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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SPIB

Z-value: 3.46

Motif logo

Transcription factors associated with SPIB

Gene Symbol Gene ID Gene Info
ENSG00000269404.2 Spi-B transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SPIBhg19_v2_chr19_+_50922187_509222150.392.1e-09Click!

Activity profile of SPIB motif

Sorted Z-values of SPIB motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_15114492 143.03 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_160681593 122.48 ENST00000368045.3
ENST00000368046.3
CD48 molecule
chr12_-_15114603 91.99 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr1_-_31230650 90.05 ENST00000294507.3
lysosomal protein transmembrane 5
chr16_+_30194916 88.03 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
coronin, actin binding protein, 1A
chr3_-_121379739 82.42 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr5_+_169064245 75.38 ENST00000256935.8
dedicator of cytokinesis 2
chr13_+_31309645 67.19 ENST00000380490.3
arachidonate 5-lipoxygenase-activating protein
chr7_+_74188309 65.58 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr22_+_37309662 60.36 ENST00000403662.3
ENST00000262825.5
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chrX_-_47489244 56.72 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr17_-_29641104 54.46 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr1_+_209941827 53.50 ENST00000367023.1
TRAF3 interacting protein 3
chr21_-_46340884 51.10 ENST00000302347.5
ENST00000517819.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_68592305 50.58 ENST00000234313.7
pleckstrin
chr21_-_46340770 49.91 ENST00000397854.3
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr2_+_143886877 49.82 ENST00000295095.6
Rho GTPase activating protein 15
chr6_+_31582961 49.20 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr22_-_37640277 47.13 ENST00000401529.3
ENST00000249071.6
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr1_+_26644441 46.98 ENST00000374213.2
CD52 molecule
chr11_-_64512803 45.05 ENST00000377489.1
ENST00000354024.3
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr12_+_54891495 43.91 ENST00000293373.6
NCK-associated protein 1-like
chr19_+_48828788 43.84 ENST00000594198.1
ENST00000597279.1
ENST00000593437.1
epithelial membrane protein 3
chr20_-_62710832 43.76 ENST00000395042.1
regulator of G-protein signaling 19
chr19_+_49838653 43.25 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr6_+_31554779 41.35 ENST00000376090.2
leukocyte specific transcript 1
chr12_+_25205666 40.57 ENST00000547044.1
lymphoid-restricted membrane protein
chr20_-_62711259 40.56 ENST00000332298.5
regulator of G-protein signaling 19
chr11_-_64512273 40.06 ENST00000377497.3
ENST00000377487.1
ENST00000430645.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr19_+_48828582 40.01 ENST00000270221.6
ENST00000596315.1
epithelial membrane protein 3
chr10_-_121302195 39.68 ENST00000369103.2
regulator of G-protein signaling 10
chr19_-_10446449 39.56 ENST00000592439.1
intercellular adhesion molecule 3
chr6_-_24936170 39.48 ENST00000538035.1
family with sequence similarity 65, member B
chr17_-_29641084 39.27 ENST00000544462.1
ecotropic viral integration site 2B
chr11_-_3859089 38.94 ENST00000396979.1
ras homolog family member G
chr2_-_231084820 38.27 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chr1_-_153919128 37.99 ENST00000361217.4
DENN/MADD domain containing 4B
chr12_+_7060432 36.86 ENST00000318974.9
ENST00000456013.1
protein tyrosine phosphatase, non-receptor type 6
chr12_+_8276433 36.39 ENST00000345999.3
ENST00000352620.3
ENST00000360500.3
C-type lectin domain family 4, member A
chr7_-_36764004 36.19 ENST00000431169.1
acyloxyacyl hydrolase (neutrophil)
chr11_+_65408273 35.74 ENST00000394227.3
signal-induced proliferation-associated 1
chr22_-_37640456 35.56 ENST00000405484.1
ENST00000441619.1
ENST00000406508.1
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
chr7_-_36764142 34.98 ENST00000258749.5
ENST00000535891.1
acyloxyacyl hydrolase (neutrophil)
chr10_+_11207438 34.27 ENST00000609692.1
ENST00000354897.3
CUGBP, Elav-like family member 2
chr4_+_103423055 34.01 ENST00000505458.1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr12_+_25205568 33.97 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr6_+_31553901 32.32 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr7_+_139528952 32.16 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
thromboxane A synthase 1 (platelet)
chr20_+_30640004 32.12 ENST00000520553.1
ENST00000518730.1
ENST00000375852.2
hemopoietic cell kinase
chr3_-_151047327 32.08 ENST00000325602.5
purinergic receptor P2Y, G-protein coupled, 13
chr6_+_31553978 30.48 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr2_-_231084659 30.36 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr12_+_25205446 30.36 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr12_+_8276224 30.21 ENST00000229332.5
C-type lectin domain family 4, member A
chr14_-_23288930 30.16 ENST00000554517.1
ENST00000285850.7
ENST00000397529.2
ENST00000555702.1
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr2_-_231084617 29.93 ENST00000409815.2
SP110 nuclear body protein
chr7_+_139529040 29.64 ENST00000455353.1
ENST00000458722.1
ENST00000411653.1
thromboxane A synthase 1 (platelet)
chr11_-_64512469 29.52 ENST00000377485.1
RAS guanyl releasing protein 2 (calcium and DAG-regulated)
chr1_+_161475208 29.39 ENST00000367972.4
ENST00000271450.6
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr19_+_6772710 28.86 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
vav 1 guanine nucleotide exchange factor
chr12_+_8276495 28.31 ENST00000546339.1
C-type lectin domain family 4, member A
chr17_+_7462103 27.74 ENST00000396545.4
tumor necrosis factor (ligand) superfamily, member 13
chr6_-_133079022 27.71 ENST00000525289.1
ENST00000326499.6
vanin 2
chr17_-_73389854 26.85 ENST00000578961.1
ENST00000392564.1
ENST00000582582.1
growth factor receptor-bound protein 2
chr11_-_33891362 26.30 ENST00000395833.3
LIM domain only 2 (rhombotin-like 1)
chr6_+_31554826 26.27 ENST00000376089.2
ENST00000396112.2
leukocyte specific transcript 1
chr8_-_101734308 25.85 ENST00000519004.1
ENST00000519363.1
ENST00000520142.1
poly(A) binding protein, cytoplasmic 1
chr7_+_50344289 25.45 ENST00000413698.1
ENST00000359197.5
ENST00000331340.3
ENST00000357364.4
ENST00000343574.5
ENST00000349824.4
ENST00000346667.4
ENST00000440768.2
IKAROS family zinc finger 1 (Ikaros)
chr19_+_42381337 25.42 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr8_-_101734170 25.35 ENST00000522387.1
ENST00000518196.1
poly(A) binding protein, cytoplasmic 1
chr2_+_233925064 25.28 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr1_+_161632937 24.85 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr9_+_93564191 24.73 ENST00000375747.1
spleen tyrosine kinase
chr19_-_13213662 24.72 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr17_-_73389737 24.62 ENST00000392563.1
growth factor receptor-bound protein 2
chr9_+_93564039 24.42 ENST00000375754.4
ENST00000375751.4
spleen tyrosine kinase
chrX_+_11777671 24.40 ENST00000380693.3
ENST00000380692.2
male-specific lethal 3 homolog (Drosophila)
chr8_+_74903580 24.03 ENST00000284818.2
ENST00000518893.1
lymphocyte antigen 96
chr14_+_88471468 23.91 ENST00000267549.3
G protein-coupled receptor 65
chr10_+_11206925 23.83 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CUGBP, Elav-like family member 2
chr5_-_140013275 23.72 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14 molecule
chr11_-_47399942 23.35 ENST00000227163.4
spleen focus forming virus (SFFV) proviral integration oncogene
chr12_-_7656357 22.76 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163 molecule
chr17_+_7461781 22.36 ENST00000349228.4
tumor necrosis factor (ligand) superfamily, member 13
chr3_+_16926441 22.34 ENST00000418129.2
ENST00000396755.2
phospholipase C-like 2
chr3_+_121774202 22.07 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
CD86 molecule
chr15_+_77287426 21.77 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr17_+_7461849 21.43 ENST00000338784.4
tumor necrosis factor (ligand) superfamily, member 13
chr3_-_16555150 21.13 ENST00000334133.4
raftlin, lipid raft linker 1
chr11_-_47400078 20.96 ENST00000378538.3
spleen focus forming virus (SFFV) proviral integration oncogene
chr5_+_54398463 20.88 ENST00000274306.6
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr15_+_91427642 20.64 ENST00000328850.3
ENST00000414248.2
feline sarcoma oncogene
chr19_-_10230562 20.39 ENST00000587146.1
ENST00000588709.1
ENST00000253108.4
eukaryotic translation initiation factor 3, subunit G
chr14_+_102228123 20.37 ENST00000422945.2
ENST00000554442.1
ENST00000556260.2
ENST00000328724.5
ENST00000557268.1
protein phosphatase 2, regulatory subunit B', gamma
chrX_+_24072833 20.07 ENST00000253039.4
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr1_+_15736359 20.05 ENST00000375980.4
EF-hand domain family, member D2
chr9_+_93589734 19.49 ENST00000375746.1
spleen tyrosine kinase
chr3_+_46395219 19.23 ENST00000445132.2
ENST00000292301.4
chemokine (C-C motif) receptor 2
chr1_+_149754227 19.12 ENST00000444948.1
ENST00000369168.4
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr15_-_65809991 18.99 ENST00000559526.1
ENST00000358939.4
ENST00000560665.1
ENST00000321118.7
ENST00000339244.5
ENST00000300141.6
dipeptidyl-peptidase 8
chr15_-_65810042 18.70 ENST00000321147.6
dipeptidyl-peptidase 8
chr1_+_90287480 18.47 ENST00000394593.3
leucine rich repeat containing 8 family, member D
chr2_+_162087577 18.42 ENST00000439442.1
TRAF family member-associated NFKB activator
chr22_-_37880543 18.40 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr8_+_98656693 18.08 ENST00000519934.1
metadherin
chr1_-_159893507 17.88 ENST00000368096.1
transgelin 2
chr2_-_74405929 17.82 ENST00000396049.4
MOB kinase activator 1A
chr3_-_52273098 17.72 ENST00000499914.2
ENST00000305533.5
ENST00000597542.1
twinfilin actin-binding protein 2
toll-like receptor 9
chr15_-_65809581 17.39 ENST00000341861.5
dipeptidyl-peptidase 8
chrX_+_11776701 17.34 ENST00000476743.1
ENST00000421368.2
ENST00000398527.2
male-specific lethal 3 homolog (Drosophila)
chr17_+_7462031 17.15 ENST00000380535.4
tumor necrosis factor (ligand) superfamily, member 13
chr19_-_18391708 17.14 ENST00000600972.1
jun D proto-oncogene
chr20_+_2821340 17.06 ENST00000380445.3
ENST00000380469.3
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr10_-_98031310 16.85 ENST00000427367.2
ENST00000413476.2
B-cell linker
chr1_-_120935894 16.69 ENST00000369383.4
ENST00000369384.4
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr19_-_10230540 16.48 ENST00000589454.1
eukaryotic translation initiation factor 3, subunit G
chrX_+_109246285 16.25 ENST00000372073.1
ENST00000372068.2
ENST00000288381.4
transmembrane protein 164
chr6_+_15246501 16.05 ENST00000341776.2
jumonji, AT rich interactive domain 2
chr6_+_31554456 15.97 ENST00000339530.4
leukocyte specific transcript 1
chr11_-_47400062 15.79 ENST00000533030.1
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_+_31554612 15.74 ENST00000211921.7
leukocyte specific transcript 1
chr17_+_7461580 15.70 ENST00000483039.1
ENST00000396542.1
tumor necrosis factor (ligand) superfamily, member 13
chrX_+_123094672 15.47 ENST00000354548.5
ENST00000458700.1
stromal antigen 2
chr11_+_46366918 15.28 ENST00000528615.1
ENST00000395574.3
diacylglycerol kinase, zeta
chr3_+_121796697 15.24 ENST00000482356.1
ENST00000393627.2
CD86 molecule
chr1_+_44440575 15.24 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr18_-_47813940 15.20 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC finger protein 1
chr6_-_132834184 15.02 ENST00000367941.2
ENST00000367937.4
syntaxin 7
chr17_+_65373531 14.86 ENST00000580974.1
phosphatidylinositol transfer protein, cytoplasmic 1
chr11_-_64889529 14.85 ENST00000531743.1
ENST00000527548.1
ENST00000526555.1
ENST00000279259.3
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr11_-_60719213 14.16 ENST00000227880.3
solute carrier family 15 (oligopeptide transporter), member 3
chr15_+_91427691 14.01 ENST00000559355.1
ENST00000394302.1
feline sarcoma oncogene
chr19_+_3136115 13.98 ENST00000262958.3
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr19_-_54746600 13.93 ENST00000245621.5
ENST00000270464.5
ENST00000419410.2
ENST00000391735.3
ENST00000396365.2
ENST00000440558.2
ENST00000407860.2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr10_-_98031265 13.88 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr11_-_64889252 13.77 ENST00000525297.1
ENST00000529259.1
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chrX_-_74376108 13.74 ENST00000339447.4
ENST00000373394.3
ENST00000529949.1
ENST00000534524.1
ENST00000253577.3
ATP-binding cassette, sub-family B (MDR/TAP), member 7
chr17_+_7461613 13.69 ENST00000438470.1
ENST00000436057.1
tumor necrosis factor (ligand) superfamily, member 13
chr18_-_47018769 13.40 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
ribosomal protein L17
chr5_+_112312416 13.38 ENST00000389063.2
decapping mRNA 2
chr5_+_35856951 13.36 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr19_+_2476116 13.12 ENST00000215631.4
ENST00000587345.1
growth arrest and DNA-damage-inducible, beta
chr1_+_39456895 13.12 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr17_+_65374075 12.81 ENST00000581322.1
phosphatidylinositol transfer protein, cytoplasmic 1
chr11_-_64546202 12.58 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
splicing factor 1
chr6_-_41254403 12.49 ENST00000589614.1
ENST00000334475.6
ENST00000591620.1
ENST00000244709.4
triggering receptor expressed on myeloid cells 1
chr2_+_113931513 12.48 ENST00000245796.6
ENST00000441564.3
pleckstrin and Sec7 domain containing 4
chr12_-_9102549 12.46 ENST00000000412.3
mannose-6-phosphate receptor (cation dependent)
chr2_+_202125219 12.28 ENST00000323492.7
caspase 8, apoptosis-related cysteine peptidase
chr11_-_64889649 12.10 ENST00000434372.2
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr1_+_159272111 12.01 ENST00000368114.1
Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
chr2_+_127413677 11.99 ENST00000356887.7
glycophorin C (Gerbich blood group)
chr9_+_82186872 11.89 ENST00000376544.3
ENST00000376520.4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr10_+_114133773 11.80 ENST00000354655.4
acyl-CoA synthetase long-chain family member 5
chr10_-_65028817 11.70 ENST00000542921.1
jumonji domain containing 1C
chr1_+_32757668 11.35 ENST00000373548.3
histone deacetylase 1
chr7_-_37488834 11.26 ENST00000310758.4
engulfment and cell motility 1
chr11_-_67120974 11.13 ENST00000539074.1
ENST00000312419.3
polymerase (DNA-directed), delta 4, accessory subunit
chr2_+_127413704 10.95 ENST00000409836.3
glycophorin C (Gerbich blood group)
chr15_+_59279851 10.93 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
ring finger protein 111
chr9_-_35618364 10.84 ENST00000378431.1
ENST00000378430.3
ENST00000259633.4
CD72 molecule
chr9_+_127624387 10.79 ENST00000353214.2
actin related protein 2/3 complex, subunit 5-like
chr1_+_40505891 10.65 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP, adenylate cyclase-associated protein 1 (yeast)
chr16_+_30960375 10.59 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
ORAI calcium release-activated calcium modulator 3
chrX_+_11776410 10.52 ENST00000361672.2
male-specific lethal 3 homolog (Drosophila)
chr19_+_51728316 10.41 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr20_-_33732952 10.24 ENST00000541621.1
ER degradation enhancer, mannosidase alpha-like 2
chr19_-_54726850 10.18 ENST00000245620.9
ENST00000346401.6
ENST00000424807.1
ENST00000445347.1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
chr2_+_3622795 10.18 ENST00000304921.5
ribosomal protein S7
chr14_+_102276132 10.14 ENST00000350249.3
ENST00000557621.1
ENST00000556946.1
protein phosphatase 2, regulatory subunit B', gamma
chr14_+_102276209 10.05 ENST00000445439.3
ENST00000334743.5
ENST00000557095.1
protein phosphatase 2, regulatory subunit B', gamma
chr22_-_32026810 9.86 ENST00000266095.5
ENST00000397500.1
phosphatidylserine decarboxylase
chr1_-_47069955 9.74 ENST00000341183.5
ENST00000496619.1
MAP kinase interacting serine/threonine kinase 1
chr14_+_102276192 9.64 ENST00000557714.1
protein phosphatase 2, regulatory subunit B', gamma
chr4_+_68424434 9.60 ENST00000265404.2
ENST00000396225.1
signal transducing adaptor family member 1
chr2_-_161350305 9.59 ENST00000348849.3
RNA binding motif, single stranded interacting protein 1
chr2_-_208031943 9.46 ENST00000421199.1
ENST00000457962.1
Kruppel-like factor 7 (ubiquitous)
chr19_-_3786253 9.44 ENST00000585778.1
megakaryocyte-associated tyrosine kinase
chrX_+_123094369 9.40 ENST00000455404.1
ENST00000218089.9
stromal antigen 2
chr5_-_39270725 9.34 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr4_+_113568207 9.25 ENST00000511529.1
La ribonucleoprotein domain family, member 7
chr17_-_8868991 9.22 ENST00000447110.1
phosphoinositide-3-kinase, regulatory subunit 5
chr21_+_34638656 9.05 ENST00000290200.2
interleukin 10 receptor, beta
chr12_-_8218997 9.05 ENST00000307637.4
complement component 3a receptor 1
chr17_-_61819229 9.00 ENST00000447001.3
ENST00000392950.4
STE20-related kinase adaptor alpha
chr12_-_51785182 8.96 ENST00000356317.3
ENST00000603188.1
ENST00000604847.1
ENST00000604506.1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)
chr14_-_74417096 8.95 ENST00000286544.3
family with sequence similarity 161, member B
chr7_-_102213030 8.95 ENST00000511313.1
ENST00000513438.1
ENST00000513506.1
polymerase (RNA) II (DNA directed) polypeptide J3
chr5_-_66492562 8.84 ENST00000256447.4
CD180 molecule
chr1_+_41174988 8.80 ENST00000372652.1
nuclear transcription factor Y, gamma
chr1_+_14075865 8.75 ENST00000413440.1
PR domain containing 2, with ZNF domain
chr1_+_161551101 8.75 ENST00000367962.4
ENST00000367960.5
ENST00000403078.3
ENST00000428605.2
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr18_-_32924372 8.40 ENST00000261332.6
ENST00000399061.3
zinc finger protein 24
chr19_+_14551066 8.31 ENST00000342216.4
protein kinase N1
chr2_+_3622932 8.14 ENST00000406376.1
ribosomal protein S7
chr2_-_242089677 8.10 ENST00000405260.1
PAS domain containing serine/threonine kinase
chr1_-_47069886 7.98 ENST00000371946.4
ENST00000371945.4
ENST00000428112.2
ENST00000529170.1
MAP kinase interacting serine/threonine kinase 1
chr17_+_75137034 7.80 ENST00000436233.4
ENST00000443798.4
SEC14-like 1 (S. cerevisiae)
chr11_+_75110530 7.78 ENST00000531188.1
ENST00000530164.1
ENST00000422465.2
ENST00000278572.6
ENST00000534440.1
ENST00000527446.1
ENST00000526608.1
ENST00000527273.1
ENST00000524851.1
ribosomal protein S3
chr10_+_104503727 7.68 ENST00000448841.1
WW domain binding protein 1-like

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
58.8 235.0 GO:0071461 cellular response to redox state(GO:0071461)
22.0 88.0 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
20.2 60.7 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
20.2 80.6 GO:0032672 regulation of interleukin-3 production(GO:0032672) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401)
15.0 60.1 GO:0044027 hypermethylation of CpG island(GO:0044027)
15.0 45.0 GO:0042097 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
14.6 43.9 GO:0045588 positive regulation of gamma-delta T cell differentiation(GO:0045588)
13.2 52.8 GO:0002434 immune complex clearance(GO:0002434) immune complex clearance by monocytes and macrophages(GO:0002436) regulation of immune complex clearance by monocytes and macrophages(GO:0090264)
10.7 32.1 GO:0002522 leukocyte migration involved in immune response(GO:0002522)
9.8 49.2 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
9.8 118.1 GO:0048298 positive regulation of isotype switching to IgA isotypes(GO:0048298)
9.4 75.4 GO:0044351 macropinocytosis(GO:0044351)
9.2 36.9 GO:0033277 abortive mitotic cell cycle(GO:0033277)
8.4 50.6 GO:0070560 protein secretion by platelet(GO:0070560)
8.4 25.3 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
7.6 128.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
7.5 82.7 GO:0060753 regulation of mast cell chemotaxis(GO:0060753)
7.5 67.2 GO:2001300 lipoxin metabolic process(GO:2001300)
7.4 22.3 GO:0001923 B-1 B cell differentiation(GO:0001923)
7.1 35.7 GO:0042631 cellular response to water deprivation(GO:0042631)
6.8 34.0 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
6.2 36.9 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
5.9 23.7 GO:0071725 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
5.7 51.2 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
5.7 56.7 GO:0036066 protein O-linked fucosylation(GO:0036066)
5.0 30.2 GO:0000821 regulation of arginine metabolic process(GO:0000821) basic amino acid transmembrane transport(GO:1990822)
4.9 98.6 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
4.6 36.9 GO:0075525 viral translational termination-reinitiation(GO:0075525)
4.4 17.7 GO:0032661 regulation of interleukin-18 production(GO:0032661) positive regulation of interferon-alpha biosynthetic process(GO:0045356) negative regulation of calcium-transporting ATPase activity(GO:1901895)
4.2 20.8 GO:1904154 positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
4.1 24.9 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
4.1 12.3 GO:0052056 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
3.9 66.6 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
3.8 76.3 GO:0032060 bleb assembly(GO:0032060)
3.7 32.9 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
3.4 61.8 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.2 25.8 GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255)
3.2 54.1 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
3.1 12.5 GO:0070945 neutrophil mediated killing of gram-negative bacterium(GO:0070945)
3.1 18.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
3.0 21.1 GO:0032594 protein transport within lipid bilayer(GO:0032594) protein transport into membrane raft(GO:0032596)
3.0 12.0 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
3.0 53.7 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
2.8 27.7 GO:0015939 pantothenate metabolic process(GO:0015939)
2.5 12.6 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
2.5 24.7 GO:0001955 blood vessel maturation(GO:0001955)
2.4 17.1 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
2.4 28.7 GO:0032071 regulation of endodeoxyribonuclease activity(GO:0032071)
2.3 11.4 GO:0061198 fungiform papilla formation(GO:0061198)
2.2 43.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
1.9 13.4 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
1.8 59.0 GO:0043984 histone H4-K16 acetylation(GO:0043984)
1.8 58.1 GO:0006376 mRNA splice site selection(GO:0006376)
1.7 5.2 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
1.7 13.4 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
1.7 15.0 GO:1902474 positive regulation of protein localization to synapse(GO:1902474)
1.6 164.2 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.6 1.6 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
1.6 16.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
1.5 18.4 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.5 124.8 GO:0071277 cellular response to calcium ion(GO:0071277)
1.4 50.2 GO:0016601 Rac protein signal transduction(GO:0016601)
1.4 5.7 GO:0018094 protein polyglycylation(GO:0018094)
1.4 7.1 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
1.4 10.9 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
1.3 8.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
1.3 14.6 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
1.3 5.2 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
1.3 3.9 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
1.2 13.7 GO:0015886 heme transport(GO:0015886)
1.2 5.0 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
1.2 12.5 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.1 6.9 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
1.1 33.1 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
1.1 5.5 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
1.1 26.3 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
1.1 10.6 GO:0002115 store-operated calcium entry(GO:0002115)
1.1 22.1 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
1.1 8.4 GO:0042552 myelination(GO:0042552)
1.0 27.7 GO:0045730 respiratory burst(GO:0045730)
1.0 4.0 GO:2000434 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
1.0 3.9 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
1.0 6.7 GO:0031642 negative regulation of myelination(GO:0031642)
1.0 23.9 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.9 108.2 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.9 9.0 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.8 108.2 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.8 13.1 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.7 17.9 GO:0030855 epithelial cell differentiation(GO:0030855)
0.7 4.5 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.7 7.3 GO:0071763 nuclear membrane organization(GO:0071763)
0.7 2.9 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.7 5.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.7 4.3 GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.7 19.1 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.7 8.9 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.7 110.9 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.6 15.3 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.6 12.5 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.6 11.7 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.6 57.8 GO:0030183 B cell differentiation(GO:0030183)
0.6 78.1 GO:0007338 single fertilization(GO:0007338)
0.6 15.2 GO:0007035 vacuolar acidification(GO:0007035)
0.5 3.8 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.5 5.9 GO:0090168 Golgi reassembly(GO:0090168)
0.5 23.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 1.5 GO:2000397 ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.5 18.1 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.5 3.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.4 27.7 GO:0015914 phospholipid transport(GO:0015914)
0.4 4.7 GO:0051168 nuclear export(GO:0051168)
0.4 11.1 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.4 13.9 GO:0002260 lymphocyte homeostasis(GO:0002260)
0.4 15.6 GO:0035329 hippo signaling(GO:0035329)
0.4 5.5 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.4 4.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 2.9 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.4 4.6 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3 2.4 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 17.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.3 0.7 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.3 11.5 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.3 11.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.3 18.2 GO:0006953 acute-phase response(GO:0006953)
0.3 4.4 GO:0015671 oxygen transport(GO:0015671)
0.3 25.5 GO:0030218 erythrocyte differentiation(GO:0030218)
0.3 10.6 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.3 39.9 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.3 1.6 GO:0035655 interleukin-18-mediated signaling pathway(GO:0035655) cellular response to interleukin-18(GO:0071351)
0.3 6.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.2 15.8 GO:0006611 protein export from nucleus(GO:0006611)
0.2 5.1 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991)
0.2 4.3 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.2 8.2 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.2 9.0 GO:0016266 O-glycan processing(GO:0016266)
0.2 24.8 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.2 30.2 GO:0045047 protein targeting to ER(GO:0045047)
0.2 2.7 GO:1904896 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.2 3.4 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.2 6.4 GO:0000186 activation of MAPKK activity(GO:0000186)
0.2 8.8 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.2 10.4 GO:0043312 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.2 96.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 18.5 GO:0044070 regulation of anion transport(GO:0044070)
0.1 2.9 GO:0030225 macrophage differentiation(GO:0030225)
0.1 4.0 GO:0006308 DNA catabolic process(GO:0006308)
0.1 0.5 GO:0003219 cardiac right ventricle formation(GO:0003219)
0.1 4.6 GO:0046686 response to cadmium ion(GO:0046686)
0.1 5.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 1.5 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 5.1 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 14.1 GO:0006413 translational initiation(GO:0006413)
0.1 3.1 GO:0007566 embryo implantation(GO:0007566)
0.1 1.5 GO:0003094 glomerular filtration(GO:0003094)
0.1 40.3 GO:0006954 inflammatory response(GO:0006954)
0.1 41.2 GO:0016032 viral process(GO:0016032)
0.1 4.5 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.1 3.9 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 3.4 GO:0006468 protein phosphorylation(GO:0006468)
0.0 6.1 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.1 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 3.1 GO:0015992 proton transport(GO:0015992)
0.0 0.4 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.3 GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0 2.5 GO:0002250 adaptive immune response(GO:0002250)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
20.2 101.0 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
13.4 94.1 GO:0019815 B cell receptor complex(GO:0019815)
8.5 42.7 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
8.4 59.0 GO:0072487 MSL complex(GO:0072487)
8.2 65.6 GO:0032010 phagolysosome(GO:0032010)
7.8 7.8 GO:0071159 NF-kappaB complex(GO:0071159)
7.5 45.0 GO:0070436 Grb2-EGFR complex(GO:0070436)
6.9 137.2 GO:0001891 phagocytic cup(GO:0001891)
4.7 14.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
3.5 17.7 GO:0032009 early phagosome(GO:0032009)
3.4 36.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
3.1 43.9 GO:0031209 SCAR complex(GO:0031209)
2.8 34.0 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
2.8 11.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
2.7 51.2 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
2.6 18.1 GO:0046581 intercellular canaliculus(GO:0046581)
2.1 17.1 GO:0035976 AP1 complex(GO:0035976)
1.8 98.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.8 25.5 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
1.8 10.5 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
1.7 15.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
1.5 36.9 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
1.4 125.8 GO:0035580 specific granule lumen(GO:0035580)
1.4 75.2 GO:0001772 immunological synapse(GO:0001772)
1.3 3.9 GO:0034657 GID complex(GO:0034657)
1.3 3.8 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.2 17.1 GO:0030897 HOPS complex(GO:0030897)
1.2 21.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
1.2 15.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.2 4.6 GO:0032044 DSIF complex(GO:0032044)
1.2 163.6 GO:0032587 ruffle membrane(GO:0032587)
1.1 37.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
1.1 78.9 GO:0030670 phagocytic vesicle membrane(GO:0030670)
1.1 4.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
1.1 74.8 GO:0035577 azurophil granule membrane(GO:0035577)
1.0 5.1 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
1.0 154.6 GO:0031225 anchored component of membrane(GO:0031225)
1.0 5.9 GO:0008537 proteasome activator complex(GO:0008537)
0.9 11.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.9 6.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.9 3.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.9 16.5 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.8 13.4 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.8 25.8 GO:0030686 90S preribosome(GO:0030686)
0.8 8.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.7 5.1 GO:0005787 signal peptidase complex(GO:0005787)
0.7 5.6 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.7 77.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.7 12.3 GO:0097342 ripoptosome(GO:0097342)
0.6 11.4 GO:0016580 Sin3 complex(GO:0016580)
0.6 16.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.5 33.1 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.5 18.4 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.5 9.4 GO:0030904 retromer complex(GO:0030904)
0.4 5.4 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 115.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 7.1 GO:0031932 TORC2 complex(GO:0031932)
0.4 3.4 GO:0005955 calcineurin complex(GO:0005955)
0.4 60.7 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.3 82.7 GO:0030667 secretory granule membrane(GO:0030667)
0.3 80.3 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 8.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3 70.3 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 32.8 GO:0043679 axon terminus(GO:0043679)
0.3 2.7 GO:0000815 ESCRT III complex(GO:0000815)
0.3 7.1 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.3 5.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.3 22.9 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 103.8 GO:0005667 transcription factor complex(GO:0005667)
0.2 60.3 GO:0000790 nuclear chromatin(GO:0000790)
0.2 72.7 GO:0031965 nuclear membrane(GO:0031965)
0.2 2.8 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.2 19.2 GO:0043204 perikaryon(GO:0043204)
0.2 3.9 GO:0097225 sperm midpiece(GO:0097225)
0.2 1.5 GO:0000813 ESCRT I complex(GO:0000813)
0.2 2.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.2 2.5 GO:0000974 Prp19 complex(GO:0000974)
0.2 15.4 GO:0019867 mitochondrial outer membrane(GO:0005741) outer membrane(GO:0019867) organelle outer membrane(GO:0031968)
0.2 110.3 GO:0000139 Golgi membrane(GO:0000139)
0.2 17.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.2 213.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 8.3 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.9 GO:0005682 U5 snRNP(GO:0005682)
0.1 10.6 GO:0035578 azurophil granule lumen(GO:0035578)
0.1 0.4 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.1 17.5 GO:0005681 spliceosomal complex(GO:0005681)
0.1 22.4 GO:0005911 cell-cell junction(GO:0005911)
0.1 14.7 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 28.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 3.5 GO:0005882 intermediate filament(GO:0005882)
0.1 4.5 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.4 GO:0016605 PML body(GO:0016605)
0.1 121.2 GO:0070062 extracellular exosome(GO:0070062)
0.0 82.9 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.3 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 1.8 GO:0030027 lamellipodium(GO:0030027)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
23.7 71.2 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
23.5 235.0 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
22.4 67.2 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
20.6 61.8 GO:0036134 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
20.2 60.7 GO:0004914 interleukin-5 receptor activity(GO:0004914)
14.4 101.0 GO:0030369 ICAM-3 receptor activity(GO:0030369)
11.0 32.9 GO:0045322 unmethylated CpG binding(GO:0045322)
8.4 25.3 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
8.4 33.6 GO:0019770 IgG receptor activity(GO:0019770)
7.9 23.7 GO:0016019 peptidoglycan receptor activity(GO:0016019)
7.2 28.7 GO:0019763 immunoglobulin receptor activity(GO:0019763)
6.6 65.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
6.4 19.2 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
6.4 114.6 GO:0019992 diacylglycerol binding(GO:0019992)
5.8 75.4 GO:0042608 T cell receptor binding(GO:0042608)
5.5 27.7 GO:0017159 pantetheine hydrolase activity(GO:0017159)
5.5 88.0 GO:0032036 myosin heavy chain binding(GO:0032036)
5.5 60.1 GO:0051525 NFAT protein binding(GO:0051525)
4.7 14.2 GO:0015333 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
4.6 18.4 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
4.5 13.4 GO:0004917 interleukin-7 receptor activity(GO:0004917)
4.0 48.5 GO:0019864 IgG binding(GO:0019864)
4.0 68.6 GO:0035325 receptor signaling protein tyrosine kinase activity(GO:0004716) Toll-like receptor binding(GO:0035325)
3.8 116.4 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
3.7 51.5 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
3.7 40.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
3.6 10.9 GO:0032184 SUMO polymer binding(GO:0032184)
3.3 9.9 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
3.1 27.7 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
3.1 9.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
3.1 18.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
3.0 51.2 GO:0008494 translation activator activity(GO:0008494)
2.7 30.2 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
2.7 27.3 GO:1990948 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
2.7 130.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
2.6 43.4 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
2.5 55.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.4 14.6 GO:0039552 RIG-I binding(GO:0039552)
2.4 19.0 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
2.3 100.4 GO:0001784 phosphotyrosine binding(GO:0001784)
2.3 50.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
1.8 18.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
1.7 6.7 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.5 70.7 GO:0036002 pre-mRNA binding(GO:0036002)
1.5 15.0 GO:0019869 chloride channel inhibitor activity(GO:0019869)
1.5 13.4 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
1.5 8.9 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
1.4 5.7 GO:0070735 protein-glycine ligase activity(GO:0070735)
1.4 8.3 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
1.4 13.7 GO:0015232 heme transporter activity(GO:0015232)
1.3 9.0 GO:0004920 interleukin-10 receptor activity(GO:0004920)
1.1 6.9 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
1.0 7.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.9 17.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 10.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.9 4.5 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.9 15.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.8 5.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.8 23.5 GO:0032452 histone demethylase activity(GO:0032452)
0.8 5.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.8 59.0 GO:0035064 methylated histone binding(GO:0035064)
0.8 10.6 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.8 11.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.8 20.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.8 3.8 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.8 15.8 GO:0001055 RNA polymerase II activity(GO:0001055)
0.7 134.0 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.7 19.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.7 35.6 GO:0015026 coreceptor activity(GO:0015026)
0.7 5.5 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.7 50.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.7 10.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.7 15.2 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.7 34.6 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.6 9.0 GO:0004875 complement receptor activity(GO:0004875)
0.6 10.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.6 34.7 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.6 24.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.6 9.0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.6 58.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.6 18.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.6 17.0 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.6 5.6 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.5 9.8 GO:0005537 mannose binding(GO:0005537)
0.5 5.2 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.5 12.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 2.9 GO:0042296 ISG15 transferase activity(GO:0042296)
0.4 14.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.4 22.8 GO:0005044 scavenger receptor activity(GO:0005044)
0.4 2.1 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 11.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 117.1 GO:0003924 GTPase activity(GO:0003924)
0.4 10.5 GO:0042288 MHC class I protein binding(GO:0042288)
0.4 7.1 GO:0019789 SUMO transferase activity(GO:0019789)
0.4 3.6 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.3 4.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 37.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 1.5 GO:0046790 virion binding(GO:0046790)
0.3 15.3 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3 7.3 GO:0005521 lamin binding(GO:0005521)
0.3 2.9 GO:0051434 BH3 domain binding(GO:0051434)
0.3 68.6 GO:0030246 carbohydrate binding(GO:0030246)
0.2 12.8 GO:0019843 rRNA binding(GO:0019843)
0.2 21.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 5.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.2 6.4 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.2 48.0 GO:0051015 actin filament binding(GO:0051015)
0.2 60.4 GO:0005096 GTPase activator activity(GO:0005096)