.3 13.0 GO:0001739 sex chromatin(GO:0001739)
1.3 20.3 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
1.1 34.5 GO:0005838 proteasome regulatory particle(GO:0005838)
1.1 62.2 GO:0005871 kinesin complex(GO:0005871)
1.1 4.2 GO:0097454 Schwann cell microvillus(GO:0097454)
1.0 5.2 GO:0030891 VCB complex(GO:0030891)
0.9 7.5 GO:0097255 R2TP complex(GO:0097255)
0.9 6.6 GO:0061617 MICOS complex(GO:0061617)
0.9 2.8 GO:1903349 omegasome membrane(GO:1903349)
0.9 5.5 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.9 5.3 GO:0071256 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.8 15.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.8 14.6 GO:0097342 ripoptosome(GO:0097342)
0.8 2.4 GO:0031523 Myb complex(GO:0031523)
0.8 4.7 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.8 5.4 GO:0097452 GAIT complex(GO:0097452)
0.8 20.7 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.7 4.5 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.7 8.9 GO:0033093 Weibel-Palade body(GO:0033093)
0.7 4.3 GO:0070545 PeBoW complex(GO:0070545)
0.7 4.3 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.7 10.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.7 8.9 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.7 7.4 GO:0000124 SAGA complex(GO:0000124)
0.7 4.6 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.6 4.3 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.6 4.3 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.6 4.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.6 6.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.5 4.9 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.5 3.8 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.5 3.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.5 6.1 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.5 5.1 GO:0070187 telosome(GO:0070187)
0.5 3.5 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.5 7.1 GO:0000346 transcription export complex(GO:0000346)
0.5 13.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.5 31.0 GO:0005747 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.5 4.6 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.5 4.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.4 11.4 GO:0097228 sperm principal piece(GO:0097228)
0.4 9.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4 9.4 GO:0071141 SMAD protein complex(GO:0071141)
0.4 3.3 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.4 7.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 31.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.4 4.0 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.4 5.3 GO:0005686 U2 snRNP(GO:0005686)
0.4 37.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 22.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 5.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 5.3 GO:0032433 filopodium tip(GO:0032433)
0.3 18.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 10.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 10.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 18.1 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 9.2 GO:0005844 polysome(GO:0005844)
0.3 7.7 GO:0005876 spindle microtubule(GO:0005876)
0.2 7.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 36.7 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 14.0 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.2 4.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.2 2.2 GO:0042555 MCM complex(GO:0042555)
0.2 4.4 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.2 1.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.2 17.8 GO:0030175 filopodium(GO:0030175)
0.2 1.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 1.8 GO:0030008 TRAPP complex(GO:0030008)
0.2 2.9 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 2.0 GO:0005916 fascia adherens(GO:0005916)
0.1 7.7 GO:0035577 azurophil granule membrane(GO:0035577)
0.1 21.4 GO:0001650 fibrillar center(GO:0001650)
0.1 7.1 GO:0002102 podosome(GO:0002102)
0.1 20.9 GO:0034399 nuclear periphery(GO:0034399)
0.1 6.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.6 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 1.0 GO:0016011 dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.1 2.3 GO:0000242 pericentriolar material(GO:0000242)
0.1 2.2 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 1.8 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 1.1 GO:1990909 Wnt signalosome(GO:1990909)
0.1 9.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 4.9 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 9.7 GO:0016605 PML body(GO:0016605)
0.1 7.2 GO:0005814 centriole(GO:0005814)
0.1 3.0 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 4.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 25.9 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.7 GO:0005811 lipid particle(GO:0005811)
0.1 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.0 GO:0097542 ciliary tip(GO:0097542)
0.1 2.5 GO:0043657 host(GO:0018995) host cell(GO:0043657)
0.1 41.4 GO:0005730 nucleolus(GO:0005730)
0.0 3.0 GO:0035580 specific granule lumen(GO:0035580)
0.0 2.4 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 3.5 GO:0032587 ruffle membrane(GO:0032587)
0.0 2.2 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.0 12.8 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 1.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 9.3 GO:0043025 neuronal cell body(GO:0043025)
0.0 1.2 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.7 GO:0016234 inclusion body(GO:0016234)
0.0 1.5 GO:0005882 intermediate filament(GO:0005882)
0.0 17.3 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 24.4 GO:0005739 mitochondrion(GO:0005739)
0.0 0.4 GO:0031526 brush border membrane(GO:0031526)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 37.4 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
9.0 27.1 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
7.8 23.3 GO:0098626 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
5.3 32.0 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
4.3 12.9 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
4.0 11.9 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
3.6 17.9 GO:0047134 protein-disulfide reductase activity(GO:0047134)
3.5 34.7 GO:0030911 TPR domain binding(GO:0030911)
3.3 13.3 GO:0043515 kinetochore binding(GO:0043515)
3.2 12.8 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
2.8 11.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
2.6 7.8 GO:0010698 acetyltransferase activator activity(GO:0010698)
2.4 11.9 GO:0070404 NADH binding(GO:0070404)
2.2 11.2 GO:0033592 RNA strand annealing activity(GO:0033592)
2.1 6.4 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) NADH pyrophosphatase activity(GO:0035529) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
2.1 10.4 GO:0004771 sterol esterase activity(GO:0004771)
2.1 8.3 GO:0000104 succinate dehydrogenase activity(GO:0000104)
2.1 18.7 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
1.9 5.6 GO:0004492 methylmalonyl-CoA decarboxylase activity(GO:0004492)
1.7 5.2 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.7 5.0 GO:0032089 NACHT domain binding(GO:0032089)
1.7 8.3 GO:0004905 type I interferon receptor activity(GO:0004905)
1.7 5.0 GO:0005137 interleukin-5 receptor binding(GO:0005137)
1.6 4.9 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
1.6 9.4 GO:0035500 MH2 domain binding(GO:0035500)
1.5 12.3 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
1.5 4.6 GO:0015616 DNA translocase activity(GO:0015616)
1.5 12.1 GO:0015217 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) purine nucleotide transmembrane transporter activity(GO:0015216) ADP transmembrane transporter activity(GO:0015217)
1.5 7.3 GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors(GO:0030613) oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor(GO:0030614)
1.4 13.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.4 20.1 GO:0043024 ribosomal small subunit binding(GO:0043024)
1.4 8.6 GO:0003998 acylphosphatase activity(GO:0003998)
1.4 4.3 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
1.3 5.2 GO:0036033 mediator complex binding(GO:0036033)
1.3 14.0 GO:0046790 virion binding(GO:0046790)
1.2 12.3 GO:0019237 centromeric DNA binding(GO:0019237)
1.2 3.6 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.2 8.3 GO:0032552 deoxyribonucleotide binding(GO:0032552)
1.0 6.2 GO:0046979 TAP2 binding(GO:0046979)
1.0 14.3 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
1.0 9.5 GO:0030620 U2 snRNA binding(GO:0030620)
0.9 8.5 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.9 10.1 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.9 5.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.9 5.5 GO:0008046 axon guidance receptor activity(GO:0008046)
0.9 27.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 5.3 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.8 8.4 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.8 3.3 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.8 18.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.8 6.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.8 8.4 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.8 17.4 GO:0030515 snoRNA binding(GO:0030515)
0.7 31.2 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.7 21.4 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.6 14.1 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.6 24.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.6 6.9 GO:0015266 protein channel activity(GO:0015266)
0.6 2.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.6 7.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.6 2.4 GO:0016972 flavin-linked sulfhydryl oxidase activity(GO:0016971) thiol oxidase activity(GO:0016972)
0.6 47.0 GO:0003777 microtubule motor activity(GO:0003777)
0.6 18.4 GO:0001848 complement binding(GO:0001848)
0.6 29.7 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.5 22.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.5 4.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.5 3.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.5 15.0 GO:0005540 hyaluronic acid binding(GO:0005540)
0.5 11.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.5 3.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.5 4.2 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.4 7.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.4 7.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 4.3 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.4 7.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 4.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 1.8 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 1.0 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
0.3 8.9 GO:0031489 myosin V binding(GO:0031489)
0.3 2.0 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.3 72.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.3 23.3 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 3.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.3 10.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.3 7.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 7.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.3 4.1 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.3 4.6 GO:0004526 ribonuclease P activity(GO:0004526)
0.3 17.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.3 8.5 GO:0070840 dynein complex binding(GO:0070840)
0.3 11.0 GO:0019894 kinesin binding(GO:0019894)
0.3 8.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 24.6 GO:0003697 single-stranded DNA binding(GO:0003697)
0.2 11.3 GO:0004812 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2 6.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 0.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.2 16.2 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 2.5 GO:0046870 cadmium ion binding(GO:0046870)
0.2 0.6 GO:0016435 rRNA (guanine) methyltransferase activity(GO:0016435)
0.2 1.2 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.2 1.8 GO:0005000 vasopressin receptor activity(GO:0005000)
0.2 18.2 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 4.9 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.2 7.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.2 2.3 GO:0015643 toxic substance binding(GO:0015643)
0.2 1.2 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.2 7.3 GO:0003785 actin monomer binding(GO:0003785)
0.2 2.8 GO:0008179 adenylate cyclase binding(GO:0008179)
0.2 18.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 0.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 9.2 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 3.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.2 3.9 GO:0008198 ferrous iron binding(GO:0008198)
0.2 3.4 GO:0002162 dystroglycan binding(GO:0002162)
0.2 4.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 5.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.1 0.7 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 3.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 2.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 5.4 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 1.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.1 1.3 GO:0016494 C-X-C chemokine receptor activity(GO:0016494)
0.1 10.9 GO:0008013 beta-catenin binding(GO:0008013)
0.1 6.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.1 1.7 GO:0005536 glucose binding(GO:0005536)
0.1 0.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 1.3 GO:0005123 death receptor binding(GO:0005123)
0.1 2.2 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 7.5 GO:1902936 phosphatidylinositol bisphosphate binding(GO:1902936)
0.1 6.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.1 1.6 GO:0042923 neuropeptide binding(GO:0042923)
0.1 0.8 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1 0.7 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 0.8 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.2 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.6 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 1.2 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 1.5 GO:0001972 retinoic acid binding(GO:0001972)
0.0 3.7 GO:0051087 chaperone binding(GO:0051087)
0.0 3.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 4.4 GO:0005262 calcium channel activity(GO:0005262)
0.0 4.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.1 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.0 4.3 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 39.4 GO:0003723 RNA binding(GO:0003723)
0.0 6.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.5 GO:0005496 steroid binding(GO:0005496)
0.0 6.3 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.1 GO:0045029 UDP-activated nucleotide receptor activity(GO:0045029)
0.0 0.9 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 2.9 GO:0016887 ATPase activity(GO:0016887)
0.0 1.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 1.0 GO:0002020 protease binding(GO:0002020)
0.0 0.8 GO:0047485 protein N-terminus binding(GO:0047485)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 32.0 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
1.0 63.7 PID AURORA B PATHWAY Aurora B signaling
0.8 24.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7 25.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.5 17.5 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.5 24.9 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.5 23.4 PID MYC PATHWAY C-MYC pathway
0.4 22.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.4 5.0 PID IL5 PATHWAY IL5-mediated signaling events
0.4 11.9 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 13.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 5.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2 16.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.2 5.0 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2 5.2 PID ATM PATHWAY ATM pathway
0.2 26.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.2 15.7 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.2 10.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 4.3 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.2 5.0 PID FANCONI PATHWAY Fanconi anemia pathway
0.1 12.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 9.3 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 1.7 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 7.8 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.1 1.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 11.6 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.1 5.0 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 3.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.1 4.3 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 2.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.1 2.0 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 6.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.0 4.0 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 2.4 PID E2F PATHWAY E2F transcription factor network
0.0 2.6 PID CMYB PATHWAY C-MYB transcription factor network
0.0 1.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.0 PID ARF6 PATHWAY Arf6 signaling events
0.0 1.1 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 59.5 REACTOME KINESINS Genes involved in Kinesins
1.9 36.6 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
1.4 44.8 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
1.3 24.1 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
1.2 41.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.2 42.7 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
1.1 15.8 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
1.0 80.5 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
1.0 24.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
1.0 17.1 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.9 17.5 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.9 59.2 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.8 69.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.8 12.8 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.7 16.2 REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.6 6.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.6 27.1 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 47.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.5 9.7 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.5 14.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.5 37.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.5 4.9 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.4 46.6 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.4 11.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.4 9.5 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
0.3 11.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3 20.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.3 6.0 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.3 3.8 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.3 7.2 REACTOME VIRAL MESSENGER RNA SYNTHESIS Genes involved in Viral Messenger RNA Synthesis
0.3 7.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 5.5 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.3 4.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.3 7.7 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.3 5.7 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.2 4.0 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.2 8.1 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.2 1.8 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.2 6.9 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.2 4.1 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2 36.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 4.2 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.2 8.7 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.2 1.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.2 5.0 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 3.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 3.7 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.7 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.1 2.4 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.1 2.0 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 2.4 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 3.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 9.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.3 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 9.6 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 2.1 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.1 1.4 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 2.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 5.5 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases