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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SPI1

Z-value: 3.78

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Transcription factors associated with SPI1

Gene Symbol Gene ID Gene Info
ENSG00000066336.7 Spi-1 proto-oncogene

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPI1hg19_v2_chr11_-_47400078_47400127,
hg19_v2_chr11_-_47399942_47399961
0.591.3e-21Click!

Activity profile of SPI1 motif

Sorted Z-values of SPI1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_198608146 141.46 ENST00000367376.2
ENST00000352140.3
ENST00000594404.1
ENST00000598951.1
ENST00000530727.1
ENST00000442510.2
ENST00000367367.4
ENST00000348564.6
ENST00000367364.1
ENST00000413409.2
protein tyrosine phosphatase, receptor type, C
chr13_-_46756351 99.44 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr3_-_121379739 86.66 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr12_-_15114603 79.79 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr12_-_15114492 73.40 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr6_-_32811771 64.75 ENST00000395339.3
ENST00000374882.3
proteasome (prosome, macropain) subunit, beta type, 8
chr6_-_32160622 60.33 ENST00000487761.1
ENST00000375040.3
G-protein signaling modulator 3
chr1_-_167487808 58.48 ENST00000392122.3
CD247 molecule
chr2_+_69001913 57.98 ENST00000409030.3
ENST00000409220.1
Rho GTPase activating protein 25
chr1_-_167487758 57.94 ENST00000362089.5
CD247 molecule
chr12_+_54891495 57.08 ENST00000293373.6
NCK-associated protein 1-like
chr1_-_183560011 56.31 ENST00000367536.1
neutrophil cytosolic factor 2
chr11_-_58343319 55.98 ENST00000395074.2
leupaxin
chr2_+_233925064 55.62 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr5_-_169725231 55.37 ENST00000046794.5
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
chr11_-_3862206 54.92 ENST00000351018.4
ras homolog family member G
chr6_+_31553901 53.38 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr5_+_169064245 53.06 ENST00000256935.8
dedicator of cytokinesis 2
chr7_-_5569588 52.67 ENST00000417101.1
actin, beta
chr19_+_49838653 51.63 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr6_+_32811885 51.40 ENST00000458296.1
ENST00000413039.1
ENST00000429600.1
ENST00000412095.1
ENST00000415067.1
ENST00000395330.1
TAP1 and PSMB8 antisense RNA 1
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_62084241 50.05 ENST00000449662.2
intercellular adhesion molecule 2
chr1_-_150738261 49.57 ENST00000448301.2
ENST00000368985.3
cathepsin S
chr11_+_128563652 49.48 ENST00000527786.2
Fli-1 proto-oncogene, ETS transcription factor
chr12_+_7055767 49.38 ENST00000447931.2
protein tyrosine phosphatase, non-receptor type 6
chr12_-_118797475 49.24 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
TAO kinase 3
chr6_-_31704282 49.24 ENST00000375784.3
ENST00000375779.2
chloride intracellular channel 1
chr17_+_4618734 49.01 ENST00000571206.1
arrestin, beta 2
chr12_+_7055631 48.85 ENST00000543115.1
ENST00000399448.1
protein tyrosine phosphatase, non-receptor type 6
chr8_+_56792355 48.60 ENST00000519728.1
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr19_-_10450328 48.50 ENST00000160262.5
intercellular adhesion molecule 3
chr19_-_10450287 47.83 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr6_+_31553978 47.52 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr1_-_207095324 47.39 ENST00000530505.1
ENST00000367091.3
ENST00000442471.2
Fas apoptotic inhibitory molecule 3
chr2_+_85804614 47.09 ENST00000263864.5
ENST00000409760.1
vesicle-associated membrane protein 8
chr19_-_8642289 46.89 ENST00000596675.1
ENST00000338257.8
myosin IF
chr1_+_111415757 46.83 ENST00000429072.2
ENST00000271324.5
CD53 molecule
chr2_-_175499294 46.54 ENST00000392547.2
WAS/WASL interacting protein family, member 1
chr1_-_183559693 46.23 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
neutrophil cytosolic factor 2
chr1_-_25256368 44.01 ENST00000308873.6
runt-related transcription factor 3
chr22_-_37640277 43.68 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr6_-_42016385 43.26 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
cyclin D3
chr12_-_92539614 43.16 ENST00000256015.3
B-cell translocation gene 1, anti-proliferative
chr16_-_88717423 42.81 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
cytochrome b-245, alpha polypeptide
chr14_-_35344093 42.63 ENST00000382422.2
bromodomain adjacent to zinc finger domain, 1A
chr22_+_37678424 42.41 ENST00000248901.6
cytohesin 4
chr19_-_36399149 42.13 ENST00000585901.2
ENST00000544690.2
ENST00000424586.3
ENST00000262629.4
ENST00000589517.1
TYRO protein tyrosine kinase binding protein
chr15_+_75074410 40.99 ENST00000439220.2
c-src tyrosine kinase
chr8_+_56792377 40.37 ENST00000520220.2
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
chr2_+_143886877 39.57 ENST00000295095.6
Rho GTPase activating protein 15
chr17_+_43299241 38.91 ENST00000328118.3
formin-like 1
chrX_+_128913906 38.58 ENST00000356892.3
SAM and SH3 domain containing 3
chr19_+_1077393 38.37 ENST00000590577.1
histocompatibility (minor) HA-1
chr16_-_88717482 38.02 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr14_-_23451467 37.53 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
ajuba LIM protein
chr14_-_23285011 36.97 ENST00000397532.3
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr21_-_46340770 36.36 ENST00000397854.3
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr14_-_23285069 35.99 ENST00000554758.1
ENST00000397528.4
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr12_+_25205666 35.82 ENST00000547044.1
lymphoid-restricted membrane protein
chr12_+_25205568 35.44 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr2_+_68961934 34.32 ENST00000409202.3
Rho GTPase activating protein 25
chr2_+_68961905 34.08 ENST00000295381.3
Rho GTPase activating protein 25
chr11_+_60223225 33.77 ENST00000524807.1
ENST00000345732.4
membrane-spanning 4-domains, subfamily A, member 1
chr11_-_72432950 33.41 ENST00000426523.1
ENST00000429686.1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr1_-_31230650 32.96 ENST00000294507.3
lysosomal protein transmembrane 5
chr22_-_37640456 32.63 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr2_-_235405168 32.46 ENST00000339728.3
ADP-ribosylation factor-like 4C
chr15_+_75074385 32.39 ENST00000220003.9
c-src tyrosine kinase
chr11_+_60223312 32.38 ENST00000532491.1
ENST00000532073.1
ENST00000534668.1
ENST00000528313.1
ENST00000533306.1
membrane-spanning 4-domains, subfamily A, member 1
chr17_-_29641104 32.25 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr9_-_137809718 31.81 ENST00000371806.3
ficolin (collagen/fibrinogen domain containing) 1
chr2_+_109204909 31.73 ENST00000393310.1
LIM and senescent cell antigen-like domains 1
chr3_+_151986709 31.19 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr11_-_47399942 30.95 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_-_131826457 30.91 ENST00000437654.1
ENST00000245414.4
interferon regulatory factor 1
chr8_+_22438009 30.87 ENST00000409417.1
PDZ and LIM domain 2 (mystique)
chr17_+_43299156 30.80 ENST00000331495.3
formin-like 1
chr2_-_64371546 30.77 ENST00000358912.4
pellino E3 ubiquitin protein ligase 1
chr15_-_80263506 30.65 ENST00000335661.6
BCL2-related protein A1
chr1_+_145439306 30.50 ENST00000425134.1
thioredoxin interacting protein
chr3_-_16555150 30.14 ENST00000334133.4
raftlin, lipid raft linker 1
chr1_+_9711781 30.07 ENST00000536656.1
ENST00000377346.4
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
chr11_+_65407331 29.91 ENST00000527525.1
signal-induced proliferation-associated 1
chr7_+_98972298 29.80 ENST00000252725.5
actin related protein 2/3 complex, subunit 1B, 41kDa
chr16_+_30484021 29.62 ENST00000358164.5
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr12_+_25205446 29.31 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr2_-_85637459 29.05 ENST00000409921.1
capping protein (actin filament), gelsolin-like
chr7_-_115670804 28.99 ENST00000320239.7
transcription factor EC
chr6_+_31554826 28.97 ENST00000376089.2
ENST00000396112.2
leukocyte specific transcript 1
chrX_-_47489244 28.86 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr19_-_47220335 28.53 ENST00000601806.1
ENST00000593363.1
ENST00000598633.1
ENST00000595515.1
ENST00000433867.1
protein kinase D2
chr9_+_77703414 28.50 ENST00000346234.6
osteoclast stimulating factor 1
chr15_+_77287426 28.10 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr7_-_115670792 28.02 ENST00000265440.7
ENST00000393485.1
transcription factor EC
chr3_-_185641681 27.85 ENST00000259043.7
transformer 2 beta homolog (Drosophila)
chr1_+_32716840 27.51 ENST00000336890.5
lymphocyte-specific protein tyrosine kinase
chr2_-_96811170 27.50 ENST00000288943.4
dual specificity phosphatase 2
chr12_-_51718436 27.41 ENST00000544402.1
bridging integrator 2
chr12_+_53848549 27.28 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
poly(rC) binding protein 2
chr1_-_207095212 26.89 ENST00000420007.2
Fas apoptotic inhibitory molecule 3
chr22_+_37257015 26.64 ENST00000447071.1
ENST00000248899.6
ENST00000397147.4
neutrophil cytosolic factor 4, 40kDa
chr16_-_21663919 26.37 ENST00000569602.1
immunoglobulin superfamily, member 6
chr4_+_103423055 26.33 ENST00000505458.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr1_+_32739733 26.24 ENST00000333070.4
lymphocyte-specific protein tyrosine kinase
chr7_+_74188309 26.04 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr16_+_30483962 26.04 ENST00000356798.6
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr11_-_47400078 25.86 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_+_31582961 25.85 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr8_+_22437965 25.69 ENST00000409141.1
ENST00000265810.4
PDZ and LIM domain 2 (mystique)
chr1_-_159894319 25.61 ENST00000320307.4
transgelin 2
chr17_+_7461781 25.36 ENST00000349228.4
tumor necrosis factor (ligand) superfamily, member 13
chr15_-_40600026 25.26 ENST00000456256.2
ENST00000557821.1
phospholipase C, beta 2
chr4_-_40631859 25.23 ENST00000295971.7
ENST00000319592.4
RNA binding motif protein 47
chr1_-_111743285 25.13 ENST00000357640.4
DENN/MADD domain containing 2D
chr14_-_24616426 24.84 ENST00000216802.5
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
chr11_+_65408273 24.81 ENST00000394227.3
signal-induced proliferation-associated 1
chr15_+_81589254 24.81 ENST00000394652.2
interleukin 16
chr1_-_159893507 24.70 ENST00000368096.1
transgelin 2
chr4_-_174255536 24.49 ENST00000446922.2
high mobility group box 2
chr17_+_7461580 24.44 ENST00000483039.1
ENST00000396542.1
tumor necrosis factor (ligand) superfamily, member 13
chr16_-_89043377 24.34 ENST00000436887.2
ENST00000448839.1
ENST00000360302.2
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr8_-_134072593 24.30 ENST00000427060.2
Src-like-adaptor
chr17_+_72462525 24.11 ENST00000360141.3
CD300a molecule
chr17_-_20370847 24.10 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr11_+_128563948 23.67 ENST00000534087.2
Fli-1 proto-oncogene, ETS transcription factor
chr2_+_161993412 23.60 ENST00000259075.2
ENST00000432002.1
TRAF family member-associated NFKB activator
chr17_+_7461613 23.52 ENST00000438470.1
ENST00000436057.1
tumor necrosis factor (ligand) superfamily, member 13
chr19_+_41768401 23.25 ENST00000352456.3
ENST00000595018.1
ENST00000597725.1
heterogeneous nuclear ribonucleoprotein U-like 1
chr19_+_42381173 23.11 ENST00000221972.3
CD79a molecule, immunoglobulin-associated alpha
chr14_+_102276209 22.96 ENST00000445439.3
ENST00000334743.5
ENST00000557095.1
protein phosphatase 2, regulatory subunit B', gamma
chr1_+_32716857 22.80 ENST00000482949.1
ENST00000495610.2
lymphocyte-specific protein tyrosine kinase
chr2_+_65454926 22.77 ENST00000542850.1
ENST00000377982.4
ARP2 actin-related protein 2 homolog (yeast)
chr2_+_65454863 22.77 ENST00000260641.5
ARP2 actin-related protein 2 homolog (yeast)
chrX_-_70331298 22.60 ENST00000456850.2
ENST00000473378.1
ENST00000487883.1
ENST00000374202.2
interleukin 2 receptor, gamma
chr17_+_7461849 22.58 ENST00000338784.4
tumor necrosis factor (ligand) superfamily, member 13
chr11_-_67120974 22.45 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr8_-_102216925 22.33 ENST00000517844.1
zinc finger protein 706
chr6_+_89790490 22.26 ENST00000336032.3
proline-rich nuclear receptor coactivator 1
chr3_-_18480260 22.03 ENST00000454909.2
SATB homeobox 1
chr12_-_53601055 21.96 ENST00000552972.1
ENST00000422257.3
ENST00000267082.5
integrin, beta 7
chr6_+_89790459 21.89 ENST00000369472.1
proline-rich nuclear receptor coactivator 1
chr4_-_103746683 21.86 ENST00000504211.1
ENST00000508476.1
ubiquitin-conjugating enzyme E2D 3
chr4_-_103747011 21.82 ENST00000350435.7
ubiquitin-conjugating enzyme E2D 3
chr16_-_89043605 21.75 ENST00000268679.4
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr19_+_6772710 21.70 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
vav 1 guanine nucleotide exchange factor
chrX_-_107018969 21.59 ENST00000372383.4
TSC22 domain family, member 3
chr12_-_53601000 21.46 ENST00000338737.4
ENST00000549086.2
integrin, beta 7
chr1_+_153330322 21.38 ENST00000368738.3
S100 calcium binding protein A9
chr11_-_72433346 21.35 ENST00000334211.8
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chrX_-_154688276 21.27 ENST00000369445.2
coagulation factor VIII-associated 3
chrX_+_154114635 21.03 ENST00000369446.2
coagulation factor VIII-associated 1
chr10_-_72362515 21.01 ENST00000373209.2
ENST00000441259.1
perforin 1 (pore forming protein)
chr2_-_153573887 21.01 ENST00000493468.2
ENST00000545856.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chrX_+_48542168 20.94 ENST00000376701.4
Wiskott-Aldrich syndrome
chr11_-_47400062 20.90 ENST00000533030.1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_102323740 20.83 ENST00000398136.2
transmembrane protein 123
chr8_+_74903580 20.83 ENST00000284818.2
ENST00000518893.1
lymphocyte antigen 96
chr21_-_15918618 20.55 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr7_-_76829125 20.54 ENST00000248598.5
fibrinogen-like 2
chr11_+_75110530 20.53 ENST00000531188.1
ENST00000530164.1
ENST00000422465.2
ENST00000278572.6
ENST00000534440.1
ENST00000527446.1
ENST00000526608.1
ENST00000527273.1
ENST00000524851.1
ribosomal protein S3
chr2_+_109204743 20.52 ENST00000332345.6
LIM and senescent cell antigen-like domains 1
chr2_-_153574480 20.51 ENST00000410080.1
PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr4_+_103422471 20.44 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr4_-_185395672 20.40 ENST00000393593.3
interferon regulatory factor 2
chr10_-_27149851 20.39 ENST00000376142.2
ENST00000359188.4
ENST00000376139.2
ENST00000376160.1
abl-interactor 1
chr2_+_182321925 20.35 ENST00000339307.4
ENST00000397033.2
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr1_-_184943610 20.15 ENST00000367511.3
family with sequence similarity 129, member A
chr16_-_21663950 19.97 ENST00000268389.4
immunoglobulin superfamily, member 6
chr16_-_28506840 19.97 ENST00000569430.1
ceroid-lipofuscinosis, neuronal 3
chr12_-_110888103 19.97 ENST00000426440.1
ENST00000228825.7
actin related protein 2/3 complex, subunit 3, 21kDa
chr19_+_42387228 19.72 ENST00000354532.3
ENST00000599846.1
ENST00000347545.4
Rho guanine nucleotide exchange factor (GEF) 1
chr16_+_30205225 19.69 ENST00000345535.4
ENST00000251303.6
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr10_-_43892668 19.68 ENST00000544000.1
heterogeneous nuclear ribonucleoprotein F
chr17_+_72462766 19.50 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300a molecule
chr16_+_67063142 19.49 ENST00000412916.2
core-binding factor, beta subunit
chr10_-_27149904 19.42 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
abl-interactor 1
chr8_-_102217515 19.41 ENST00000520347.1
ENST00000523922.1
ENST00000520984.1
zinc finger protein 706
chr7_+_99971129 19.29 ENST00000394000.2
ENST00000350573.2
paired immunoglobin-like type 2 receptor alpha
chr16_+_29465822 19.23 ENST00000330181.5
ENST00000351581.4
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chrX_+_11777671 19.22 ENST00000380693.3
ENST00000380692.2
male-specific lethal 3 homolog (Drosophila)
chr5_+_35856951 19.19 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr14_+_23340822 19.16 ENST00000359591.4
low density lipoprotein receptor-related protein 10
chr16_+_67063036 19.12 ENST00000290858.6
ENST00000564034.1
core-binding factor, beta subunit
chr16_+_28505955 19.12 ENST00000564831.1
ENST00000328423.5
ENST00000431282.1
apolipoprotein B receptor
chr17_-_34417479 19.00 ENST00000225245.5
chemokine (C-C motif) ligand 3
chr3_-_105588231 18.88 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
Cbl proto-oncogene B, E3 ubiquitin protein ligase
chr4_-_103746924 18.61 ENST00000505207.1
ENST00000502404.1
ENST00000507845.1
ubiquitin-conjugating enzyme E2D 3
chr7_+_99971068 18.52 ENST00000198536.2
ENST00000453419.1
paired immunoglobin-like type 2 receptor alpha
chr10_-_27149792 18.07 ENST00000376140.3
ENST00000376170.4
abl-interactor 1
chr10_-_98031310 18.02 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr19_+_48248779 17.99 ENST00000246802.5
glioma tumor suppressor candidate region gene 2
chr9_-_88969303 17.94 ENST00000277141.6
ENST00000375963.3
zinc finger, CCHC domain containing 6
chrX_+_118602363 17.79 ENST00000317881.8
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr8_-_101965559 17.79 ENST00000353245.3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr7_+_50344289 17.66 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKAROS family zinc finger 1 (Ikaros)
chr11_+_1874200 17.64 ENST00000311604.3
lymphocyte-specific protein 1
chr5_-_142783694 17.58 ENST00000394466.2
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr2_+_202125219 17.51 ENST00000323492.7
caspase 8, apoptosis-related cysteine peptidase
chr12_-_120638902 17.49 ENST00000551150.1
ENST00000313104.5
ENST00000547191.1
ENST00000546989.1
ENST00000392514.4
ENST00000228306.4
ENST00000550856.1
ribosomal protein, large, P0
chr17_-_38721711 17.46 ENST00000578085.1
ENST00000246657.2
chemokine (C-C motif) receptor 7

Network of associatons between targets according to the STRING database.

First level regulatory network of SPI1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
38.3 153.2 GO:0071461 cellular response to redox state(GO:0071461)
29.7 89.0 GO:0070668 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
28.3 141.5 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) bone marrow development(GO:0048539)
24.7 197.8 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
20.4 101.9 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
19.4 77.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
18.5 55.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
15.9 63.8 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
15.7 47.1 GO:1903595 positive regulation of histamine secretion by mast cell(GO:1903595)
15.2 45.5 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
14.7 73.4 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
14.3 57.1 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
13.7 54.8 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
12.2 73.0 GO:0000821 regulation of arginine metabolic process(GO:0000821)
12.0 12.0 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
11.7 47.0 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
10.9 54.7 GO:0042631 cellular response to water deprivation(GO:0042631)
10.7 32.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
10.4 124.3 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
10.3 30.9 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
10.2 30.7 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
9.8 49.0 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
9.3 46.4 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
9.1 36.4 GO:2000538 regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
9.0 36.1 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
8.9 143.1 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
8.9 35.6 GO:0010796 regulation of multivesicular body size(GO:0010796)
8.8 43.9 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
8.4 25.3 GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
7.8 23.5 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
7.8 147.6 GO:0035855 megakaryocyte development(GO:0035855)
7.7 30.8 GO:0008063 Toll signaling pathway(GO:0008063)
7.3 51.0 GO:0006226 dUMP biosynthetic process(GO:0006226)
7.2 36.0 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
7.1 21.4 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
7.0 27.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
6.9 76.3 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
6.6 53.1 GO:0044351 macropinocytosis(GO:0044351)
6.5 104.2 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
6.1 127.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
5.8 46.1 GO:1903715 regulation of aerobic respiration(GO:1903715)
5.7 34.3 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
5.6 16.7 GO:0052250 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
5.5 22.2 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
5.5 44.1 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
5.2 25.8 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
5.1 36.0 GO:0002349 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
5.1 15.2 GO:0002339 B cell selection(GO:0002339) B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
4.9 34.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
4.9 4.9 GO:0006624 vacuolar protein processing(GO:0006624)
4.9 24.4 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
4.8 33.6 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
4.6 18.5 GO:0030242 pexophagy(GO:0030242)
4.5 9.1 GO:0033029 regulation of neutrophil apoptotic process(GO:0033029)
4.4 13.3 GO:0007518 myoblast fate determination(GO:0007518)
4.4 21.8 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
4.4 13.1 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
4.3 30.1 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
4.2 25.4 GO:1904431 positive regulation of t-circle formation(GO:1904431)
4.2 25.2 GO:0016554 cytidine to uridine editing(GO:0016554)
4.2 41.7 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
4.1 12.3 GO:0006597 spermine biosynthetic process(GO:0006597)
4.0 16.1 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
4.0 12.0 GO:1903676 regulation of cap-dependent translational initiation(GO:1903674) positive regulation of cap-dependent translational initiation(GO:1903676)
4.0 55.7 GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
3.9 30.8 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
3.8 19.2 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
3.8 7.7 GO:0010572 positive regulation of platelet activation(GO:0010572)
3.8 19.0 GO:0043307 eosinophil activation(GO:0043307)
3.8 26.5 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
3.8 112.7 GO:0045730 respiratory burst(GO:0045730)
3.8 116.4 GO:0070207 protein homotrimerization(GO:0070207)
3.7 18.4 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
3.7 22.0 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.7 69.7 GO:0051014 actin filament severing(GO:0051014)
3.6 3.6 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
3.5 13.9 GO:1902044 regulation of Fas signaling pathway(GO:1902044)
3.4 13.6 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
3.4 26.8 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
3.3 43.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
3.3 19.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
3.2 42.1 GO:0002281 macrophage activation involved in immune response(GO:0002281)
3.1 24.5 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
3.0 15.2 GO:0071895 odontoblast differentiation(GO:0071895)
3.0 12.0 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
3.0 17.8 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
2.9 20.5 GO:0050869 negative regulation of B cell activation(GO:0050869)
2.9 11.5 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
2.9 28.9 GO:0036066 protein O-linked fucosylation(GO:0036066)
2.8 56.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
2.8 8.4 GO:1905224 clathrin-coated pit assembly(GO:1905224)
2.7 40.8 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
2.7 8.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076) positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
2.7 38.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
2.7 48.2 GO:0002347 response to tumor cell(GO:0002347)
2.7 5.3 GO:0002384 hepatic immune response(GO:0002384)
2.6 10.3 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
2.5 10.2 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
2.5 5.0 GO:0045903 positive regulation of translational fidelity(GO:0045903)
2.5 10.0 GO:0000255 allantoin metabolic process(GO:0000255)
2.5 22.6 GO:0002315 marginal zone B cell differentiation(GO:0002315)
2.4 7.3 GO:1903772 ubiquitin-dependent endocytosis(GO:0070086) regulation of viral budding via host ESCRT complex(GO:1903772) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
2.4 14.6 GO:1903800 regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
2.4 77.8 GO:0060216 definitive hemopoiesis(GO:0060216)
2.4 12.1 GO:0002634 regulation of germinal center formation(GO:0002634)
2.4 9.6 GO:0071802 negative regulation of podosome assembly(GO:0071802)
2.4 9.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
2.4 62.1 GO:0010447 response to acidic pH(GO:0010447)
2.3 58.3 GO:0016601 Rac protein signal transduction(GO:0016601)
2.3 18.0 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
2.2 55.4 GO:0043101 purine-containing compound salvage(GO:0043101)
2.2 37.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
2.1 20.9 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
2.0 6.1 GO:2000017 positive regulation of determination of dorsal identity(GO:2000017)
2.0 5.9 GO:0001928 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
2.0 37.4 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
2.0 3.9 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
1.9 21.4 GO:0061635 regulation of protein complex stability(GO:0061635)
1.9 5.8 GO:0034184 positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
1.9 42.0 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
1.8 25.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
1.8 24.8 GO:0050930 induction of positive chemotaxis(GO:0050930)
1.8 3.5 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030947)
1.7 10.5 GO:0043316 cytotoxic T cell degranulation(GO:0043316) positive regulation of constitutive secretory pathway(GO:1903435)
1.7 12.1 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
1.7 27.4 GO:0097320 membrane tubulation(GO:0097320)
1.7 23.9 GO:0051683 establishment of Golgi localization(GO:0051683)
1.7 13.7 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
1.7 8.5 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) positive regulation of IRE1-mediated unfolded protein response(GO:1903896)
1.7 1.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
1.7 5.1 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
1.7 210.8 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.7 18.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.7 36.4 GO:0008053 mitochondrial fusion(GO:0008053)
1.6 13.1 GO:0035897 proteolysis in other organism(GO:0035897)
1.6 94.5 GO:0045576 mast cell activation(GO:0045576)
1.6 25.6 GO:0071044 histone mRNA catabolic process(GO:0071044)
1.6 236.6 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
1.6 11.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.5 4.6 GO:0060380 regulation of single-stranded telomeric DNA binding(GO:0060380) positive regulation of single-stranded telomeric DNA binding(GO:0060381) regulation of telomeric DNA binding(GO:1904742) positive regulation of telomeric DNA binding(GO:1904744)
1.5 4.5 GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome(GO:0098968)
1.5 7.4 GO:0072719 cellular response to cisplatin(GO:0072719)
1.5 59.5 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
1.4 19.9 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.4 5.6 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
1.4 13.8 GO:0071763 nuclear membrane organization(GO:0071763)
1.4 6.9 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
1.4 100.1 GO:0002220 innate immune response activating cell surface receptor signaling pathway(GO:0002220) stimulatory C-type lectin receptor signaling pathway(GO:0002223)
1.4 31.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.4 12.3 GO:0001887 selenium compound metabolic process(GO:0001887)
1.4 4.1 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957)
1.4 12.2 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
1.3 34.8 GO:0043984 histone H4-K16 acetylation(GO:0043984)
1.3 9.0 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
1.3 10.1 GO:0006116 NADH oxidation(GO:0006116)
1.3 13.9 GO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
1.3 8.8 GO:1902410 mitotic cytokinetic process(GO:1902410)
1.2 17.3 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
1.2 3.7 GO:0010286 heat acclimation(GO:0010286) cellular heat acclimation(GO:0070370)
1.2 50.0 GO:0000188 inactivation of MAPK activity(GO:0000188)
1.2 8.4 GO:0021847 ventricular zone neuroblast division(GO:0021847)
1.2 3.6 GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
1.2 13.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
1.2 8.2 GO:0071569 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
1.2 17.5 GO:0036295 cellular response to increased oxygen levels(GO:0036295)
1.2 7.0 GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation(GO:0006616)
1.2 29.2 GO:0007202 activation of phospholipase C activity(GO:0007202)
1.2 5.8 GO:0006642 triglyceride mobilization(GO:0006642)
1.2 8.1 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
1.1 3.4 GO:0018201 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
1.1 27.2 GO:0046339 diacylglycerol metabolic process(GO:0046339)
1.1 19.1 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
1.1 16.8 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
1.1 53.4 GO:0042100 B cell proliferation(GO:0042100)
1.1 7.8 GO:2001138 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
1.1 3.3 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
1.1 7.6 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
1.1 6.5 GO:0098789 pre-mRNA cleavage required for polyadenylation(GO:0098789)
1.1 88.6 GO:0050672 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.1 4.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.1 153.5 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
1.1 14.9 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
1.0 12.1 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
1.0 5.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
1.0 17.7 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
1.0 10.8 GO:0010815 bradykinin catabolic process(GO:0010815)
1.0 12.5 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
1.0 5.7 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.9 12.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.9 28.5 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.9 26.7 GO:0006266 DNA ligation(GO:0006266)
0.9 4.5 GO:0019230 proprioception(GO:0019230)
0.9 11.5 GO:0043562 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.9 6.1 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.9 58.5 GO:0070527 platelet aggregation(GO:0070527)
0.9 2.6 GO:0060613 fat pad development(GO:0060613)
0.8 5.0 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.8 11.5 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.8 12.3 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.8 29.5 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
0.8 14.6 GO:0016180 snRNA processing(GO:0016180)
0.8 12.0 GO:0039703 viral RNA genome replication(GO:0039694) RNA replication(GO:0039703)
0.8 1.5 GO:0061056 sclerotome development(GO:0061056)
0.8 12.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.7 95.8 GO:0007338 single fertilization(GO:0007338)
0.7 18.3 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.7 5.8 GO:0002517 T cell tolerance induction(GO:0002517)
0.7 104.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.7 7.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.7 22.2 GO:0038095 Fc-epsilon receptor signaling pathway(GO:0038095)
0.7 3.5 GO:0021759 globus pallidus development(GO:0021759)
0.7 9.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.7 9.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.7 2.0 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.7 2.0 GO:0033385 geranylgeranyl diphosphate metabolic process(GO:0033385) geranylgeranyl diphosphate biosynthetic process(GO:0033386)
0.6 5.2 GO:1903748 negative regulation of establishment of protein localization to mitochondrion(GO:1903748)
0.6 21.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.6 6.2 GO:0048194 Golgi vesicle budding(GO:0048194)
0.6 35.1 GO:0030183 B cell differentiation(GO:0030183)
0.6 0.6 GO:2000137 cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) negative regulation of cell proliferation involved in heart morphogenesis(GO:2000137)
0.6 24.1 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.6 2.8 GO:0051182 coenzyme transport(GO:0051182)
0.6 6.2 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.6 3.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.5 24.2 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.5 15.5 GO:0006491 N-glycan processing(GO:0006491)
0.5 20.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.5 4.8 GO:0050765 negative regulation of phagocytosis(GO:0050765)
0.5 11.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.5 4.1 GO:0001780 neutrophil homeostasis(GO:0001780)
0.5 15.1 GO:0046039 GTP metabolic process(GO:0046039)
0.5 9.2 GO:0007035 vacuolar acidification(GO:0007035)
0.5 7.2 GO:0038092 nodal signaling pathway(GO:0038092)
0.4 0.8 GO:0007296 vitellogenesis(GO:0007296)
0.4 4.4 GO:0045116 protein neddylation(GO:0045116)
0.4 2.4 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.4 1.9 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.4 1.5 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.4 17.6 GO:0006968 cellular defense response(GO:0006968)
0.4 5.5 GO:0017145 stem cell division(GO:0017145)
0.4 78.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.4 7.2 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.4 1.1 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.4 2.8 GO:0038203 TORC2 signaling(GO:0038203)
0.3 3.5 GO:0040016 embryonic cleavage(GO:0040016)
0.3 39.5 GO:0034605 cellular response to heat(GO:0034605)
0.3 11.0 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.3 2.5 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.3 6.4 GO:0003334 keratinocyte development(GO:0003334)
0.3 5.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.3 43.2 GO:0006338 chromatin remodeling(GO:0006338)
0.3 5.5 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 1.8 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.3 2.6 GO:0034508 centromere complex assembly(GO:0034508)
0.3 0.3 GO:0045416 positive regulation of interleukin-8 biosynthetic process(GO:0045416)
0.3 17.7 GO:0030218 erythrocyte differentiation(GO:0030218)
0.3 20.4 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.3 9.3 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.3 8.5 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.3 0.5 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.3 20.2 GO:0045727 positive regulation of translation(GO:0045727)
0.2 4.2 GO:0032897 negative regulation of viral transcription(GO:0032897)
0.2 4.0 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.2 4.6 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.2 9.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.2 4.4 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 17.7 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.2 1.4 GO:0031584 activation of phospholipase D activity(GO:0031584)
0.2 8.4 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 0.8 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.2 8.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.2 4.7 GO:0006298 mismatch repair(GO:0006298)
0.2 6.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.2 4.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.2 2.3 GO:0060117 auditory receptor cell development(GO:0060117)
0.2 7.1 GO:0061001 regulation of dendritic spine morphogenesis(GO:0061001)
0.2 2.1 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.2 11.8 GO:0042113 B cell activation(GO:0042113)
0.2 0.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.2 1.9 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.2 3.5 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.2 2.4 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.2 0.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.2 1.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.2 23.0 GO:0002576 platelet degranulation(GO:0002576)
0.2 1.9 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.2 9.2 GO:0048678 response to axon injury(GO:0048678)
0.2 40.6 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.2 6.1 GO:0016266 O-glycan processing(GO:0016266)
0.1 8.0 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 1.5 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.1 0.7 GO:0019896 axonal transport of mitochondrion(GO:0019896)
0.1 3.7 GO:0048268 clathrin coat assembly(GO:0048268)
0.1 1.7 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.1 5.6 GO:0071391 cellular response to estrogen stimulus(GO:0071391)
0.1 1.6 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 0.3 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.1 2.1 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 1.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.1 3.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.6 GO:0097480 synaptic vesicle transport(GO:0048489) establishment of synaptic vesicle localization(GO:0097480)
0.1 1.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 1.0 GO:0042108 positive regulation of cytokine biosynthetic process(GO:0042108)
0.1 0.4 GO:0032048 cardiolipin metabolic process(GO:0032048) cardiolipin acyl-chain remodeling(GO:0035965)
0.1 0.7 GO:0036507 protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) endoplasmic reticulum mannose trimming(GO:1904380)
0.1 0.2 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 1.6 GO:0032456 endocytic recycling(GO:0032456)
0.1 0.9 GO:0010659 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659)
0.1 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 1.0 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0 0.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 0.3 GO:0048305 immunoglobulin secretion(GO:0048305)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 10.4 GO:0051260 protein homooligomerization(GO:0051260)
0.0 1.0 GO:0031294 lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295)
0.0 2.1 GO:0019369 arachidonic acid metabolic process(GO:0019369)
0.0 2.9 GO:1990830 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.0 1.5 GO:0048278 vesicle docking(GO:0048278)
0.0 0.6 GO:0021983 pituitary gland development(GO:0021983)
0.0 0.4 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 0.2 GO:0055078 sodium ion homeostasis(GO:0055078)
0.0 1.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 2.1 GO:0001503 ossification(GO:0001503)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.6 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.0 1.1 GO:0008033 tRNA processing(GO:0008033)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
21.5 236.5 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
19.4 155.2 GO:0032010 phagolysosome(GO:0032010)
17.8 89.0 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
15.9 63.8 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
15.3 92.0 GO:0034687 integrin alphaL-beta2 complex(GO:0034687)
14.5 116.2 GO:1990111 spermatoproteasome complex(GO:1990111)
11.1 55.4 GO:0036398 TCR signalosome(GO:0036398)
9.6 19.1 GO:0042627 chylomicron(GO:0042627)
9.2 55.4 GO:1902560 GMP reductase complex(GO:1902560)
9.0 125.9 GO:0031209 SCAR complex(GO:0031209)
8.2 164.3 GO:0001891 phagocytic cup(GO:0001891)
7.8 102.0 GO:0043020 NADPH oxidase complex(GO:0043020)
7.1 49.6 GO:0036021 endolysosome lumen(GO:0036021)
6.9 27.5 GO:0097422 tubular endosome(GO:0097422)
6.8 20.5 GO:0071159 NF-kappaB complex(GO:0071159)
6.4 31.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
6.1 6.1 GO:1902911 serine/threonine protein kinase complex(GO:1902554) protein kinase complex(GO:1902911)
5.7 34.3 GO:0071817 MMXD complex(GO:0071817)
5.6 22.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
5.4 26.8 GO:0098837 postsynaptic recycling endosome(GO:0098837)
5.3 37.1 GO:0019815 B cell receptor complex(GO:0019815)
5.0 95.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
5.0 50.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
5.0 34.8 GO:0072487 MSL complex(GO:0072487)
4.2 12.5 GO:0034271 phosphatidylinositol 3-kinase complex, class III, type I(GO:0034271) phosphatidylinositol 3-kinase complex, class III, type II(GO:0034272)
4.1 69.7 GO:0032059 bleb(GO:0032059)
4.1 52.7 GO:0097433 dense body(GO:0097433)
4.0 216.8 GO:0001772 immunological synapse(GO:0001772)
3.9 42.6 GO:0031010 ISWI-type complex(GO:0031010)
3.8 15.2 GO:0030905 retromer, tubulation complex(GO:0030905)
3.8 11.4 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
3.7 22.4 GO:0008537 proteasome activator complex(GO:0008537)
3.6 32.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
3.3 10.0 GO:0070195 growth hormone receptor complex(GO:0070195)
3.3 49.8 GO:0008290 F-actin capping protein complex(GO:0008290)
3.2 16.1 GO:0042643 actomyosin, actin portion(GO:0042643)
3.1 12.2 GO:0005687 U4 snRNP(GO:0005687)
3.0 21.0 GO:0044194 cytolytic granule(GO:0044194)
2.9 46.9 GO:0016461 unconventional myosin complex(GO:0016461)
2.8 22.6 GO:0042382 paraspeckles(GO:0042382)
2.8 22.5 GO:0097504 Gemini of coiled bodies(GO:0097504)
2.5 44.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
2.5 9.9 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
2.2 32.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
2.2 13.1 GO:1990037 Lewy body core(GO:1990037)
2.2 167.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
2.1 29.3 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
2.0 13.9 GO:0030870 Mre11 complex(GO:0030870)
1.9 13.6 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.9 13.3 GO:0016272 prefoldin complex(GO:0016272)
1.9 13.3 GO:0070765 gamma-secretase complex(GO:0070765)
1.9 7.5 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
1.8 10.8 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.7 55.0 GO:0005685 U1 snRNP(GO:0005685)
1.6 8.2 GO:0000125 PCAF complex(GO:0000125)
1.6 14.6 GO:0032039 integrator complex(GO:0032039)
1.6 4.8 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
1.6 1.6 GO:0034719 SMN-Sm protein complex(GO:0034719)
1.6 11.0 GO:0097452 GAIT complex(GO:0097452)
1.5 132.6 GO:0035580 specific granule lumen(GO:0035580)
1.5 4.5 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
1.4 5.8 GO:0030915 Smc5-Smc6 complex(GO:0030915)
1.4 15.2 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.4 6.9 GO:0032021 NELF complex(GO:0032021)
1.4 8.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
1.3 94.3 GO:0035577 azurophil granule membrane(GO:0035577)
1.3 5.3 GO:0005896 interleukin-6 receptor complex(GO:0005896)
1.3 5.3 GO:0032044 DSIF complex(GO:0032044)
1.2 8.7 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
1.2 16.1 GO:0005577 fibrinogen complex(GO:0005577)
1.2 45.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
1.2 5.9 GO:0033263 CORVET complex(GO:0033263)
1.2 15.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.1 11.9 GO:0016602 CCAAT-binding factor complex(GO:0016602)
1.1 7.6 GO:0017119 Golgi transport complex(GO:0017119)
1.1 45.2 GO:0002102 podosome(GO:0002102)
1.1 15.1 GO:0042588 zymogen granule(GO:0042588)
1.1 8.4 GO:0045009 melanosome membrane(GO:0033162) chitosome(GO:0045009)
1.0 7.3 GO:0000813 ESCRT I complex(GO:0000813)
1.0 113.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
1.0 5.0 GO:0034457 Mpp10 complex(GO:0034457)
1.0 17.5 GO:0097342 ripoptosome(GO:0097342)
1.0 11.6 GO:0030008 TRAPP complex(GO:0030008)
1.0 4.8 GO:0032009 early phagosome(GO:0032009)
1.0 5.7 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.9 12.1 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.9 9.3 GO:0005916 fascia adherens(GO:0005916)
0.9 3.6 GO:0055087 Ski complex(GO:0055087)
0.9 274.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.9 7.0 GO:0035976 AP1 complex(GO:0035976)
0.9 7.0 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786)
0.8 5.0 GO:1990130 Iml1 complex(GO:1990130)
0.8 5.0 GO:0005865 striated muscle thin filament(GO:0005865)
0.8 112.0 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.8 5.7 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.8 6.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.8 4.8 GO:0000322 storage vacuole(GO:0000322)
0.8 2.4 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
0.8 2.4 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.7 12.3 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.7 69.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.7 12.0 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 5.6 GO:0071439 clathrin complex(GO:0071439)
0.7 50.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.7 8.8 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.7 34.3 GO:0043198 dendritic shaft(GO:0043198)
0.7 53.9 GO:0034707 chloride channel complex(GO:0034707)
0.7 97.8 GO:0005795 Golgi stack(GO:0005795)
0.7 6.5 GO:0005641 nuclear envelope lumen(GO:0005641)
0.6 1.9 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.6 100.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.6 34.0 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.6 18.7 GO:0000793 condensed chromosome(GO:0000793)
0.5 21.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.5 18.2 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 11.5 GO:0031105 septin complex(GO:0031105)
0.5 14.9 GO:0005720 nuclear heterochromatin(GO:0005720)
0.5 28.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.5 2.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.5 12.9 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.5 7.7 GO:0036452 ESCRT complex(GO:0036452)
0.4 10.8 GO:0071564 npBAF complex(GO:0071564)
0.4 1.7 GO:0035032 phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.4 27.6 GO:0005637 nuclear inner membrane(GO:0005637)
0.4 9.0 GO:0031201 SNARE complex(GO:0031201)
0.4 4.0 GO:0005655 nucleolar ribonuclease P complex(GO:0005655)
0.4 6.2 GO:0097225 sperm midpiece(GO:0097225)
0.4 34.2 GO:0005884 actin filament(GO:0005884)
0.4 2.1 GO:0035371 microtubule plus-end(GO:0035371)
0.3 29.2 GO:0005758 mitochondrial intermembrane space(GO:0005758) organelle envelope lumen(GO:0031970)
0.3 2.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 122.8 GO:0016607 nuclear speck(GO:0016607)
0.3 6.4 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 53.4 GO:0030667 secretory granule membrane(GO:0030667)
0.3 3.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 22.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.3 2.9 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.3 5.1 GO:0000242 pericentriolar material(GO:0000242)
0.3 13.3 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 7.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.3 3.2 GO:0032433 filopodium tip(GO:0032433)
0.3 22.3 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 145.6 GO:0000139 Golgi membrane(GO:0000139)
0.2 30.9 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.2 6.4 GO:0009925 basal plasma membrane(GO:0009925)
0.2 10.6 GO:0005902 microvillus(GO:0005902)
0.2 22.9 GO:0016605 PML body(GO:0016605)
0.2 52.0 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 4.5 GO:0000421 autophagosome membrane(GO:0000421)
0.2 2.8 GO:0031932 TORC2 complex(GO:0031932) TOR complex(GO:0038201)
0.2 3.2 GO:0000145 exocyst(GO:0000145)
0.2 4.3 GO:0005770 late endosome(GO:0005770)
0.2 17.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 9.5 GO:0005923 bicellular tight junction(GO:0005923)
0.2 4.1 GO:0000930 gamma-tubulin complex(GO:0000930)
0.2 2.3 GO:0032420 stereocilium(GO:0032420)
0.2 0.6 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.1 1.1 GO:0070187 telosome(GO:0070187)
0.1 8.9 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 9.5 GO:0005667 transcription factor complex(GO:0005667)
0.1 0.7 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.1 548.0 GO:0005829 cytosol(GO:0005829)
0.1 4.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 1.5 GO:0032587 ruffle membrane(GO:0032587)
0.1 8.7 GO:0031965 nuclear membrane(GO:0031965)
0.1 0.5 GO:0035861 site of double-strand break(GO:0035861)
0.1 2.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 0.7 GO:1904115 axon cytoplasm(GO:1904115)
0.0 5.0 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 3.8 GO:0030529 intracellular ribonucleoprotein complex(GO:0030529)
0.0 4.8 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.3 GO:0031093 platelet alpha granule lumen(GO:0031093)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
18.5 55.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
16.3 49.0 GO:0031859 platelet activating factor receptor binding(GO:0031859)
15.3 153.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
13.9 41.8 GO:0004917 interleukin-7 receptor activity(GO:0004917)
13.8 96.6 GO:0043208 glycosphingolipid binding(GO:0043208)
13.3 133.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
13.1 92.0 GO:0030369 ICAM-3 receptor activity(GO:0030369)
12.8 76.6 GO:0042610 CD8 receptor binding(GO:0042610)
12.7 51.0 GO:0004132 dCMP deaminase activity(GO:0004132)
10.9 32.8 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
10.7 74.9 GO:0042608 T cell receptor binding(GO:0042608)
10.4 31.2 GO:0001069 regulatory region RNA binding(GO:0001069)
9.2 55.4 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
9.2 27.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
8.4 25.3 GO:0016603 glutaminyl-peptide cyclotransferase activity(GO:0016603)
8.1 146.4 GO:0005522 profilin binding(GO:0005522)
7.8 211.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
7.1 21.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
7.1 77.7 GO:0051525 NFAT protein binding(GO:0051525)
6.6 19.9 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
6.6 26.3 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
6.6 19.7 GO:0017108 5'-flap endonuclease activity(GO:0017108)
6.4 25.6 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
6.3 38.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
6.3 69.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
6.0 102.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
5.4 26.8 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
5.1 56.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
4.5 67.2 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
4.1 57.9 GO:0030957 Tat protein binding(GO:0030957)
4.1 12.3 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
3.9 116.2 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
3.8 15.3 GO:0019770 IgG receptor activity(GO:0019770)
3.8 11.4 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
3.8 19.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
3.7 56.1 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
3.7 118.5 GO:0070064 proline-rich region binding(GO:0070064)
3.7 22.0 GO:0035800 deubiquitinase activator activity(GO:0035800)
3.5 28.0 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
3.5 17.5 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
3.4 6.8 GO:0019763 immunoglobulin receptor activity(GO:0019763)
3.4 43.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
3.2 22.4 GO:0061133 endopeptidase activator activity(GO:0061133)
3.0 15.2 GO:1990460 leptin receptor binding(GO:1990460)
3.0 57.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
2.9 132.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
2.9 23.5 GO:0016842 amidine-lyase activity(GO:0016842)
2.9 8.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
2.9 8.7 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
2.9 11.5 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
2.7 19.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
2.7 31.8 GO:0033691 sialic acid binding(GO:0033691)
2.6 10.6 GO:0019826 oxygen sensor activity(GO:0019826)
2.5 20.4 GO:1990405 protein antigen binding(GO:1990405)
2.5 10.2 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
2.5 17.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
2.5 74.9 GO:0023026 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
2.5 32.1 GO:0019957 C-C chemokine binding(GO:0019957)
2.4 14.6 GO:0035500 MH2 domain binding(GO:0035500)
2.4 21.6 GO:0043426 MRF binding(GO:0043426)
2.4 31.0 GO:0045294 alpha-catenin binding(GO:0045294)
2.4 40.0 GO:0004143 diacylglycerol kinase activity(GO:0004143)
2.3 7.0 GO:0005047 signal recognition particle binding(GO:0005047)
2.3 57.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
2.3 142.9 GO:1990782 protein tyrosine kinase binding(GO:1990782)
2.2 56.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.2 44.8 GO:0051400 BH domain binding(GO:0051400)
2.2 31.2 GO:0003680 AT DNA binding(GO:0003680)
2.2 33.1 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
2.2 12.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
2.1 29.6 GO:0019864 IgG binding(GO:0019864)
2.1 16.6 GO:0008266 poly(U) RNA binding(GO:0008266)
2.0 12.1 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.9 13.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
1.9 3.9 GO:0019976 interleukin-2 receptor activity(GO:0004911) interleukin-2 binding(GO:0019976)
1.9 7.8 GO:0001632 leukotriene B4 receptor activity(GO:0001632)
1.9 7.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
1.9 9.3 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
1.8 5.5 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
1.8 5.3 GO:0004915 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
1.8 8.8 GO:0004906 interferon-gamma receptor activity(GO:0004906)
1.8 7.0 GO:0070051 fibrinogen binding(GO:0070051)
1.7 12.2 GO:0030621 U4 snRNA binding(GO:0030621)
1.7 13.9 GO:0070087 chromo shadow domain binding(GO:0070087)
1.7 6.9 GO:0016936 galactoside binding(GO:0016936)
1.7 15.1 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
1.7 8.4 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
1.7 11.6 GO:1990226 histone methyltransferase binding(GO:1990226)
1.7 24.8 GO:0042609 CD4 receptor binding(GO:0042609)
1.6 8.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.6 4.8 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.6 73.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
1.6 28.5 GO:0035497 cAMP response element binding(GO:0035497)
1.6 31.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
1.6 17.1 GO:0034452 dynactin binding(GO:0034452)
1.5 9.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
1.5 6.0 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
1.5 28.5 GO:0004697 protein kinase C activity(GO:0004697)
1.5 32.2 GO:0000339 RNA cap binding(GO:0000339)
1.5 49.6 GO:0043236 laminin binding(GO:0043236)
1.4 37.3 GO:0031489 myosin V binding(GO:0031489)
1.4 5.7 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
1.4 8.4 GO:0004167 dopachrome isomerase activity(GO:0004167)
1.4 20.9 GO:0043274 phospholipase binding(GO:0043274)
1.4 13.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
1.3 44.3 GO:0042288 MHC class I protein binding(GO:0042288)
1.3 5.3 GO:0017160 Ral GTPase binding(GO:0017160)
1.2 14.9 GO:0045159 myosin II binding(GO:0045159)
1.2 3.6 GO:0004967 glucagon receptor activity(GO:0004967)
1.2 38.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)
1.2 62.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
1.2 112.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.2 40.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.2 38.9 GO:0070717 poly-purine tract binding(GO:0070717)
1.1 6.9 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.1 3.4 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
1.1 19.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
1.1 6.7 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
1.1 9.9 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
1.1 66.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 11.4 GO:0005049 nuclear export signal receptor activity(GO:0005049)
1.0 3.0 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
1.0 49.2 GO:0004364 glutathione transferase activity(GO:0004364)
1.0 24.2 GO:0043014 alpha-tubulin binding(GO:0043014)
0.9 15.2 GO:0045295 gamma-catenin binding(GO:0045295)
0.9 93.6 GO:0017124 SH3 domain binding(GO:0017124)
0.9 20.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.9 2.8 GO:0051185 coenzyme transporter activity(GO:0051185)
0.9 12.0 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.9 211.5 GO:0051015 actin filament binding(GO:0051015)
0.9 8.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.9 52.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.9 6.2 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.9 4.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.9 13.1 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.9 21.0 GO:0022829 wide pore channel activity(GO:0022829)
0.9 19.1 GO:0005521 lamin binding(GO:0005521)
0.9 15.6 GO:0017091 AU-rich element binding(GO:0017091)
0.8 18.7 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.8 31.4 GO:0017025 TBP-class protein binding(GO:0017025)
0.8 5.7 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.8 109.6 GO:0005178 integrin binding(GO:0005178)
0.8 21.6 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.8 4.7 GO:0008853 exodeoxyribonuclease III activity(GO:0008853)
0.8 241.3 GO:0005096 GTPase activator activity(GO:0005096)
0.8 22.4 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.8 25.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.8 7.7 GO:0046790 virion binding(GO:0046790)
0.8 4.6 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.8 13.6 GO:0097602 cullin family protein binding(GO:0097602)
0.7 15.4 GO:0046961 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.7 11.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.7 3.6 GO:0001594 trace-amine receptor activity(GO:0001594)
0.7 7.2 GO:0042287 MHC protein binding(GO:0042287)
0.7 148.5 GO:0003735 structural constituent of ribosome(GO:0003735)
0.7 39.5 GO:0035064 methylated histone binding(GO:0035064)
0.7 3.3 GO:0019003 GDP binding(GO:0019003)
0.6 187.2 GO:0003924 GTPase activity(GO:0003924)
0.6 18.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.6 2.5 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.6 8.5 GO:0098847 sequence-specific single stranded DNA binding(GO:0098847)
0.6 1.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.5 4.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.5 2.1 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.5 18.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.5 4.8 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.5 12.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.5 28.4 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.5 7.0 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.5 5.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.5 10.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.5 2.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.5 7.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.5 18.9 GO:0005484 SNAP receptor activity(GO:0005484)
0.5 52.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.5 14.5 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.4 2.2 GO:0050693 LBD domain binding(GO:0050693)
0.4 4.3 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.4 7.2 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.4 0.8 GO:0032564 adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.4 6.1 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.4 9.5 GO:0051393 alpha-actinin binding(GO:0051393)
0.4 2.0 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.4 48.8 GO:0047485 protein N-terminus binding(GO:0047485)
0.4 9.7 GO:0001671 ATPase activator activity(GO:0001671)
0.4 9.6 GO:0046965 retinoid X receptor binding(GO:0046965)
0.4 1.9 GO:0034511 U3 snoRNA binding(GO:0034511)
0.4 17.5 GO:0016831 carboxy-lyase activity(GO:0016831)
0.4 22.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.4 4.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.4 12.9 GO:0004407 histone deacetylase activity(GO:0004407)
0.4 1.1 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.3 17.8 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 0.7 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.3 5.8 GO:0035004 phosphatidylinositol 3-kinase activity(GO:0035004) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.3 84.2 GO:0003713 transcription coactivator activity(GO:0003713)
0.3 1.5 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.3 3.5 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 21.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.3 13.3 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.3 5.3 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 4.0 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 29.3 GO:0003774 motor activity(GO:0003774)
0.2 9.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.2 0.7 GO:0050811 GABA receptor binding(GO:0050811)
0.2 9.4 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 3.7 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 2.3 GO:0071889 14-3-3 protein binding(GO:0071889)
0.2 0.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 6.3 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.2 4.5 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.2 41.8 GO:0003712 transcription cofactor activity(GO:0003712)
0.2 3.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.1 1.7 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 2.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 1.7 GO:0048487 beta-tubulin binding(GO:0048487)
0.1 2.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 2.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 1.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 0.6 GO:0036122 BMP binding(GO:0036122)
0.1 4.1 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 15.4 GO:0003682 chromatin binding(GO:0003682)
0.0 2.1 GO:0004386 helicase activity(GO:0004386)
0.0 0.5 GO:0030346 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386) protein phosphatase 2B binding(GO:0030346)
0.0 3.0 GO:0000149 SNARE binding(GO:0000149)
0.0 1.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.2 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 2.0 GO:0044325 ion channel binding(GO:0044325)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 684.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
6.1 280.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events
4.7 407.9 PID RAC1 PATHWAY RAC1 signaling pathway
4.5 316.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
4.3 225.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
2.9 17.2 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
2.8 42.2 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
2.6 186.9 PID RHOA REG PATHWAY Regulation of RhoA activity
2.6 23.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
2.5 73.9 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
2.1 49.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
2.1 33.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
2.1 150.5 PID ILK PATHWAY Integrin-linked kinase signaling
2.0 66.2 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
1.7 47.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
1.7 163.6 PID CMYB PATHWAY C-MYB transcription factor network
1.6 16.4 PID S1P S1P4 PATHWAY S1P4 pathway
1.6 61.6 PID BCR 5PATHWAY BCR signaling pathway
1.5 20.4 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
1.4 211.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
1.3 38.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
1.2 32.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
1.2 29.7 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
1.1 27.3 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events
1.1 5.6 PID IL3 PATHWAY IL3-mediated signaling events
1.1 15.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.1 17.3 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
1.0 9.1 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
1.0 35.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.9 22.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.9 5.3 ST STAT3 PATHWAY STAT3 Pathway
0.9 17.5 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.8 3.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.7 51.9 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.7 22.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.6 7.0 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.5 54.9 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.5 12.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 39.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.4 19.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3 5.9 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.3 11.0 PID BARD1 PATHWAY BARD1 signaling events
0.3 10.0 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.3 7.3 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.3 5.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 10.9 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.2 4.4 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 2.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 3.1 PID ATR PATHWAY ATR signaling pathway
0.1 4.7 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 5.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 1.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 3.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 3.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 2.1 PID E2F PATHWAY E2F transcription factor network
0.0 1.4 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.6 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 2.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.5 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.7 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
16.4 98.2 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
15.9 429.7 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
5.8 253.3 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
5.4 310.9 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
5.0 49.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
4.3 349.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
4.2 67.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
4.0 19.9 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
3.2 41.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
2.9 17.5 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
2.7 52.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
2.6 28.5 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
2.4 65.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
2.2 368.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
2.2 315.2 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
2.2 55.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
2.2 44.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
2.2 50.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
2.0 47.1 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
2.0 23.9 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
2.0 61.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.9 22.4 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.9 54.1 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
1.8 59.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
1.8 38.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
1.7 65.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
1.5 38.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
1.5 21.1 REACTOME G ALPHA1213 SIGNALLING EVENTS Genes involved in G alpha (12/13) signalling events
1.5 51.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
1.4 56.9 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
1.4 16.6 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
1.4 23.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.4 103.2 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.3 22.9 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
1.3 49.4 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
1.3 31.0 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
1.3 22.9 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
1.3 25.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
1.3 40.4 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
1.2 9.9 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
1.2 7.3 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.2 46.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
1.2 28.3 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
1.1 66.2 REACTOME G1 PHASE Genes involved in G1 Phase
1.1 6.7 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
1.1 5.3 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
1.0 8.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
1.0 13.1 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
1.0 101.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
1.0 45.4 REACTOME MYOGENESIS Genes involved in Myogenesis
0.9 16.4 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.8 124.5 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.8 13.5 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.7 8.2 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.7 10.3 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.7 13.1 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.7 14.0 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.7 10.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.6 5.7 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.6 16.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.6 10.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.6 5.3 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.6 11.6 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.5 6.0 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.5 21.7 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.5 5.9 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.5 12.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 17.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.5 22.5 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.4 10.5 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.4 10.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.4 9.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 7.2 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.4 5.8 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.4 15.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.3 26.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.3 6.5 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.3 2.2 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.3 17.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 14.7 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 7.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 12.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 5.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 4.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 17.7 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 3.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 5.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 3.0 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 1.1 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.1 2.1 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 5.8 REACTOME APOPTOTIC EXECUTION PHASE Genes involved in Apoptotic execution phase
0.1 1.5 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.1 1.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1 2.9 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.9 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 3.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.5 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen