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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SREBF1_TFE3
Z-value: 1.71
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Transcription factors associated with SREBF1_TFE3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TFE3 | hg19_v2_chrX_-_48901012_48901050 | 0.43 | 2.2e-11 | Click! |
| SREBF1 | hg19_v2_chr17_-_17740287_17740316 | -0.08 | 2.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SREBF1_TFE3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.3 | 81.2 | GO:0043323 | regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323) |
| 3.5 | 74.4 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 12.3 | 61.3 | GO:0033274 | response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829) |
| 15.2 | 60.9 | GO:0002086 | maltose metabolic process(GO:0000023) diaphragm contraction(GO:0002086) |
| 5.3 | 58.8 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 0.4 | 57.8 | GO:0019886 | antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886) |
| 2.0 | 56.6 | GO:0006884 | cell volume homeostasis(GO:0006884) |
| 2.8 | 53.2 | GO:0042340 | keratan sulfate catabolic process(GO:0042340) |
| 5.5 | 49.4 | GO:1904715 | negative regulation of chaperone-mediated autophagy(GO:1904715) |
| 6.9 | 41.5 | GO:0010807 | regulation of synaptic vesicle priming(GO:0010807) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 245.7 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 103.6 | GO:0005615 | extracellular space(GO:0005615) |
| 12.1 | 96.5 | GO:0097208 | alveolar lamellar body(GO:0097208) |
| 0.1 | 95.4 | GO:0045202 | synapse(GO:0045202) |
| 0.3 | 82.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 70.0 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.2 | 58.2 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 7.7 | 53.6 | GO:0098575 | lumenal side of lysosomal membrane(GO:0098575) |
| 0.4 | 50.7 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.9 | 50.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 91.0 | GO:0001618 | virus receptor activity(GO:0001618) |
| 3.2 | 73.8 | GO:0036442 | hydrogen-exporting ATPase activity(GO:0036442) proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 3.3 | 73.0 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 1.0 | 62.8 | GO:0005507 | copper ion binding(GO:0005507) |
| 12.3 | 61.3 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 20.3 | 60.9 | GO:0004574 | oligo-1,6-glucosidase activity(GO:0004574) |
| 0.6 | 59.1 | GO:0019905 | syntaxin binding(GO:0019905) |
| 7.0 | 56.4 | GO:0004308 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 11.3 | 45.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 2.0 | 44.5 | GO:0070001 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 93.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.2 | 71.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 1.3 | 53.5 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.5 | 50.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.5 | 49.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 1.1 | 36.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.5 | 28.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.5 | 25.3 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.8 | 24.2 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 21.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 134.8 | REACTOME GLYCOSPHINGOLIPID METABOLISM | Genes involved in Glycosphingolipid metabolism |
| 3.3 | 107.0 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.7 | 100.9 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 1.0 | 71.0 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 0.4 | 54.0 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.6 | 50.8 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.2 | 42.0 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.6 | 33.6 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.6 | 29.6 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.4 | 28.5 | REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE | Genes involved in Cell death signalling via NRAGE, NRIF and NADE |