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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SPI1

Z-value: 3.78

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Transcription factors associated with SPI1

Gene Symbol Gene ID Gene Info
ENSG00000066336.7 Spi-1 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPI1hg19_v2_chr11_-_47400078_47400127,
hg19_v2_chr11_-_47399942_47399961
0.591.3e-21Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_198608146 141.46 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
protein tyrosine phosphatase, receptor type, C
chr13_-_46756351 99.44 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_121379739 86.66 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr12_-_15114603 79.79 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_15114492 73.40 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr6_-_32811771 64.75 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chr6_-_32160622 60.33 ENST00000487761.1
ENST00000375040.3
G-protein signaling modulator 3
chr1_-_167487808 58.48 ENST00000392122.3
CD247 molecule
chr2_+_69001913 57.98 ENST00000409030.3
ENST00000409220.1
Rho GTPase activating protein 25
chr1_-_167487758 57.94 ENST00000362089.5
CD247 molecule
chr12_+_54891495 57.08 ENST00000293373.6
NCK-associated protein 1-like
chr1_-_183560011 56.31 ENST00000367536.1
neutrophil cytosolic factor 2
chr11_-_58343319 55.98 ENST00000395074.2
leupaxin
chr2_+_233925064 55.62 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr5_-_169725231 55.37 ENST00000046794.5
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_3862206 54.92 ENST00000351018.4
ras homolog family member G
chr6_+_31553901 53.38 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr5_+_169064245 53.06 ENST00000256935.8
dedicator of cytokinesis 2
chr7_-_5569588 52.67 ENST00000417101.1
actin, beta
chr19_+_49838653 51.63 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr6_+_32811885 51.40 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_62084241 50.05 ENST00000449662.2
intercellular adhesion molecule 2
chr1_-_150738261 49.57 ENST00000448301.2
ENST00000368985.3
cathepsin S
chr11_+_128563652 49.48 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr12_+_7055767 49.38 ENST00000447931.2
protein tyrosine phosphatase, non-receptor type 6
chr12_-_118797475 49.24 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAO kinase 3
chr6_-_31704282 49.24 ENST00000375784.3
ENST00000375779.2
chloride intracellular channel 1
chr17_+_4618734 49.01 ENST00000571206.1
arrestin, beta 2
chr12_+_7055631 48.85 ENST00000543115.1
ENST00000399448.1
protein tyrosine phosphatase, non-receptor type 6
chr8_+_56792355 48.60 ENST00000519728.1
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr19_-_10450328 48.50 ENST00000160262.5
intercellular adhesion molecule 3
chr19_-_10450287 47.83 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr6_+_31553978 47.52 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr1_-_207095324 47.39 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
Fas apoptotic inhibitory molecule 3
chr2_+_85804614 47.09 ENST00000263864.5
ENST00000409760.1
vesicle-associated membrane protein 8
chr19_-_8642289 46.89 ENST00000596675.1
ENST00000338257.8
myosin IF
chr1_+_111415757 46.83 ENST00000429072.2
ENST00000271324.5
CD53 molecule
chr2_-_175499294 46.54 ENST00000392547.2
WAS/WASL interacting protein family, member 1
chr1_-_183559693 46.23 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
neutrophil cytosolic factor 2
chr1_-_25256368 44.01 ENST00000308873.6
runt-related transcription factor 3
chr22_-_37640277 43.68 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_-_42016385 43.26 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
cyclin D3
chr12_-_92539614 43.16 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr16_-_88717423 42.81 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
cytochrome b-245, alpha polypeptide
chr14_-_35344093 42.63 ENST00000382422.2
bromodomain adjacent to zinc finger domain, 1A
chr22_+_37678424 42.41 ENST00000248901.6
cytohesin 4
chr19_-_36399149 42.13 ENST00000585901.2
ENST00000544690.2
ENST00000424586.3
ENST00000262629.4
ENST00000589517.1
TYRO protein tyrosine kinase binding protein
chr15_+_75074410 40.99 ENST00000439220.2
c-src tyrosine kinase
chr8_+_56792377 40.37 ENST00000520220.2
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr2_+_143886877 39.57 ENST00000295095.6
Rho GTPase activating protein 15
chr17_+_43299241 38.91 ENST00000328118.3
formin-like 1
chrX_+_128913906 38.58 ENST00000356892.3
SAM and SH3 domain containing 3
chr19_+_1077393 38.37 ENST00000590577.1
histocompatibility (minor) HA-1
chr16_-_88717482 38.02 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr14_-_23451467 37.53 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
ajuba LIM protein
chr14_-_23285011 36.97 ENST00000397532.3
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr21_-_46340770 36.36 ENST00000397854.3
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr14_-_23285069 35.99 ENST00000554758.1
ENST00000397528.4
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_+_25205666 35.82 ENST00000547044.1
lymphoid-restricted membrane protein
chr12_+_25205568 35.44 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr2_+_68961934 34.32 ENST00000409202.3
Rho GTPase activating protein 25
chr2_+_68961905 34.08 ENST00000295381.3
Rho GTPase activating protein 25
chr11_+_60223225 33.77 ENST00000524807.1
ENST00000345732.4
membrane-spanning 4-domains, subfamily A, member 1
chr11_-_72432950 33.41 ENST00000426523.1
ENST00000429686.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr1_-_31230650 32.96 ENST00000294507.3
lysosomal protein transmembrane 5
chr22_-_37640456 32.63 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_-_235405168 32.46 ENST00000339728.3
ADP-ribosylation factor-like 4C
chr15_+_75074385 32.39 ENST00000220003.9
c-src tyrosine kinase
chr11_+_60223312 32.38 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
membrane-spanning 4-domains, subfamily A, member 1
chr17_-_29641104 32.25 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr9_-_137809718 31.81 ENST00000371806.3
ficolin (collagen/fibrinogen domain containing) 1
chr2_+_109204909 31.73 ENST00000393310.1
LIM and senescent cell antigen-like domains 1
chr3_+_151986709 31.19 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr11_-_47399942 30.95 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_-_131826457 30.91 ENST00000437654.1
ENST00000245414.4
interferon regulatory factor 1
chr8_+_22438009 30.87 ENST00000409417.1
PDZ and LIM domain 2 (mystique)
chr17_+_43299156 30.80 ENST00000331495.3
formin-like 1
chr2_-_64371546 30.77 ENST00000358912.4
pellino E3 ubiquitin protein ligase 1
chr15_-_80263506 30.65 ENST00000335661.6
BCL2-related protein A1
chr1_+_145439306 30.50 ENST00000425134.1
thioredoxin interacting protein
chr3_-_16555150 30.14 ENST00000334133.4
raftlin, lipid raft linker 1
chr1_+_9711781 30.07 ENST00000536656.1
ENST00000377346.4
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr11_+_65407331 29.91 ENST00000527525.1
signal-induced proliferation-associated 1
chr7_+_98972298 29.80 ENST00000252725.5
actin related protein 2/3 complex, subunit 1B, 41kDa
chr16_+_30484021 29.62 ENST00000358164.5
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr12_+_25205446 29.31 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr2_-_85637459 29.05 ENST00000409921.1
capping protein (actin filament), gelsolin-like
chr7_-_115670804 28.99 ENST00000320239.7
transcription factor EC
chr6_+_31554826 28.97 ENST00000376089.2
ENST00000396112.2
leukocyte specific transcript 1
chrX_-_47489244 28.86 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr19_-_47220335 28.53 ENST00000601806.1
ENST00000593363.1
ENST00000598633.1
ENST00000595515.1
ENST00000433867.1
protein kinase D2
chr9_+_77703414 28.50 ENST00000346234.6
osteoclast stimulating factor 1
chr15_+_77287426 28.10 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr7_-_115670792 28.02 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chr3_-_185641681 27.85 ENST00000259043.7
transformer 2 beta homolog (Drosophila)
chr1_+_32716840 27.51 ENST00000336890.5
lymphocyte-specific protein tyrosine kinase
chr2_-_96811170 27.50 ENST00000288943.4
dual specificity phosphatase 2
chr12_-_51718436 27.41 ENST00000544402.1
bridging integrator 2
chr12_+_53848549 27.28 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
poly(rC) binding protein 2
chr1_-_207095212 26.89 ENST00000420007.2
Fas apoptotic inhibitory molecule 3
chr22_+_37257015 26.64 ENST00000447071.1
ENST00000248899.6
ENST00000397147.4
neutrophil cytosolic factor 4, 40kDa
chr16_-_21663919 26.37 ENST00000569602.1
immunoglobulin superfamily, member 6
chr4_+_103423055 26.33 ENST00000505458.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_32739733 26.24 ENST00000333070.4
lymphocyte-specific protein tyrosine kinase
chr7_+_74188309 26.04 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr16_+_30483962 26.04 ENST00000356798.6
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr11_-_47400078 25.86 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_+_31582961 25.85 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr8_+_22437965 25.69 ENST00000409141.1
ENST00000265810.4
PDZ and LIM domain 2 (mystique)
chr1_-_159894319 25.61 ENST00000320307.4
transgelin 2
chr17_+_7461781 25.36 ENST00000349228.4
tumor necrosis factor (ligand) superfamily, member 13
chr15_-_40600026 25.26 ENST00000456256.2
ENST00000557821.1
phospholipase C, beta 2
chr4_-_40631859 25.23 ENST00000295971.7
ENST00000319592.4
RNA binding motif protein 47
chr1_-_111743285 25.13 ENST00000357640.4
DENN/MADD domain containing 2D
chr14_-_24616426 24.84 ENST00000216802.5
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_+_65408273 24.81 ENST00000394227.3
signal-induced proliferation-associated 1
chr15_+_81589254 24.81 ENST00000394652.2
interleukin 16
chr1_-_159893507 24.70 ENST00000368096.1
transgelin 2
chr4_-_174255536 24.49 ENST00000446922.2
high mobility group box 2
chr17_+_7461580 24.44 ENST00000483039.1
ENST00000396542.1
tumor necrosis factor (ligand) superfamily, member 13
chr16_-_89043377 24.34 ENST00000436887.2
ENST00000448839.1
ENST00000360302.2
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr8_-_134072593 24.30 ENST00000427060.2
Src-like-adaptor
chr17_+_72462525 24.11 ENST00000360141.3
CD300a molecule
chr17_-_20370847 24.10 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr11_+_128563948 23.67 ENST00000534087.2
Fli-1 proto-oncogene, ETS transcription factor
chr2_+_161993412 23.60 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr17_+_7461613 23.52 ENST00000438470.1
ENST00000436057.1
tumor necrosis factor (ligand) superfamily, member 13
chr19_+_41768401 23.25 ENST00000352456.3
ENST00000595018.1
ENST00000597725.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_+_42381173 23.11 ENST00000221972.3
CD79a molecule, immunoglobulin-associated alpha
chr14_+_102276209 22.96 ENST00000445439.3
ENST00000334743.5
ENST00000557095.1
protein phosphatase 2, regulatory subunit B', gamma
chr1_+_32716857 22.80 ENST00000482949.1
ENST00000495610.2
lymphocyte-specific protein tyrosine kinase
chr2_+_65454926 22.77 ENST00000542850.1
ENST00000377982.4
ARP2 actin-related protein 2 homolog (yeast)
chr2_+_65454863 22.77 ENST00000260641.5
ARP2 actin-related protein 2 homolog (yeast)
chrX_-_70331298 22.60 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
interleukin 2 receptor, gamma
chr17_+_7461849 22.58 ENST00000338784.4
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_67120974 22.45 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr8_-_102216925 22.33 ENST00000517844.1
zinc finger protein 706
chr6_+_89790490 22.26 ENST00000336032.3
proline-rich nuclear receptor coactivator 1
chr3_-_18480260 22.03 ENST00000454909.2
SATB homeobox 1
chr12_-_53601055 21.96 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
integrin, beta 7
chr6_+_89790459 21.89 ENST00000369472.1
proline-rich nuclear receptor coactivator 1
chr4_-_103746683 21.86 ENST00000504211.1
ENST00000508476.1
ubiquitin-conjugating enzyme E2D 3
chr4_-_103747011 21.82 ENST00000350435.7
ubiquitin-conjugating enzyme E2D 3
chr16_-_89043605 21.75 ENST00000268679.4
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr19_+_6772710 21.70 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
vav 1 guanine nucleotide exchange factor
chrX_-_107018969 21.59 ENST00000372383.4
TSC22 domain family, member 3
chr12_-_53601000 21.46 ENST00000338737.4
ENST00000549086.2
integrin, beta 7
chr1_+_153330322 21.38 ENST00000368738.3
S100 calcium binding protein A9
chr11_-_72433346 21.35 ENST00000334211.8
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_-_154688276 21.27 ENST00000369445.2
coagulation factor VIII-associated 3
chrX_+_154114635 21.03 ENST00000369446.2
coagulation factor VIII-associated 1
chr10_-_72362515 21.01 ENST00000373209.2
ENST00000441259.1
perforin 1 (pore forming protein)
chr2_-_153573887 21.01 ENST00000493468.2
ENST00000545856.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chrX_+_48542168 20.94 ENST00000376701.4
Wiskott-Aldrich syndrome
chr11_-_47400062 20.90 ENST00000533030.1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_102323740 20.83 ENST00000398136.2
transmembrane protein 123
chr8_+_74903580 20.83 ENST00000284818.2
ENST00000518893.1
lymphocyte antigen 96
chr21_-_15918618 20.55 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_76829125 20.54 ENST00000248598.5
fibrinogen-like 2
chr11_+_75110530 20.53 ENST00000531188.1
ENST00000530164.1
ENST00000422465.2
ENST00000278572.6
ENST00000534440.1
ENST00000527446.1
ENST00000526608.1
ENST00000527273.1
ENST00000524851.1
ribosomal protein S3
chr2_+_109204743 20.52 ENST00000332345.6
LIM and senescent cell antigen-like domains 1
chr2_-_153574480 20.51 ENST00000410080.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr4_+_103422471 20.44 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_-_185395672 20.40 ENST00000393593.3
interferon regulatory factor 2
chr10_-_27149851 20.39 ENST00000376142.2
ENST00000359188.4
ENST00000376139.2
ENST00000376160.1
abl-interactor 1
chr2_+_182321925 20.35 ENST00000339307.4
ENST00000397033.2
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr1_-_184943610 20.15 ENST00000367511.3
family with sequence similarity 129, member A
chr16_-_21663950 19.97 ENST00000268389.4
immunoglobulin superfamily, member 6
chr16_-_28506840 19.97 ENST00000569430.1
ceroid-lipofuscinosis, neuronal 3
chr12_-_110888103 19.97 ENST00000426440.1
ENST00000228825.7
actin related protein 2/3 complex, subunit 3, 21kDa
chr19_+_42387228 19.72 ENST00000354532.3
ENST00000599846.1
ENST00000347545.4
Rho guanine nucleotide exchange factor (GEF) 1
chr16_+_30205225 19.69 ENST00000345535.4
ENST00000251303.6
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr10_-_43892668 19.68 ENST00000544000.1
heterogeneous nuclear ribonucleoprotein F
chr17_+_72462766 19.50 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300a molecule
chr16_+_67063142 19.49 ENST00000412916.2
core-binding factor, beta subunit
chr10_-_27149904 19.42 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
abl-interactor 1
chr8_-_102217515 19.41 ENST00000520347.1
ENST00000523922.1
ENST00000520984.1
zinc finger protein 706
chr7_+_99971129 19.29 ENST00000394000.2
ENST00000350573.2
paired immunoglobin-like type 2 receptor alpha
chr16_+_29465822 19.23 ENST00000330181.5
ENST00000351581.4
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chrX_+_11777671 19.22 ENST00000380693.3
ENST00000380692.2
male-specific lethal 3 homolog (Drosophila)
chr5_+_35856951 19.19 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr14_+_23340822 19.16 ENST00000359591.4
low density lipoprotein receptor-related protein 10
chr16_+_67063036 19.12 ENST00000290858.6
ENST00000564034.1
core-binding factor, beta subunit
chr16_+_28505955 19.12 ENST00000564831.1
ENST00000328423.5
ENST00000431282.1
apolipoprotein B receptor
chr17_-_34417479 19.00 ENST00000225245.5
chemokine (C-C motif) ligand 3
chr3_-_105588231 18.88 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr4_-_103746924 18.61 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
ubiquitin-conjugating enzyme E2D 3
chr7_+_99971068 18.52 ENST00000198536.2
ENST00000453419.1
paired immunoglobin-like type 2 receptor alpha
chr10_-_27149792 18.07 ENST00000376140.3
ENST00000376170.4
abl-interactor 1
chr10_-_98031310 18.02 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr19_+_48248779 17.99 ENST00000246802.5
glioma tumor suppressor candidate region gene 2
chr9_-_88969303 17.94 ENST00000277141.6
ENST00000375963.3
zinc finger, CCHC domain containing 6
chrX_+_118602363 17.79 ENST00000317881.8
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr8_-_101965559 17.79 ENST00000353245.3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr7_+_50344289 17.66 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKAROS family zinc finger 1 (Ikaros)
chr11_+_1874200 17.64 ENST00000311604.3
lymphocyte-specific protein 1
chr5_-_142783694 17.58 ENST00000394466.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr2_+_202125219 17.51 ENST00000323492.7
caspase 8, apoptosis-related cysteine peptidase
chr12_-_120638902 17.49 ENST00000551150.1
ENST00000313104.5
ENST00000547191.1
ENST00000546989.1
ENST00000392514.4
ENST00000228306.4
ENST00000550856.1
ribosomal protein, large, P0
chr17_-_38721711 17.46 ENST00000578085.1
ENST00000246657.2
chemokine (C-C motif) receptor 7

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
38.3 153.2 GO:0071461 cellular response to redox state(GO:0071461)
29.7 89.0 GO:0070668 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
28.3 141.5 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
24.7 197.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
20.4 101.9 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
19.4 77.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
18.5 55.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
15.9 63.8 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
15.7 47.1 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
15.2 45.5 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
14.7 73.4 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
14.3 57.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
13.7 54.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
12.2 73.0 GO:0000821 regulation of arginine metabolic process(GO:0000821)
12.0 12.0 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
11.7 47.0 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
10.9 54.7 GO:0042631 cellular response to water deprivation(GO:0042631)
10.7 32.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
10.4 124.3 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
10.3 30.9 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
10.2 30.7 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
9.8 49.0 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
9.3 46.4 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
9.1 36.4 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
9.0 36.1 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
8.9 143.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
8.9 35.6 GO:0010796 regulation of multivesicular body size(GO:0010796)
8.8 43.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
8.4 25.3 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
7.8 23.5 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
7.8 147.6 GO:0035855 megakaryocyte development(GO:0035855)
7.7 30.8 GO:0008063 Toll signaling pathway(GO:0008063)
7.3 51.0 GO:0006226 dUMP biosynthetic process(GO:0006226)
7.2 36.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
7.1 21.4 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
7.0 27.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
6.9 76.3 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
6.6 53.1 GO:0044351 macropinocytosis(GO:0044351)
6.5 104.2 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
6.1 127.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
5.8 46.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
5.7 34.3 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
5.6 16.7 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
5.5 22.2 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
5.5 44.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
5.2 25.8 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
5.1 36.0 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
5.1 15.2 GO:0002339 B cell selection(GO:0002339) B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
4.9 34.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
4.9 4.9 GO:0006624 vacuolar protein processing(GO:0006624)
4.9 24.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
4.8 33.6 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
4.6 18.5 GO:0030242 pexophagy(GO:0030242)
4.5 9.1 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
4.4 13.3 GO:0007518 myoblast fate determination(GO:0007518)
4.4 21.8 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
4.4 13.1 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
4.3 30.1 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
4.2 25.4 GO:1904431 positive regulation of t-circle formation(GO:1904431)
4.2 25.2 GO:0016554 cytidine to uridine editing(GO:0016554)
4.2 41.7 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
4.1 12.3 GO:0006597 spermine biosynthetic process(GO:0006597)
4.0 16.1 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
4.0 12.0 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
4.0 55.7 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
3.9 30.8 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
3.8 19.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
3.8 7.7 GO:0010572 positive regulation of platelet activation(GO:0010572)
3.8 19.0 GO:0043307 eosinophil activation(GO:0043307)
3.8 26.5 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
3.8 112.7 GO:0045730 respiratory burst(GO:0045730)
3.8 116.4 GO:0070207 protein homotrimerization(GO:0070207)
3.7 18.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
3.7 22.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.7 69.7 GO:0051014 actin filament severing(GO:0051014)
3.6 3.6 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
3.5 13.9 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
3.4 13.6 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
3.4 26.8 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
3.3 43.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
3.3 19.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
3.2 42.1 GO:0002281 macrophage activation involved in immune response(GO:0002281)
3.1 24.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
3.0 15.2 GO:0071895 odontoblast differentiation(GO:0071895)
3.0 12.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
3.0 17.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
2.9 20.5 GO:0050869 negative regulation of B cell activation(GO:0050869)
2.9 11.5 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
2.9 28.9 GO:0036066 protein O-linked fucosylation(GO:0036066)
2.8 56.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
2.8 8.4 GO:1905224 clathrin-coated pit assembly(GO:1905224)
2.7 40.8 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
2.7 8.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
2.7 38.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
2.7 48.2 GO:0002347 response to tumor cell(GO:0002347)
2.7 5.3 GO:0002384 hepatic immune response(GO:0002384)
2.6 10.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
2.5 10.2 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.5 5.0 GO:0045903 positive regulation of translational fidelity(GO:0045903)
2.5 10.0 GO:0000255 allantoin metabolic process(GO:0000255)
2.5 22.6 GO:0002315 marginal zone B cell differentiation(GO:0002315)
2.4 7.3 GO:1903772 ubiquitin-dependent endocytosis(GO:0070086) regulation of viral budding via host ESCRT complex(GO:1903772) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
2.4 14.6 GO:1903800 regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
2.4 77.8 GO:0060216 definitive hemopoiesis(GO:0060216)
2.4 12.1 GO:0002634 regulation of germinal center formation(GO:0002634)
2.4 9.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
2.4 9.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
2.4 62.1 GO:0010447 response to acidic pH(GO:0010447)
2.3 58.3 GO:0016601 Rac protein signal transduction(GO:0016601)
2.3 18.0 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
2.2 55.4 GO:0043101 purine-containing compound salvage(GO:0043101)
2.2 37.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
2.1 20.9 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
2.0 6.1 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
2.0 5.9 GO:0001928 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
2.0 37.4 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
2.0 3.9 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
1.9 21.4 GO:0061635 regulation of protein complex stability(GO:0061635)
1.9 5.8 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
1.9 42.0 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
1.8 25.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
1.8 24.8 GO:0050930 induction of positive chemotaxis(GO:0050930)
1.8 3.5 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
1.7 10.5 GO:0043316 cytotoxic T cell degranulation(GO:0043316) positive regulation of constitutive secretory pathway(GO:1903435)
1.7 12.1 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
1.7 27.4 GO:0097320 membrane tubulation(GO:0097320)
1.7 23.9 GO:0051683 establishment of Golgi localization(GO:0051683)
1.7 13.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.7 8.5 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
1.7 1.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.7 5.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.7 210.8 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.7 18.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.7 36.4 GO:0008053 mitochondrial fusion(GO:0008053)
1.6 13.1 GO:0035897 proteolysis in other organism(GO:0035897)
1.6 94.5 GO:0045576 mast cell activation(GO:0045576)
1.6 25.6 GO:0071044 histone mRNA catabolic process(GO:0071044)
1.6 236.6 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.6 11.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.5 4.6 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) regulation of telomeric DNA binding(GO:1904742) positive regulation of telomeric DNA binding(GO:1904744)
1.5 4.5 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
1.5 7.4 GO:0072719 cellular response to cisplatin(GO:0072719)
1.5 59.5 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
1.4 19.9 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.4 5.6 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
1.4 13.8 GO:0071763 nuclear membrane organization(GO:0071763)
1.4 6.9 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
1.4 100.1 GO:0002220 innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223)
1.4 31.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.4 12.3 GO:0001887 selenium compound metabolic process(GO:0001887)
1.4 4.1 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957)
1.4 12.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
1.3 34.8 GO:0043984 histone H4-K16 acetylation(GO:0043984)
1.3 9.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
1.3 10.1 GO:0006116 NADH oxidation(GO:0006116)
1.3 13.9 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
1.3 8.8 GO:1902410 mitotic cytokinetic process(GO:1902410)
1.2 17.3 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
1.2 3.7 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
1.2 50.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
1.2 8.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
1.2 3.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.2 13.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
1.2 8.2 GO:0071569 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
1.2 17.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
1.2 7.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
1.2 29.2 GO:0007202 activation of phospholipase C activity(GO:0007202)
1.2 5.8 GO:0006642 triglyceride mobilization(GO:0006642)
1.2 8.1 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
1.1 3.4 GO:0018201 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
1.1 27.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
1.1 19.1 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
1.1 16.8 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
1.1 53.4 GO:0042100 B cell proliferation(GO:0042100)
1.1 7.8 GO:2001138 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
1.1 3.3 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
1.1 7.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.1 6.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.1 88.6 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.1 4.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.1 153.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
1.1 14.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
1.0 12.1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
1.0 5.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
1.0 17.7 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
1.0 10.8 GO:0010815 bradykinin catabolic process(GO:0010815)
1.0 12.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
1.0 5.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.9 12.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.9 28.5 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.9 26.7 GO:0006266 DNA ligation(GO:0006266)
0.9 4.5 GO:0019230 proprioception(GO:0019230)
0.9 11.5 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.9 6.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.9 58.5 GO:0070527 platelet aggregation(GO:0070527)
0.9 2.6 GO:0060613 fat pad development(GO:0060613)
0.8 5.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.8 11.5 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.8 12.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.8 29.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.8 14.6 GO:0016180 snRNA processing(GO:0016180)
0.8 12.0 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.8 1.5 GO:0061056 sclerotome development(GO:0061056)
0.8 12.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.7 95.8 GO:0007338 single fertilization(GO:0007338)
0.7 18.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.7 5.8 GO:0002517 T cell tolerance induction(GO:0002517)
0.7 104.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.7 7.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.7 22.2 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.7 3.5 GO:0021759 globus pallidus development(GO:0021759)
0.7 9.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.7 9.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.7 2.0 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.7 2.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.6 5.2 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.6 21.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.6 6.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.6 35.1 GO:0030183 B cell differentiation(GO:0030183)
0.6 0.6 GO:2000137 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.6 24.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.6 2.8 GO:0051182 coenzyme transport(GO:0051182)
0.6 6.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.6 3.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.5 24.2 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.5 15.5 GO:0006491 N-glycan processing(GO:0006491)
0.5 20.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 4.8 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.5 11.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.5 4.1 GO:0001780 neutrophil homeostasis(GO:0001780)
0.5 15.1 GO:0046039 GTP metabolic process(GO:0046039)
0.5 9.2 GO:0007035 vacuolar acidification(GO:0007035)
0.5 7.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 0.8 GO:0007296 vitellogenesis(GO:0007296)
0.4 4.4 GO:0045116 protein neddylation(GO:0045116)
0.4 2.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.4 1.9 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.4 1.5 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.4 17.6 GO:0006968 cellular defense response(GO:0006968)
0.4 5.5 GO:0017145 stem cell division(GO:0017145)
0.4 78.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.4 7.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.4 1.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.4 2.8 GO:0038203 TORC2 signaling(GO:0038203)
0.3 3.5 GO:0040016 embryonic cleavage(GO:0040016)
0.3 39.5 GO:0034605 cellular response to heat(GO:0034605)
0.3 11.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 2.5 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.3 6.4 GO:0003334 keratinocyte development(GO:0003334)
0.3 5.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.3 43.2 GO:0006338 chromatin remodeling(GO:0006338)
0.3 5.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 1.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 2.6 GO:0034508 centromere complex assembly(GO:0034508)
0.3 0.3 GO:0045416 positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.3 17.7 GO:0030218 erythrocyte differentiation(GO:0030218)
0.3 20.4 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.3 9.3 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.3 8.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.3 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.3 20.2 GO:0045727 positive regulation of translation(GO:0045727)
0.2 4.2 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 4.0 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 4.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 9.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.2 4.4 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 17.7 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 1.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 8.4 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 0.8 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.2 8.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.2 4.7 GO:0006298 mismatch repair(GO:0006298)
0.2 6.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 4.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.2 2.3 GO:0060117 auditory receptor cell development(GO:0060117)
0.2 7.1 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.2 2.1 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.2 11.8 GO:0042113 B cell activation(GO:0042113)
0.2 0.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 1.9 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.2 3.5 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.2 2.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 0.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 1.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 23.0 GO:0002576 platelet degranulation(GO:0002576)
0.2 1.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 9.2 GO:0048678 response to axon injury(GO:0048678)
0.2 40.6 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.2 6.1 GO:0016266 O-glycan processing(GO:0016266)
0.1 8.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.7 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 3.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 5.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 1.6 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 0.3 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.1 2.1 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 1.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 3.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.6 GO:0097480 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.1 1.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.0 GO:0042108 positive regulation of cytokine biosynthetic process(GO:0042108)
0.1 0.4 GO:0032048 cardiolipin metabolic process(GO:0032048) cardiolipin acyl-chain remodeling(GO:0035965)
0.1 0.7 GO:0036507 protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) endoplasmic reticulum mannose trimming(GO:1904380)
0.1 0.2 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 1.6 GO:0032456 endocytic recycling(GO:0032456)
0.1 0.9 GO:0010659 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659)
0.1 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 1.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 10.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.0 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 2.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 2.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.5 GO:0048278 vesicle docking(GO:0048278)
0.0 0.6 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.2 GO:0055078 sodium ion homeostasis(GO:0055078)
0.0 1.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 2.1 GO:0001503 ossification(GO:0001503)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 1.1 GO:0008033 tRNA processing(GO:0008033)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
21.5 236.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
19.4 155.2 GO:0032010 phagolysosome(GO:0032010)
17.8 89.0 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
15.9 63.8 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
15.3 92.0 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
14.5 116.2 GO:1990111 spermatoproteasome complex(GO:1990111)
11.1 55.4 GO:0036398 TCR signalosome(GO:0036398)
9.6 19.1 GO:0042627 chylomicron(GO:0042627)
9.2 55.4 GO:1902560 GMP reductase complex(GO:1902560)
9.0 125.9 GO:0031209 SCAR complex(GO:0031209)
8.2 164.3 GO:0001891 phagocytic cup(GO:0001891)
7.8 102.0 GO:0043020 NADPH oxidase complex(GO:0043020)
7.1 49.6 GO:0036021 endolysosome lumen(GO:0036021)
6.9 27.5 GO:0097422 tubular endosome(GO:0097422)
6.8 20.5 GO:0071159 NF-kappaB complex(GO:0071159)
6.4 31.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
6.1 6.1 GO:1902911 serine/threonine protein kinase complex(GO:1902554) protein kinase complex(GO:1902911)
5.7 34.3 GO:0071817 MMXD complex(GO:0071817)
5.6 22.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
5.4 26.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
5.3 37.1 GO:0019815 B cell receptor complex(GO:0019815)
5.0 95.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
5.0 50.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
5.0 34.8 GO:0072487 MSL complex(GO:0072487)
4.2 12.5 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
4.1 69.7 GO:0032059 bleb(GO:0032059)
4.1 52.7 GO:0097433 dense body(GO:0097433)
4.0 216.8 GO:0001772 immunological synapse(GO:0001772)
3.9 42.6 GO:0031010 ISWI-type complex(GO:0031010)
3.8 15.2 GO:0030905 retromer, tubulation complex(GO:0030905)
3.8 11.4 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
3.7 22.4 GO:0008537 proteasome activator complex(GO:0008537)
3.6 32.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
3.3 10.0 GO:0070195 growth hormone receptor complex(GO:0070195)
3.3 49.8 GO:0008290 F-actin capping protein complex(GO:0008290)
3.2 16.1 GO:0042643 actomyosin, actin portion(GO:0042643)
3.1 12.2 GO:0005687 U4 snRNP(GO:0005687)
3.0 21.0 GO:0044194 cytolytic granule(GO:0044194)
2.9 46.9 GO:0016461 unconventional myosin complex(GO:0016461)
2.8 22.6 GO:0042382 paraspeckles(GO:0042382)
2.8 22.5 GO:0097504 Gemini of coiled bodies(GO:0097504)
2.5 44.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
2.5 9.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.2 32.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
2.2 13.1 GO:1990037 Lewy body core(GO:1990037)
2.2 167.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
2.1 29.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
2.0 13.9 GO:0030870 Mre11 complex(GO:0030870)
1.9 13.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.9 13.3 GO:0016272 prefoldin complex(GO:0016272)
1.9 13.3 GO:0070765 gamma-secretase complex(GO:0070765)
1.9 7.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
1.8 10.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.7 55.0 GO:0005685 U1 snRNP(GO:0005685)
1.6 8.2 GO:0000125 PCAF complex(GO:0000125)
1.6 14.6 GO:0032039 integrator complex(GO:0032039)
1.6 4.8 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
1.6 1.6 GO:0034719 SMN-Sm protein complex(GO:0034719)
1.6 11.0 GO:0097452 GAIT complex(GO:0097452)
1.5 132.6 GO:0035580 specific granule lumen(GO:0035580)
1.5 4.5 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
1.4 5.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.4 15.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.4 6.9 GO:0032021 NELF complex(GO:0032021)
1.4 8.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
1.3 94.3 GO:0035577 azurophil granule membrane(GO:0035577)
1.3 5.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.3 5.3 GO:0032044 DSIF complex(GO:0032044)
1.2 8.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.2 16.1 GO:0005577 fibrinogen complex(GO:0005577)
1.2 45.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
1.2 5.9 GO:0033263 CORVET complex(GO:0033263)
1.2 15.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.1 11.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.1 7.6 GO:0017119 Golgi transport complex(GO:0017119)
1.1 45.2 GO:0002102 podosome(GO:0002102)
1.1 15.1 GO:0042588 zymogen granule(GO:0042588)
1.1 8.4 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.0 7.3 GO:0000813 ESCRT I complex(GO:0000813)
1.0 113.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 5.0 GO:0034457 Mpp10 complex(GO:0034457)
1.0 17.5 GO:0097342 ripoptosome(GO:0097342)
1.0 11.6 GO:0030008 TRAPP complex(GO:0030008)
1.0 4.8 GO:0032009 early phagosome(GO:0032009)
1.0 5.7 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.9 12.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.9 9.3 GO:0005916 fascia adherens(GO:0005916)
0.9 3.6 GO:0055087 Ski complex(GO:0055087)
0.9 274.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.9 7.0 GO:0035976 AP1 complex(GO:0035976)
0.9 7.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.8 5.0 GO:1990130 Iml1 complex(GO:1990130)
0.8 5.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.8 112.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 5.7 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.8 6.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.8 4.8 GO:0000322 storage vacuole(GO:0000322)
0.8 2.4 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.8 2.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.7 12.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.7 69.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.7 12.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 5.6 GO:0071439 clathrin complex(GO:0071439)
0.7 50.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 8.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.7 34.3 GO:0043198 dendritic shaft(GO:0043198)
0.7 53.9 GO:0034707 chloride channel complex(GO:0034707)
0.7 97.8 GO:0005795 Golgi stack(GO:0005795)
0.7 6.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 1.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 100.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 34.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.6 18.7 GO:0000793 condensed chromosome(GO:0000793)
0.5 21.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.5 18.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 11.5 GO:0031105 septin complex(GO:0031105)
0.5 14.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.5 28.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 2.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.5 12.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 7.7 GO:0036452 ESCRT complex(GO:0036452)
0.4 10.8 GO:0071564 npBAF complex(GO:0071564)
0.4 1.7 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.4 27.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 9.0 GO:0031201 SNARE complex(GO:0031201)
0.4 4.0 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.4 6.2 GO:0097225 sperm midpiece(GO:0097225)
0.4 34.2 GO:0005884 actin filament(GO:0005884)
0.4 2.1 GO:0035371 microtubule plus-end(GO:0035371)
0.3 29.2 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.3 2.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 122.8 GO:0016607 nuclear speck(GO:0016607)
0.3 6.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 53.4 GO:0030667 secretory granule membrane(GO:0030667)
0.3 3.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 22.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 2.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.3 5.1 GO:0000242 pericentriolar material(GO:0000242)
0.3 13.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 7.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 3.2 GO:0032433 filopodium tip(GO:0032433)
0.3 22.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 145.6 GO:0000139 Golgi membrane(GO:0000139)
0.2 30.9 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.2 6.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 10.6 GO:0005902 microvillus(GO:0005902)
0.2 22.9 GO:0016605 PML body(GO:0016605)
0.2 52.0 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 4.5 GO:0000421 autophagosome membrane(GO:0000421)
0.2 2.8 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.2 3.2 GO:0000145 exocyst(GO:0000145)
0.2 4.3 GO:0005770 late endosome(GO:0005770)
0.2 17.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 9.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 4.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.3 GO:0032420 stereocilium(GO:0032420)
0.2 0.6 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.1 GO:0070187 telosome(GO:0070187)
0.1 8.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 9.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.7 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 548.0 GO:0005829 cytosol(GO:0005829)
0.1 4.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.1 8.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 5.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.8 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 4.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0031093 platelet alpha granule lumen(GO:0031093)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
18.5 55.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
16.3 49.0 GO:0031859 platelet activating factor receptor binding(GO:0031859)
15.3 153.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
13.9 41.8 GO:0004917 interleukin-7 receptor activity(GO:0004917)
13.8 96.6 GO:0043208 glycosphingolipid binding(GO:0043208)
13.3 133.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
13.1 92.0 GO:0030369 ICAM-3 receptor activity(GO:0030369)
12.8 76.6 GO:0042610 CD8 receptor binding(GO:0042610)
12.7 51.0 GO:0004132 dCMP deaminase activity(GO:0004132)
10.9 32.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
10.7 74.9 GO:0042608 T cell receptor binding(GO:0042608)
10.4 31.2 GO:0001069 regulatory region RNA binding(GO:0001069)
9.2 55.4 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
9.2 27.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
8.4 25.3 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
8.1 146.4 GO:0005522 profilin binding(GO:0005522)
7.8 211.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
7.1 21.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
7.1 77.7 GO:0051525 NFAT protein binding(GO:0051525)
6.6 19.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
6.6 26.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
6.6 19.7 GO:0017108 5'-flap endonuclease activity(GO:0017108)
6.4 25.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
6.3 38.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
6.3 69.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
6.0 102.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
5.4 26.8 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
5.1 56.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
4.5 67.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
4.1 57.9 GO:0030957 Tat protein binding(GO:0030957)
4.1 12.3 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
3.9 116.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
3.8 15.3 GO:0019770 IgG receptor activity(GO:0019770)
3.8 11.4 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
3.8 19.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
3.7 56.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
3.7 118.5 GO:0070064 proline-rich region binding(GO:0070064)
3.7 22.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
3.5 28.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
3.5 17.5 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
3.4 6.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
3.4 43.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
3.2 22.4 GO:0061133 endopeptidase activator activity(GO:0061133)
3.0 15.2 GO:1990460 leptin receptor binding(GO:1990460)
3.0 57.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
2.9 132.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
2.9 23.5 GO:0016842 amidine-lyase activity(GO:0016842)
2.9 8.8