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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for SRF
Z-value: 2.36
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Transcription factors associated with SRF
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SRF | hg19_v2_chr6_+_43139037_43139094 | 0.09 | 1.8e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SRF
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 207.1 | GO:0070527 | platelet aggregation(GO:0070527) |
| 23.7 | 142.0 | GO:0090131 | mesenchyme migration(GO:0090131) |
| 26.5 | 132.3 | GO:0055014 | atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014) |
| 1.5 | 111.7 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.2 | 75.1 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 6.6 | 52.5 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 6.6 | 39.7 | GO:1903921 | protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923) |
| 5.5 | 33.0 | GO:0007296 | vitellogenesis(GO:0007296) |
| 2.9 | 32.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 5.2 | 31.4 | GO:0016479 | negative regulation of transcription from RNA polymerase I promoter(GO:0016479) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.3 | 189.4 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 1.6 | 151.1 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 3.4 | 137.1 | GO:0031430 | M band(GO:0031430) |
| 4.2 | 79.6 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 5.1 | 66.2 | GO:0097433 | dense body(GO:0097433) |
| 7.6 | 60.8 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 53.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 8.8 | 53.1 | GO:0032982 | myosin filament(GO:0032982) |
| 10.5 | 52.3 | GO:0042643 | actomyosin, actin portion(GO:0042643) |
| 0.5 | 39.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.6 | 152.9 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 1.7 | 132.3 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 1.2 | 112.1 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.4 | 62.7 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.9 | 59.9 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 58.8 | GO:0005524 | ATP binding(GO:0005524) |
| 0.4 | 54.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 10.5 | 52.5 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.1 | 42.5 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 4.0 | 32.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 186.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 1.7 | 143.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 3.8 | 132.3 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 1.1 | 61.9 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 52.8 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.7 | 38.0 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.6 | 33.0 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.3 | 30.5 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.5 | 21.7 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.5 | 19.4 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 358.2 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 1.2 | 171.2 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 1.1 | 54.2 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 0.1 | 26.3 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.7 | 21.7 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.7 | 21.0 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.7 | 19.4 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 19.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 0.5 | 18.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 16.4 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |