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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for SPIC

Z-value: 2.86

Motif logo

Transcription factors associated with SPIC

Gene Symbol Gene ID Gene Info
ENSG00000166211.6 Spi-C transcription factor

Activity profile of SPIC motif

Sorted Z-values of SPIC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_121379739 67.66 ENST00000428394.2
ENST00000314583.3
hematopoietic cell-specific Lyn substrate 1
chr12_-_15114603 58.42 ENST00000228945.4
Rho GDP dissociation inhibitor (GDI) beta
chr16_+_30194916 55.19 ENST00000570045.1
ENST00000565497.1
ENST00000570244.1
coronin, actin binding protein, 1A
chr1_-_160681593 51.35 ENST00000368045.3
ENST00000368046.3
CD48 molecule
chr12_-_15114492 50.41 ENST00000541546.1
Rho GDP dissociation inhibitor (GDI) beta
chr12_+_54892550 49.15 ENST00000545638.2
NCK-associated protein 1-like
chr13_-_46756351 48.29 ENST00000323076.2
lymphocyte cytosolic protein 1 (L-plastin)
chr19_+_49838653 47.81 ENST00000598095.1
ENST00000426897.2
ENST00000323906.4
ENST00000535669.2
ENST00000597602.1
ENST00000595660.1
CD37 molecule
chr6_+_31554826 46.39 ENST00000376089.2
ENST00000396112.2
leukocyte specific transcript 1
chr6_-_32557610 45.85 ENST00000360004.5
major histocompatibility complex, class II, DR beta 1
chr4_-_103682071 44.81 ENST00000505239.1
mannosidase, beta A, lysosomal
chr19_-_10446449 43.29 ENST00000592439.1
intercellular adhesion molecule 3
chr13_+_31309645 40.77 ENST00000380490.3
arachidonate 5-lipoxygenase-activating protein
chr19_-_8642289 39.96 ENST00000596675.1
ENST00000338257.8
myosin IF
chr12_+_25205666 39.63 ENST00000547044.1
lymphoid-restricted membrane protein
chr1_-_31230650 38.73 ENST00000294507.3
lysosomal protein transmembrane 5
chr12_+_25205568 38.24 ENST00000548766.1
ENST00000556887.1
lymphoid-restricted membrane protein
chr14_-_23285011 37.59 ENST00000397532.3
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr14_-_23285069 37.40 ENST00000554758.1
ENST00000397528.4
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr1_-_183560011 37.18 ENST00000367536.1
neutrophil cytosolic factor 2
chr22_+_23247030 36.84 ENST00000390324.2
immunoglobulin lambda joining 3
chr22_+_37309662 36.05 ENST00000403662.3
ENST00000262825.5
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr22_+_37257015 35.51 ENST00000447071.1
ENST00000248899.6
ENST00000397147.4
neutrophil cytosolic factor 4, 40kDa
chrX_-_107018969 35.26 ENST00000372383.4
TSC22 domain family, member 3
chr16_-_88717482 35.00 ENST00000261623.3
cytochrome b-245, alpha polypeptide
chr4_-_74853897 34.79 ENST00000296028.3
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
chr17_-_29641104 33.98 ENST00000577894.1
ENST00000330927.4
ecotropic viral integration site 2B
chr1_+_111415757 33.90 ENST00000429072.2
ENST00000271324.5
CD53 molecule
chr12_+_7055767 32.42 ENST00000447931.2
protein tyrosine phosphatase, non-receptor type 6
chr7_+_74188309 32.40 ENST00000289473.4
ENST00000433458.1
neutrophil cytosolic factor 1
chr21_-_46340884 31.48 ENST00000302347.5
ENST00000517819.1
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr6_+_31582961 31.45 ENST00000376059.3
ENST00000337917.7
allograft inflammatory factor 1
chr16_+_81812863 31.08 ENST00000359376.3
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr21_-_46340770 30.16 ENST00000397854.3
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr16_-_88717423 29.92 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
cytochrome b-245, alpha polypeptide
chr19_-_10450328 29.79 ENST00000160262.5
intercellular adhesion molecule 3
chr1_-_150738261 29.50 ENST00000448301.2
ENST00000368985.3
cathepsin S
chr12_+_54891495 29.43 ENST00000293373.6
NCK-associated protein 1-like
chr19_-_39826639 29.23 ENST00000602185.1
ENST00000598034.1
ENST00000601387.1
ENST00000595636.1
ENST00000253054.8
ENST00000594700.1
ENST00000597595.1
glia maturation factor, gamma
chr12_+_7055631 29.08 ENST00000543115.1
ENST00000399448.1
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31554779 28.89 ENST00000376090.2
leukocyte specific transcript 1
chr19_-_10450287 28.77 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
intercellular adhesion molecule 3
chr2_+_143886877 28.67 ENST00000295095.6
Rho GTPase activating protein 15
chr1_-_25256368 28.46 ENST00000308873.6
runt-related transcription factor 3
chr17_-_29641084 27.78 ENST00000544462.1
ecotropic viral integration site 2B
chr19_-_39108568 26.95 ENST00000586296.1
mitogen-activated protein kinase kinase kinase kinase 1
chr11_+_1874200 24.79 ENST00000311604.3
lymphocyte-specific protein 1
chr10_-_98031310 24.73 ENST00000427367.2
ENST00000413476.2
B-cell linker
chrX_-_47489244 24.21 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
complement factor properdin
chr1_-_183559693 23.80 ENST00000367535.3
ENST00000413720.1
ENST00000418089.1
neutrophil cytosolic factor 2
chr17_-_20370847 23.79 ENST00000423676.3
ENST00000324290.5
lectin, galactoside-binding, soluble, 9B
chr19_+_13261216 23.46 ENST00000587885.1
ENST00000292433.3
immediate early response 2
chr5_-_140013275 23.24 ENST00000512545.1
ENST00000302014.6
ENST00000401743.2
CD14 molecule
chr17_+_72462525 22.67 ENST00000360141.3
CD300a molecule
chr6_+_31553978 22.54 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
leukocyte specific transcript 1
chr11_-_615570 22.49 ENST00000525445.1
ENST00000348655.6
ENST00000397566.1
interferon regulatory factor 7
chr19_+_42381337 22.18 ENST00000597454.1
ENST00000444740.2
CD79a molecule, immunoglobulin-associated alpha
chr11_-_615942 22.02 ENST00000397562.3
ENST00000330243.5
ENST00000397570.1
ENST00000397574.2
interferon regulatory factor 7
chr2_+_233925064 21.57 ENST00000359570.5
ENST00000538935.1
inositol polyphosphate-5-phosphatase, 145kDa
chr19_-_54784937 21.35 ENST00000434421.1
ENST00000314446.5
ENST00000391749.4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
chr10_-_98031265 21.13 ENST00000224337.5
ENST00000371176.2
B-cell linker
chr9_+_134000948 20.69 ENST00000359428.5
ENST00000411637.2
ENST00000451030.1
nucleoporin 214kDa
chr16_+_31271274 20.68 ENST00000287497.8
ENST00000544665.3
integrin, alpha M (complement component 3 receptor 3 subunit)
chr19_-_39108552 20.58 ENST00000591517.1
mitogen-activated protein kinase kinase kinase kinase 1
chr6_+_31554612 20.36 ENST00000211921.7
leukocyte specific transcript 1
chr3_+_16926441 20.24 ENST00000418129.2
ENST00000396755.2
phospholipase C-like 2
chr6_-_133079022 19.97 ENST00000525289.1
ENST00000326499.6
vanin 2
chr5_-_130970723 19.85 ENST00000308008.6
ENST00000296859.6
ENST00000507093.1
ENST00000510071.1
ENST00000509018.1
ENST00000307984.5
Rap guanine nucleotide exchange factor (GEF) 6
chr12_-_7656357 19.78 ENST00000396620.3
ENST00000432237.2
ENST00000359156.4
CD163 molecule
chr7_+_150264365 19.36 ENST00000255945.2
ENST00000461940.1
GTPase, IMAP family member 4
chr19_-_39108643 19.31 ENST00000396857.2
mitogen-activated protein kinase kinase kinase kinase 1
chr14_+_88471468 19.17 ENST00000267549.3
G protein-coupled receptor 65
chr17_+_34431212 19.16 ENST00000394495.1
chemokine (C-C motif) ligand 4
chr4_-_103682145 19.14 ENST00000226578.4
mannosidase, beta A, lysosomal
chr3_-_50375657 18.78 ENST00000395126.3
Ras association (RalGDS/AF-6) domain family member 1
chr18_-_47813940 18.54 ENST00000586837.1
ENST00000412036.2
ENST00000589940.1
CXXC finger protein 1
chr1_-_150552006 18.46 ENST00000307940.3
ENST00000369026.2
myeloid cell leukemia sequence 1 (BCL2-related)
chr12_+_25205446 18.33 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
lymphoid-restricted membrane protein
chr17_+_42422662 18.30 ENST00000593167.1
ENST00000585512.1
ENST00000591740.1
ENST00000592783.1
ENST00000587387.1
ENST00000588237.1
ENST00000589265.1
granulin
chr1_+_161475208 18.28 ENST00000367972.4
ENST00000271450.6
Fc fragment of IgG, low affinity IIa, receptor (CD32)
chr11_-_72463421 18.24 ENST00000393609.3
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr7_-_76829125 18.18 ENST00000248598.5
fibrinogen-like 2
chr17_+_72462766 17.97 ENST00000392625.3
ENST00000361933.3
ENST00000310828.5
CD300a molecule
chr2_-_231084820 17.84 ENST00000258382.5
ENST00000338556.3
SP110 nuclear body protein
chrX_+_24072833 17.53 ENST00000253039.4
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr5_+_178977546 17.52 ENST00000319449.4
ENST00000377001.2
RUN and FYVE domain containing 1
chr16_-_88851618 17.50 ENST00000301015.9
piezo-type mechanosensitive ion channel component 1
chr1_-_153518270 17.46 ENST00000354332.4
ENST00000368716.4
S100 calcium binding protein A4
chr11_-_60719213 17.45 ENST00000227880.3
solute carrier family 15 (oligopeptide transporter), member 3
chr12_+_7060432 17.43 ENST00000318974.9
ENST00000456013.1
protein tyrosine phosphatase, non-receptor type 6
chr6_+_31553901 17.35 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
leukocyte specific transcript 1
chr5_-_150603679 17.35 ENST00000355417.2
coiled-coil domain containing 69
chr4_+_8201091 17.31 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3 domain and tetratricopeptide repeats 1
chr6_+_27114861 17.11 ENST00000377459.1
histone cluster 1, H2ah
chrY_+_2709527 17.00 ENST00000250784.8
ribosomal protein S4, Y-linked 1
chr19_+_859654 16.90 ENST00000592860.1
complement factor D (adipsin)
chr11_+_5710919 16.62 ENST00000379965.3
ENST00000425490.1
tripartite motif containing 22
chr19_-_36233332 16.59 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGF-like family receptor 1
chr19_+_55084438 16.48 ENST00000439534.1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
chr16_-_21663919 16.38 ENST00000569602.1
immunoglobulin superfamily, member 6
chr16_+_30205225 16.36 ENST00000345535.4
ENST00000251303.6
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr19_+_41903709 16.36 ENST00000542943.1
ENST00000457836.2
branched chain keto acid dehydrogenase E1, alpha polypeptide
chr2_+_68592305 16.25 ENST00000234313.7
pleckstrin
chr6_+_31554456 16.05 ENST00000339530.4
leukocyte specific transcript 1
chr16_+_29465822 15.99 ENST00000330181.5
ENST00000351581.4
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr2_+_182321925 15.92 ENST00000339307.4
ENST00000397033.2
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
chr19_-_51875894 15.90 ENST00000600427.1
ENST00000595217.1
ENST00000221978.5
natural killer cell group 7 sequence
chr22_-_37880543 15.86 ENST00000442496.1
MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr19_+_859425 15.75 ENST00000327726.6
complement factor D (adipsin)
chr10_+_97471508 15.71 ENST00000453258.2
ectonucleoside triphosphate diphosphohydrolase 1
chr14_-_89883412 15.66 ENST00000557258.1
forkhead box N3
chr19_+_6772710 15.57 ENST00000304076.2
ENST00000602142.1
ENST00000596764.1
vav 1 guanine nucleotide exchange factor
chr3_+_151986709 15.54 ENST00000495875.2
ENST00000493459.1
ENST00000324210.5
ENST00000459747.1
muscleblind-like splicing regulator 1
chr20_-_4795747 15.48 ENST00000379376.2
Ras association (RalGDS/AF-6) domain family member 2
chr1_-_161519579 15.40 ENST00000426740.1
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr20_+_2821340 15.31 ENST00000380445.3
ENST00000380469.3
vacuolar protein sorting 16 homolog (S. cerevisiae)
chr14_+_21423611 15.26 ENST00000304625.2
ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
chr21_-_15918618 15.01 ENST00000400564.1
ENST00000400566.1
SAM domain, SH3 domain and nuclear localization signals 1
chr19_+_1041212 14.83 ENST00000433129.1
ATP-binding cassette, sub-family A (ABC1), member 7
chr12_-_8218997 14.81 ENST00000307637.4
complement component 3a receptor 1
chr1_+_161632937 14.60 ENST00000236937.9
ENST00000367961.4
ENST00000358671.5
Fc fragment of IgG, low affinity IIb, receptor (CD32)
chr1_-_161519682 14.55 ENST00000367969.3
ENST00000443193.1
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
chr7_+_100450328 14.49 ENST00000540482.1
ENST00000418037.1
ENST00000428758.1
ENST00000275729.3
ENST00000415287.1
ENST00000354161.3
ENST00000416675.1
solute carrier family 12, member 9
chr19_+_55128576 14.47 ENST00000396331.1
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr2_-_231084659 14.36 ENST00000258381.6
ENST00000358662.4
ENST00000455674.1
ENST00000392048.3
SP110 nuclear body protein
chr19_+_55141861 14.36 ENST00000396327.3
ENST00000324602.7
ENST00000434867.2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr19_-_13213662 14.30 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr1_+_181057638 14.19 ENST00000367577.4
immediate early response 5
chr2_-_231084617 14.08 ENST00000409815.2
SP110 nuclear body protein
chr19_+_35645618 13.96 ENST00000392218.2
ENST00000543307.1
ENST00000392219.2
ENST00000541435.2
ENST00000590686.1
ENST00000342879.3
ENST00000588699.1
FXYD domain containing ion transport regulator 5
chrY_+_15016725 13.86 ENST00000336079.3
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr15_-_90358048 13.62 ENST00000300060.6
ENST00000560137.1
alanyl (membrane) aminopeptidase
chr19_+_55141948 13.41 ENST00000396332.4
ENST00000427581.2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr7_-_150329421 13.38 ENST00000493969.1
ENST00000328902.5
GTPase, IMAP family member 6
chr2_+_89998789 13.29 ENST00000453166.2
immunoglobulin kappa variable 2D-28
chr15_-_80263506 13.27 ENST00000335661.6
BCL2-related protein A1
chr17_-_76123101 13.19 ENST00000392467.3
transmembrane channel-like 6
chr11_-_64647144 12.95 ENST00000359393.2
ENST00000433803.1
ENST00000411683.1
EH-domain containing 1
chr17_-_34625719 12.93 ENST00000422211.2
ENST00000542124.1
chemokine (C-C motif) ligand 3-like 1
chr17_-_34524157 12.69 ENST00000378354.4
ENST00000394484.1
chemokine (C-C motif) ligand 3-like 3
chr2_+_89999259 12.63 ENST00000558026.1
immunoglobulin kappa variable 2D-28
chr6_+_31554636 12.50 ENST00000433492.1
leukocyte specific transcript 1
chr15_+_77287426 12.36 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
proline-serine-threonine phosphatase interacting protein 1
chr14_+_91581011 12.31 ENST00000523894.1
ENST00000522322.1
ENST00000523771.1
chromosome 14 open reading frame 159
chr16_-_21663950 11.91 ENST00000268389.4
immunoglobulin superfamily, member 6
chr16_-_15736881 11.89 ENST00000540441.2
KIAA0430
chr11_+_43380459 11.80 ENST00000299240.6
ENST00000039989.4
tetratricopeptide repeat domain 17
chr3_-_49142504 11.71 ENST00000306125.6
ENST00000420147.2
glutaminyl-tRNA synthetase
chr1_+_149230680 11.65 ENST00000443018.1
RP11-403I13.5
chr18_-_11908329 11.58 ENST00000344987.7
ENST00000588103.1
ENST00000588191.1
ENST00000317235.7
ENST00000309976.9
ENST00000588186.1
ENST00000589267.1
metallophosphoesterase 1
chr3_+_158519654 11.15 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
major facilitator superfamily domain containing 1
chr19_-_18391708 11.10 ENST00000600972.1
jun D proto-oncogene
chr2_+_202125219 11.05 ENST00000323492.7
caspase 8, apoptosis-related cysteine peptidase
chr19_+_46010674 10.84 ENST00000245932.6
ENST00000592139.1
ENST00000590603.1
vasodilator-stimulated phosphoprotein
chr3_+_5229356 10.71 ENST00000256497.4
ER degradation enhancer, mannosidase alpha-like 1
chr17_+_18380051 10.70 ENST00000581545.1
ENST00000582333.1
ENST00000328114.6
ENST00000412421.2
ENST00000583322.1
ENST00000584941.1
lectin, galactoside-binding, soluble, 9C
chr15_-_65282274 10.41 ENST00000204566.2
spastic paraplegia 21 (autosomal recessive, Mast syndrome)
chr11_+_65408273 10.40 ENST00000394227.3
signal-induced proliferation-associated 1
chr17_+_37356555 10.12 ENST00000579374.1
ribosomal protein L19
chr1_+_202830876 10.09 ENST00000456105.2
RP11-480I12.7
chr7_+_108210012 9.97 ENST00000249356.3
DnaJ (Hsp40) homolog, subfamily B, member 9
chr12_-_6772303 9.96 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
inhibitor of growth family, member 4
chr17_+_37356528 9.93 ENST00000225430.4
ribosomal protein L19
chr17_+_37356586 9.91 ENST00000579260.1
ENST00000582193.1
ribosomal protein L19
chr14_+_23340822 9.90 ENST00000359591.4
low density lipoprotein receptor-related protein 10
chr19_-_19754404 9.90 ENST00000587205.1
ENST00000445806.2
ENST00000203556.4
GEM interacting protein
chr1_+_158985457 9.84 ENST00000567661.1
ENST00000474473.1
interferon, gamma-inducible protein 16
chr18_+_21033239 9.77 ENST00000581585.1
ENST00000577501.1
RIO kinase 3
chr19_+_35645817 9.71 ENST00000423817.3
FXYD domain containing ion transport regulator 5
chr16_+_89627061 9.67 ENST00000311528.5
ENST00000563270.1
ENST00000567815.1
ENST00000452368.3
ENST00000467736.1
ENST00000393099.3
ribosomal protein L13
chrX_+_11776701 9.67 ENST00000476743.1
ENST00000421368.2
ENST00000398527.2
male-specific lethal 3 homolog (Drosophila)
chr6_+_106534192 9.66 ENST00000369091.2
ENST00000369096.4
PR domain containing 1, with ZNF domain
chr19_+_51728316 9.57 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33 molecule
chr2_-_152146385 9.52 ENST00000414946.1
ENST00000243346.5
N-myc (and STAT) interactor
chr19_+_852291 9.47 ENST00000263621.1
elastase, neutrophil expressed
chr6_+_14117872 9.25 ENST00000379153.3
CD83 molecule
chr16_-_15736953 9.25 ENST00000548025.1
ENST00000551742.1
ENST00000602337.1
ENST00000344181.3
ENST00000396368.3
KIAA0430
chr16_-_87799505 9.25 ENST00000353170.5
ENST00000561825.1
ENST00000270583.5
ENST00000562261.1
ENST00000347925.5
kelch domain containing 4
chr19_-_6481776 9.25 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENN/MADD domain containing 1C
chr6_-_99873145 9.24 ENST00000369239.5
ENST00000438806.1
PNN-interacting serine/arginine-rich protein
chr17_-_34417479 9.23 ENST00000225245.5
chemokine (C-C motif) ligand 3
chr19_+_17970693 9.21 ENST00000600147.1
ENST00000599898.1
ribosomal protein L18a
chr1_+_6640108 9.20 ENST00000377674.4
ENST00000488936.1
zinc finger and BTB domain containing 48
chr10_-_27149904 9.18 ENST00000376166.1
ENST00000376138.3
ENST00000355394.4
ENST00000346832.5
ENST00000376134.3
ENST00000376137.4
ENST00000536334.1
ENST00000490841.2
abl-interactor 1
chr16_+_69796209 9.08 ENST00000359154.2
ENST00000561780.1
ENST00000563659.1
ENST00000448661.1
WW domain containing E3 ubiquitin protein ligase 2
chr18_-_61089665 9.08 ENST00000238497.5
vacuolar protein sorting 4 homolog B (S. cerevisiae)
chr1_-_153919128 8.94 ENST00000361217.4
DENN/MADD domain containing 4B
chr11_-_62380199 8.71 ENST00000419857.1
ENST00000394773.2
echinoderm microtubule associated protein like 3
chr18_-_53253323 8.65 ENST00000540999.1
ENST00000563888.2
transcription factor 4
chr1_-_47069955 8.63 ENST00000341183.5
ENST00000496619.1
MAP kinase interacting serine/threonine kinase 1
chr3_-_49142178 8.63 ENST00000452739.1
ENST00000414533.1
ENST00000417025.1
glutaminyl-tRNA synthetase
chr10_-_121302195 8.60 ENST00000369103.2
regulator of G-protein signaling 10
chr17_-_79269067 8.57 ENST00000288439.5
ENST00000374759.3
solute carrier family 38, member 10
chr7_-_99097863 8.53 ENST00000426306.2
ENST00000337673.6
zinc finger protein 394
chr9_+_134065506 8.45 ENST00000483497.2
nucleoporin 214kDa
chr9_+_125132803 8.42 ENST00000540753.1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr11_+_2421718 8.37 ENST00000380996.5
ENST00000333256.6
ENST00000380992.1
ENST00000437110.1
ENST00000435795.1
tumor suppressing subtransferable candidate 4
chr3_+_47324424 8.36 ENST00000437353.1
ENST00000232766.5
ENST00000455924.2
kelch-like family member 18
chr14_-_74417096 8.22 ENST00000286544.3
family with sequence similarity 161, member B
chr2_+_202122703 8.15 ENST00000447616.1
ENST00000358485.4
caspase 8, apoptosis-related cysteine peptidase

Network of associatons between targets according to the STRING database.

First level regulatory network of SPIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
27.2 108.8 GO:0071461 cellular response to redox state(GO:0071461)
19.6 78.6 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
18.6 74.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
17.2 51.7 GO:0002316 follicular B cell differentiation(GO:0002316)
17.0 85.1 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124)
13.8 55.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
13.0 64.9 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
12.5 75.0 GO:1990822 basic amino acid transmembrane transport(GO:1990822)
12.2 36.7 GO:0038043 interleukin-5-mediated signaling pathway(GO:0038043)
10.6 42.2 GO:0035548 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
9.2 45.8 GO:0002399 MHC class II protein complex assembly(GO:0002399)
7.9 23.7 GO:0046586 regulation of calcium-dependent cell-cell adhesion(GO:0046586)
7.2 21.6 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
6.8 20.3 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
6.7 20.2 GO:0001923 B-1 B cell differentiation(GO:0001923)
6.5 6.5 GO:1904124 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
6.4 19.2 GO:0052053 modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
6.3 31.5 GO:0014738 regulation of muscle hyperplasia(GO:0014738)
5.8 23.2 GO:0071727 toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
5.3 21.3 GO:0002774 Fc receptor mediated inhibitory signaling pathway(GO:0002774)
5.2 67.7 GO:0045651 positive regulation of macrophage differentiation(GO:0045651)
5.0 35.3 GO:0070236 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
4.9 14.8 GO:1902994 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
4.8 33.7 GO:0033625 positive regulation of integrin activation(GO:0033625)
4.6 18.2 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
4.5 95.5 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
4.5 40.6 GO:2001300 lipoxin metabolic process(GO:2001300)
4.4 17.8 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
4.2 12.7 GO:0045404 interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
4.1 28.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
4.0 63.9 GO:0009313 oligosaccharide catabolic process(GO:0009313)
4.0 15.9 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
3.8 122.0 GO:0045730 respiratory burst(GO:0045730)
3.6 25.1 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
3.2 22.7 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
3.2 12.7 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
3.2 9.5 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
3.1 18.5 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
3.0 9.1 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611) negative regulation of exosomal secretion(GO:1903542) regulation of centriole elongation(GO:1903722)
3.0 17.9 GO:0010940 positive regulation of necrotic cell death(GO:0010940)
2.9 66.8 GO:0000185 activation of MAPKKK activity(GO:0000185)
2.8 48.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
2.8 69.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
2.7 16.4 GO:1904431 positive regulation of t-circle formation(GO:1904431)
2.7 10.8 GO:1904379 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
2.6 25.7 GO:0015939 pantothenate metabolic process(GO:0015939)
2.5 10.0 GO:0043983 histone H4-K12 acetylation(GO:0043983)
2.5 17.3 GO:0097319 fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
2.4 16.8 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
2.4 4.8 GO:0006438 valyl-tRNA aminoacylation(GO:0006438)
2.4 14.3 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
2.1 4.2 GO:0060559 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
2.1 10.4 GO:0042631 cellular response to water deprivation(GO:0042631)
2.1 12.4 GO:0052565 response to defense-related nitric oxide production by other organism involved in symbiotic interaction(GO:0052551) response to defense-related host nitric oxide production(GO:0052565)
2.0 46.8 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
2.0 5.9 GO:0097327 response to antineoplastic agent(GO:0097327)
1.9 17.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
1.9 5.7 GO:0052027 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
1.9 11.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
1.8 5.5 GO:0070902 mitochondrial tRNA pseudouridine synthesis(GO:0070902)
1.8 5.4 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
1.7 153.4 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
1.7 10.2 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
1.7 5.1 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
1.6 8.1 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
1.6 6.3 GO:0018094 protein polyglycylation(GO:0018094)
1.5 17.0 GO:0002315 marginal zone B cell differentiation(GO:0002315)
1.5 9.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
1.5 6.1 GO:0019086 late viral transcription(GO:0019086)
1.5 3.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
1.5 44.9 GO:0010447 response to acidic pH(GO:0010447)
1.5 2.9 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
1.4 5.7 GO:0060010 Sertoli cell fate commitment(GO:0060010)
1.4 14.3 GO:0001955 blood vessel maturation(GO:0001955)
1.4 7.1 GO:0019805 tryptophan catabolic process to kynurenine(GO:0019441) quinolinate biosynthetic process(GO:0019805)
1.4 5.6 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
1.3 18.5 GO:0034498 early endosome to Golgi transport(GO:0034498)
1.3 15.5 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
1.3 22.8 GO:0035855 megakaryocyte development(GO:0035855)
1.3 1.3 GO:1903094 regulation of protein K48-linked deubiquitination(GO:1903093) negative regulation of protein K48-linked deubiquitination(GO:1903094) negative regulation of ubiquitin-specific protease activity(GO:2000157)
1.2 14.8 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
1.2 8.6 GO:0043654 recognition of apoptotic cell(GO:0043654)
1.2 6.0 GO:1903026 transcription factor catabolic process(GO:0036369) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026)
1.2 10.7 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.2 7.1 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948) regulation of receptor catabolic process(GO:2000644)
1.2 19.8 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
1.2 15.0 GO:0050869 negative regulation of B cell activation(GO:0050869)
1.1 5.5 GO:0031642 negative regulation of myelination(GO:0031642)
1.1 3.3 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
1.1 6.5 GO:0070383 DNA cytosine deamination(GO:0070383)
1.1 5.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.0 6.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
1.0 3.1 GO:0032887 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
1.0 3.0 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
1.0 27.3 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.0 7.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
1.0 8.0 GO:0051601 exocyst localization(GO:0051601)
1.0 15.7 GO:0034656 nucleobase-containing small molecule catabolic process(GO:0034656)
1.0 1.0 GO:0051462 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462)
1.0 4.8 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.9 1.9 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
0.9 2.8 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.9 6.3 GO:0007000 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180) nucleolus organization(GO:0007000)
0.9 7.1 GO:0034427 nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.9 5.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.9 4.3 GO:0035063 nuclear speck organization(GO:0035063)
0.8 2.5 GO:1901668 regulation of superoxide dismutase activity(GO:1901668)
0.8 2.5 GO:0090149 mitochondrial membrane fission(GO:0090149)
0.8 7.3 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.8 3.1 GO:0043321 regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.8 7.6 GO:0002115 store-operated calcium entry(GO:0002115)
0.7 22.1 GO:0034142 toll-like receptor 4 signaling pathway(GO:0034142)
0.7 4.4 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.7 2.1 GO:0097359 UDP-glucosylation(GO:0097359)
0.7 4.8 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.7 3.4 GO:0042989 sequestering of actin monomers(GO:0042989)
0.7 17.6 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 6.8 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.7 3.4 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.7 7.3 GO:0032688 negative regulation of interferon-beta production(GO:0032688)
0.7 12.4 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.6 5.2 GO:0035897 proteolysis in other organism(GO:0035897)
0.6 6.3 GO:0045023 G0 to G1 transition(GO:0045023)
0.6 24.1 GO:0097421 liver regeneration(GO:0097421)
0.6 4.3 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885)
0.6 6.0 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.6 97.0 GO:0006906 vesicle fusion(GO:0006906)
0.6 8.4 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.6 3.5 GO:0060701 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.6 2.3 GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.6 59.9 GO:0030183 B cell differentiation(GO:0030183)
0.6 4.5 GO:1902570 protein localization to nucleolus(GO:1902570)
0.6 91.9 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.6 5.6 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.6 3.9 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.5 2.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.5 1.6 GO:0003352 regulation of cilium movement(GO:0003352) regulation of cilium beat frequency(GO:0003356) regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.5 2.1 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.5 6.9 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.5 2.1 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.5 5.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.5 16.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.5 9.7 GO:0051255 spindle midzone assembly(GO:0051255)
0.5 1.5 GO:0001300 chronological cell aging(GO:0001300)
0.5 18.0 GO:0006506 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.5 23.1 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.5 8.6 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.5 8.4 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.5 6.1 GO:0002227 innate immune response in mucosa(GO:0002227)
0.5 0.9 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.5 3.7 GO:0070424 regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070424)
0.5 7.9 GO:0006622 protein targeting to lysosome(GO:0006622)
0.5 3.7 GO:0040034 regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.5 2.3 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
0.5 1.8 GO:0060684 epithelial-mesenchymal cell signaling(GO:0060684)
0.4 4.5 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.4 7.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.4 9.2 GO:0010833 telomere maintenance via telomere lengthening(GO:0010833)
0.4 9.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.4 3.5 GO:0032790 ribosome disassembly(GO:0032790)
0.4 1.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.4 21.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.4 36.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.4 0.4 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.4 37.0 GO:0002819 regulation of adaptive immune response(GO:0002819)
0.4 5.4 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.4 9.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.4 9.8 GO:0045824 negative regulation of innate immune response(GO:0045824)
0.4 3.3 GO:0008340 determination of adult lifespan(GO:0008340)
0.4 3.9 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.4 65.4 GO:0006909 phagocytosis(GO:0006909)
0.4 1.1 GO:0038163 endomitotic cell cycle(GO:0007113) thrombopoietin-mediated signaling pathway(GO:0038163) positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.4 8.8 GO:0043984 histone H4-K16 acetylation(GO:0043984)
0.3 1.4 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.3 1.7 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.3 8.0 GO:0000460 maturation of 5.8S rRNA(GO:0000460)
0.3 6.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.3 3.3 GO:0021562 vestibulocochlear nerve development(GO:0021562)
0.3 1.0 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.3 1.3 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.3 47.4 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.3 6.4 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.3 13.6 GO:0043171 peptide catabolic process(GO:0043171)
0.3 12.3 GO:0006536 glutamate metabolic process(GO:0006536)
0.3 5.1 GO:0009435 NAD biosynthetic process(GO:0009435)
0.3 0.9 GO:0019605 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.3 2.9 GO:0021859 pyramidal neuron differentiation(GO:0021859) pyramidal neuron development(GO:0021860)
0.3 7.3 GO:0006825 copper ion transport(GO:0006825)
0.3 2.5 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.3 4.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.3 5.4 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.3 1.9 GO:0010818 T cell chemotaxis(GO:0010818)
0.3 0.8 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.3 1.8 GO:0090043 regulation of tubulin deacetylation(GO:0090043)
0.3 3.9 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.3 2.6 GO:0051014 actin filament severing(GO:0051014)
0.3 5.0 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.2 5.5 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.2 10.4 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.2 1.0 GO:0002281 macrophage activation involved in immune response(GO:0002281)
0.2 2.0 GO:1901673 regulation of mitotic spindle assembly(GO:1901673)
0.2 13.7 GO:0006968 cellular defense response(GO:0006968)
0.2 26.6 GO:1990823 response to leukemia inhibitory factor(GO:1990823) cellular response to leukemia inhibitory factor(GO:1990830)
0.2 1.1 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.2 12.8 GO:0051865 protein autoubiquitination(GO:0051865)
0.2 3.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 3.0 GO:0044803 multi-organism membrane organization(GO:0044803)
0.2 1.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.2 0.8 GO:0001757 somite specification(GO:0001757)
0.2 1.6 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.2 1.2 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.2 5.7 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.2 0.8 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.2 14.3 GO:0038034 signal transduction in absence of ligand(GO:0038034) extrinsic apoptotic signaling pathway in absence of ligand(GO:0097192)
0.2 12.0 GO:0006953 acute-phase response(GO:0006953)
0.2 7.4 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.2 0.6 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.2 6.2 GO:0070206 protein trimerization(GO:0070206)
0.2 1.3 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.2 0.5 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.2 5.7 GO:0006298 mismatch repair(GO:0006298)
0.2 0.3 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.2 0.8 GO:0071233 cellular response to leucine(GO:0071233) cellular response to leucine starvation(GO:1990253)
0.2 1.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 2.6 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 3.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 1.3 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.1 3.3 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 4.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 2.4 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.1 1.8 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 2.1 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.1 8.0 GO:1900034 regulation of cellular response to heat(GO:1900034)
0.1 1.1 GO:0044872 lipoprotein transport(GO:0042953) lipoprotein localization(GO:0044872)
0.1 3.7 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.1 2.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 3.6 GO:0001881 receptor recycling(GO:0001881)
0.1 1.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 1.5 GO:0016180 snRNA processing(GO:0016180)
0.1 1.0 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.6 GO:0006290 pyrimidine dimer repair(GO:0006290) activation of JNKK activity(GO:0007256)
0.1 6.5 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 12.8 GO:0071774 response to fibroblast growth factor(GO:0071774)
0.1 5.7 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.1 0.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.1 1.4 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 12.9 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.1 2.8 GO:0007035 vacuolar acidification(GO:0007035)
0.1 11.8 GO:0044782 cilium organization(GO:0044782)
0.1 7.7 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.1 4.2 GO:0016266 O-glycan processing(GO:0016266)
0.1 2.5 GO:0002076 osteoblast development(GO:0002076)
0.1 13.1 GO:0043484 regulation of RNA splicing(GO:0043484)
0.1 0.3 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.1 1.9 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.1 0.8 GO:0070995 NADPH oxidation(GO:0070995)
0.1 15.3 GO:0002250 adaptive immune response(GO:0002250)
0.1 0.8 GO:0035247 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247)
0.1 0.3 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 35.5 GO:0002283 neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1 0.7 GO:0017062 respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.1 0.7 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.1 4.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.1 1.5 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.1 1.1 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 10.9 GO:0015992 proton transport(GO:0015992)
0.1 1.8 GO:0030199 collagen fibril organization(GO:0030199)
0.1 8.0 GO:0007269 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.1 19.9 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 7.6 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 4.0 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 1.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.1 GO:0046068 cGMP metabolic process(GO:0046068)
0.1 7.5 GO:0007265 Ras protein signal transduction(GO:0007265)
0.1 7.3 GO:0048839 inner ear development(GO:0048839)
0.1 0.7 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 0.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 0.2 GO:1902961 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
0.1 1.6 GO:0036297 interstrand cross-link repair(GO:0036297)
0.1 4.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 1.9 GO:0015701 bicarbonate transport(GO:0015701)
0.1 0.5 GO:0035878 nail development(GO:0035878)
0.1 0.4 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.0 0.3 GO:0034379 very-low-density lipoprotein particle assembly(GO:0034379)
0.0 10.0 GO:0045666 positive regulation of neuron differentiation(GO:0045666)
0.0 1.3 GO:0045732 positive regulation of protein catabolic process(GO:0045732)
0.0 1.4 GO:0007190 activation of adenylate cyclase activity(GO:0007190)
0.0 0.4 GO:0000963 mitochondrial RNA processing(GO:0000963)
0.0 0.2 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.1 GO:0045776 negative regulation of blood pressure(GO:0045776)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 2.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 0.3 GO:0097352 autophagosome maturation(GO:0097352) vacuole fusion(GO:0097576)
0.0 0.1 GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway(GO:0033143) regulation of intracellular estrogen receptor signaling pathway(GO:0033146)
0.0 0.5 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 1.1 GO:0009060 aerobic respiration(GO:0009060)
0.0 2.3 GO:0050900 leukocyte migration(GO:0050900)
0.0 0.3 GO:1901655 cellular response to ketone(GO:1901655)
0.0 0.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
16.5 132.0 GO:0032010 phagolysosome(GO:0032010)
16.5 82.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
9.7 29.1 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
7.5 149.8 GO:0001891 phagocytic cup(GO:0001891)
7.2 101.4 GO:0031209 SCAR complex(GO:0031209)
7.2 78.9 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
5.0 64.9 GO:0043020 NADPH oxidase complex(GO:0043020)
4.5 31.7 GO:0036021 endolysosome lumen(GO:0036021)
4.3 13.0 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
4.0 20.1 GO:0005602 complement component C1 complex(GO:0005602)
4.0 15.9 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
3.4 17.0 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
3.3 16.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
3.2 22.2 GO:0019815 B cell receptor complex(GO:0019815)
3.2 9.5 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.7 10.8 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
2.6 10.2 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
2.5 40.0 GO:0016461 unconventional myosin complex(GO:0016461)
2.3 174.7 GO:0035577 azurophil granule membrane(GO:0035577)
2.2 17.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
2.2 45.8 GO:0042613 MHC class II protein complex(GO:0042613)
1.9 5.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.8 5.5 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
1.8 24.5 GO:0030897 HOPS complex(GO:0030897)
1.7 6.8 GO:0055087 Ski complex(GO:0055087)
1.6 90.5 GO:0001772 immunological synapse(GO:0001772)
1.4 5.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.4 18.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
1.4 25.2 GO:0097342 ripoptosome(GO:0097342)
1.4 18.2 GO:0005577 fibrinogen complex(GO:0005577)
1.4 11.1 GO:0035976 AP1 complex(GO:0035976)
1.4 9.7 GO:0072487 MSL complex(GO:0072487)
1.4 17.6 GO:0048188 Set1C/COMPASS complex(GO:0048188)
1.3 5.1 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
1.3 5.1 GO:0005797 Golgi medial cisterna(GO:0005797)
1.1 23.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.0 3.1 GO:0031251 PAN complex(GO:0031251)
1.0 3.1 GO:0055028 cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
1.0 7.1 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.0 3.0 GO:0019034 viral replication complex(GO:0019034)
1.0 1.0 GO:0071159 NF-kappaB complex(GO:0071159)
0.9 28.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.9 7.9 GO:0044754 autolysosome(GO:0044754)
0.9 77.3 GO:0070821 tertiary granule membrane(GO:0070821)
0.9 4.3 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.9 4.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.8 1.7 GO:0032021 NELF complex(GO:0032021)
0.8 69.8 GO:1904724 tertiary granule lumen(GO:1904724)
0.7 8.9 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.7 8.5 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.7 12.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.7 5.4 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.6 5.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.6 8.5 GO:0090543 Flemming body(GO:0090543)
0.6 4.8 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.6 6.4 GO:0042588 zymogen granule(GO:0042588)
0.5 7.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.5 55.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 12.4 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.5 1.5 GO:0072563 endothelial microparticle(GO:0072563)
0.5 2.4 GO:1990393 3M complex(GO:1990393)
0.5 72.7 GO:0031225 anchored component of membrane(GO:0031225)
0.5 4.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.5 46.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.5 3.2 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.4 24.9 GO:0000786 nucleosome(GO:0000786)
0.4 1.3 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.4 2.5 GO:1990130 Iml1 complex(GO:1990130)
0.4 118.3 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 29.7 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 56.5 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.4 8.4 GO:0042627 chylomicron(GO:0042627)
0.4 12.3 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.4 0.4 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.4 8.8 GO:0034451 centriolar satellite(GO:0034451)
0.4 20.6 GO:0031201 SNARE complex(GO:0031201)
0.3 4.0 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568)
0.3 9.3 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.3 9.2 GO:0000781 chromosome, telomeric region(GO:0000781)
0.3 3.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.3 1.3 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.3 0.8 GO:0035189 Rb-E2F complex(GO:0035189)
0.2 1.7 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 5.4 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 6.7 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.2 11.6 GO:0005801 cis-Golgi network(GO:0005801)
0.2 7.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.2 4.0 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 7.8 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 1.6 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.2 5.0 GO:0005921 gap junction(GO:0005921)
0.2 0.8 GO:0030914 STAGA complex(GO:0030914)
0.2 1.3 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.2 1.2 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.2 33.0 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.2 2.6 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 1.0 GO:0043196 varicosity(GO:0043196)
0.2 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.2 6.2 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.2 6.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.2 295.3 GO:0005887 integral component of plasma membrane(GO:0005887)
0.2 10.1 GO:0031902 late endosome membrane(GO:0031902)
0.2 8.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.2 20.7 GO:0031901 early endosome membrane(GO:0031901)
0.2 12.6 GO:0043679 axon terminus(GO:0043679)
0.2 13.2 GO:0010008 endosome membrane(GO:0010008)
0.2 1.5 GO:0032039 integrator complex(GO:0032039)
0.2 3.1 GO:0035580 specific granule lumen(GO:0035580)
0.2 10.9 GO:0005905 clathrin-coated pit(GO:0005905)
0.2 0.8 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.2 20.4 GO:0030139 endocytic vesicle(GO:0030139)
0.2 56.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 7.9 GO:0072686 mitotic spindle(GO:0072686)
0.1 23.2 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 1.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.1 7.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 0.4 GO:0000799 nuclear condensin complex(GO:0000799)
0.1 8.5 GO:0015030 Cajal body(GO:0015030)
0.1 12.0 GO:0005814 centriole(GO:0005814)
0.1 2.2 GO:0042383 sarcolemma(GO:0042383)
0.1 11.3 GO:0032587 ruffle membrane(GO:0032587)
0.1 8.0 GO:0043202 lysosomal lumen(GO:0043202)
0.1 3.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 13.1 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.0 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.1 GO:0051233 spindle midzone(GO:0051233)
0.1 9.7 GO:0030667 secretory granule membrane(GO:0030667)
0.1 2.4 GO:0005861 troponin complex(GO:0005861)
0.1 10.2 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 6.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 3.6 GO:0005802 trans-Golgi network(GO:0005802)
0.1 1.0 GO:0005685 U1 snRNP(GO:0005685)
0.1 2.1 GO:0032040 small-subunit processome(GO:0032040)
0.1 12.3 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 2.2 GO:0005819 spindle(GO:0005819)
0.1 0.2 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1 10.6 GO:0044454 nuclear chromosome part(GO:0044454)
0.1 0.4 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 1.4 GO:0070069 cytochrome complex(GO:0070069)
0.0 2.8 GO:0030175 filopodium(GO:0030175)
0.0 5.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 1.4 GO:0097546 ciliary base(GO:0097546)
0.0 4.9 GO:0030133 transport vesicle(GO:0030133)
0.0 4.1 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.8 GO:0032982 myosin filament(GO:0032982)
0.0 7.0 GO:0031965 nuclear membrane(GO:0031965)
0.0 12.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.3 GO:0005903 brush border(GO:0005903)
0.0 2.3 GO:0072562 blood microparticle(GO:0072562)
0.0 1.6 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 5.9 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 3.3 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0031226 intrinsic component of plasma membrane(GO:0031226)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
13.5 40.6 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
12.9 128.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
12.2 36.7 GO:0004914 interleukin-5 receptor activity(GO:0004914)
10.9 108.8 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
10.6 42.2 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
8.8 61.6 GO:0030369 ICAM-3 receptor activity(GO:0030369)
7.7 23.2 GO:0016019 peptidoglycan receptor activity(GO:0016019)
7.2 21.6 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
7.0 28.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
6.8 75.0 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
6.8 20.3 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
6.2 18.5 GO:0045322 unmethylated CpG binding(GO:0045322)
5.8 17.4 GO:0022897 peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897)
5.5 16.4 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
5.3 21.3 GO:0032396 inhibitory MHC class I receptor activity(GO:0032396)
5.2 15.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
5.2 15.5 GO:0001069 regulatory region RNA binding(GO:0001069)
5.1 20.6 GO:0019770 IgG receptor activity(GO:0019770)
4.9 14.8 GO:0090556 apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
4.0 76.8 GO:0015923 mannosidase activity(GO:0015923)
4.0 20.0 GO:0017159 pantetheine hydrolase activity(GO:0017159)
4.0 15.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
3.9 35.3 GO:0043426 MRF binding(GO:0043426)
3.8 19.2 GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
3.8 64.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
3.7 66.8 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
3.4 55.2 GO:0032036 myosin heavy chain binding(GO:0032036)
3.4 20.7 GO:0001851 complement component C3b binding(GO:0001851)
3.4 48.2 GO:0019864 IgG binding(GO:0019864)
3.1 25.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
3.1 40.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
2.9 17.5 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
2.9 77.8 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
2.8 28.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
2.7 30.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
2.7 51.6 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
2.5 15.3 GO:0004522 ribonuclease A activity(GO:0004522)
2.5 17.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
2.5 12.3 GO:0047820 D-glutamate cyclase activity(GO:0047820)
2.4 4.8 GO:0004832 valine-tRNA ligase activity(GO:0004832)
2.4 14.3 GO:0035800 deubiquitinase activator activity(GO:0035800)
2.2 17.9 GO:0005497 androgen binding(GO:0005497)
2.1 6.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
2.1 8.4 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
2.0 32.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
2.0 15.9 GO:1990405 protein antigen binding(GO:1990405)
1.8 5.5 GO:0004730 pseudouridylate synthase activity(GO:0004730)
1.8 5.4 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
1.8 51.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
1.7 18.5 GO:0051434 BH3 domain binding(GO:0051434)
1.7 21.8 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
1.6 6.3 GO:0070735 protein-glycine ligase activity(GO:0070735)
1.5 6.1 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
1.5 17.8 GO:0089720 caspase binding(GO:0089720)
1.5 13.3 GO:0051400 BH domain binding(GO:0051400)
1.4 11.6 GO:0034235 GPI anchor binding(GO:0034235)
1.4 5.7 GO:0004594 pantothenate kinase activity(GO:0004594)
1.4 5.6 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
1.4 5.5 GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
1.4 6.8 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
1.3 14.8 GO:0004875 complement receptor activity(GO:0004875)
1.3 39.4 GO:0023026 MHC class II protein complex binding(GO:0023026)
1.3 7.9 GO:0050681 steroid hormone receptor binding(GO:0035258) androgen receptor binding(GO:0050681)
1.3 6.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
1.3 5.1 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
1.3 10.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
1.3 1.3 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
1.2 21.0 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
1.2 3.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
1.1 15.7 GO:0017110 nucleoside-diphosphatase activity(GO:0017110)
1.1