ISMARA results: SP4

Project

averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for SP4_PML

Z-value: 1.94

Motif logo

Transcription factors associated with SP4_PML

Gene Symbol	Gene ID	Gene Info
SP4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000105866.9	Sp4 transcription factor
PML Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140464.15	PML nuclear body scaffold

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
PML	hg19_v2_chr15_+_74287118_74287144	-0.22	1.3e-03	Click!
SP4	hg19_v2_chr7_+_21467642_21467671	-0.13	6.4e-02	Click!

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_-_23618582 Show fit	45.27	ENST00000398411.1 ENST00000376925.3	CST3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cystatin C
chr5_+_17217669 Show fit	44.87	ENST00000322611.3	BASP1 Ensembl NCBI GeneCards UniProt NextProt Show fit	brain abundant, membrane attached signal protein 1
chr1_-_20812690 Show fit	42.12	ENST00000375078.3	CAMK2N1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium/calmodulin-dependent protein kinase II inhibitor 1
chr2_-_175869936 Show fit	38.87	ENST00000409900.3	CHN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	chimerin 1
chr11_-_12030629 Show fit	38.33	ENST00000396505.2	DKK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	dickkopf WNT signaling pathway inhibitor 3
chr12_-_124457257 Show fit	36.72	ENST00000545891.1	CCDC92 Ensembl NCBI GeneCards UniProt NextProt Show fit	coiled-coil domain containing 92
chr3_-_149688502 Show fit	36.56	ENST00000481767.1 ENST00000475518.1	PFN2 Ensembl NCBI GeneCards UniProt NextProt Show fit	profilin 2
chr18_-_74844727 Show fit	35.81	ENST00000355994.2 ENST00000579129.1	MBP Ensembl NCBI GeneCards UniProt NextProt Show fit	myelin basic protein
chr10_-_15413035 Show fit	35.35	ENST00000378116.4 ENST00000455654.1	FAM171A1 Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 171, member A1
chr9_+_137979506 Show fit	35.08	ENST00000539529.1 ENST00000392991.4 ENST00000371793.3	OLFM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	olfactomedin 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
3.3	195.6	GO:0021762	substantia nigra development(GO:0021762)
11.0	131.5	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
1.0	98.1	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
3.3	96.9	GO:0048268	clathrin coat assembly(GO:0048268)
1.4	96.8	GO:0035773	insulin secretion involved in cellular response to glucose stimulus(GO:0035773)
1.5	89.2	GO:0042147	retrograde transport, endosome to Golgi(GO:0042147)
1.8	85.8	GO:0006735	NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
2.5	85.0	GO:0008045	motor neuron axon guidance(GO:0008045)
5.5	82.3	GO:0090168	Golgi reassembly(GO:0090168)
5.9	76.1	GO:2001135	regulation of endocytic recycling(GO:2001135)

Showing 1 to 10 of 1,054 entries

Gene overrepresentation in cellular_component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.8	486.2	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.6	317.5	GO:0000139	Golgi membrane(GO:0000139)
1.2	257.6	GO:0005802	trans-Golgi network(GO:0005802)
2.9	242.0	GO:0043195	terminal bouton(GO:0043195)
1.4	182.9	GO:0030426	growth cone(GO:0030426)
3.2	170.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
2.1	133.8	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.4	113.0	GO:0005874	microtubule(GO:0005874)
5.1	107.3	GO:0044295	axonal growth cone(GO:0044295)
0.6	101.9	GO:0030027	lamellipodium(GO:0030027)

Showing 1 to 10 of 352 entries

Gene overrepresentation in molecular_function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	265.6	GO:0003924	GTPase activity(GO:0003924)
0.5	182.4	GO:0004842	ubiquitin-protein transferase activity(GO:0004842)
1.1	160.6	GO:0044325	ion channel binding(GO:0044325)
2.2	159.6	GO:0001540	beta-amyloid binding(GO:0001540)
4.2	129.8	GO:0017075	syntaxin-1 binding(GO:0017075)
2.6	118.6	GO:0003785	actin monomer binding(GO:0003785)
5.7	113.9	GO:0050780	dopamine receptor binding(GO:0050780)
7.6	106.1	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
1.4	101.1	GO:0019003	GDP binding(GO:0019003)
3.6	99.6	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)

Showing 1 to 10 of 627 entries

Gene overrepresentation in C2:CP category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.2	171.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
2.9	158.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
2.0	137.0	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
1.8	132.9	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
3.0	106.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
2.4	94.9	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
4.3	93.6	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
1.5	88.6	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.3	83.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	80.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression

Showing 1 to 10 of 100 entries

Gene overrepresentation in C2:CP:REACTOME category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.1	199.2	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.2	196.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
1.4	168.6	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
3.4	167.5	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
3.0	163.0	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
4.0	110.9	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
4.0	109.1	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
5.5	99.6	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
4.9	97.7	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
1.9	85.7	REACTOME GLYCOLYSIS	Genes involved in Glycolysis

Showing 1 to 10 of 149 entries

Results for SP4_PML

Z-value: 1.94

Motif logo

Transcription factors associated with SP4_PML

Activity-expression correlation:

Activity profile of SP4_PML motif

Sorted Z-values of SP4_PML motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP4_PML

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: