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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for T

Z-value: 1.14

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Transcription factors associated with T

Gene Symbol Gene ID Gene Info
T
ENSG00000164458.5 T

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thg19_v2_chr6_-_166582107_166582188-0.433.6e-11Click!

Activity profile of T motif

Sorted Z-values of T motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_24126023 47.24 ENST00000429356.1
GALE
UDP-galactose-4-epimerase
chr2_-_85636928 20.34 ENST00000449030.1
CAPG
capping protein (actin filament), gelsolin-like
chr9_+_36572851 19.35 ENST00000298048.2
ENST00000538311.1
ENST00000536987.1
ENST00000545008.1
ENST00000536860.1
ENST00000536329.1
ENST00000541717.1
ENST00000543751.1
MELK
maternal embryonic leucine zipper kinase
chr2_-_152146385 19.23 ENST00000414946.1
ENST00000243346.5
NMI
N-myc (and STAT) interactor
chr3_+_133502877 18.77 ENST00000466490.2
SRPRB
signal recognition particle receptor, B subunit
chrX_+_133594168 15.22 ENST00000298556.7
HPRT1
hypoxanthine phosphoribosyltransferase 1
chr15_+_78832747 14.94 ENST00000560217.1
ENST00000044462.7
ENST00000559082.1
ENST00000559948.1
ENST00000413382.2
ENST00000559146.1
ENST00000558281.1
PSMA4
proteasome (prosome, macropain) subunit, alpha type, 4
chr16_-_88717423 14.07 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
CYBA
cytochrome b-245, alpha polypeptide
chr20_+_1115821 12.94 ENST00000435720.1
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr20_+_1093891 12.23 ENST00000333082.3
ENST00000381898.4
ENST00000381899.4
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr9_+_131452239 11.63 ENST00000372688.4
ENST00000372686.5
SET
SET nuclear oncogene
chr17_-_26662440 11.36 ENST00000578122.1
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chr16_+_69221028 11.27 ENST00000336278.4
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr3_+_142315225 11.11 ENST00000457734.2
ENST00000483373.1
ENST00000475296.1
ENST00000495744.1
ENST00000476044.1
ENST00000461644.1
PLS1
plastin 1
chr5_-_112257914 10.80 ENST00000513339.1
ENST00000545426.1
ENST00000504247.1
REEP5
receptor accessory protein 5
chr20_+_34129770 10.51 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
ERGIC3
ERGIC and golgi 3
chr17_-_40306934 10.20 ENST00000592574.1
ENST00000550406.1
ENST00000547517.1
ENST00000393860.3
ENST00000346213.4
CTD-2132N18.3
RAB5C
Uncharacterized protein
RAB5C, member RAS oncogene family
chr6_+_83073334 10.18 ENST00000369750.3
TPBG
trophoblast glycoprotein
chr2_+_58134756 10.03 ENST00000435505.2
ENST00000417641.2
VRK2
vaccinia related kinase 2
chr10_-_97050777 9.92 ENST00000329399.6
PDLIM1
PDZ and LIM domain 1
chr9_-_75567962 9.66 ENST00000297785.3
ENST00000376939.1
ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr12_-_56709674 9.38 ENST00000551286.1
ENST00000549318.1
CNPY2
RP11-977G19.10
canopy FGF signaling regulator 2
Uncharacterized protein
chr21_+_30502806 9.13 ENST00000399928.1
ENST00000399926.1
MAP3K7CL
MAP3K7 C-terminal like
chr19_-_10514184 9.02 ENST00000589629.1
ENST00000222005.2
CDC37
cell division cycle 37
chr16_-_88717482 8.97 ENST00000261623.3
CYBA
cytochrome b-245, alpha polypeptide
chr12_-_56710118 8.91 ENST00000273308.4
CNPY2
canopy FGF signaling regulator 2
chr12_-_6960407 8.62 ENST00000540683.1
ENST00000229265.6
ENST00000535406.1
ENST00000422785.3
CDCA3
cell division cycle associated 3
chr1_-_211752073 8.28 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr2_+_122494676 8.12 ENST00000455432.1
TSN
translin
chr1_+_114471972 8.08 ENST00000369559.4
ENST00000369554.2
HIPK1
homeodomain interacting protein kinase 1
chr1_-_115124257 7.62 ENST00000369541.3
BCAS2
breast carcinoma amplified sequence 2
chr7_+_107220660 6.85 ENST00000465919.1
ENST00000445771.2
ENST00000479917.1
ENST00000421217.1
ENST00000457837.1
BCAP29
B-cell receptor-associated protein 29
chr19_-_44174330 6.72 ENST00000340093.3
PLAUR
plasminogen activator, urokinase receptor
chr2_-_200322723 6.40 ENST00000417098.1
SATB2
SATB homeobox 2
chr17_+_34538310 6.39 ENST00000444414.1
ENST00000378350.4
ENST00000389068.5
ENST00000588929.1
ENST00000589079.1
ENST00000589336.1
ENST00000400702.4
ENST00000591167.1
ENST00000586598.1
ENST00000591637.1
ENST00000378352.4
ENST00000358756.5
CCL4L1
chemokine (C-C motif) ligand 4-like 1
chr20_+_3190006 6.22 ENST00000380113.3
ENST00000455664.2
ENST00000399838.3
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
chr12_+_19358228 6.19 ENST00000424268.1
ENST00000543806.1
PLEKHA5
pleckstrin homology domain containing, family A member 5
chr16_-_2314222 6.13 ENST00000566397.1
RNPS1
RNA binding protein S1, serine-rich domain
chr10_+_5488564 6.06 ENST00000449083.1
ENST00000380359.3
NET1
neuroepithelial cell transforming 1
chr11_-_85779971 6.05 ENST00000393346.3
PICALM
phosphatidylinositol binding clathrin assembly protein
chr17_-_56084578 5.94 ENST00000582730.2
ENST00000584773.1
ENST00000585096.1
ENST00000258962.4
SRSF1
serine/arginine-rich splicing factor 1
chr16_+_67596310 5.80 ENST00000264010.4
ENST00000401394.1
CTCF
CCCTC-binding factor (zinc finger protein)
chr12_-_6961050 5.58 ENST00000538862.2
CDCA3
cell division cycle associated 3
chr5_-_176433350 5.34 ENST00000377227.4
ENST00000377219.2
UIMC1
ubiquitin interaction motif containing 1
chr10_-_5060201 5.34 ENST00000407674.1
AKR1C2
aldo-keto reductase family 1, member C2
chr16_+_69458537 5.33 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr10_-_5060147 5.28 ENST00000604507.1
AKR1C2
aldo-keto reductase family 1, member C2
chr7_-_76255444 5.27 ENST00000454397.1
POMZP3
POM121 and ZP3 fusion
chr20_-_60942361 5.15 ENST00000252999.3
LAMA5
laminin, alpha 5
chr14_-_45603657 4.99 ENST00000396062.3
FKBP3
FK506 binding protein 3, 25kDa
chr1_+_114472222 4.87 ENST00000369558.1
ENST00000369561.4
HIPK1
homeodomain interacting protein kinase 1
chr1_+_114471809 4.87 ENST00000426820.2
HIPK1
homeodomain interacting protein kinase 1
chr11_-_66112555 4.84 ENST00000425825.2
ENST00000359957.3
BRMS1
breast cancer metastasis suppressor 1
chr10_+_51565188 4.79 ENST00000430396.2
ENST00000374087.4
ENST00000414907.2
NCOA4
nuclear receptor coactivator 4
chr17_-_26662464 4.78 ENST00000579419.1
ENST00000585313.1
ENST00000395418.3
ENST00000578985.1
ENST00000577498.1
ENST00000585089.1
ENST00000357896.3
IFT20
intraflagellar transport 20 homolog (Chlamydomonas)
chrX_+_51636629 4.75 ENST00000375722.1
ENST00000326587.7
ENST00000375695.2
MAGED1
melanoma antigen family D, 1
chr12_+_54378923 4.71 ENST00000303460.4
HOXC10
homeobox C10
chr4_+_26322185 4.68 ENST00000361572.6
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr17_+_34640031 4.66 ENST00000339270.6
ENST00000482104.1
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr7_+_134576317 4.63 ENST00000424922.1
ENST00000495522.1
CALD1
caldesmon 1
chr1_+_114472481 4.60 ENST00000369555.2
HIPK1
homeodomain interacting protein kinase 1
chr19_+_11546440 4.58 ENST00000589126.1
ENST00000588269.1
ENST00000587509.1
ENST00000592741.1
ENST00000593101.1
ENST00000587327.1
PRKCSH
protein kinase C substrate 80K-H
chr1_-_45452240 4.53 ENST00000372183.3
ENST00000372182.4
ENST00000360403.2
EIF2B3
eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
chrX_+_100663243 4.43 ENST00000316594.5
HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr4_+_26322409 4.25 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
RBPJ
recombination signal binding protein for immunoglobulin kappa J region
chr8_-_99954788 4.23 ENST00000523601.1
STK3
serine/threonine kinase 3
chr19_+_11546093 4.22 ENST00000591462.1
PRKCSH
protein kinase C substrate 80K-H
chr17_+_34639793 4.18 ENST00000394465.2
ENST00000394463.2
ENST00000378342.4
CCL4L2
chemokine (C-C motif) ligand 4-like 2
chr8_-_141810634 4.15 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
PTK2
protein tyrosine kinase 2
chr17_-_19281203 4.07 ENST00000487415.2
B9D1
B9 protein domain 1
chr3_-_125094093 3.93 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr17_-_20370847 3.91 ENST00000423676.3
ENST00000324290.5
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr22_+_19929130 3.90 ENST00000361682.6
ENST00000403184.1
ENST00000403710.1
ENST00000407537.1
COMT
catechol-O-methyltransferase
chr21_-_27107344 3.88 ENST00000457143.2
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr21_-_27107198 3.79 ENST00000400094.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr1_+_89150245 3.65 ENST00000370513.5
PKN2
protein kinase N2
chr5_+_50678921 3.65 ENST00000230658.7
ISL1
ISL LIM homeobox 1
chr21_-_27107283 3.55 ENST00000284971.3
ENST00000400099.1
ATP5J
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
chr1_+_39456895 3.47 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1
akirin 1
chr5_+_85913721 3.45 ENST00000247655.3
ENST00000509578.1
ENST00000515763.1
COX7C
cytochrome c oxidase subunit VIIc
chr2_+_162087577 3.38 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr2_+_120687335 3.33 ENST00000544261.1
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr15_-_83621435 3.16 ENST00000450735.2
ENST00000426485.1
ENST00000399166.2
ENST00000304231.8
HOMER2
homer homolog 2 (Drosophila)
chr5_-_137514333 3.10 ENST00000411594.2
ENST00000430331.1
BRD8
bromodomain containing 8
chrX_+_109245863 3.00 ENST00000372072.3
TMEM164
transmembrane protein 164
chr2_+_189839046 3.00 ENST00000304636.3
ENST00000317840.5
COL3A1
collagen, type III, alpha 1
chr7_-_87849340 2.98 ENST00000419179.1
ENST00000265729.2
SRI
sorcin
chr1_+_89149905 2.87 ENST00000316005.7
ENST00000370521.3
ENST00000370505.3
PKN2
protein kinase N2
chr4_-_73434498 2.83 ENST00000286657.4
ADAMTS3
ADAM metallopeptidase with thrombospondin type 1 motif, 3
chr19_-_44174305 2.81 ENST00000601723.1
ENST00000339082.3
PLAUR
plasminogen activator, urokinase receptor
chr22_+_35776828 2.79 ENST00000216117.8
HMOX1
heme oxygenase (decycling) 1
chr4_-_140005443 2.75 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
ELF2
E74-like factor 2 (ets domain transcription factor)
chr12_-_49351303 2.73 ENST00000256682.4
ARF3
ADP-ribosylation factor 3
chr2_+_234601512 2.71 ENST00000305139.6
UGT1A6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr17_-_74497432 2.70 ENST00000590288.1
ENST00000313080.4
ENST00000592123.1
ENST00000591255.1
ENST00000585989.1
ENST00000591697.1
ENST00000389760.4
RHBDF2
rhomboid 5 homolog 2 (Drosophila)
chr22_+_40441456 2.69 ENST00000402203.1
TNRC6B
trinucleotide repeat containing 6B
chr6_-_106773291 2.50 ENST00000343245.3
ATG5
autophagy related 5
chr19_+_11546153 2.48 ENST00000591946.1
ENST00000252455.2
ENST00000412601.1
PRKCSH
protein kinase C substrate 80K-H
chr6_+_26158343 2.45 ENST00000377777.4
ENST00000289316.2
HIST1H2BD
histone cluster 1, H2bd
chr1_-_205290865 2.45 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr4_-_151936865 2.26 ENST00000535741.1
LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr12_-_49351228 2.22 ENST00000541959.1
ENST00000447318.2
ARF3
ADP-ribosylation factor 3
chr17_+_57970469 2.16 ENST00000443572.2
ENST00000406116.3
ENST00000225577.4
ENST00000393021.3
RPS6KB1
ribosomal protein S6 kinase, 70kDa, polypeptide 1
chr17_+_75084717 2.11 ENST00000561721.2
ENST00000589827.1
ENST00000392476.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr1_-_224517823 1.78 ENST00000469968.1
ENST00000436927.1
ENST00000469075.1
ENST00000488718.1
ENST00000482491.1
ENST00000340871.4
ENST00000492281.1
ENST00000361463.3
ENST00000391875.2
ENST00000461546.1
NVL
nuclear VCP-like
chr14_+_96722539 1.61 ENST00000553356.1
BDKRB1
bradykinin receptor B1
chr6_-_106773610 1.52 ENST00000369076.3
ENST00000369070.1
ATG5
autophagy related 5
chr1_+_27648709 1.45 ENST00000608611.1
ENST00000466759.1
ENST00000464813.1
ENST00000498220.1
TMEM222
transmembrane protein 222
chr3_-_52488048 1.43 ENST00000232975.3
TNNC1
troponin C type 1 (slow)
chr17_+_38296576 1.39 ENST00000264645.7
CASC3
cancer susceptibility candidate 3
chr11_-_64889252 1.33 ENST00000525297.1
ENST00000529259.1
FAU
Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed
chr6_-_26124138 1.30 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr14_-_107211459 1.28 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr1_+_27648648 1.24 ENST00000374076.4
TMEM222
transmembrane protein 222
chr3_-_52443799 1.13 ENST00000470173.1
ENST00000296288.5
BAP1
BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
chr12_-_90024360 1.13 ENST00000393164.2
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_-_153066998 1.09 ENST00000368750.3
SPRR2E
small proline-rich protein 2E
chr21_+_19617140 1.08 ENST00000299295.2
ENST00000338326.3
CHODL
chondrolectin
chr7_-_38370536 1.08 ENST00000390343.2
TRGV8
T cell receptor gamma variable 8
chr2_-_85895295 0.94 ENST00000428225.1
ENST00000519937.2
SFTPB
surfactant protein B
chr22_-_41215291 0.93 ENST00000542412.1
ENST00000544408.1
SLC25A17
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr4_-_69817481 0.92 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr1_-_13052998 0.91 ENST00000436041.1
WI2-3308P17.2
Uncharacterized protein
chr1_-_204135450 0.87 ENST00000272190.8
ENST00000367195.2
REN
renin
chr14_-_107114267 0.73 ENST00000454421.2
IGHV3-64
immunoglobulin heavy variable 3-64
chr11_+_64073699 0.66 ENST00000405666.1
ENST00000468670.1
ESRRA
estrogen-related receptor alpha
chr1_-_204165610 0.63 ENST00000367194.4
KISS1
KiSS-1 metastasis-suppressor
chr7_-_81399355 0.51 ENST00000457544.2
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr13_+_53602894 0.45 ENST00000219022.2
OLFM4
olfactomedin 4
chr3_+_137728842 0.35 ENST00000183605.5
CLDN18
claudin 18
chr1_+_150980889 0.30 ENST00000450884.1
ENST00000271620.3
ENST00000271619.8
ENST00000368937.1
ENST00000431193.1
ENST00000368936.1
PRUNE
prune exopolyphosphatase
chr2_-_208030647 0.20 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_-_52867569 0.14 ENST00000252250.6
KRT6C
keratin 6C
chr2_-_216003127 0.11 ENST00000412081.1
ENST00000272895.7
ABCA12
ATP-binding cassette, sub-family A (ABC1), member 12
chr10_-_23003460 0.10 ENST00000376573.4
PIP4K2A
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr6_+_29079668 0.08 ENST00000377169.1
OR2J3
olfactory receptor, family 2, subfamily J, member 3
chr2_-_39664405 0.07 ENST00000341681.5
ENST00000263881.3
MAP4K3
mitogen-activated protein kinase kinase kinase kinase 3
chr2_-_27341966 0.06 ENST00000402394.1
ENST00000402550.1
ENST00000260595.5
CGREF1
cell growth regulator with EF-hand domain 1
chr2_+_108905325 0.01 ENST00000438339.1
ENST00000409880.1
ENST00000437390.2
SULT1C2
sulfotransferase family, cytosolic, 1C, member 2

Network of associatons between targets according to the STRING database.

First level regulatory network of T

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.4 19.2 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
5.1 15.2 GO:0046098 hypoxanthine salvage(GO:0043103) guanine metabolic process(GO:0046098)
4.6 23.0 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
3.6 47.2 GO:0019388 galactose catabolic process(GO:0019388)
3.2 9.7 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
3.0 8.9 GO:1905068 arterial endothelial cell fate commitment(GO:0060844) blood vessel lumenization(GO:0072554) positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
2.5 22.4 GO:0060235 lens induction in camera-type eye(GO:0060235)
2.4 9.5 GO:0038195 urokinase plasminogen activator signaling pathway(GO:0038195)
2.2 11.1 GO:1902896 terminal web assembly(GO:1902896)
2.0 18.3 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
1.9 5.8 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
1.7 8.3 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
1.6 16.1 GO:0035845 photoreceptor cell outer segment organization(GO:0035845)
1.5 10.6 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
1.3 4.0 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
1.2 6.2 GO:0009146 purine nucleoside triphosphate catabolic process(GO:0009146)
1.2 3.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
1.0 20.3 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.9 2.8 GO:0006788 heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806)
0.9 5.3 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.9 5.3 GO:0035803 egg coat formation(GO:0035803)
0.9 6.1 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.8 4.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.8 10.2 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.8 3.9 GO:0031337 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.7 2.2 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
0.7 6.9 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.7 5.9 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.6 6.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.6 8.1 GO:0030422 production of siRNA involved in RNA interference(GO:0030422)
0.6 4.7 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.6 1.1 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.6 4.5 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.6 3.4 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.5 6.5 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.5 2.8 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.5 6.1 GO:0051451 myoblast migration(GO:0051451)
0.5 4.1 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.4 11.6 GO:0006337 nucleosome disassembly(GO:0006337)
0.4 4.8 GO:2000210 positive regulation of anoikis(GO:2000210)
0.4 3.0 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.4 40.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.4 11.3 GO:0006491 N-glycan processing(GO:0006491)
0.4 9.0 GO:0098779 mitophagy in response to mitochondrial depolarization(GO:0098779)
0.4 3.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.4 1.4 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.4 11.2 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.3 3.3 GO:0048875 chemical homeostasis within a tissue(GO:0048875)
0.2 1.1 GO:1901660 calcium ion export(GO:1901660) calcium ion export from cell(GO:1990034)
0.2 6.1 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 0.9 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.2 2.1 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.2 2.7 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.2 13.7 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631)
0.2 18.8 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.2 3.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.2 2.7 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 6.5 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.2 3.1 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.2 4.8 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 9.1 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 0.6 GO:0033686 positive regulation of luteinizing hormone secretion(GO:0033686)
0.1 1.4 GO:0008298 intracellular mRNA localization(GO:0008298)
0.1 5.0 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.4 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.1 3.1 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 5.2 GO:0001755 neural crest cell migration(GO:0001755)
0.1 0.9 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 7.0 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 4.8 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 2.8 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.1 1.3 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 3.9 GO:0021762 substantia nigra development(GO:0021762)
0.1 2.5 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 1.6 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 1.8 GO:0051973 positive regulation of telomerase activity(GO:0051973)
0.0 0.3 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 2.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 2.6 GO:0042058 regulation of epidermal growth factor receptor signaling pathway(GO:0042058)
0.0 9.2 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.7 GO:1900078 positive regulation of cellular response to insulin stimulus(GO:1900078)
0.0 1.1 GO:0007517 muscle organ development(GO:0007517)
0.0 0.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.1 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.0 4.1 GO:0043010 camera-type eye development(GO:0043010)
0.0 3.3 GO:0001666 response to hypoxia(GO:0001666)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.1 GO:1902636 kinociliary basal body(GO:1902636)
2.7 18.8 GO:0005785 signal recognition particle receptor complex(GO:0005785)
1.9 11.1 GO:1990357 terminal web(GO:1990357)
1.8 8.9 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
1.4 20.3 GO:0008290 F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543)
1.4 23.0 GO:0043020 NADPH oxidase complex(GO:0043020)
1.3 5.2 GO:0043260 laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260)
1.2 14.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
1.2 25.2 GO:0005839 proteasome core complex(GO:0005839)
1.1 9.5 GO:0071438 invadopodium membrane(GO:0071438)
1.0 6.1 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.7 6.1 GO:0061574 ASAP complex(GO:0061574)
0.7 4.0 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.6 11.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.6 4.5 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.5 10.8 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.5 4.7 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.5 7.6 GO:0005662 DNA replication factor A complex(GO:0005662)
0.5 5.3 GO:0070531 BRCA1-A complex(GO:0070531)
0.4 3.0 GO:0044326 dendritic spine neck(GO:0044326)
0.4 11.3 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 7.3 GO:0035145 exon-exon junction complex(GO:0035145)
0.3 4.8 GO:0044754 autolysosome(GO:0044754)
0.3 4.6 GO:0030478 actin cap(GO:0030478)
0.3 4.1 GO:0036038 MKS complex(GO:0036038)
0.3 21.8 GO:0005811 lipid particle(GO:0005811)
0.3 3.0 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2 3.4 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.2 1.4 GO:1990584 cardiac Troponin complex(GO:1990584)
0.2 0.9 GO:0097208 alveolar lamellar body(GO:0097208)
0.2 4.8 GO:0070822 Sin3-type complex(GO:0070822)
0.2 22.1 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 3.1 GO:0000812 Swr1 complex(GO:0000812)
0.1 19.3 GO:0005938 cell cortex(GO:0005938)
0.1 16.8 GO:0016605 PML body(GO:0016605)
0.1 10.5 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 6.4 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 6.5 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 3.2 GO:0032420 stereocilium(GO:0032420)
0.1 3.8 GO:0000786 nucleosome(GO:0000786)
0.1 1.1 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 1.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 7.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 4.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 2.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.0 1.5 GO:0030315 T-tubule(GO:0030315)
0.0 3.9 GO:0043197 dendritic spine(GO:0043197)
0.0 1.1 GO:0031519 PcG protein complex(GO:0031519)
0.0 5.1 GO:0031965 nuclear membrane(GO:0031965)
0.0 3.6 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.0 47.5 GO:0070062 extracellular exosome(GO:0070062)
0.0 0.7 GO:0045171 intercellular bridge(GO:0045171)
0.0 24.3 GO:0005783 endoplasmic reticulum(GO:0005783)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
15.7 47.2 GO:0003978 UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978)
6.3 18.8 GO:0005047 signal recognition particle binding(GO:0005047)
3.2 16.1 GO:0002046 opsin binding(GO:0002046)
3.2 9.5 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
2.1 6.2 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
1.9 9.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.8 10.6 GO:0047115 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
1.2 25.2 GO:0070628 proteasome binding(GO:0070628)
1.2 23.0 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
1.0 5.9 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.9 2.8 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.8 8.3 GO:0000150 recombinase activity(GO:0000150)
0.7 2.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.7 4.0 GO:0019776 Atg8 ligase activity(GO:0019776)
0.6 6.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.6 5.3 GO:0032190 acrosin binding(GO:0032190)
0.6 3.4 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.6 3.9 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.5 1.6 GO:0004947 bradykinin receptor activity(GO:0004947)
0.5 6.1 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.5 14.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.5 4.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.5 3.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.4 8.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.4 9.9 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.4 2.1 GO:0039552 RIG-I binding(GO:0039552)
0.3 1.4 GO:0031013 troponin I binding(GO:0031013)
0.3 9.1 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 5.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.3 11.6 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.3 6.5 GO:0004697 protein kinase C activity(GO:0004697)
0.2 4.1 GO:0008432 JUN kinase binding(GO:0008432)
0.2 2.9 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 3.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.2 11.3 GO:0005080 protein kinase C binding(GO:0005080)
0.2 3.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 3.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 4.6 GO:0005523 tropomyosin binding(GO:0005523)
0.2 9.0 GO:0051879 Hsp90 protein binding(GO:0051879)
0.2 5.0 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.2 9.2 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 11.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 31.4 GO:0051015 actin filament binding(GO:0051015)
0.1 4.8 GO:0051059 NF-kappaB binding(GO:0051059)
0.1 10.2 GO:0019003 GDP binding(GO:0019003)
0.1 3.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 3.4 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1 4.8 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 11.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.1 4.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 3.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 3.0 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.1 4.8 GO:0050681 androgen receptor binding(GO:0050681)
0.1 1.0 GO:0030280 structural constituent of epidermis(GO:0030280)
0.1 12.4 GO:0005516 calmodulin binding(GO:0005516)
0.1 8.1 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 10.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 4.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 29.4 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 2.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 1.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.1 GO:0034191 lipid-transporting ATPase activity(GO:0034040) apolipoprotein A-I receptor binding(GO:0034191)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.6 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 6.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 3.9 GO:0030246 carbohydrate binding(GO:0030246)
0.0 7.6 GO:0003712 transcription cofactor activity(GO:0003712)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 9.5 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.3 23.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.2 5.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 5.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 8.9 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 12.5 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.1 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 13.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 9.0 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 5.3 PID ATM PATHWAY ATM pathway
0.1 6.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 4.9 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 3.0 NABA COLLAGENS Genes encoding collagen proteins
0.1 4.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 1.9 PID RHOA PATHWAY RhoA signaling pathway
0.0 4.8 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 2.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 4.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 5.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 5.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 9.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.7 8.9 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.7 11.3 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.6 15.2 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.6 63.1 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.5 8.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.5 11.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.3 4.7 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 9.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.3 9.0 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.3 18.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 2.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 5.0 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.2 16.3 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.2 9.3 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.2 3.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.2 4.2 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 47.2 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 2.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 6.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 4.0 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 2.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 5.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.4 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 4.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.8 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 1.4 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 4.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 3.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.1 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 5.9 REACTOME TRANSLATION Genes involved in Translation