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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SP3
Z-value: 2.42
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg19_v2_chr2_-_174830430_174830563 | 0.53 | 1.7e-17 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.7 | 644.3 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 7.8 | 643.8 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 6.6 | 456.9 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 4.9 | 371.1 | GO:0097031 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 7.7 | 340.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 6.5 | 297.6 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 3.5 | 278.3 | GO:0006353 | DNA-templated transcription, termination(GO:0006353) |
| 2.6 | 263.2 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 11.6 | 220.1 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 7.0 | 215.7 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 2831.1 | GO:0070062 | extracellular exosome(GO:0070062) |
| 3.2 | 1735.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 5.6 | 941.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 5.3 | 698.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 1.9 | 575.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.6 | 444.5 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 4.2 | 371.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 7.3 | 308.3 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 11.2 | 302.6 | GO:0000314 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 5.4 | 277.3 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.4 | 1878.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.8 | 863.2 | GO:0003723 | RNA binding(GO:0003723) |
| 3.8 | 705.3 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 9.5 | 409.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 3.1 | 401.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 5.3 | 370.1 | GO:0019003 | GDP binding(GO:0019003) |
| 7.3 | 334.9 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 10.9 | 328.0 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.8 | 277.5 | GO:0005178 | integrin binding(GO:0005178) |
| 5.2 | 246.1 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.8 | 1088.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 4.2 | 354.5 | PID E2F PATHWAY | E2F transcription factor network |
| 7.9 | 323.5 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 6.7 | 322.0 | PID BARD1 PATHWAY | BARD1 signaling events |
| 5.7 | 319.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 6.0 | 317.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 4.7 | 309.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 4.1 | 295.3 | PID CERAMIDE PATHWAY | Ceramide signaling pathway |
| 2.6 | 238.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 4.8 | 225.1 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 851.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 10.8 | 840.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 3.4 | 489.1 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 14.4 | 445.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 7.4 | 435.8 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 12.2 | 415.8 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 5.2 | 412.6 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 9.8 | 372.1 | REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS | Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins |
| 7.2 | 365.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 8.1 | 349.0 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |